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1. 发明授权

US07850977B2 Promoterless cassettes for expression of alphavirus structural proteins 有权
标题翻译：用于表达甲病毒结构蛋白的无启动盒
公开(公告)号：US07850977B2
公开(公告)日：2010-12-14
申请号：US12143320
申请日：2008-06-20
申请人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
发明人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
IPC分类号： A61K39/12 , C12N7/01 , C12N7/02 , C12N5/10 , C12N15/40 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/285 , A61K2039/5256 , C12N2710/24134 , C12N2770/36134 , C12N2770/36143
摘要： The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5′ replication recognition sequence, wherein at least one initiation codon has been removed from the 5′ replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3′ replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5′ and 3′ replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus nonstructural proteins.
摘要翻译：本发明提供了分离的RNA分子，其包含：a）甲病毒5'复制识别序列，其中至少一个起始密码子已从5'复制识别序列中除去; b）编码甲病毒结构蛋白的核苷酸序列; 和c）甲病毒3'复制识别序列，条件是RNA分子不含有引导（b）的核苷酸序列的转录的启动子，并且其中（a（a））的甲病毒5'和3'复制识别序列）和（c）在甲病毒非结构蛋白存在下直接复制RNA分子。

2. 发明申请

US20100183665A1 PROMOTERLESS CASSETTES FOR EXPRESSION OF ALPHA VIRUS STRUCTURAL PROTEINS 有权
标题翻译：用于表达ALPHA病毒结构蛋白的无乳剂
公开(公告)号：US20100183665A1
公开(公告)日：2010-07-22
申请号：US12665497
申请日：2008-06-20
申请人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
发明人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
IPC分类号： A61K39/12 , C07H21/02 , C12P19/34 , A61K31/7088 , C12N5/10 , C12N15/63 , A61P31/12
CPC分类号： C12N15/86 , A61K39/12 , A61K39/285 , A61K2039/5256 , C12N2710/24134 , C12N2770/36134 , C12N2770/36143
摘要： The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5′ replication recognition sequence, wherein at least one initiation codon has been removed from the 5′ replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3′ replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5′ and 3′ replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus non-structural proteins.
摘要翻译：本发明提供了分离的RNA分子，其包含：a）甲病毒5'复制识别序列，其中至少一个起始密码子已从5'复制识别序列中除去; b）编码甲病毒结构蛋白的核苷酸序列; 和c）甲病毒3'复制识别序列，条件是RNA分子不含有引导（b）的核苷酸序列的转录的启动子，并且其中（a（a））的甲病毒5'和3'复制识别序列）和（c）在甲病毒非结构蛋白存在下直接复制RNA分子。

3. 发明授权

US08460913B2 Promoterless cassettes for expression of alpha virus structural proteins 有权
标题翻译：用于表达α病毒结构蛋白的无启动子盒
公开(公告)号：US08460913B2
公开(公告)日：2013-06-11
申请号：US12665497
申请日：2008-06-20
申请人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
发明人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
IPC分类号： C12N7/02
CPC分类号： C12N15/86 , A61K39/12 , A61K39/285 , A61K2039/5256 , C12N2710/24134 , C12N2770/36134 , C12N2770/36143
摘要： The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5′ replication recognition sequence, wherein at least one initiation codon has been removed from the 5′ replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3′ replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5′ and 3′ replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus non-structural proteins.
摘要翻译：本发明提供了分离的RNA分子，其包含：a）甲病毒5'复制识别序列，其中至少一个起始密码子已从5'复制识别序列中除去; b）编码甲病毒结构蛋白的核苷酸序列; 和c）甲病毒3'复制识别序列，条件是RNA分子不含有引导（b）的核苷酸序列的转录的启动子，并且其中（a（a））的甲病毒5'和3'复制识别序列）和（c）在甲病毒非结构蛋白存在下直接复制RNA分子。

4. 发明申请

US20090075384A1 PROMOTERLESS CASSETTES FOR EXPRESSION OF ALPHAVIRUS STRUCTURAL PROTEINS 有权
标题翻译：表达ALPHAVIRUS结构蛋白的无瘤体
公开(公告)号：US20090075384A1
公开(公告)日：2009-03-19
申请号：US12143320
申请日：2008-06-20
申请人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
发明人： Kurt I. Kamrud , Jonathan F. Smith , Maureen Maughan
IPC分类号： C12N15/09 , C07H21/02 , A61K35/76 , A61K39/12 , C12N5/10 , C12N15/63
CPC分类号： C12N15/86 , A61K39/12 , A61K39/285 , A61K2039/5256 , C12N2710/24134 , C12N2770/36134 , C12N2770/36143
摘要： The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5′ replication recognition sequence, wherein at least one initiation codon has been removed from the 5′ replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3′ replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5′ and 3′ replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus nonstructural proteins.
摘要翻译：本发明提供分离的RNA分子，其包含：a）甲病毒5'复制识别序列，其中至少一个起始密码子已经从5'复制识别序列中去除; b）编码甲病毒结构蛋白的核苷酸序列; 和c）甲病毒3'复制识别序列，条件是RNA分子不含有引导（b）的核苷酸序列的转录的启动子，并且其中（a（a））的甲病毒5'和3'复制识别序列）和（c）在甲病毒非结构蛋白存在下直接复制RNA分子。

