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1. 发明授权

US09833464B2 Target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and manufacturing method thereof 有权
公开(公告)号：US09833464B2
公开(公告)日：2017-12-05
申请号：US13519821
申请日：2010-12-29
申请人： In San Kim , Byung Heon Lee , Maggie J M Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
发明人： In San Kim , Byung Heon Lee , Maggie J M Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
IPC分类号： A61K31/70 , A61K31/704 , A61K47/48 , A61K9/127 , A61K38/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

2. 发明授权

US08697841B2 Peptide for transmigration across blood brain barrier and delivery systems comprising the same 有权
标题翻译：用于通过血脑屏障和包含其的递送系统进行迁移的肽
公开(公告)号：US08697841B2
公开(公告)日：2014-04-15
申请号：US12979804
申请日：2010-12-28
申请人： Maggie J. M. Lu , Hsiang-Fa Liang , Shing-Ming Cheng , Yi-Ju Ko , Li-Wen Chang
发明人： Maggie J. M. Lu , Hsiang-Fa Liang , Shing-Ming Cheng , Yi-Ju Ko , Li-Wen Chang
IPC分类号： C07K7/08 , A61K38/10 , C07K17/02 , C07K17/14
CPC分类号： A61K31/7088 , A61K9/1075 , A61K9/1271 , A61K31/7105 , A61K31/711 , A61K47/6907 , A61K47/6911 , A61K49/0032 , A61K49/0082 , A61K49/0084
摘要： An isolated peptide including an amino acid sequence of SEQ ID NO: 1 is provided. The disclosure also provides a delivery system comprising a carrier having a surface, a drug or a dye encapsulated in the carrier, and the disclosed peptide (having an amino acid sequence of SEQ ID NO: 1) grafted on the surface of the carrier.
摘要翻译：提供了包含SEQ ID NO：1的氨基酸序列的分离的肽。本公开还提供了一种递送系统，其包含载体，该载体具有包封在载体中的表面，药物或染料，以及接枝在载体表面上的所公开的肽（具有SEQ ID NO：1的氨基酸序列）。

3. 发明申请

US20100188596A1 Display 有权
标题翻译：显示
公开(公告)号：US20100188596A1
公开(公告)日：2010-07-29
申请号：US12654996
申请日：2010-01-13
申请人： Chen-Tsun Juan , Bor-Bin Chou , Li-Wen Chang
发明人： Chen-Tsun Juan , Bor-Bin Chou , Li-Wen Chang
IPC分类号： G02F1/1333
CPC分类号： G02F1/133308 , G02F2201/36
摘要： A display includes a frame, a liquid crystal panel device, a flat light source device, a bracket structure, and a driving circuit board. The liquid crystal panel device and the flat light source device are disposed on the frame. The flat light source device has an illuminant surface toward the liquid crystal panel device. A first airway is formed between the flat light source and the liquid crystal panel device. The driving circuit board is fixed on the bracket structure and electrically connected with the liquid crystal panel device. A gap is formed between the driving circuit board and the flat light source to be an outlet of the first airway. The surface of the driving circuit board and the illuminant surface form an included angle, and the included angle is greater than or equal to 5 degrees and less than or equal to 135 degrees.
摘要翻译：显示器包括框架，液晶面板装置，平面光源装置，支架结构和驱动电路板。液晶面板装置和平面光源装置设置在框架上。平面光源装置具有朝向液晶面板装置的发光体表面。在平面光源和液晶面板装置之间形成第一气道。驱动电路板固定在支架结构上并与液晶面板装置电连接。在作为第一气道的出口的驱动电路基板和平面光源之间形成间隙。驱动电路板的表面和发光体表面形成夹角，夹角大于或等于5度且小于或等于135度。

4. 发明申请

US20120294931A1 TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 有权
标题翻译：用于诊断和治疗含有特异性靶向白细胞介素-4受体的肽的含有脂蛋白的癌症靶向药物递送系统及其制造方法
公开(公告)号：US20120294931A1
公开(公告)日：2012-11-22
申请号：US13519821
申请日：2010-12-29
申请人： In San Kim , Byung Heon Lee , Maggie JM Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
发明人： In San Kim , Byung Heon Lee , Maggie JM Lu , Hsiang-Fa Liang , Yi-ju Ko , Ya-Chin Lo , Li-Wen Chang , Ming-Cheng Wei
IPC分类号： A61K9/127 , A61P35/00 , A61K31/704
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
摘要翻译：本发明涉及用于诊断和治疗特异性靶向白介素-4受体的肽标记的含有脂质体的癌症靶向药物递送系统及其制造方法。含有根据本发明制备的用IL4RPep肽标记的抗癌药物的脂质体可将药物递送至IL-4受体被特异性结合IL-4受体的IL4Rep肽过表达的癌细胞，并且药物递送可以识别癌症细胞特异性地通过标记。因此，IL4RPep肽可以增加药物对癌症组织的影响，同时显着降低对正常组织的副作用，这使得体内（分子）成像和肿瘤早期诊断成为可能。因此，含有本发明的IL4Pep肽标记的抗癌药物的脂质体可以作为靶向药物递送系统有效地应用于癌症的诊断和治疗。

