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1. 发明授权

US07829665B2 Macrocyclic inhibitors of hepatitis C virus replication 有权
标题翻译：丙型肝炎病毒复制的大环抑制剂
公开(公告)号：US07829665B2
公开(公告)日：2010-11-09
申请号：US11491126
申请日：2006-07-21
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07K7/50
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

2. 发明申请

US20090148407A1 Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication 审中-公开
标题翻译：丙型肝炎病毒复制的新型大环抑制剂
公开(公告)号：US20090148407A1
公开(公告)日：2009-06-11
申请号：US11996902
申请日：2006-07-17
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/21 , C07K5/12 , A61K38/12 , C07D209/18 , C12N9/99 , A61K39/395
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式（I）至通式（VIII）的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

3. 发明授权

US08299021B2 Macrocyclic inhibitors of hepatitis C virus replication 失效
标题翻译：丙型肝炎病毒复制的大环抑制剂
公开(公告)号：US08299021B2
公开(公告)日：2012-10-30
申请号：US13450885
申请日：2012-04-19
申请人： Lawrence M Blatt , Scott D Seiwert , Steven W Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M Blatt , Scott D Seiwert , Steven W Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/00
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

4. 发明申请

US20120208995A1 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 失效
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：US20120208995A1
公开(公告)日：2012-08-16
申请号：US13450885
申请日：2012-04-19
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07D498/18
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

5. 发明申请

US20090169510A1 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：US20090169510A1
公开(公告)日：2009-07-02
申请号：US12106234
申请日：2008-04-18
申请人： Lawrence M Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07K5/12 , A61K38/12 , A61K38/21 , C12N9/99 , A61P31/12
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

6. 发明申请

US20070054842A1 Novel macrocyclic inhibitors of hepatitis C virus replication 有权
标题翻译：丙型肝炎病毒复制的新型大环抑制剂
公开(公告)号：US20070054842A1
公开(公告)日：2007-03-08
申请号：US11491126
申请日：2006-07-21
申请人： Lawrence Blatt , Scott Seiwert , Steven Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence Blatt , Scott Seiwert , Steven Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/12
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

7. 发明申请

US20060098085A1 Display management during a multi-party conversation 有权
公开(公告)号：US20060098085A1
公开(公告)日：2006-05-11
申请号：US10982655
申请日：2004-11-05
申请人： Paul Nichols , Myra Rice , Carey Moulton
发明人： Paul Nichols , Myra Rice , Carey Moulton
IPC分类号： H04N7/14
CPC分类号： H04M1/72544 , H04M1/72583 , H04M2250/22 , H04M2250/62 , H04N2007/145
摘要： A method and apparatus for managing a display during a teleconference between a primary participant and one or more secondary participants is described herein. According to the present invention, a primary image corresponding to the primary participant and a subset of secondary images that correspond to secondary participants are displayed on first and second sections of the display, respectively. By scrolling through the secondary images during the teleconference, different subsets of the secondary images may be displayed. Another exemplary embodiment of the present invention comprises superimposing an image over another image. By adjusting the opacity of at least one of the images, the user may view and/or access both images during the teleconference. According to another exemplary embodiment, a user may interchange the primary image with a selected one of the secondary images, responsive to user input, to focus on the selected image.

8. 发明授权

US6065901A System and method of gas dispersal and collection for preventing gas contamination 失效
标题翻译：用于防止气体污染的气体分散和收集系统和方法
公开(公告)号：US6065901A
公开(公告)日：2000-05-23
申请号：US809861
申请日：1997-04-02
申请人： Richard Stevens , Paul Nichols , Malcolm Martin
发明人： Richard Stevens , Paul Nichols , Malcolm Martin
IPC分类号： E02D31/00 , E02B13/00
CPC分类号： E02D31/00 , Y10S454/909
摘要： A system for use in preventing a flow of gas from a gas-containing region (20) to an adjacent region (22) and/or for collecting or dispersing gas at the interface between the regions, comprising a composite barrier (10) installed so as to separate the two regions (20, 22), the barrier (10) comprising a gas-impermeable layer (11) and a gas-permeable membrane (12) interconnected so as to define an interspace (16) between them and arranged with the permeable layer (12) facing the region containing gas (20) to be dispersed or collected. A method is also described comprising the steps of connecting an aperture (36) or aperture of the barrier communicating with the interspace (16) thereof to pumping means (37) which, in operation, act to pump gas into or out from the interspace (16) by creating a pressure differential across the permeable membrane such as to cause gas to flow therethrough across a major proportion of its surface area.
摘要翻译： PCT No.PCT / GB95 / 02364 Sec。 371日期1997年4月2日 102（e）日期1997年4月2日PCT提交1995年10月5日PCT公布。出版物WO96 / 11304 PCT 日期1996年4月18日一种用于防止气体从含气体区域（20）流动到相邻区域（22）和/或用于在区域之间的界面处收集或分散气体的系统，其包括复合屏障（10），以分离所述两个区域（20,22），所述阻挡层（10）包括不透气层（11）和气体可渗透膜（12），所述气体可渗透膜互相连接以限定空隙（16）并且配置有面向包含气体（20）的区域的可渗透层（12）以被分散或收集。还描述了一种方法，其包括以下步骤：将与所述空间（16）连通的所述屏障的孔（36）或孔连接到泵送装置（37），所述泵装置（37）在作用中用于将气体泵入或从所述空间中排出 16）通过在渗透膜两端产生压差，使得气体在其表面积的主要比例上流过其中。

