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1. 发明申请

US20110312972A1 SUBSTITUTED 3-BENZOFURANYL-INDOL-2-ONE-3-ACETAMIDIDOPIPERAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译：取代的3-苯并呋喃-2-吲哚-2-酮-3-乙酰氨基哌啶衍生物，其制备方法及其治疗方法
公开(公告)号：US20110312972A1
公开(公告)日：2011-12-22
申请号：US13201141
申请日：2010-02-09
申请人： Marco Baroni , Letizia Puleo
发明人： Marco Baroni , Letizia Puleo
IPC分类号： A61K31/496 , A61P3/00 , A61P3/10 , C07D407/14 , A61P3/04
CPC分类号： A61K31/496 , A61K31/454 , C07D405/04 , C07D405/14
摘要： The invention relates to disubstituted 3-benzofuranyl-indol-2-one-3-acetamidopiperazine derivatives of the general formula (I) where R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are such as defined in claim 1, to a method for preparing same, and to the therapeutic use of said compounds.
摘要翻译：本发明涉及通式（I）的二取代3-苯并呋喃基 - 吲哚-2-酮-3-乙酰氨基哌嗪衍生物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如定义在权利要求1中，涉及其制备方法和所述化合物的治疗用途。

2. 发明授权

US07211578B2 Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity 失效
标题翻译：具有TNF活性的含氮四氢吡啶基 - 烷基 - 杂环
公开(公告)号：US07211578B2
公开(公告)日：2007-05-01
申请号：US10495890
申请日：2002-11-18
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
IPC分类号： C07D401/10 , A61K31/4523 , A61K31/4545
CPC分类号： C07D401/10
摘要： This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.
摘要翻译：本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。

3. 发明申请

US20050004132A1 Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity 失效
标题翻译：具有tnf活性的含氮四氢吡啶基 - 烷基 - 杂环
公开(公告)号：US20050004132A1
公开(公告)日：2005-01-06
申请号：US10495890
申请日：2002-11-18
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas , Letizia Puleo
IPC分类号： C07D401/08 , A61K31/4545 , A61K31/497 , A61P1/00 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/02 , A61P43/00 , C07D401/10 , C07D401/14 , C07D403/08 , A61K31/506 , A61K31/444 , C07
CPC分类号： C07D401/10
摘要： This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.
摘要翻译：本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。

4. 发明授权

US08202871B2 Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof 有权
标题翻译： 3-位上二取代的吲哚-2-酮衍生物及其治疗用途
公开(公告)号：US08202871B2
公开(公告)日：2012-06-19
申请号：US13012321
申请日：2011-01-24
申请人： Marco Baroni , Letizia Puleo
发明人： Marco Baroni , Letizia Puleo
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4439 , C07D209/40 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/141
CPC分类号： C07D209/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present application discloses compounds of the formula: and pharmaceutical compositions containing same and their use for treating and preventing various pathologies, including obesity, appetite disorders, excess weight and diabetes.
摘要翻译：本申请公开了下式的化合物：和含有它们的药物组合物及其用于治疗和预防各种病症的用途，包括肥胖症，食欲障碍，超重和糖尿病。

5. 发明申请

US20120040996A1 3-BENZOFURANYL-INDOL-2-ONE DERIVATIVES SUBSTITUTED AT THE 3 POSITION, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译：在3位置取代3-BENZOFURANYL-INDOL-2-ONE衍生物，其制备方法及其治疗方法
公开(公告)号：US20120040996A1
公开(公告)日：2012-02-16
申请号：US13201138
申请日：2010-02-09
申请人： Marco Baroni , Letizia Puleo
发明人： Marco Baroni , Letizia Puleo
IPC分类号： A61K31/496 , A61P3/10 , A61P3/04 , C07D405/14 , C07D405/10
CPC分类号： C07D407/14
摘要： The invention relates to 3-benzofuranyl-indol-2-one derivatives substituted at the 3 position and of the formula (I) where R1, R2, R3, R4, R5 and n are such as defined in claim 1, to a method for preparing same, and to the therapeutic use of said compounds.
摘要翻译：本发明涉及在3位被取代的3-苯并呋喃基 - 吲哚-2-酮衍生物和式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5和n如权利要求1中所定义，制备相同的物质，以及所述化合物的治疗用途。

