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1. 发明授权

US08080050B2 Prosthesis delivery systems and methods 有权
标题翻译：假体输送系统和方法
公开(公告)号：US08080050B2
公开(公告)日：2011-12-20
申请号：US11633724
申请日：2006-12-05
申请人： Andrew L. Chiang , Lee Bolduc
发明人： Andrew L. Chiang , Lee Bolduc
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/954 , A61F2/966 , A61F2002/065 , A61F2002/9511 , A61F2002/9517 , A61F2002/9665 , A61F2220/0075
摘要： Apparatus and method deliver a prosthesis into a hollow body organ or blood vessel. The systems and methods make use of a catheter. A carrier on the distal end of the catheter is sized and configured to carry the prosthesis. A release mechanism and an enclosure mechanism on the distal end are operable to retain and enclose the prosthesis on the carrier. The release mechanism and the enclosure mechanism are also operable to selectively expose and release the prosthesis from the carrier for deployment in the hollow body organ or blood vessel.
摘要翻译：装置和方法将假体递送到中空身体器官或血管中。系统和方法利用导管。在导管的远端上的载体的尺寸和构造用于承载假体。远端上的释放机构和封闭机构可操作以将假体保持并包围在载体上。释放机构和封闭机构还可操作以选择性地将假体从载体上释放并释放，以展开在中空体器官或血管中。

2. 发明授权

US07637932B2 Devices, systems, and methods for prosthesis delivery and implantation 有权
标题翻译：用于假体输送和植入的装置，系统和方法
公开(公告)号：US07637932B2
公开(公告)日：2009-12-29
申请号：US11255116
申请日：2005-10-20
申请人： Lee Bolduc , Gilbert Laroya , Joshua Stafford
发明人： Lee Bolduc , Gilbert Laroya , Joshua Stafford
IPC分类号： A61F2/06
CPC分类号： A61B17/064 , A61B17/068 , A61B50/20 , A61B50/30 , A61B2017/0649 , A61B2017/0688 , A61B2017/2905 , A61F2/07 , A61F2/86 , A61F2/88 , A61F2/89 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2002/9534 , A61F2220/0075 , Y10T29/49947
摘要： Devices, systems, and methods use a catheter device sized and configured for introduction to a targeted site in a hollow body organ or blood vessel. The catheter device includes a first release mechanisms coupled to the prosthesis to secure at least one region of the prosthesis to the catheter shaft, and a second release mechanism coupled to the prosthesis in cooperation with the first release mechanism to prevent full release of the at least one region of the at least one region of the prosthesis from the catheter shaft after actuation of the first release mechanism. A fastening device sized and configured for introduction to the targeted site in the hollow body organ or blood vessel occupied by the catheter device, includes an actuator to deploy a fastener in the at least one region of the prosthesis after actuation of the first release mechanism and before actuation of the second release mechanism.
摘要翻译：装置，系统和方法使用尺寸和构造用于引入中空身体器官或血管中的目标部位的导管装置。导管装置包括联接到假体的第一释放机构以将假体的至少一个区域固定到导管轴，以及与第一释放机构协作地联接到假体的第二释放机构，以防止至少完全释放在第一释放机构致动之后，从导管轴将假体的至少一个区域的一个区域。紧固装置的尺寸和构造用于引入到由导管装置占据的中空体器官或血管中的目标部位，包括在第一释放机构致动之后将紧固件展开在假体的至少一个区域中的致动器，以及在第二释放机构的致动之前。