9. 发明申请

US20070276145A1 Method of Preparing a Ring Compound Having Two Adjacent Chiral Centers 审中-公开
标题翻译：制备具有两个相邻手性中心的环化合物的方法
公开(公告)号：US20070276145A1
公开(公告)日：2007-11-29
申请号：US10554135
申请日：2004-04-19
申请人： Lisa Schultze , John Demattei , Brad Barnett , Anthony Piscopio , Paul Nichols
发明人： Lisa Schultze , John Demattei , Brad Barnett , Anthony Piscopio , Paul Nichols
IPC分类号： C07D207/16 , C07C201/12
CPC分类号： C07D207/277 , C07C201/12 , C07C205/53
摘要： A method of synthesizing a chiral compound having a quaternary carbon atom bearing diastereotopic groups from (a) a nitroolefin and (b) an α-substituted β-dicarbonyl or an equivalent compound having an acidic C—H moiety compound is disclosed. A subsequent intramolecular reaction between one of the substituents comprising the stereogenic carbon atom and one of the diastereotopic groups comprising the quaternary carbon atom creates a new compound having two contiguous stereogenic centers, one of which is quaternary, with control over the relative stereochemistry.
摘要翻译：公开了一种合成具有（a）硝基烯烃和（b）具有酸性C-H部分化合物的α-取代的β-二羰基或等价化合物的具有非对映体基团的季碳原子的手性化合物的方法。包含立体碳原子的一个取代基和包含季碳原子的非对映体基团之一之间的随后的分子内反应产生具有两个连续的立体中心的新化合物，其中一个是季铵化合物，可控制相对的立体化学。

10. 发明申请

US20060141990A1 SYSTEM AND METHOD OF PREDICTING USER INPUT TO A MOBILE TERMINAL 有权
标题翻译：用户输入到移动终端的系统和方法
公开(公告)号：US20060141990A1
公开(公告)日：2006-06-29
申请号：US10905909
申请日：2005-01-26
申请人： Robert Zak , Peter Mangum , Michael Welch , Paul Nichols , Myra Rice
发明人： Robert Zak , Peter Mangum , Michael Welch , Paul Nichols , Myra Rice
IPC分类号： H04Q7/32
CPC分类号： H04M1/72522 , G06F3/0237 , H04M1/2745 , H04M1/274583 , H04M2001/274541 , H04M2250/22 , H04M2250/56
摘要： A method of predicting user input to a mobile terminal is presented. The mobile terminal creates a raw user input data record comprised of input to the mobile terminal. A contextual data record is appended to the raw user input data record and both are stored. Another process processes the records contained in the raw user input database to identify repetitive patterns of user input. Identified patterns are stored in a recognized input pattern database. The mobile terminal then monitors current input and compares it to the repetitive patterns stored in the recognized input pattern database. Upon matching the current input to a repetitive pattern within a specified tolerance, the mobile terminal prompts the user to allow the mobile terminal to complete the process of inputting the data.
摘要翻译：提出了一种预测用户对移动终端输入的方法。移动终端创建包括输入到移动终端的原始用户输入数据记录。上下文数据记录附加到原始用户输入数据记录，并且两者都被存储。另一个进程处理原始用户输入数据库中包含的记录，以识别用户输入的重复模式。识别的模式存储在识别的输入模式数据库中。然后，移动终端监视当前输入并将其与存储在识别的输入模式数据库中的重复模式进行比较。当将当前输入匹配到指定容限内的重复模式时，移动终端提示用户允许移动终端完成输入数据的处理。

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