5. 发明申请

US20050123555A1 Alphavirus vectors and virosomes with modified HIV genes for use as vaccines 审中-公开
标题翻译：甲病毒载体和具有修饰的HIV基因的病毒体用作疫苗
公开(公告)号：US20050123555A1
公开(公告)日：2005-06-09
申请号：US10929234
申请日：2004-08-30
申请人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
发明人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
IPC分类号： A61K39/00 , A61K39/21 , C07K14/16 , C07K14/18 , C12N7/02 , C12Q1/68 , A61K39/29 , C07H21/02 , C12N7/00 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/575 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2770/36143 , C12N2770/36151
摘要： The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof of a human immunodeficiency virus, 2) an isolated nucleic acid encoding a gag gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the gag gene product or immunogenic fragment thereof is modified to inhibit formation of virus-like particles containing the gag gene product or the immunogenic fragment thereof and their release from a cell, and 3) an isolated nucleic acid encoding a pol gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the pol gene product or immunogenic fragment thereof is modified to inhibit protease, integrase, RNase H and/or reverse transcriptase activity, and wherein the nucleic acids are each contained within a separate alphavirus replicon particle.
摘要翻译：本发明提供方法和组合物，其包含包含两种或多种分离的核酸的甲型病毒复制子颗粒群，所述分离的核酸选自1）编码人免疫缺陷病毒的env基因产物或其免疫原性片段的分离的核酸，2）分离的核酸酸编码人免疫缺陷病毒的gag基因产物或其免疫原性片段，其中修饰gag基因产物或其免疫原性片段以抑制含有gag基因产物或其免疫原性片段的病毒样颗粒的形成，以及它们从细胞，以及3）编码人免疫缺陷病毒的pol基因产物或其免疫原性片段的分离的核酸，其中pol基因产物或其免疫原性片段被修饰以抑制蛋白酶，整合酶，RNA酶H和/或逆转录酶活性，并且其中所述核酸各自包含在单独的阿夫法韦内我们复制品颗粒。

6. 发明申请

US20120128714A1 Alphavirus Replicon Particles Expressing TRP2 审中-公开
标题翻译：表达TRP2的甲病毒复制子颗粒
公开(公告)号：US20120128714A1
公开(公告)日：2012-05-24
申请号：US13263369
申请日：2010-04-08
申请人： Jedd D. Wolchok , Francesca Avogadri , Robert A. Olmsted , Maureen Maughan
发明人： Jedd D. Wolchok , Francesca Avogadri , Robert A. Olmsted , Maureen Maughan
IPC分类号： A61K39/00 , A61P35/00 , A61P35/04 , A61P37/04
CPC分类号： A61K39/0011 , A61K2039/5254 , A61K2039/5256
摘要： The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and/or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogenic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered.
摘要翻译：通过向受试者施用包含甲病毒颗粒的药物组合物，特别是委内瑞兰马脑炎病毒复制子颗粒，其表达黑素瘤抗原多巴胺互变异构酶（DCT，TRP2）的细胞中可以诱导或显着增加对黑素瘤细胞和肿瘤的免疫应答受试者，在给药时未患黑素瘤的受试者中，黑素瘤受试者的肿瘤消退和/或抑制，黑素瘤的发生或复发的风险降低和/或黑色素瘤的严重程度降低。本文所述的药物组合物可以与其它治疗剂联合使用，其可以在多于一次的情况下施用，并且可以与其它组合物（例如蛋白质或其它免疫原性组合物和/或佐剂）的施用组合，具有有益效果对其已被施用的人或动物受试者。

7. 发明授权

US06783939B2 Alphavirus vectors and virosomes with modified HIV genes for use in vaccines 有权
标题翻译：甲病毒载体和具有修饰的HIV基因的病毒体用于疫苗
公开(公告)号：US06783939B2
公开(公告)日：2004-08-31
申请号：US09991258
申请日：2001-11-16
申请人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
发明人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/575 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2770/36143 , C12N2770/36151
摘要： The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof of a human immunodeficiency virus, 2) an isolated nucleic acid encoding a g&agr;g gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the g&agr;g gene product or immunogenic fragment thereof is modified to inhibit formation of virus-like particles containing the g&agr;g gene product or the immunogenic fragment thereof and their release from a cell, and 3) an isolated nucleic acid encoding a pol gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the pol gene product or immunogenic fragment thereof is modified to inhibit protease, integrase, RNase H and/or reverse transcriptase activity, and wherein the nucleic acids are each contained within a separate alphavirus replicon particle.
摘要翻译：本发明提供方法和组合物，其包含包含两种或多种分离的核酸的甲型病毒复制子颗粒群，所述分离的核酸选自1）编码人免疫缺陷病毒的env基因产物或其免疫原性片段的分离的核酸，2）分离的核酸编码人免疫缺陷病毒的galphag基因产物或其免疫原性片段的酸，其中所述galphag基因产物或其免疫原性片段被修饰以抑制含有galphag基因产物或其免疫原性片段的病毒样颗粒的形成及其从细胞，以及3）编码人免疫缺陷病毒的pol基因产物或其免疫原性片段的分离的核酸，其中pol基因产物或其免疫原性片段被修饰以抑制蛋白酶，整合酶，RNA酶H和/或逆转录酶活性，并且其中所述核酸各自包含在分离物内食用甲病毒复制子颗粒。

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