3. 发明授权

US07491232B2 Catheter-based fastener implantation apparatus and methods with implantation force resolution 有权
标题翻译：基于导管的紧固件植入装置和具有植入力分辨率的方法
公开(公告)号：US07491232B2
公开(公告)日：2009-02-17
申请号：US10669881
申请日：2003-09-24
申请人： Lee Bolduc , Juan C. Parodi
发明人： Lee Bolduc , Juan C. Parodi
IPC分类号： A61F2/06
CPC分类号： A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/00734 , A61B2017/0647 , A61B2017/0648 , A61B2017/0649 , A61B2017/2905 , A61F2/064 , A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/065
摘要： Apparatus and methods implant a fastener in a targeted body region, e.g., a hollow body cavity or an intraluminal space. The apparatus and methods deploy in the targeted body region a fastener attachment assembly that carries an actuated member. The actuated member is selectively operable to generate an implantation force to implant a fastener into tissue within the targeted body region. The fastener can be implanted, e.g., to secure a prosthesis, e.g., an endovascular graft. The systems and apparatus apply a resolution force at or near the actuated member, thereby making possible a stable and dependable catheter-based fastening platform.
摘要翻译：装置和方法将紧固件植入目标身体区域，例如中空体腔或管腔内空间。装置和方法在目标身体区域中展开携带致动构件的紧固件附接组件。致动构件可选择性地操作以产生植入力，以将紧固件植入到目标身体区域内的组织中。紧固件可以植入，例如以固定假体，例如血管内移植物。系统和装置在致动构件处或附近施加分辨力，从而使得可能的稳定且可靠的基于导管的紧固平台成为可能。

4. 发明申请

US20080097523A1 Surgical helical fastener with applicator 审中-公开
标题翻译：手术螺旋紧固件与敷料器
公开(公告)号：US20080097523A1
公开(公告)日：2008-04-24
申请号：US11978893
申请日：2007-10-30
申请人： Lee Bolduc , Thomas Kramer , Brian Hodges , Tim McCoy , John Lunsford
发明人： Lee Bolduc , Thomas Kramer , Brian Hodges , Tim McCoy , John Lunsford
IPC分类号： A61B17/064 , A61B17/068
CPC分类号： A61B17/064 , A61B17/0469 , A61B17/068 , A61B17/1285 , A61B2017/00004 , A61B2017/06076 , A61B2017/06171 , A61B2017/0649 , A61F2/0063 , Y10S227/901 , Y10S227/902 , Y10S606/91 , Y10S606/916
摘要： A helical fastener having a high retentive surface area is provided and has a first end for enhancing penetration into tissue and a second end comprising a coil sectioning a diameter of the fastener for receiving longitudinal and rotational forces. The helical fasteners are attached to body tissue by a fastener applicator having a proximal portion comprising a handle and an actuator and an elongate distal portion for housing a plurality of fasteners. A transferring action of the actuator provides longitudinal and rotational movement of the fasteners out of the distal portion and into body tissue.
摘要翻译：提供具有高保持表面积的螺旋紧固件，并具有用于增强穿入组织的第一端和包括用于接收纵向和旋转力的用于紧固紧固件的直径的线圈的第二端。螺旋紧固件通过紧固件施用器附接到身体组织，所述紧固件施加器具有包括手柄和致动器的近侧部分和用于容纳多个紧固件的细长远侧部分。致动器的转移动作提供紧固件从远端部分到身体组织的纵向和旋转运动。

5. 发明申请

US20070032863A1 Catheter-based fastener implantation methods 有权
标题翻译：基于导管的紧固件植入方法
公开(公告)号：US20070032863A1
公开(公告)日：2007-02-08
申请号：US11580584
申请日：2006-10-13
申请人： Lee Bolduc
发明人： Lee Bolduc
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/064 , A61B17/068 , A61B17/122 , A61B2017/0647 , A61B2017/0649 , A61B2017/081 , A61F2/848 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2230/0013
摘要： Methods implant one or more fastening structure(s) in a targeted body region, e.g., within a hollow body organ or an intraluminal space. The fastening structure(s) are implanted to a vessel wall, and serve to secure a prosthesis within the hollow body organ or intraluminal space.
摘要翻译：方法将一个或多个紧固结构植入目标体区，例如在中空身体器官或管腔内空间内。将紧固结构植入血管壁，并用于将假体固定在中空身体器官或腔内空间内。