6. 发明授权

US08353145B2 Capping machine 有权
标题翻译：封盖机
公开(公告)号：US08353145B2
公开(公告)日：2013-01-15
申请号：US12671142
申请日：2008-08-01
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67B3/20 , B67B3/22 , B67B3/28
CPC分类号： B67B3/10 , B67B3/2033 , B67B3/28
摘要： A capping machine (1) of carousel design comprises a centre shaft (2) turning on a fixed base frame (3) about a vertical axis of rotation (Y), a set of capping units (4) encircling and revolving as one with the shaft (2) about the axis of rotation (Y), and a cylindrical cam (5) interposed between the shaft (2) and the capping units (4), by which the single units (4) are caused to move toward and away from the fixed base frame (3). During operation, the cam (5) is held in at least one predetermined fixed position relative to the base frame (3) by a single supporting element (6) anchored to the base frame (3), concealed internally of the rotating shaft (2) and connected to the cam (5), which represents a departure from the conventional method of supporting the cam on two or more columns located externally of the carousel structure and exposed to view.
摘要翻译：圆盘传送带设计的封盖机（1）包括围绕垂直旋转轴线（Y）转动固定基座框架（3）的中心轴（2），围绕旋转的一组封盖单元（4）轴（2）围绕旋转轴线（Y），以及插入在轴（2）和封盖单元（4）之间的圆柱形凸轮（5），单个单元（4）通过该圆筒凸轮朝向和远离从固定基架（3）。在操作期间，凸轮（5）通过锚固到基架（3）的单个支撑元件（6）相对于基架（3）保持在至少一个预定的固定位置，隐藏在旋转轴（2）的内部）并且连接到凸轮（5），这代表了偏离凸轮在传送带结构外部暴露在两个或更多个柱上的常规方法的偏离。

7. 发明授权

US08153637B2 Phenyl-alkyl piperazines having TNF-modulating activity, preparation method, and therapeutic use thereof 有权
标题翻译：具有TNF调节活性的苯基 - 烷基哌嗪，其制备方法及其治疗用途
公开(公告)号：US08153637B2
公开(公告)日：2012-04-10
申请号：US12970047
申请日：2010-12-16
申请人： Marco Baroni , Olaf Ritzeler , Marco Zanchet
发明人： Marco Baroni , Olaf Ritzeler , Marco Zanchet
IPC分类号： A61K31/495 , A61K31/496 , C07D213/74 , C07D295/096 , C07D295/04
CPC分类号： C07D295/073 , C07D213/76
摘要： The present invention relates to phenyl-alkyl piperazines of formula (I): in which A, R1, R2 and R3 are as defined herein, having TNF-modulating activity. The invention also relates to the preparation thereof, pharmaceutical compositions thereof, and to the therapeutic use thereof.
摘要翻译：本发明涉及式（I）的苯基 - 烷基哌嗪：其中A，R 1，R 2和R 3如本文所定义，具有TNF调节活性。本发明还涉及其制备，其药物组合物及其治疗用途。

