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1. 发明申请

US20190298715A1 IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY 审中-公开
公开(公告)号：US20190298715A1
公开(公告)日：2019-10-03
申请号：US16338085
申请日：2017-09-29
申请人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Gregory Motz , Konstantinos John Mavrakias , Jinbiao Liu , Lei Liu , Qiangang Zheng , Guoliang Xun , Qitao Xiao
IPC分类号： A61K31/496 , A61K31/444 , C12N15/113 , A61K31/404 , A61K35/17
摘要： Provided herein is the use of LSD1 inhibitors in connection with use and manufacture of immune effector cells (e.g., T cells, NK cells), e.g., engineered to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.

2. 发明申请

US20190196448A1 Method for Simulating Daylight Performance of Buildings Based on Regional Daylight Climate Data 审中-公开
公开(公告)号：US20190196448A1
公开(公告)日：2019-06-27
申请号：US16010497
申请日：2018-06-17
申请人： Cheng Sun , Yunsong Han , Ying Zi , Dagang Qu , Yongheng Jia , Lei Liu , Hong Yu
发明人： Cheng Sun , Yunsong Han , Ying Zi , Dagang Qu , Yongheng Jia , Lei Liu , Hong Yu
IPC分类号： G05B19/4099 , B33Y50/02
摘要： The present invention provides a method for simulating daylight performance of buildings based on regional daylight climate data. The method comprises the steps of: establishing a regional sky luminance distribution database from measured data; mapping sky luminance data to an artificial sky lamp group; using a 3D printing machine to fabricate a scaled physical model based on real parameters of the building to be simulated; and using the scaled physical model in the artificial sky integrated with regional sky luminance distribution data to make the daylight performance simulation. This method can achieve high-precision simulation of the daylight performance of buildings by using regional sky daylight climate data with a highly accurate physical model of the building.

3. 发明申请

US20150283318A1 Methods to detect and treat diseases 审中-公开
标题翻译：检测和治疗疾病的方法
公开(公告)号：US20150283318A1
公开(公告)日：2015-10-08
申请号：US14246117
申请日：2014-04-06
申请人： Tianxin Wang , Wenbin Ma , Yiwang Chen , Lei Liu
发明人： Tianxin Wang , Wenbin Ma , Yiwang Chen , Lei Liu
IPC分类号： A61M1/36 , A61N5/10 , A61B18/04 , A61B18/18 , A61B18/02 , G01N33/48 , A61B18/20
CPC分类号： A61M1/3679 , A61B18/02 , A61B18/04 , A61B18/1815 , A61B18/20 , A61B2018/00577 , A61M1/3472 , A61M1/3486 , A61M1/3621 , A61M1/3681 , A61M1/3683 , A61M1/3687 , A61M2202/0415 , A61M2205/053 , A61M2205/75 , A61N5/10 , G01N33/48
摘要： The current invention discloses methods to treat disease caused by virus infection, bacterial infection, parasites infection, autoimmune disease, disease caused by production of unwanted antibodies, sepsis as well as methods to treat cancer and methods for virus infection detection using blood purification method. The current invention provides a method to treat pathogen infection by inactivating the pathogens in the blood. During the treatment, blood is withdrawn from a patient and is separated into its plasma and cellular components. The plasma portion is treated with physical means such as UV radiation to inactivate the pathogens inside and then is returned to the patient. The current invention also provide a method to treat cancer especially to prevent tumor metastasis and tumor recurrence by removing and/or inactivating (e.g. killing) the circulating tumor cells (CTC) in the blood after removing the tumor or treating the tumor with therapeutical means.
摘要翻译：本发明公开了使用血液净化方法治疗由病毒感染，细菌感染，寄生虫感染，自身免疫病，由不想要的抗体产生引起的疾病，败血症以及治疗癌症的方法等疾病的方法。本发明提供了通过灭活血液中的病原体来治疗病原体感染的方法。在治疗期间，将血液从患者中取出并分离成其血浆和细胞组分。用诸如UV辐射的物理手段处理血浆部分以使内部的病原体灭活，然后返回到患者体内。本发明还提供了一种治疗癌症的方法，特别是通过在除去肿瘤之后除去和/或灭活（例如杀死）血液中的循环肿瘤细胞（CTC）或用治疗方法治疗肿瘤来预防肿瘤转移和肿瘤复发。

