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1. 发明申请

US20130323222A1 HUMAN TISSUE KALLIKREIN 1 GLYCOSYLATION ISOFORMS 审中-公开
标题翻译：人体组织KALLIKREIN 1 GLYCOSYLATION ISOFORMS
公开(公告)号：US20130323222A1
公开(公告)日：2013-12-05
申请号：US13909220
申请日：2013-06-04
申请人： Matthew Charles , Tadeusz Kolodka , Mark Williams
发明人： Matthew Charles , Tadeusz Kolodka , Mark Williams
IPC分类号： C12N9/96
CPC分类号： A61K38/4853 , C12N9/6445 , C12N9/96 , C12Y304/21035
摘要： Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical compositions containing such glycoforms or mixtures thereof, methods of obtaining the rhKLK1 glycoforms, and therapeutic uses thereof
摘要翻译：提供了每个KLK1分子具有确定数量的寡糖单位的组织激肽释放酶-1（KLK1）糖型的制剂。还提供了这些糖型的混合物，含有这种糖形式的药物组合物或其混合物，获得rhKLK1糖型的方法及其治疗用途

2. 发明申请

US20090030180A1 Hyaluronic Acid Binding Peptides Enhance Host Defense Against Pathogenic Bacteria 有权
标题翻译：透明质酸结合肽增强宿主防治病原菌
公开(公告)号：US20090030180A1
公开(公告)日：2009-01-29
申请号：US11917012
申请日：2006-06-08
申请人： Tadeusz Kolodka , Bernard T. Charlton , Wendy Johnson
发明人： Tadeusz Kolodka , Bernard T. Charlton , Wendy Johnson
IPC分类号： C07K7/00
CPC分类号： C07K14/001 , A61K38/00
摘要： Several species of bacteria capable of invasive infections, such as S. pyogenes, S. equi and P. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such as Staphylococcus aureus and related Staphylococci have capsules that contain acidic polysaccharides. Bacterial capsule or bacterial surface binding peptides were synthesized and tested in a culture model of invasive bacterial infections, specifically translocation through polarized keratinocyte cultures. The peptides reduced the translo-cation of a variety of bacterial species, with a concomitant increase in bacterial internalization by the keratinocytes. In vivo, subcutaneous inoculation of encapsulated GAS treated with peptides delayed bacterial dissemination. In a mouse surgical wound control model infected with S. aureus, treatment with peptides reduced the numbers of bacteria and inflammation at the wound site.
摘要翻译：能够侵入性感染的几种细菌，如化脓性链球菌，马氏足球杆菌和多发性球菌，在其胶囊中含有透明质酸（HA）。细菌物种如金黄色葡萄球菌和相关葡萄球菌含有含有酸性多糖的胶囊。在侵入性细菌感染的培养模型中，特异性通过极化角化细胞培养物移位合成细菌胶囊或细菌表面结合肽并进行测试。这些肽减少了各种细菌物种的转铁蛋白，伴随角质细胞细菌内化的增加。在体内，皮下接种用肽处理的包封的GAS延迟细菌传播。在用金黄色葡萄球菌感染的小鼠手术伤口控制模型中，用肽处理减少伤口部位的细菌数量和炎症。

3. 发明授权

US08044022B2 Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria 有权
标题翻译：透明质酸结合肽增强宿主防御病原菌
公开(公告)号：US08044022B2
公开(公告)日：2011-10-25
申请号：US11917012
申请日：2006-06-08
申请人： Tadeusz Kolodka , Bernard T. Charlton , Wendy Johnson
发明人： Tadeusz Kolodka , Bernard T. Charlton , Wendy Johnson
IPC分类号： A01N37/18 , A61K38/04 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/001 , A61K38/00
摘要： Several species of bacteria capable of invasive infections, such as S. pyogenes, S. equi and P. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such as Staphylococcus aureus and related Staphylococci have capsules that contain acidic polysaccharides. Bacterial capsule or bacterial surface binding peptides were synthesized and tested in a culture model of invasive bacterial infections, specifically translocation through polarized keratinocyte cultures. The peptides reduced the translocation of a variety of bacterial species, with a concomitant increase in bacterial internalization by the keratinocytes. In vivo, subcutaneous inoculation of encapsulated GAS treated with peptides delayed bacterial dissemination. In a mouse surgical wound model infected with S. aureus, treatment with peptides reduced the numbers of bacteria and inflammation at the wound site.
摘要翻译：能够侵入性感染的几种细菌，如化脓性链球菌，马氏足球杆菌和多发性球菌，在其胶囊中含有透明质酸（HA）。细菌物种如金黄色葡萄球菌和相关葡萄球菌含有含有酸性多糖的胶囊。在侵入性细菌感染的培养模型中，特异性通过极化角化细胞培养物移位合成细菌胶囊或细菌表面结合肽并进行测试。肽减少了各种细菌物种的易位，伴随角质细胞细菌内化的增加。在体内，皮下接种用肽处理的包封的GAS延迟细菌传播。在用金黄色葡萄球菌感染的小鼠手术伤口模型中，用肽处理减少了创伤部位的细菌数量和炎症。

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