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1. 发明授权

US08084611B2 Process for preparing tetrahydroquinoline derivatives 有权
标题翻译：制备四氢喹啉衍生物的方法
公开(公告)号：US08084611B2
公开(公告)日：2011-12-27
申请号：US12295618
申请日：2007-03-29
申请人： Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
发明人： Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
IPC分类号： C07D215/38
CPC分类号： C07D215/42 , C07D215/233
摘要： The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof.Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.
摘要翻译：本发明提供一种可用于治疗和/或预防动脉硬化疾病，血脂异常等疾病的光学活性四氢喹啉衍生物的方法及其合成中间体的制备方法。具体地说，（2R，4S）-2-乙基-6-三氟甲基-1,2,3,4-四氢喹啉-4-基胺或其盐在不使用光学拆分的情况下以较少的步骤制备，并且光学活性的四氢喹啉衍生物由胺化合物得到。

2. 发明申请

US20090292125A1 PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES 有权
标题翻译：制备四氢喹啉衍生物的方法
公开(公告)号：US20090292125A1
公开(公告)日：2009-11-26
申请号：US12295618
申请日：2007-03-29
申请人： Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
发明人： Masaki Okamoto , Akira Sakuragi , Yoshikazu Mori , Takeshi Hamada , Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Norimitsu Hayashi
IPC分类号： C07D215/38
CPC分类号： C07D215/42 , C07D215/233
摘要： The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof.Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.
摘要翻译：本发明提供一种可用于治疗和/或预防动脉硬化疾病，血脂异常等疾病的光学活性四氢喹啉衍生物的方法及其合成中间体的制备方法。具体地说，（2R，4S）-2-乙基-6-三氟甲基-1,2,3,4-四氢喹啉-4-基胺或其盐在不使用光学拆分的情况下以较少的步骤制备，并且光学活性的四氢喹啉衍生物由胺化合物得到。

3. 发明申请

US20090023729A1 Trisubstituted amine compound 审中-公开
标题翻译：三取代胺化合物
公开(公告)号：US20090023729A1
公开(公告)日：2009-01-22
申请号：US12219776
申请日：2008-07-28
申请人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
发明人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
IPC分类号： A61K31/506 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , A61K31/4155 , A61P9/10 , A61K31/4439 , C07D239/47 , C07D239/48 , A61K31/5377
CPC分类号： C07D401/12
摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
摘要翻译：本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的杂环基等; R1是任选取代的烷基，其中烷基进一步可以任选地被任选取代的杂环基取代，等等; 并且R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其具有对胆固醇酯转移蛋白（CETP）的抑制活性，从而可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。

4. 发明申请

US20090029994A1 Trisubstituted amine compound 有权
标题翻译：三取代胺化合物
公开(公告)号：US20090029994A1
公开(公告)日：2009-01-29
申请号：US12219775
申请日：2008-07-28
申请人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
发明人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
IPC分类号： A61K31/506 , A61P9/10 , A61P9/00 , A61P29/00 , A61P19/00 , A61P37/00 , C07D401/04 , C07D239/47 , C07D413/04 , A61K31/4412 , A61K31/444 , C07D413/14 , C07D401/12 , C07D239/48 , C07D403/12 , C07D213/72 , A61K31/5377 , A61K31/496
CPC分类号： C07D239/47 , C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D257/06 , C07D401/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
摘要翻译：本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的苯基等; R1是任选取代的烷基等; 并且R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其对胆固醇酯转移蛋白（CETP）具有抑制活性，因此可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。

5. 发明授权

US08076364B2 Trisubstituted amine compound 有权
标题翻译：三取代胺化合物
公开(公告)号：US08076364B2
公开(公告)日：2011-12-13
申请号：US12973403
申请日：2010-12-20
申请人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
发明人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D239/47 , C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D257/06 , C07D401/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
摘要翻译：本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的苯基等; R1是任选取代的烷基等; 并且R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其对胆固醇酯转移蛋白（CETP）具有抑制活性，因此可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。

6. 发明授权

US07906517B2 Trisubstituted amine compound 有权
公开(公告)号：US07906517B2
公开(公告)日：2011-03-15
申请号：US12219775
申请日：2008-07-28
申请人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
发明人： Yoshinori Nakamura , Norimitsu Hayashi , Takanori Higashijima , Hitoshi Kubota , Kozo Oka
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D239/47 , C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D257/06 , C07D401/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