4. 发明授权

US09125418B2 Agricultural compositions 有权
标题翻译：农作物
公开(公告)号：US09125418B2
公开(公告)日：2015-09-08
申请号：US12369123
申请日：2009-02-11
申请人： Kuide Qin , Lei Liu
发明人： Kuide Qin , Lei Liu
IPC分类号： A01N59/16 , A01N25/04 , A01N25/30 , A01N47/14 , A01N25/22
CPC分类号： A01N59/16 , A01N25/22 , A01N25/04 , A01N25/30 , A01N47/14 , A01N2300/00
摘要： Compositions have been discovered that are suitable for forming a stable dispersion. The compositions comprise an agriculturally active compound and a multivalent metal oligomeric or polymeric compound having a molecular weight of from about 150 to about 15,000 Daltons.
摘要翻译：已发现适于形成稳定分散体的组合物。组合物包含农业活性化合物和分子量为约150至约15,000道尔顿的多价金属低聚物或聚合物。

5. 发明授权

US08805759B1 System and method for psychographic profiling of targeted populations of individuals 有权
标题翻译：针对目标人群的心理剖析的系统和方法
公开(公告)号：US08805759B1
公开(公告)日：2014-08-12
申请号：US12538224
申请日：2009-08-10
申请人： Alexandra N. Cha , Hyuk Cha , Lei Liu
发明人： Alexandra N. Cha , Hyuk Cha , Lei Liu
IPC分类号： G06F17/00 , G06N5/00 , G06N99/00 , G06N5/04 , G06Q10/10
CPC分类号： G06F17/00 , G06N5/00 , G06N5/04 , G06N99/005 , G06Q10/10
摘要： A system and method are provided for psychographically profiling a target population of individuals, programmably implemented in a server apparatus. The psychographic segmentation portion includes a questionnaire processing part, a segment solution part, and a typing tool part. The questionnaire processing part acquires a plurality of responses to a predetermined set of questionnaire questions by an initial pool of target population members. The questionnaire processing part uses a combination of weighted statistical methodologies to arrive at a rule-based decision on whether the question would serve as a good wedge variable. Optionally, the rule based decision is then compared to an expert's opinion and the weights and threshold parameters of the weighted statistical combination are adjusted accordingly to more accurately match the expert's decision. The identified wedge variables are used for effectively segregating the target population into groups of homogenous individuals. The typing tool part selectively generates an abbreviated set of questions from the predetermined set of questionnaire questions for profiling an individual respondent to at least one of the segments.
摘要翻译：提供了一种系统和方法，用于心理地剖析个体的目标群体，可编程地在服务器设备中实现。心理分割部分包括问卷处理部分，片段解决部分和打字工具部分。问卷处理部分通过初始的目标人群成员获取对预定的一组问卷问题的多个响应。问卷处理部分使用加权统计方法的组合来得出关于该问题是否将作为一个好的楔形变量的基于规则的决策。可选地，然后将基于规则的决策与专家意见进行比较，并相应地调整加权统计组合的权重和阈值参数以更准确地匹配专家的决定。确定的楔形变量用于有效地将目标群体分离成同质个体群体。打字工具部分从预定的一组问卷问题中选择性地生成一组简短的问题，以便对个别回答者进行分析，以对至少一个分段进行分析。