8. 发明授权

US07823717B2 Rotary conveyor 有权
标题翻译：旋转输送机
公开(公告)号：US07823717B2
公开(公告)日：2010-11-02
申请号：US12227287
申请日：2007-05-17
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B65G29/00
CPC分类号： B65G47/847 , B65B43/46 , B65B43/50 , B67C7/0053
摘要： A rotary conveyor (1) utilized in equipment (1a) for filling containers (2) with liquid or powder products includes a supporting shaft (8) aligned on a longitudinal axis (X) and coupled to relative drive components (10) associated with the shaft (8), by which the shaft is set in rotation about the axis (X). A support element (11) is keyed to the shaft (8), presenting a peripheral rim (12) with a plurality of slots (13) each designed to accommodate a container (2) transferred from a transport and/or processing device (3) forming part of the equipment (1a). The slots (13) incorporate restraining components (14) having grippers (15) movable between a position of engagement, in which the containers (2) are locked to the support element (11), and a position of disengagement in which no restraining force is applied to the containers (2).
摘要翻译：在用于用液体或粉末产品填充容器（2）的设备（1a）中使用的旋转式输送机（1）包括在纵向轴线（X）上对准的支撑轴（8），并连接到与轴（8），轴绕轴线（X）旋转。支撑元件（11）与轴（8）键合，呈现具有多个槽（13）的周边边缘（12），每个狭槽设计成容纳从运输和/或处理装置（3）传送的容器（2））形成设备（1a）的一部分。狭槽（13）包括具有夹持器（15）的限制部件（14），该夹具（15）能够在容器（2）锁定在支撑元件（11）的接合位置之间移动，并且其中没有约束力被施加到容器（2）。

9. 发明申请

US20100224283A1 Carousel for Processing Containers Filled With Liquid or Powder Products 有权
标题翻译：用于加工液体或粉末产品的容器的转盘
公开(公告)号：US20100224283A1
公开(公告)日：2010-09-09
申请号：US12223193
申请日：2007-02-12
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67C3/24 , B65G29/00 , B65B1/32
CPC分类号： B67C3/22 , B67C2003/2668
摘要： Containers for packaging liquid or powder products are directed onto a carousel (1) presenting a support element (9) equipped with a number of peripheral stations (10), each accommodating a relative container (2), and set in rotation about a vertical axis (X) by a drive system (6) housed internally of floor-standing frame (5) on which the carousel (1) is mounted. The support element (9) presents substantially disc-like appearance and is hollow, composed of a top panel (11) and a bottom panel (12) distanced one from another in such a way as to create an annular chamber (13) between the two panels.
摘要翻译：用于将液体或粉末产品包装的容器被引导到转盘（1）上，所述转盘（1）具有配备有多个周边站（10）的支撑元件（9），每个周边站（10）容纳相对容器（2），并且围绕垂直轴（6）安装在其上安装有转盘（1）的落地架（5）的内部。支撑元件（9）呈现基本上圆盘状的外观并且是中空的，由顶板（11）和底板（12）组成，以便在彼此间隔开的方式上形成环形室（13）两个面板。

10. 发明申请

US20090250314A1 Rotary Conveyor 有权
标题翻译：旋转输送机
公开(公告)号：US20090250314A1
公开(公告)日：2009-10-08
申请号：US12227287
申请日：2007-05-17
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B65G29/00
CPC分类号： B65G47/847 , B65B43/46 , B65B43/50 , B67C7/0053
摘要： A rotary conveyor (1) utilized in equipment (Ia) for filling containers (2) with liquid or powder products comprises a supporting shaft (8) aligned on a longitudinal axis (X) and coupled to relative drive components (10) associated with the shaft (8), by which the shaft is set in rotation about the axis (X), also a support element (11) keyed to the shaft (8), presenting a peripheral rim (12) with a plurality of slots (13) each designed to accommodate a container (2) transferred from a transport and/or processing device (3) forming part of the equipment (1a). The slots (13) incorporate restraining components (14) consisting in grippers (15) capable of movement between a position of engagement, in which the containers (2) are locked to the support element (11), and a position of disengagement in which no restraining force is applied to the containers (2).
摘要翻译：在用于用液体或粉末产品填充容器（2）的设备（1a）中使用的旋转输送机（1）包括在纵向轴线（X）上对准的支撑轴（8），并连接到与轴（8），轴被围绕轴线（X）设置成旋转，还有一个与轴（8）相关联的支撑元件（11），呈现具有多个槽（13）的周边边缘（12）每个设计用于容纳从构成设备（1a）的一部分的运输和/或处理装置（3）转移的容器（2）。狭槽（13）包括限制部件（14），其包括能够在容器（2）锁定到支撑元件（11）的接合位置之间移动的夹具（15）和脱开位置对容器（2）不施加约束力。

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