6. 发明申请

US20070021829A1 Endovascular aneurysm repair method 有权
标题翻译：血管内动脉瘤修复方法
公开(公告)号：US20070021829A1
公开(公告)日：2007-01-25
申请号：US11540427
申请日：2006-09-29
申请人： Lee Bolduc
发明人： Lee Bolduc
IPC分类号： A61F2/06
CPC分类号： A61B17/10 , A61B17/064 , A61B17/068 , A61B17/072 , A61B2017/00292 , A61B2017/00778 , A61B2017/0646 , A61B2017/0649 , A61F2/06 , A61F2/064 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2002/061 , A61F2002/065 , A61F2002/067 , A61F2002/075 , Y10S623/903
摘要： A method for repairing a diseased or damaged section of an aorta (i) introduces an intraluminal directing device from a remote access site to a location within a prosthesis at a target site in an aorta where the diseased or damaged section exists, the intraluminal directing device including a deflectable distal region; (ii) establishes a path to a desired fastening site on the prosthesis by manipulating the intraluminal directing device within the prosthesis to orient the distal region with respect to the desired fastening site; (iii) introduces from an intraluminal fastener applier, that is introduced along the path established in (ii), at least one tissue-piercing fastener into tissue at the desired fastening site to anchor the prosthesis; (iv) establishes a path to a different desired fastening site on the prosthesis by manipulating the intraluminal directing device within the prosthesis to orient the distal region with respect to the different desired fastening site; (v) introduces from an intraluminal fastener applier, that is introduced through the path established in (iv), at least one tissue-piercing fastener into tissue at the different desired fastening site to further anchor the prosthesis; and (vi) repeats (iv) and (v) until a desired plurality of tissue-piercing fasteners are introduced into tissue to anchor the prosthesis.
摘要翻译：用于修复主动脉的病变或损伤部分的方法（i）将管腔内引导装置从远程进入位置引入到患有或受损部分的主动脉中的靶位置处的假体内的位置，管腔内引导装置包括可偏转的远端区域; （ii）通过操纵假体内的管腔内引导装置来建立相对于期望的紧固位置定向远侧区域的通向假体上期望的紧固部位的路径; （iii）从沿着所述（ii）中建立的路径引入的腔内紧固件敷贴器引入至少一个组织刺穿紧固件到达期望的紧固位置处的组织以锚定假体; （iv）通过操纵所述假体内的管腔内引导装置来建立相对于所述不同所需紧固位置定向所述远侧区域的通向所述假体上的不同期望紧固部位的路径; （v）从通过（iv）中建立的路径引入的管腔内紧固件施加器将至少一个组织刺穿紧固件引入到不同所需紧固位置处的组织中以进一步锚定假体; 和（vi）重复（iv）和（v），直到将期望的多个组织刺穿紧固件引入组织以锚定假体。

7. 发明申请

US20050256531A9 Catheter-based fastener implantation apparatus and methods with implantation force resolution 有权
标题翻译：基于导管的紧固件植入装置和具有植入力分辨率的方法
公开(公告)号：US20050256531A9
公开(公告)日：2005-11-17
申请号：US10669881
申请日：2003-09-24
申请人： Lee Bolduc , Juan Parodi
发明人： Lee Bolduc , Juan Parodi
IPC分类号： A61B20060101 , A61B17/00 , A61B17/064 , A61B17/068 , A61B17/08 , A61F2/06
CPC分类号： A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/00734 , A61B2017/0647 , A61B2017/0648 , A61B2017/0649 , A61B2017/2905 , A61F2/064 , A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/065
摘要： Apparatus and methods implant a fastener in a targeted body region, e.g., a hollow body cavity or an intraluminal space. The apparatus and methods deploy in the targeted body region a fastener attachment assembly that carries an actuated member. The actuated member is selectively operable to generate an implantation force to implant a fastener into tissue within the targeted body region. The fastener can be implanted, e.g., to secure a prosthesis, e.g., an endovascular graft. The systems and apparatus apply a resolution force at or near the actuated member, thereby making possible a stable and dependable catheter-based fastening platform.
摘要翻译：装置和方法将紧固件植入目标身体区域，例如中空体腔或管腔内空间。装置和方法在目标身体区域中展开携带致动构件的紧固件附接组件。致动构件可选择性地操作以产生植入力，以将紧固件植入到目标身体区域内的组织中。紧固件可以植入，例如以固定假体，例如血管内移植物。系统和装置在致动构件处或附近施加分辨力，从而使得可能的稳定且可靠的基于导管的紧固平台成为可能。

