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1. 发明授权

US10159847B2 Implantable medical devices with active component monitoring 有权
公开(公告)号：US10159847B2
公开(公告)日：2018-12-25
申请号：US14717773
申请日：2015-05-20
申请人： Medtronic, Inc.
发明人： Marshall J. Rasmussen , Lonny V. Cabelka , Randolph E. Crutchfield , Jon E. Zimmer
IPC分类号： A61N1/39 , A61N1/37 , A61N1/36
摘要： An implantable medical device includes a housing, a power source and an operational circuit that is coupled to the power source. The operational circuit includes a first electrode terminal and a second electrode terminal, an output circuit configured to deliver an electrical stimulation therapy through the first and second electrode terminals and a control circuit configured to evaluate an electrical parameter associated with the output circuit and to control generation of the electrical stimulation therapy responsive to a result of the evaluated parameter. Among other things, the implantable medical device may modify a parameter of the therapy delivery in response to a result of the evaluation.

2. 发明申请

US20160067507A1 IMPLANTABLE MEDICAL DEVICES HAVING MULTI-CELL POWER SOURCES 有权
标题翻译：具有多个电源的可植入医疗器械
公开(公告)号：US20160067507A1
公开(公告)日：2016-03-10
申请号：US14695309
申请日：2015-04-24
申请人： Medtronic, Inc.
发明人： Lonny V. Cabelka , Mark R. Boone , Randolph E. Crutchfield , Kevin P. Kuehn , John T. Meador , John D. Norton , Craig L. Schmidt
IPC分类号： A61N1/39 , H01M10/42
CPC分类号： A61N1/3975 , A61N1/378 , A61N1/3782 , A61N1/3931 , A61N1/3937 , A61N1/3956 , A61N1/3981 , H01M10/4257 , H01M2010/4271
摘要： An implantable medical device includes a low-power circuit and a multi-cell power source. The cells of the power source are coupled in a parallel configuration. The implantable medical device includes both a low power circuit that is selectively coupled between the first and second cells and a high power output circuit that is directly coupled to the first and second cells in a parallel configuration. An isolation circuit is coupled to the first cell, the second cell and the low power circuit to maintain a current isolation between the first cell and the second cell at least during delivery of current having a large magnitude to the high power output circuit.
摘要翻译：可植入医疗装置包括低功率电路和多电池电源。电源的电池以并联结构耦合。可植入医疗装置包括选择性地耦合在第一和第二小室之间的低功率电路和以并联配置直接耦合到第一和第二小区的高功率输出电路。至少在向大功率输出电路传送具有大幅度的电流时，隔离电路耦合到第一单元，第二单元和低功率电路，以保持第一单元和第二单元之间的电流隔离。

3. 发明申请

US20150306407A1 THERAPY DELIVERY METHODS AND CIRCUITS FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的治疗方法和电路
公开(公告)号：US20150306407A1
公开(公告)日：2015-10-29
申请号：US14260313
申请日：2014-04-24
申请人： Medtronic, Inc.
发明人： Randolph E. Crutchfield , Lonny V. Cabelka
IPC分类号： A61N1/39 , A61N1/38
CPC分类号： A61N1/3925 , A61N1/36125 , A61N1/362 , A61N1/3706 , A61N1/385 , A61N1/3906 , A61N1/3912 , A61N1/3956 , A61N1/3975
摘要： Techniques are disclosed for modulating the generation of charge current by operational circuitry included in an implantable medical device (IMD) for delivery of an induction stimulation pulse waveform by the IMD. The modulation may include modulating a charging circuit of the operational circuitry to facilitate the regulation of the induction stimulation pulse waveform. The techniques include monitoring an electrical parameter of a charging path during the delivery of the induction stimulation pulse and modulating the charging circuit based on the monitored electrical parameter.
摘要翻译：公开了用于通过包括在用于由IMD传送感应刺激脉冲波形的可植入医疗装置（IMD）中的操作电路来调制充电电流的产生的技术。调制可以包括调制操作电路的充电电路以便于调节感应刺激脉冲波形。这些技术包括在传送感应刺激脉冲期间监测充电路径的电参数并且基于所监视的电参数来调制充电电路。

