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1. 发明授权

US08332007B2 Quantitative three-dimensional mapping of oxygen tension 失效
标题翻译：氧气张力的定量三维映射
公开(公告)号：US08332007B2
公开(公告)日：2012-12-11
申请号：US12686139
申请日：2010-01-12
申请人： Mahnaz Shahidi
发明人： Mahnaz Shahidi
IPC分类号： A61B5/00
CPC分类号： A61B5/14555
摘要： Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with an oxygen sensitive probe by imaging the target tissue. In one embodiment, the invention provides a noninvasive method for monitoring oxygen tension in a chorioretinal tissue sensitized with an oxygen sensitive probe. In another aspect, apparatus is disclosed that can determine oxygen tension in tissue by quantifying a signal emitted by an oxygen sensitive probe within the three-dimensional map of a tissue to determine oxygen tension and provide a three-dimensional map of oxygen tension variations.
摘要翻译：公开了用于测量和映射组织中的氧张力的方法和装置，特别是允许直接非侵入性测量视网膜组织氧气张力。一方面，本发明涉及通过对靶组织进行成像来测定用氧敏感探针致敏的靶组织中的氧张力的方法。在一个实施方案中，本发明提供用于监测用氧敏感探针致敏的脉络膜视网膜组织中的氧张力的非侵入性方法。在另一方面，公开了可以通过在组织的三维图中定量氧敏感探针发出的信号来确定组织中的氧张力以确定氧气张力并提供氧气张力变化的三维图谱的装置。

2. 发明授权

US08801183B2 Assessment of microvascular circulation 有权
标题翻译：微血管循环评估
公开(公告)号：US08801183B2
公开(公告)日：2014-08-12
申请号：US13512218
申请日：2010-11-30
申请人： Mahnaz Shahidi , Justin Wanek , Bruce Gaynes
发明人： Mahnaz Shahidi , Justin Wanek , Bruce Gaynes
IPC分类号： A61B3/14
CPC分类号： A61B3/14 , A61B3/10 , A61B3/1241 , A61B3/145 , A61B5/02007 , A61B5/026 , A61B5/113 , G01N2021/5957
摘要： Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.
摘要翻译：公开了定量测量体内血管直径，血液速度和其他流动动力学的方法和组合物。这样的方法和组合物可以优化旨在预防或降低心血管和血液疾病风险的治疗干预措施。在一个方面，所述方法和装置包括从受试者眼睛的结膜中的血管的二维图像计算血管特征。在另一方面，获得血管的一系列时间图像以确定血流特性。该装置可以包括例如生物显微镜，照明光源和高速相机，以便随后由编程的处理器分析的数据来获取一系列时间图像。

3. 发明申请

US20130070201A1 ASSESSMENT OF MICROVASCULAR CIRCULATION 有权
标题翻译：微血管循环评估
公开(公告)号：US20130070201A1
公开(公告)日：2013-03-21
申请号：US13512218
申请日：2010-11-30
申请人： Mahnaz Shahidi , Justin Wanek , Bruce Gaynes
发明人： Mahnaz Shahidi , Justin Wanek , Bruce Gaynes
IPC分类号： A61B3/14
CPC分类号： A61B3/14 , A61B3/10 , A61B3/1241 , A61B3/145 , A61B5/02007 , A61B5/026 , A61B5/113 , G01N2021/5957
摘要： Methods and compositions are disclosed to quantitatively measure in vivo blood vessel diameter, blood velocity, and other flow dynamics. Such methods and compositions can optimize therapeutic interventions designed to prevent or reduce the risk of cardiovascular and blood disorders. In one aspect, the methods and apparatus involve calculating blood vessel characteristics from a two dimensional image of a blood vessel in the conjunctiva of a subject's eye. In another aspect, a series of temporal images of a blood vessel are obtained to determine blood flow properties. The apparatus can include, for example, a biomicroscope, an illuminating light source and a high speed camera to acquire the series of temporal images with the data then analyzed by a programmed processor.
摘要翻译：公开了定量测量体内血管直径，血液速度和其他流动动力学的方法和组合物。这样的方法和组合物可以优化旨在预防或降低心血管和血液疾病风险的治疗干预措施。在一个方面，所述方法和装置包括从受试者眼睛的结膜中的血管的二维图像计算血管特征。在另一方面，获得血管的一系列时间图像以确定血流特性。该装置可以包括例如生物显微镜，照明光源和高速相机，以便随后由编程的处理器分析的数据来获取一系列时间图像。

4. 发明申请

US20100191081A1 QUANTITATIVE THREE-DIMENSIONAL MAPPING OF OXYGEN TENSION 失效
标题翻译：定量三维张力的氧化张力
公开(公告)号：US20100191081A1
公开(公告)日：2010-07-29
申请号：US12686139
申请日：2010-01-12
申请人： Mahnaz Shahidi
发明人： Mahnaz Shahidi
IPC分类号： A61B5/1455
CPC分类号： A61B5/14555
摘要： Methods and apparatus are disclosed for measuring and mapping oxygen tension in a tissue and, in particular, permit direct non-invasive measurement of retinal tissue oxygen tension. In one aspect, the invention is directed to methods for determining oxygen tension in a target tissue sensitized with an oxygen sensitive probe by imaging the target tissue. In one embodiment, the invention provides a noninvasive method for monitoring oxygen tension in a chorioretinal tissue sensitized with an oxygen sensitive probe. In another aspect, apparatus is disclosed that can determine oxygen tension in tissue by quantifying a signal emitted by an oxygen sensitive probe within the three-dimensional map of a tissue to determine oxygen tension and provide a three-dimensional map of oxygen tension variations.
摘要翻译：公开了用于测量和映射组织中的氧张力的方法和装置，特别是允许直接非侵入性测量视网膜组织氧气张力。一方面，本发明涉及通过对靶组织进行成像来测定用氧敏感探针致敏的靶组织中的氧张力的方法。在一个实施方案中，本发明提供用于监测用氧敏感探针致敏的脉络膜视网膜组织中的氧张力的非侵入性方法。在另一方面，公开了可以通过在组织的三维图中定量氧敏感探针发出的信号来确定组织中的氧张力以确定氧气张力并提供氧气张力变化的三维图谱的装置。

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