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1. 发明授权

US08865896B2 Method for preparing adenine compound 有权
标题翻译：制备腺嘌呤化合物的方法
公开(公告)号：US08865896B2
公开(公告)日：2014-10-21
申请号：US12863291
申请日：2009-01-16
申请人： Kazuki Hashimoto , Wataru Katoda , Kazuhiko Takahashi , Ayumu Kurimoto
发明人： Kazuki Hashimoto , Wataru Katoda , Kazuhiko Takahashi , Ayumu Kurimoto
IPC分类号： C07D473/02 , C07D413/14 , C07D473/18
CPC分类号： C07D473/18
摘要： A method for producing adenine compound (1): wherein m and n are independently an integer of 2 to 5, R1 is C1-6 alkyl group, R2 and R3 are the same or different, and hydrogen atom, or C1-6 alkyl group, or R2 and R3 are combined with an adjacent nitrogen atom to form pyrrolidine, morpholine, piperidine, piperazine, etc., and R4 is C1-3 alkyl group, which comprises a step of reacting compound (2): and compound (3): in the presence of a boron-containing reducing agent.
摘要翻译：一种腺嘌呤化合物（1）的制造方法，其中m和n分别为2〜5的整数，R1为C1-6烷基，R2和R3相同或不同，氢原子或C1-6烷基，或R2和R3与相邻的氮原子结合形成吡咯烷，吗啉，哌啶，哌嗪等，R4为C1-3烷基，其包括使化合物（2）与化合物（3）反应的步骤：：在含硼还原剂的存在下。

2. 发明申请

US20110046369A1 METHOD FOR PREPARING ADENINE COMPOUND 有权
标题翻译：制备腺嘌呤化合物的方法
公开(公告)号：US20110046369A1
公开(公告)日：2011-02-24
申请号：US12863291
申请日：2009-01-16
申请人： Kazuki Hashimoto , Wataru Katoda , Kazuhiko Takahashi , Ayumu Kurimoto
发明人： Kazuki Hashimoto , Wataru Katoda , Kazuhiko Takahashi , Ayumu Kurimoto
IPC分类号： C07D473/18
CPC分类号： C07D473/18
摘要： A method for producing adenine compound (1): wherein m and n are independently an integer of 2 to 5, R1 is C1-6 alkyl group, R2 and R3 are the same or different, and hydrogen atom, or C1-6 alkyl group, or R2 and R3 are combined with an adjacent nitrogen atom to form pyrrolidine, morpholine, piperidine, piperazine, etc., and R4 is C1-3 alkyl group, which comprises a step of reacting compound (2): and compound (3): in the presence of a boron-containing reducing agent.
摘要翻译：一种腺嘌呤化合物（1）的制造方法，其中m和n分别为2〜5的整数，R1为C1-6烷基，R2和R3相同或不同，氢原子或C1-6烷基，或R2和R3与相邻的氮原子结合形成吡咯烷，吗啉，哌啶，哌嗪等，R4为C1-3烷基，其包括使化合物（2）与化合物（3）反应的步骤：：在含硼还原剂的存在下。

3. 发明申请

US20110054168A1 METHOD FOR PREPARING ADENINE COMPOUND 审中-公开
标题翻译：制备腺嘌呤化合物的方法
公开(公告)号：US20110054168A1
公开(公告)日：2011-03-03
申请号：US12863297
申请日：2009-01-16
申请人： Ayumu Kurimoto , Wataru Katoda , Kazuki Hashimoto , Kazuhiko Takashi
发明人： Ayumu Kurimoto , Wataru Katoda , Kazuki Hashimoto , Kazuhiko Takashi
IPC分类号： C07D473/18
CPC分类号： C07D473/18
摘要： A method for preparing compound (4): wherein m and n are independently an integer of 2 to 5, R1 is C1-6 alkyl group, R2 and R3 are combined with an adjacent nitrogen atom to form pyrrolidine, morpholine, thiomorpholine, etc., and R4 is C1-3 alkyl group, or a pharmaceutically acceptable salt, which is useful as a medicament, which comprises step (a) for preparing compound (2): wherein m, n, R1, R2 and R3 are the same as defined above, or its salt which comprises subjecting compound (1): wherein k is an integer of 1 or 2, R is hydrogen atom, halogen atom, etc., or a salt thereof to debenzylation reaction, and then step (b) for preparing compound (4) or a pharmaceutically acceptable salt which comprises reacting compound (2) or its salt prepared in the above step (a) or salt thereof and compound (3): wherein R4 is C1-3 alkyl group, in the presence of a boron-containing reducing agent.
摘要翻译：一种制备化合物（4）的方法：其中m和n独立地为2至5的整数，R 1为C 1-6烷基，R 2和R 3与相邻的氮原子结合形成吡咯烷，吗啉，硫代吗啉等。，和R4为C1-3烷基，或其药学上可接受的盐，其可用作药物，其包含用于制备化合物（2）的步骤（a）：其中m，n，R 1，R 2和R 3相同或其盐，其包括使化合物（1）：其中k为1或2的整数，R为氢原子，卤素原子等或其盐进行脱苄基化反应，然后步骤（b）为制备化合物（4）或其药学上可接受的盐，其包括使上述步骤（a）中制备的化合物（2）或其盐或其盐与化合物（3）反应：其中R 4为C 1-3烷基，在含硼还原剂。

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