8. 发明申请

US20050240260A1 Endovascular aneurysm repair system 有权
标题翻译：血管内动脉瘤修复系统
公开(公告)号：US20050240260A1
公开(公告)日：2005-10-27
申请号：US11166411
申请日：2005-06-24
申请人： Lee Bolduc
发明人： Lee Bolduc
IPC分类号： A61B17/00 , A61B17/064 , A61B17/068 , A61F2/06
CPC分类号： A61B17/10 , A61B17/064 , A61B17/068 , A61B17/072 , A61B2017/00292 , A61B2017/00778 , A61B2017/0646 , A61B2017/0649 , A61F2/06 , A61F2/064 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2002/061 , A61F2002/065 , A61F2002/067 , A61F2002/075 , Y10S623/903
摘要： Method and apparatus for implanting radially expandable prostheses in the body lumens rely on tacking or anchoring of the prostheses with separately introduced fasteners. The prostheses may be self-expanding or balloon expandable. After initial placement, a fastener applier system is introduced within the expanded prostheses to deploy a plurality of fasteners at least one prosthesis end, usually as each end of the prosthesis. The fasteners are usually helical fasteners which are delivered from a helical track in the fastener applier by rotation with a rotator wire. The fasteners will be applied singly, typically in circumferentially spaced-apart patterns about the interior of each end of the prosthesis.
摘要翻译：用于将可径向扩张的假体植入体腔内的方法和装置依赖于使用单独引入的紧固件来修补或锚定假体。假体可以是自膨胀的或球囊可膨胀的。在初始放置之后，将紧固件施加器系统引入到扩展的假体内以将至少一个假体端部（通常作为假体的每个端部）展开多个紧固件。紧固件通常是螺旋形紧固件，其通过旋转线旋转而从紧固件施加器中的螺旋轨道输送。紧固件将单独施加，通常围绕假体的每个端部的内部沿周向间隔开的图案。

9. 发明授权

US06929661B2 Multi-lumen prosthesis systems and methods 有权
公开(公告)号：US06929661B2
公开(公告)日：2005-08-16
申请号：US10693255
申请日：2003-10-24
申请人： Lee Bolduc , Andrew L. Chiang
发明人： Lee Bolduc , Andrew L. Chiang
IPC分类号： A61B17/064 , A61B17/068 , A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2220/0075
摘要： Systems and methods introduce and deploy a multi-lumen prosthesis into a blood vessel or hollow body organ. The prosthesis has a trunk divided by an internal septum, which defines, within at least a portion of the trunk interior, a multi-lumen flow channel configuration. A lumen extension component can be sized and configured to be fitted within at least one of the interior lumens to define an extended lumen.

10. 发明授权

US5582616A Surgical helical fastener with applicator 失效
公开(公告)号：US5582616A
公开(公告)日：1996-12-10
申请号：US286878
申请日：1994-08-05
申请人： Lee Bolduc , Thomas A. Kramer , Brian A. Hodges , Tim McCoy , John Lunsford
发明人： Lee Bolduc , Thomas A. Kramer , Brian A. Hodges , Tim McCoy , John Lunsford
IPC分类号： A61B17/08 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/10 , A61B17/128 , A61F2/00
CPC分类号： A61B17/064 , A61B17/068 , A61B17/0469 , A61B17/1285 , A61B2017/00004 , A61B2017/06076 , A61B2017/06171 , A61B2017/0649 , A61F2/0063 , Y10S227/901 , Y10S227/902 , Y10S606/91 , Y10S606/916
摘要： A helical fastener having a high retentive surface area is provided and has a first end for enhancing penetration into tissue and a second end comprising a coil sectioning a diameter of the fastener for receiving longitudinal and rotational forces. The helical fasteners are attached to body tissue by a fastener applicator having a proximal portion comprising a handle and an actuator and an elongate distal portion for housing a plurality of fasteners. A transferring action of the actuator provides longitudinal and rotational movement of the fasteners out of the distal portion and into body tissue.

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