6. 发明授权

US08796476B2 Pesticide compositions exhibiting enhanced activity and methods for preparing same 有权
标题翻译：表现出增强活性的农药组合物及其制备方法
公开(公告)号：US08796476B2
公开(公告)日：2014-08-05
申请号：US12768263
申请日：2010-04-27
申请人： Stephen L. Wilson , Lei Liu , James D. Thomas , Raymond E. Boucher, Jr. , James E. Dripps , Margaret S. Kempe , Martin C. Logan , Douglas J. Linscott , John M. Atkinson
发明人： Stephen L. Wilson , Lei Liu , James D. Thomas , Raymond E. Boucher, Jr. , James E. Dripps , Margaret S. Kempe , Martin C. Logan , Douglas J. Linscott , John M. Atkinson
IPC分类号： A01N25/08 , A01N43/00 , A01N35/06 , A01N35/08 , A01N37/36 , A01N37/42 , A01N43/16 , A01N43/22 , A01N43/90 , A01N59/16 , A01N25/22
CPC分类号： A01N25/00 , A01N25/08 , A01N25/22 , A01N35/06 , A01N35/08 , A01N37/36 , A01N37/42 , A01N43/00 , A01N43/16 , A01N43/22 , A01N43/90 , A01N59/16 , A01N25/10 , A01N59/22 , A01N2300/00
摘要： Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least one transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
摘要翻译：公开了具有增强的杀虫活性水平的害虫控制组合物及其制备方法。在一个实施方案中，一种方法包括提供液体组合物，其包含至少一种农药和至少一种辅助成分，其与仅在不具有至少一种辅助成分的组合物不同的组合物中相比提高了组合物的杀虫活性。至少一种辅助成分可以包括至少一种金属氧化物，至少一种过渡金属盐和至少一种蛋白质材料的组合，或至少一种蛋白质材料和至少一种聚合物材料的组合。该方法还包括喷雾干燥液体组合物以提供固体组合物。在该实施方案的一个方面，与液体组合物相比，通过喷雾干燥提供的固体组合物显示出增强的杀虫活性。

7. 发明授权

US08749982B2 Server backplate and server having same 失效
标题翻译：服务器背板和服务器具有相同的
公开(公告)号：US08749982B2
公开(公告)日：2014-06-10
申请号：US13161504
申请日：2011-06-16
申请人： Hung-Yi Wu , Lei Liu
发明人： Hung-Yi Wu , Lei Liu
IPC分类号： H05K5/00 , H05K7/00 , G06F1/16 , A47B97/00 , A47B81/00
CPC分类号： G06F1/187 , H05K7/1487
摘要： A server backplate includes a plate, a power connector, a first connector and a second connector. The plate includes a top surface, a first surface, and a second surface opposing the first surface. The top surface connects the first surface and the second surface. The power connector is arranged on the first surface and configured to couple to a power supply unit. The first connector is arranged on the first surface and configured to couple to a first storage device. The second connector is arranged on the second surface and configured to couple to a second storage device. The power connector is electrically connected to the first connector and the second connector, and the first connector is closer to the top surface than the second connector.
摘要翻译：服务器背板包括板，电源连接器，第一连接器和第二连接器。板包括顶表面，第一表面和与第一表面相对的第二表面。顶表面连接第一表面和第二表面。电源连接器布置在第一表面上并且被配置为耦合到电源单元。第一连接器布置在第一表面上并且被配置为耦合到第一存储设备。第二连接器布置在第二表面上并且被配置为耦合到第二存储设备。电源连接器电连接到第一连接器和第二连接器，并且第一连接器比第二连接器更靠近顶表面。

