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1. 发明授权

US09988677B1 DNA/RNA sequencing using a semiconducting nanopore 有权
公开(公告)号：US09988677B1
公开(公告)日：2018-06-05
申请号：US14735898
申请日：2015-06-10
申请人： Mark Fleharty , Dimiter N. Petsev , Frank B. Van Swol
发明人： Mark Fleharty , Dimiter N. Petsev , Frank B. Van Swol
IPC分类号： G01N27/00 , G01N25/18 , C12Q1/68 , G01N27/327 , G01N33/487 , G01Q60/24
CPC分类号： C12Q1/6869 , G01N33/48721 , C12Q2527/125 , C12Q2565/631
摘要： The present disclosure provides novel apparatus including, though not necessarily limited to, biosensors utilizing semiconductor materials in electrolyte solutions and methods for using the same. The biosensors rely on a unique property wherein a charged body in the electrolyte solution produces a detectable change in the local conductivity of the semiconductor as the body approaches or travels near the semiconductor.

2. 发明授权

US08105471B1 Nanofluidics for bioseparation and analysis 有权
标题翻译：用于生物分离和分析的纳米流体
公开(公告)号：US08105471B1
公开(公告)日：2012-01-31
申请号：US11184540
申请日：2005-07-19
申请人： Sang M. Han , Steven R. J. Brueck , Cornelius F. Ivory , Gabriel P. Lopez , Dimiter N. Petsev
发明人： Sang M. Han , Steven R. J. Brueck , Cornelius F. Ivory , Gabriel P. Lopez , Dimiter N. Petsev
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44752
摘要： The invention includes nanochannel devices and methods for using such nanochannel devices for separating molecules, ions and biomolecules. The nanochannel devices have at least one nanochannel through which fluid can move, wherein ionic double layers form in the fluid near walls of the nanochannel and those ionic double layers overlap within the nanochannel. Electrical voltage can be applied to the nanochannel to modify an electrostatic potential in the nanochannel and thereby control movement of ions and biomolecules through the nanochannel. The invention also includes arrays and networks of such nanochannel devices.
摘要翻译：本发明包括纳米通道装置和使用这种纳米通道装置分离分子，离子和生物分子的方法。纳米通道装置具有至少一个纳米通道，流体可以通过该纳米通道移动，其中在纳米通道壁附近的流体中形成离子双层，并且那些离子双层在纳米通道内重叠。可以将电压施加到纳米通道以修改纳米通道中的静电势，从而控制离子和生物分子通过纳米通道的运动。本发明还包括这种纳米通道装置的阵列和网络。

3. 发明授权

US07465381B2 Electrokinetic molecular separation in nanoscale fluidic channels 有权
标题翻译：纳米流体通道中的电动分子分离
公开(公告)号：US07465381B2
公开(公告)日：2008-12-16
申请号：US10958113
申请日：2004-10-04
申请人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Anthony L. Garcia , Dimiter N. Petsev , Paul Bisong , Michael J. O'Brien
发明人： Gabriel P. Lopez , Steven R. J. Brueck , Linnea K. Ista , Anthony L. Garcia , Dimiter N. Petsev , Paul Bisong , Michael J. O'Brien
IPC分类号： G01N27/447
CPC分类号： C07K1/26 , Y10S977/924 , Y10S977/962
摘要： A method for separation of mixtures in fluidic systems through electrokinetic transport by use of nanochannels when the fluidic systems approach the size of an electrical double layer, thereby allowing separation based on charge. The disclosed apparatus comprises a T-chip with a nanochannel section. The method and apparatus are useful for separation of many molecular species, including peptides, proteins, and DNA.
摘要翻译：当流体系统接近电双层的尺寸时，通过使用纳米通道的电动运输来分离流体系统中的混合物的方法，从而允许基于电荷的分离。所公开的装置包括具有纳米通道部分的T芯片。该方法和装置可用于分离许多分子物质，包括肽，蛋白质和DNA。

4. 发明申请

US20090155563A1 Mesoporous Metal Oxide Microspheres and Method for Forming Same 有权
标题翻译：介孔金属氧化物微球及其形成方法
公开(公告)号：US20090155563A1
公开(公告)日：2009-06-18
申请号：US12263947
申请日：2008-11-03
申请人： Dimiter N. Petsev , Erin Derbins , Sergio Mendez , Shailendra Rathod , Nick Carroll , David A. Weitz
发明人： Dimiter N. Petsev , Erin Derbins , Sergio Mendez , Shailendra Rathod , Nick Carroll , David A. Weitz
IPC分类号： B32B3/26 , C09K3/00
CPC分类号： C01B33/124 , Y10T428/249921 , Y10T428/2982 , Y10T428/2991
摘要： The present disclosure provides a method for forming populations of monodisperse porous silica particles. Also provided are monodisperse populations of porous silica particles, an array of physically connected monodisperse porous silica particles and a microfluidic device for forming populations of monodisperse porous silica particles.
摘要翻译：本公开提供了形成单分散多孔二氧化硅颗粒群的方法。还提供了多孔二氧化硅颗粒的单分散群体，物理连接的单分散多孔二氧化硅颗粒的阵列和用于形成单分散多孔二氧化硅颗粒群的微流体装置。

5. 发明申请

US20120065329A1 SYNTHESIS OF STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES 有权
标题翻译：稳定的弹性负离子对比剂颗粒的合成
公开(公告)号：US20120065329A1
公开(公告)日：2012-03-15
申请号：US13320454
申请日：2010-05-11
申请人： Gabriel Lopez , Nick Carroll , Kevin Cushing , Dimiter N. Petsev
发明人： Gabriel Lopez , Nick Carroll , Kevin Cushing , Dimiter N. Petsev
IPC分类号： C08L83/04
CPC分类号： C08L83/04 , A61K9/0009 , A61K9/1641 , A61K9/1682 , A61K47/34 , A61K49/225 , G01N33/538 , G01N33/54313
摘要： We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.
摘要翻译：我们描述了具有可压缩性和密度的稳定的弹性体负型声学造影颗粒的合成方法和配方。这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

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