4. 发明授权

US08972005B2 Subthreshold lead impedance measurement for subcutaneous device 有权
标题翻译：皮下装置的亚阈值导联阻抗测量
公开(公告)号：US08972005B2
公开(公告)日：2015-03-03
申请号：US13795471
申请日：2013-03-12
申请人： Medtronic, Inc.
发明人： Marshall J. Rasmussen , Forrest C. M. Pape , Lonny V. Cabelka
IPC分类号： A61N1/20 , A61N1/378 , A61N1/39 , A61N1/37 , A61N1/362
CPC分类号： A61N1/378 , A61N1/3625 , A61N1/3706 , A61N1/3912 , A61N1/3981
摘要： A subthreshold lead impedance technique is described for an implantable medical device. The lead impedance technique may be applicable to a subcutaneous implantable cardioversion defibrillator device and utilizes an output circuit of the device coupled between a first diode and a second diode to define a current path through two electrodes coupled to the output circuit. The second diode is further coupled to a switch to provide a current pathway from the first diode to circuit ground. A control circuit is coupled to the output circuit, the first diode, the second diode, and the switch to bias a leg of the output circuit in a conducting state while biasing the other legs of the output circuit in a non-conducting state.
摘要翻译：对于可植入医疗装置描述了亚阈值引线阻抗技术。引线阻抗技术可以应用于皮下植入式心脏复律除颤器装置，并利用耦合在第一二极管和第二二极管之间的器件的输出电路来限定通过耦合到输出电路的两个电极的电流路径。第二二极管还耦合到开关以提供从第一二极管到电路接地的电流通路。控制电路耦合到输出电路，第一二极管，第二二极管和开关，以将导通状态的输出电路的一侧偏压，同时将输出电路的另一个支路偏置在非导通状态。

5. 发明授权

US08886314B2 Therapy delivery method and system for implantable medical devices 有权
标题翻译：可植入医疗器械的治疗方法和系统
公开(公告)号：US08886314B2
公开(公告)日：2014-11-11
申请号：US13626988
申请日：2012-09-26
申请人： Medtronic, Inc.
发明人： Randolph E. Crutchfield , Lonny V. Cabelka , Mark R. Boone , Marshall J. Rasmussen
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3981 , A61N1/371 , A61N1/3906 , A61N1/3956 , A61N1/3987
摘要： The disclosure relates to an apparatus and method for inducing ventricular fibrillation in a patient to facilitate defibrillation threshold testing. The apparatus includes a plurality of output capacitors that are dynamically configurable in a selected stacking arrangement that facilitates delivery of energy for inducing the ventricular fibrillation. An output of the apparatus is coupled to patient electrodes and a threshold energy level delivered by the output capacitors is determined.
摘要翻译：本公开涉及一种用于诱导患者心室颤动的装置和方法，以促进除颤阈值测试。该装置包括多个输出电容器，其可以以选择的堆叠布置动态地配置，这有助于输送用于诱导心室颤动的能量。设备的输出耦合到患者电极，并确定由输出电容器传递的阈值能量水平。