5. 发明申请

US20110318898A1 HARD MASK FOR THIN FILM RESISTOR MANUFACTURE 有权
标题翻译：薄膜电阻器制造的硬掩模
公开(公告)号：US20110318898A1
公开(公告)日：2011-12-29
申请号：US12824495
申请日：2010-06-28
申请人： Li-Wen Chang , Der-Chyang Yeh , Chung-Yi Yu , Hsun-Chung Kuang , Hua-Chou Tseng , Chih-Ping Chao , Ming Chyi Liu , Yuan-Tai Tseng
发明人： Li-Wen Chang , Der-Chyang Yeh , Chung-Yi Yu , Hsun-Chung Kuang , Hua-Chou Tseng , Chih-Ping Chao , Ming Chyi Liu , Yuan-Tai Tseng
IPC分类号： H01L21/02
CPC分类号： H01L28/20 , H01L28/24
摘要： Methods of fabricating an integrated circuit device, such as a thin film resistor, are disclosed. An exemplary method includes providing a semiconductor substrate; forming a resistive layer over the semiconductor substrate; forming a hard mask layer over the resistive layer, wherein the hard mask layer includes a barrier layer over the resistive layer and a dielectric layer over the barrier layer; and forming an opening in the hard mask layer that exposes a portion of the resistive layer.
摘要翻译：公开了制造诸如薄膜电阻器的集成电路器件的方法。一种示例性方法包括提供半导体衬底; 在所述半导体衬底上形成电阻层; 在所述电阻层上形成硬掩模层，其中所述硬掩模层包括所述电阻层上的阻挡层和所述阻挡层上的电介质层; 以及在所述硬掩模层中形成暴露所述电阻层的一部分的开口。

6. 发明授权

US06649489B1 Poly etching solution to improve silicon trench for low STI profile 有权
标题翻译： Poly蚀刻解决方案，以改善硅沟槽的低STI特性
公开(公告)号：US06649489B1
公开(公告)日：2003-11-18
申请号：US10366207
申请日：2003-02-13
申请人： Li-Wen Chang , Hung-Cheng Sung , Der-Shin Shyu , Han-Ping Chen , Chen-Ming Huang , Ya-Chen Kao
发明人： Li-Wen Chang , Hung-Cheng Sung , Der-Shin Shyu , Han-Ping Chen , Chen-Ming Huang , Ya-Chen Kao
IPC分类号： H01L2176
CPC分类号： H01L21/76232
摘要： A method of etch polysilicon adjacent to a recessed STI structure feature is described. A substrate is provided with a dielectric layer thereon and a polysilicon layer on the dielectric layer. A shallow trench is formed that extends through the polysilicon and dielectric layers into the substrate. An insulating material is used to fill the trench and is then recessed in the trench below the surface of the substrate by polishing and etching steps. A conformal buffer layer is deposited which covers the polysilicon and sidewalls of the trench above the recessed insulating layer. The buffer layer is etched back to expose the insulating layer and the polysilicon is removed by a plasma etch. A spacer comprised of a portion of the buffer layer protects the substrate during the polysilicon etch to prevent unwanted trenches from being formed adjacent to the STI structure, thereby increasing the etch process window.
摘要翻译：描述了与凹陷STI结构特征相邻的蚀刻多晶硅的方法。衬底上设置介电层，并在电介质层上设置多晶硅层。形成浅沟槽，其延伸穿过多晶硅和电介质层进入衬底。绝缘材料用于填充沟槽，然后通过抛光和蚀刻步骤将其凹入到衬底表面下方的沟槽中。沉积保形缓冲层，其覆盖凹陷绝缘层上方的沟槽的多晶硅和侧壁。将缓冲层回蚀刻以暴露绝缘层，并且通过等离子体蚀刻去除多晶硅。由缓冲层的一部分构成的间隔件在多晶硅蚀刻期间保护衬底以防止在STI结构附近形成不必要的沟槽，从而增加蚀刻工艺窗口。

7. 发明授权

US08669881B2 Container data center with earthquake protection function 失效
标题翻译：集装箱数据中心具有防震功能
公开(公告)号：US08669881B2
公开(公告)日：2014-03-11
申请号：US13042431
申请日：2011-03-07
申请人： Li-Wen Chang
发明人： Li-Wen Chang
IPC分类号： G08B21/00
CPC分类号： G06F1/263 , G06F1/26 , H05K7/1495
摘要： A container data center includes a container, a plurality of power supplies, an electric switch system, a plurality of normally closed switches, an alarm device, and a controller. The electric switch system is received in the container. The plurality of normally closed switches are connected between the power supplies and the electric switch system. Each normally closed switch is connected with a corresponding one of the power supplies in series. The controller is connected to the normally closed switches and the alarm device, configured for receiving earthquake information containing an earthquake intensity, and configured for controlling the alarm device to activate alarms and controlling some of the normally closed switches or all the normally closed switches to open when the earthquake intensity is equal to or greater than a predetermined earthquake intensity.
摘要翻译：容器数据中心包括容器，多个电源，电开关系统，多个常闭开关，报警装置和控制器。电开关系统被容纳在容器中。多个常闭开关连接在电源和电开关系统之间。每个常闭开关与相应的一个电源串联连接。控制器连接到常闭开关和报警装置，用于接收包含地震烈度的地震信息，并配置为控制报警装置激活报警并控制一些常闭开关或所有常闭开关打开当地震烈度等于或大于预定的地震烈度时。