7. 发明授权

US07781443B2 Tetrahydronaphthyridine derivatives and a process for preparing the same 失效
标题翻译：四氢萘啶衍生物及其制备方法
公开(公告)号：US07781443B2
公开(公告)日：2010-08-24
申请号：US11527556
申请日：2006-09-27
申请人： Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Yasuo Yamamoto , Kozo Oka , Shigeki Igarashi
发明人： Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Yasuo Yamamoto , Kozo Oka , Shigeki Igarashi
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： C07D471/04
摘要： A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).
摘要翻译：式（I）的新化合物：其中R1是烷氧基羰基等，R2是烷基等; R3是氢等; R4是亚烷基等; R5是任选取代的杂环基; R6，R7和R8独立地是氢; 烷基，烷氧基等; R 10是任选取代的芳环等; 或其药学上可接受的盐，其对胆固醇酯转移蛋白（CETP）具有抑制活性。

8. 发明申请

US20070032485A1 Tetrahydronaphthyridine derivatives and a process for preparing the same 失效
标题翻译：四氢萘啶衍生物及其制备方法
公开(公告)号：US20070032485A1
公开(公告)日：2007-02-08
申请号：US11527556
申请日：2006-09-27
申请人： Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Yasuo Yamamoto , Kozo Oka , Shigeki Igarashi
发明人： Hitoshi Kubota , Yoshinori Nakamura , Takanori Higashijima , Yasuo Yamamoto , Kozo Oka , Shigeki Igarashi
IPC分类号： A61K31/5377 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independently hydrogen; alky, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).
摘要翻译：式（I）的新化合物：其中R 1是烷氧基羰基等，R 2是烷基等; R 3是氢等; R 4是亚烷基等; R 5是任选取代的杂环基; R 6，R 7和R 8独立地是氢; 烷基，烷氧基等; R 10是任选取代的芳环，等等; 或其药学上可接受的盐，其对胆固醇酯转移蛋白（CETP）具有抑制活性。

9. 发明申请

US20110092506A1 TRISUBSTITUTED AMINE COMPOUND 有权
标题翻译：三氯化钛化合物
公开(公告)号：US20110092506A1
公开(公告)日：2011-04-21
申请号：US12973403
申请日：2010-12-20
申请人： Yoshinori NAKAMURA , Norimitsu Hayashi , Takanori Higasahijima , Hitoshi Kubota , Kozo Oka
发明人： Yoshinori NAKAMURA , Norimitsu Hayashi , Takanori Higasahijima , Hitoshi Kubota , Kozo Oka
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/505 , A61K31/498 , A61K31/41 , A61K31/44 , A61P9/10 , A61P9/00 , A61P3/10 , A61P3/00 , A61P9/12 , A61P3/04 , A61P7/02 , A61P25/00 , A61P9/06 , A61P11/00 , A61P13/12 , A61P1/16 , A61P29/00 , A61P37/02 , A61P15/00 , A61P35/00 , A61P25/28
CPC分类号： C07D239/47 , C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D257/06 , C07D401/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted phenyl group, and the like; R1 is an optionally substituted alkyl group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.
摘要翻译：本发明涉及通式（1）的化合物：其中Y为亚甲基等; A是任选取代的杂环基等; B是任选取代的苯基等; R1是任选取代的烷基等; 并且R 2是任选取代的氨基等; 或其药学上可接受的衍生物，其具有对胆固醇酯转移蛋白（CETP）的抑制活性，从而可用于预防和/或治疗动脉硬化性疾病，高脂血症或血脂异常等。

10. 发明申请

US20120239772A1 COMMUNICATION SYSTEM AND COMMUNICATING METHOD 审中-公开
标题翻译：通信系统和通信方法
公开(公告)号：US20120239772A1
公开(公告)日：2012-09-20
申请号：US13514205
申请日：2011-01-14
申请人： Hitoshi Kubota
发明人： Hitoshi Kubota
IPC分类号： G06F15/16
CPC分类号： H04L12/18 , H04W74/0816 , H04W74/085 , H04W84/18 , H04W88/04
摘要： A communication system includes a first terminal, a second terminal, and a third terminal. The first terminal transmits message data addressed to the third terminal to plural terminals. When the second terminal receives the message data and confirms that a destination thereof is not the second terminal, the second terminal transfers the received message data. When the third terminal receives the message data and confirms that the destination thereof is the third terminal, the third terminal transmits response data corresponding to the received message data to the first terminal. A priority for transmission of the response data is set higher than that of the transferred message data, and a period of time from reception of the message data until the transmission of the corresponding response data is shorter than a period of time from reception of the message data until the transfer of the message data.
摘要翻译：通信系统包括第一终端，第二终端和第三终端。第一终端将寻址到第三终端的消息数据发送到多个终端。当第二终端接收到消息数据并确认其目的地不是第二终端时，第二终端传送接收到的消息数据。当第三终端接收到消息数据并确认其目的地是第三终端时，第三终端向第一终端发送与接收到的消息数据相对应的响应数据。将响应数据的发送的优先级设置为高于传送的消息数据的优先级，并且从接收消息数据直到对应的响应数据的发送的时间段短于从接收到消息的时间段数据直到传输消息数据。

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