6. 发明授权

US11524169B2 Charge balanced cardiac pacing from high voltage circuitry of an extra-cardiovascular implantable cardioverter defibrillator system 有权
公开(公告)号：US11524169B2
公开(公告)日：2022-12-13
申请号：US15425169
申请日：2017-02-06
申请人： Medtronic, Inc.
发明人： Yanina Grinberg , Paul D. Baker , Lonny V. Cabelka , Craig W. Dorma , Timothy A. Ebeling , Michael W. Heinks , James Vander Heyden , Joseph Ippolito , Joel R. Lauer , Robert W. Sawchuk , Brian W. Schousek
IPC分类号： A61N1/39 , A61N1/05 , A61N1/365
摘要： An extra-cardiovascular implantable cardioverter defibrillator (ICD) having a high voltage therapy module is configured to control a high voltage charging circuit to charge a capacitor to a pacing voltage amplitude to deliver charge balanced pacing pulses. The capacitor is chargeable to a shock voltage amplitude that is greater than the pacing voltage amplitude. The ICD is configured to enable switching circuitry of the high voltage therapy module to discharge the capacitor to deliver a first pulse having a first polarity and a leading voltage amplitude corresponding to the pacing voltage amplitude for pacing the patient's heart via a pacing electrode vector selected from extra-cardiovascular electrodes. The high voltage therapy module delivers a second pulse after the first pulse. The second pulse has a second polarity opposite the first polarity and balances the electrical charge delivered during the first pulse.

7. 发明申请

US20150134021A1 THERAPY DELIVERY METHOD AND SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的治疗方法和系统
公开(公告)号：US20150134021A1
公开(公告)日：2015-05-14
申请号：US14536881
申请日：2014-11-10
申请人： Medtronic, Inc.
发明人： Randolph E. Crutchfield , Lonny V. Cabelka , Mark R. Boone , Marshall J. Rasmussen
IPC分类号： A61N1/39
CPC分类号： A61N1/3981 , A61N1/371 , A61N1/3906 , A61N1/3956 , A61N1/3987
摘要： Recent advancements in power electronics technology have provided opportunities for enhancements to circuits of implantable medical devices. The enhancements have contributed to increasing circuit miniaturization and an increased efficiency in the operation of the implantable medical devices. The therapy delivery circuits and techniques of the disclosure facilitate generation of a therapy stimulation waveform that may be shaped based on the patient's physiological response to the stimulation waveform. The generated therapy stimulation waveforms include a stepped leading-edge that may be shaped having a varying slope and varying amplitudes associated with each of the segments of the slope. Unlike the truncated exponential waveform delivered by the conventional therapy delivery circuit which is based on the behavior of the output capacitors (i.e., i=C(dV/dt)), the stimulation waveform of the present disclosure may be dynamically shaped as a function of an individual patient's response. The dynamically shaped therapy stimulation waveforms facilitate achieving lower capture thresholds which reduces the device's supply consumption thereby increasing longevity of the device and facilitate a reduction of tissue damage.
摘要翻译：电力电子技术的最新进展为可植入医疗器械电路的增强提供了机会。这些增强功能有助于增加电路小型化并提高可植入医疗装置的操作效率。本公开的治疗递送电路和技术有助于产生可以基于患者对刺激波形的生理反应而变形的治疗刺激波形。产生的治疗刺激波形包括阶梯形前缘，其可以被成形为具有与斜率的每个段相关联的变化的斜率和变化的幅度。与基于输出电容器的行为（即，i = C（dV / dt））的传统治疗传递电路传递的截断指数波形不同，本公开的刺激波形可以动态地形成为个人病人的反应。动态形状的治疗刺激波形有助于实现更低的捕获阈值，这降低了装置的供应消耗，从而增加了装置的使用寿命，并有助于减少组织损伤。