8. 发明申请

US20130050917A1 PIVOTING APPARATUS 有权
标题翻译：出售设备
公开(公告)号：US20130050917A1
公开(公告)日：2013-02-28
申请号：US13450442
申请日：2012-04-18
申请人： Chih-Kuo Chuang , Li-Wen Chang
发明人： Chih-Kuo Chuang , Li-Wen Chang
IPC分类号： H05K5/02
CPC分类号： H05K5/0247
摘要： A pivoting apparatus includes first and second pivoting elements, and first and second waterproof structures. The first pivoting element is fixed to a base, and has a first internal space and an opening exposing the first internal space. The second pivoting element is pivoted on the first pivoting element and fixed to an electronic device. A second internal space and a gap exposing the second internal space are formed between the first and second pivoting elements. The second internal space communicates with the first internal space through the opening. The first waterproof structure is fixed to the first pivoting element and surrounds at least a portion of the opening to block liquid from entering the first internal space through the opening. The second waterproof structure is fixed to the second pivoting element and shields the gap to block liquid from entering the second internal space through the gap.
摘要翻译：枢转装置包括第一和第二枢转元件以及第一和第二防水结构。第一枢转元件固定在基座上，并具有第一内部空间和露出第一内部空间的开口。第二枢转元件在第一枢转元件上枢转并固定到电子设备。在第一和第二枢转元件之间形成第二内部空间和露出第二内部空间的间隙。第二内部空间通过开口与第一内部空间连通。第一防水结构固定到第一枢转元件并且围绕开口的至少一部分以阻止液体通过开口进入第一内部空间。第二防水结构被固定到第二枢转元件并且屏蔽间隙以阻止液体通过间隙进入第二内部空间。

9. 发明授权

US08334187B2 Hard mask for thin film resistor manufacture 有权
标题翻译：薄膜电阻制造的硬掩模
公开(公告)号：US08334187B2
公开(公告)日：2012-12-18
申请号：US12824495
申请日：2010-06-28
申请人： Li-Wen Chang , Der-Chyang Yeh , Chung-Yi Yu , Hsun-Chung Kuang , Hua-Chou Tseng , Chih-Ping Chao , Ming Chyi Liu , Yuan-Tai Tseng
发明人： Li-Wen Chang , Der-Chyang Yeh , Chung-Yi Yu , Hsun-Chung Kuang , Hua-Chou Tseng , Chih-Ping Chao , Ming Chyi Liu , Yuan-Tai Tseng
IPC分类号： H01L21/20
CPC分类号： H01L28/20 , H01L28/24
摘要： Methods of fabricating an integrated circuit device, such as a thin film resistor, are disclosed. An exemplary method includes providing a semiconductor substrate; forming a resistive layer over the semiconductor substrate; forming a hard mask layer over the resistive layer, wherein the hard mask layer includes a barrier layer over the resistive layer and a dielectric layer over the barrier layer; and forming an opening in the hard mask layer that exposes a portion of the resistive layer.
摘要翻译：公开了制造诸如薄膜电阻器的集成电路器件的方法。一种示例性方法包括提供半导体衬底; 在所述半导体衬底上形成电阻层; 在所述电阻层上形成硬掩模层，其中所述硬掩模层包括所述电阻层上的阻挡层和所述阻挡层上的电介质层; 以及在所述硬掩模层中形成暴露所述电阻层的一部分的开口。

10. 发明授权

US08201002B2 Control system and control method for saving power by activating power supplies with shortest recorded power supply times 有权
标题翻译：控制系统和控制方法，通过启动具有最短记录电源时间的电源来节省电力
公开(公告)号：US08201002B2
公开(公告)日：2012-06-12
申请号：US12551466
申请日：2009-08-31
申请人： Li-Wen Chang
发明人： Li-Wen Chang
IPC分类号： G06F1/00 , G06F1/26 , G06F1/32 , G06F11/30 , G05F3/02 , H02J1/00 , F02P3/02
CPC分类号： G06F1/3203 , H02J1/10 , Y10T307/729
摘要： A control system for saving power in an electronic device obtains information of maximum power that can be supplied to the electronic device by each power supply, detects how much power is demanded by the electronic device, determines minimum number of the plurality of power supplies, based on the detected power demanded by the electronic device, and turns on power supplies, of which the number is equal to the determined minimum number, and turn off the other power supplies.
摘要翻译：用于在电子设备中节省电力的控制系统通过每个电源获得可以提供给电子设备的最大功率的信息，检测电子设备要求多少功率，基于多个电源的最小数量确定根据电子设备所要求的检测到的电力，并打开数量等于所确定的最小数量的电源，并关闭其他电源。

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