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1. 发明申请

US20140328750A1 Antibodies Reactive with B7-H3 and Uses Thereof 有权
标题翻译：抗B7-H3抗体及其用途
公开(公告)号：US20140328750A1
公开(公告)日：2014-11-06
申请号：US14331876
申请日：2014-07-15
申请人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
发明人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/2809 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/94 , G01N33/57484 , A61K2300/00
摘要： The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要翻译：本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体。因此，本发明特别涉及能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的人源化B7-H3-反应性抗体。

2. 发明申请

US20120294796A1 Antibodies Reactive with B7-H3 and Uses Thereof 有权
标题翻译：抗B7-H3抗体及其用途
公开(公告)号：US20120294796A1
公开(公告)日：2012-11-22
申请号：US13463924
申请日：2012-05-04
申请人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
发明人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
IPC分类号： A61K39/395 , G01N33/574 , C12N5/10 , C12N5/16 , A61P35/02 , C07K16/00 , C07K16/18 , C07H21/04 , A61P35/00 , A61K51/00 , C12N15/63
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/2809 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/94 , G01N33/57484 , A61K2300/00
摘要： The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要翻译：本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体。因此，本发明特别涉及能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的人源化B7-H3-反应性抗体。

3. 发明授权

US08802091B2 Antibodies reactive with B7-H3 and uses thereof 有权
标题翻译：与B7-H3反应的抗体及其用途
公开(公告)号：US08802091B2
公开(公告)日：2014-08-12
申请号：US13463924
申请日：2012-05-04
申请人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
发明人： Leslie S. Johnson , Ling Huang , Paul A. Moore , Deryk T. Loo , Francine Z. Chen
IPC分类号： A61K38/00
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K16/2809 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/94 , G01N33/57484 , A61K2300/00
摘要： The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要翻译：本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体。因此，本发明特别涉及能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的人源化B7-H3-反应性抗体。

4. 发明授权

US09150656B2 Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof 有权
标题翻译：与B7-H3反应的抗体，其免疫活性片段及其用途
公开(公告)号：US09150656B2
公开(公告)日：2015-10-06
申请号：US13581340
申请日：2011-03-01
申请人： Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
发明人： Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
IPC分类号： A61K38/00 , C07K16/30 , C07K16/28 , A61K39/395 , A61K45/06 , C07K16/44 , G01N33/68 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2803 , C07K16/2827 , C07K16/2896 , C07K16/3076 , C07K16/3092 , C07K16/44 , C07K16/468 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/6893
摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
摘要翻译：本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体及其片段。因此，本发明特别涉及人源化的B7-H3-反应性抗体及其能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的免疫反应性片段。

5. 发明申请

US20130149236A1 Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof 有权
公开(公告)号：US20130149236A1
公开(公告)日：2013-06-13
申请号：US13581340
申请日：2011-03-01
申请人： Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
发明人： Leslie S. Johnson , Paul A. Moore , Ling Huang , Deryk T. Loo , Francine Zhifen Chen
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , C07K16/44 , A61K45/06 , G01N33/68
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2803 , C07K16/2827 , C07K16/2896 , C07K16/3076 , C07K16/3092 , C07K16/44 , C07K16/468 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/6893
摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

6. 发明授权

US09889197B2 Covalently-associated diabody complexes that possess charged coil domains and that are capable of enhanced binding to serum albumin 有权
公开(公告)号：US09889197B2
公开(公告)日：2018-02-13
申请号：US13811883
申请日：2011-07-29
申请人： Leslie S. Johnson , Ling Huang , Godfrey Jonah Anderson Rainey
发明人： Leslie S. Johnson , Ling Huang , Godfrey Jonah Anderson Rainey
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28 , A61K38/16 , C07K14/315 , C07K16/32 , C07K16/44
CPC分类号： A61K39/39558 , A61K38/164 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70
摘要： Diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers are disclosed. The diabody molecules comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as disulfide bonding of cysteine residues located within each polypeptide chain. The diabody molecules may further comprise an Fc region, which allows antibody-like functionality to be engineered into the molecule.

7. 发明授权

US09296816B2 Covalent diabodies and uses thereof 有权
标题翻译：共价双抗体及其用途
公开(公告)号：US09296816B2
公开(公告)日：2016-03-29
申请号：US11409339
申请日：2006-04-17
申请人： Leslie S. Johnson , Ling Huang
发明人： Leslie S. Johnson , Ling Huang
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/08 , C07K16/12 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/626
摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.
摘要翻译：本发明涉及双抗体分子及其在治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）中的用途。本发明的双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。另外，抗原可以来自相同或不同的分子。双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如但不限于位于每个多肽链内的半胱氨酸残基的二硫键。在具体实施方案中，本发明的双抗体分子还包含Fc区，其允许抗体样功能被改造成分子。

8. 发明授权

US09284375B2 Covalent diabodies and uses thereof 有权
公开(公告)号：US09284375B2
公开(公告)日：2016-03-15
申请号：US12641095
申请日：2009-12-17
申请人： Leslie S. Johnson , Ling Huang
发明人： Leslie S. Johnson , Ling Huang
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/283 , C07K2317/34 , C07K2317/52 , C07K2317/626 , C07K2317/73
摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.

9. 发明申请

US20110117089A1 BCR-Complex-Specific Antibodies And Methods Of Using Same 有权
标题翻译： BCR-复合物特异性抗体及其使用方法
公开(公告)号：US20110117089A1
公开(公告)日：2011-05-19
申请号：US12933882
申请日：2009-03-25
申请人： Leslie S. Johnson , Ling Huang
发明人： Leslie S. Johnson , Ling Huang
IPC分类号： A61K39/395 , C07K16/28 , C07H21/00 , A61P35/00 , A61P37/02 , A61P3/10 , A61P37/06
CPC分类号： C07K16/28 , C07K16/2803 , C07K2317/24 , C07K2317/56
摘要： This invention relates to chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the BCR complex. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
摘要翻译：本发明涉及特异性结合BCR复合物的嵌合和人源化抗体，特别是涉及BCR复合物的嵌合和人源化抗体。本发明还涉及将抗体及其组合物用于诊断，预后和治疗诸如癌症，自身免疫性疾病，炎症性疾病和感染性疾病的疾病的方法。

10. 发明授权

US07838635B2 CD16A binding proteins and use for the treatment of immune disorders 有权
标题翻译： CD16A结合蛋白，用于治疗免疫疾病
公开(公告)号：US07838635B2
公开(公告)日：2010-11-23
申请号：US11757939
申请日：2007-06-04
申请人： Leslie S. Johnson , Ling Huang , Hua Li , Nadine Tuaillon
发明人： Leslie S. Johnson , Ling Huang , Hua Li , Nadine Tuaillon
IPC分类号： C07K16/00 , C12P21/08 , C07K14/00 , C12N15/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/732
摘要： CD16A binding proteins useful for the reduction of a deleterious immune response are described. In one aspect, humanized anti-cd16A antibodies, optionally lacking effector function, are used for the treatment of immune disorders such as idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.
摘要翻译：描述了可用于减少有害免疫反应的CD16A结合蛋白。一方面，任选缺乏效应子功能的人源化抗-CD16A抗体用于治疗免疫疾病，例如特发性血小板减少性紫癜和自身免疫性溶血性贫血。

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