8. 发明申请

US20160067508A1 MULTIPLE TRANSFORMER CHARGING CIRCUITS FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的多变压器充电电路
公开(公告)号：US20160067508A1
公开(公告)日：2016-03-10
申请号：US14695447
申请日：2015-04-24
申请人： Medtronic, Inc.
发明人： Mark R. Boone , Randolph E. Crutchfield , Lonny V. Cabelka , Kevin P. Kuehn , John T. Meador
IPC分类号： A61N1/39
CPC分类号： A61N1/3975 , A61N1/378 , A61N1/3937 , A61N1/3956 , A61N1/3981
摘要： An implantable medical device includes a low-power circuit, a high-power circuit, and a dual-cell power source. The power source is coupled to a dual-transformer such that each cell is connected to only one of the transformers. Each transformer includes multiple windings and each of the windings is coupled to a capacitor, and the capacitors are all connected in a series configuration. The low power circuit is coupled to the power source and issues a control signal to control the delivery of charge from the power source to the plurality of capacitors through the first and second transformers.
摘要翻译：可植入医疗装置包括低功率电路，高功率电路和双电池电源。电源耦合到双变压器，使得每个单元仅连接到一个变压器。每个变压器包括多个绕组，并且每个绕组耦合到电容器，并且电容器都以串联配置连接。低功率电路耦合到电源并且发出控制信号以控制通过第一和第二变压器从电源向多个电容器传送电荷。

9. 发明申请

US20140277285A1 SUBTHRESHOLD LEAD IMPEDANCE MEASUREMENT FOR SUBCUTANEOUS DEVICE 有权
标题翻译：用于辅助设备的子带阻抗测量
公开(公告)号：US20140277285A1
公开(公告)日：2014-09-18
申请号：US13795471
申请日：2013-03-12
申请人： MEDTRONIC, INC.
发明人： Marshall J. Rasmussen , Forrest C.M. Pape , Lonny V. Cabelka
IPC分类号： A61N1/378
CPC分类号： A61N1/378 , A61N1/3625 , A61N1/3706 , A61N1/3912 , A61N1/3981
摘要： A subthreshold lead impedance technique is described for an implantable medical device. The lead impedance technique may be applicable to a subcutaneous implantable cardioversion defibrillator device and utilizes an output circuit of the device coupled between a first diode and a second diode to define a current path through two electrodes coupled to the output circuit. The second diode is further coupled to a switch to provide a current pathway from the first diode to circuit ground. A control circuit is coupled to the output circuit, the first diode, the second diode, and the switch to bias a leg of the output circuit in a conducting state while biasing the other legs of the output circuit in a non-conducting state.
摘要翻译：对于可植入医疗装置描述了亚阈值引线阻抗技术。引线阻抗技术可以应用于皮下植入式心脏复律除颤器装置，并利用耦合在第一二极管和第二二极管之间的器件的输出电路来限定通过耦合到输出电路的两个电极的电流路径。第二二极管还耦合到开关以提供从第一二极管到电路接地的电流通路。控制电路耦合到输出电路，第一二极管，第二二极管和开关，以将导通状态的输出电路的一侧偏压，同时将输出电路的另一个支路偏置在非导通状态。

10. 发明申请

US20140088659A1 THERAPY DELIVERY METHOD AND SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的治疗方法和系统
公开(公告)号：US20140088659A1
公开(公告)日：2014-03-27
申请号：US13626988
申请日：2012-09-26
申请人： MEDTRONIC, INC.
发明人： Randolph E. Crutchfield , Lonny V. Cabelka , Mark R. Boone , Marshall J. Rasmussen
IPC分类号： A61N1/39
CPC分类号： A61N1/3981 , A61N1/371 , A61N1/3906 , A61N1/3956 , A61N1/3987
摘要： The disclosure relates to an apparatus and method for inducing ventricular fibrillation in a patient to facilitate defibrillation threshold testing. The apparatus includes a plurality of output capacitors that are dynamically configurable in a selected stacking arrangement that facilitates delivery of energy for inducing the ventricular fibrillation. An output of the apparatus is coupled to patient electrodes and a threshold energy level delivered by the output capacitors is determined
摘要翻译：本公开涉及一种用于诱导患者心室颤动的装置和方法，以促进除颤阈值测试。该装置包括多个输出电容器，其可以以选择的堆叠布置动态地配置，这有助于输送用于诱导心室颤动的能量。设备的输出耦合到患者电极，并确定由输出电容器传递的阈值能量水平

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