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    • 1. 发明授权
    • Cell feature-based automatic circulating tumor cell detection
    • 基于细胞特征的自动循环肿瘤细胞检测
    • US09396532B2
    • 2016-07-19
    • US14078958
    • 2013-11-13
    • Leo GradyRamamani RamarajSarah SchlachterXuan-Lan Nguyen
    • Leo GradyRamamani RamarajSarah SchlachterXuan-Lan Nguyen
    • G06K9/00G06T7/00G02B21/36
    • G06T7/0012G02B21/365G06K9/00147G06T2200/24G06T2207/10056G06T2207/30024G06T2207/30096
    • An automated method for detecting circulating tumor cells in a microscopic image of a blood sample includes receiving, by a computer, a plurality of low-resolution images, each low resolution image providing a representation of the blood sample with one of a plurality of stains applied. The computer determines a threshold value for each of the plurality of stains based on the low resolution images and identifies a list of potential cells based on the threshold values. A gating process is performed on the list of potential circulating tumor cells to identify one or more likely or highly likely circulating tumor cells. The computer presents the subset of the low-resolution images in a verification interface comprising one or more components allowing a user to confirm that a respective low-resolution image included in the subset of the low-resolution images includes one or more circulating tumor cells.
    • 用于检测血液样本的微观图像中的循环肿瘤细胞的自动化方法包括通过计算机接收多个低分辨率图像,每个低分辨率图像提供血样的表示,其中施加多个污渍中的一个 。 计算机基于低分辨率图像确定多个染色中的每一个的阈值,并基于阈值识别潜在细胞的列表。 在潜在的循环肿瘤细胞列表上进行门控过程,以鉴定一个或多个可能或高度可能的循环肿瘤细胞。 计算机在包括一个或多个组件的验证接口中呈现低分辨率图像的子集,允许用户确认包括在低分辨率图像的子集中的相应低分辨率图像包括一个或多个循环肿瘤细胞。