8. 发明授权

US08628156B2 Computer case 失效
标题翻译：电脑机箱
公开(公告)号：US08628156B2
公开(公告)日：2014-01-14
申请号：US13220684
申请日：2011-08-30
申请人： Lei Liu
发明人： Lei Liu
IPC分类号： A47B81/00
CPC分类号： G06F1/181 , G06F1/188
摘要： A computer case includes a housing, a first sub housing, and a second sub housing. The housing includes a bottom wall, a sidewall and a fixing wall extending perpendicularly from the bottom wall, all of which cooperate to form a receiving space. The first sub housing is configured for receiving a redundant power supply. The second sub housing is configured for receiving a single power supply. Each of the first sub housing and the second sub housing is capable of being detachably received in the receiving space and secured to the housing.
摘要翻译：计算机外壳包括壳体，第一副壳体和第二副壳体。壳体包括底壁，侧壁和从底壁垂直延伸的固定壁，所有这些协作以形成接收空间。第一子壳体被配置为接收冗余电源。第二副壳体被配置为接收单个电源。第一副壳体和第二副壳体中的每一个能够可拆卸地容纳在接收空间中并固定到壳体。

9. 发明申请

US20130342279A1 METHODS AND APPARATUS FOR TERAHERTZ WAVE AMPLITUDE MODULATION 有权
标题翻译： TERAHERTZ波幅调制方法与装置
公开(公告)号：US20130342279A1
公开(公告)日：2013-12-26
申请号：US13529934
申请日：2012-06-21
申请人： Berardi Sensale-Rodriguez , Rusen Yan , Huili (Grace) Xing , Michelle M. Kelly , Tian Fang , Debdeep Jena , Lei Liu
发明人： Berardi Sensale-Rodriguez , Rusen Yan , Huili (Grace) Xing , Michelle M. Kelly , Tian Fang , Debdeep Jena , Lei Liu
IPC分类号： H03C1/02
CPC分类号： H03C1/02 , H03C7/00
摘要： A wave amplitude modulator for modulating a transmitted electromagnetic wave includes one or multiple self-gated capacitively coupled pair(s) of electron layers such as semiconductor or semimetal layers. Two electrical contacts are placed to each layer of electrons of the self-gated pair(s), and a power source is electrically connected to them. The power source, by varying the voltage applied between layers of electrons, tunes the electron density thereof, thereby adjusting the optical conductivity thereof, and the change in the optical conductivity of the layers of electrons causes an amplitude modulation of the transmitted electromagnetic wave passing through the capacitively coupled layers of electrons.
摘要翻译：用于调制发射的电磁波的波幅调制器包括一个或多个自门电容耦合的电子层对，例如半导体层或半金属层。两个电触头被放置到自门控对的每个电子层，并且电源与它们电连接。电源通过改变施加在电子层之间的电压调谐其电子密度，从而调节其光导率，并且电子层的光导率的变化引起通过的透射电磁波的幅度调制电容耦合的电子层。

10. 发明授权

US08605427B2 Heat dissipation device utilizing fan duct 失效
标题翻译：散热装置利用风机管道
公开(公告)号：US08605427B2
公开(公告)日：2013-12-10
申请号：US13072456
申请日：2011-03-25
申请人： Xiao-Zhu Chen , Lei Liu
发明人： Xiao-Zhu Chen , Lei Liu
IPC分类号： H05K7/20 , F28F7/00 , H01L23/34
CPC分类号： H05K7/20145 , H01L23/467 , H01L2924/0002 , H01L2924/00
摘要： A heat dissipation device includes a heat sink and a fan duct. The fan duct includes a cover and a baffle. The cover includes a top plate, a first sidewall and a second sidewall respectively extending from opposite sides of the top plate. The baffle is located between the first sidewall and the second sidewall of the cover and pivotally contacts the first and second sidewalls. The baffle forms an angle with the top plate and is rotatable relative to the first and second sidewalls to adjust the angle between the baffle and the top plate.
摘要翻译：散热装置包括散热器和风扇导管。风扇导管包括盖和挡板。盖子包括分别从顶板的相对侧延伸的顶板，第一侧壁和第二侧壁。挡板位于盖的第一侧壁和第二侧壁之间，并且枢转地接触第一和第二侧壁。挡板与顶板形成一角度并且可相对于第一和第二侧壁旋转，以调节挡板和顶板之间的角度。

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