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1. 发明授权

US07076290B2 Method and apparatus for detecting and discriminating arrhythmias 有权
标题翻译：用于检测和鉴别心律失常的方法和装置
公开(公告)号：US07076290B2
公开(公告)日：2006-07-11
申请号：US10682982
申请日：2003-10-10
申请人： Nirav V. Sheth , Eduardo N. Warman , Michael F. Hess
发明人： Nirav V. Sheth , Eduardo N. Warman , Michael F. Hess
IPC分类号： A61B5/04
CPC分类号： A61B5/046 , A61B5/0464 , A61B5/7264 , A61N1/3622 , A61N1/3962
摘要： An apparatus and method for discriminating arrhythmias that includes sensing a heart rate indicative of an arrhythmia associated with a first portion of a heart, determining regularity of the sensed heart rate, determining an event interval variability associated with a second portion of the heart, and classifying the arrhythmia in response to the determined event interval variability.
摘要翻译：一种用于区分心律失常的装置和方法，包括感测指示与心脏的第一部分相关联的心律失常的心率，确定感测心率的规律性，确定与心脏的第二部分相关联的事件间隔变异性，以及分类响应于确定的事件间隔变异性的心律失常。

2. 发明授权

US08332030B2 Device and method for providing atrial-synchronized ventricular pacing with selective atrial tracking 有权
标题翻译：用于提供心房同步心室起搏和选择性心房跟踪的装置和方法
公开(公告)号：US08332030B2
公开(公告)日：2012-12-11
申请号：US11115597
申请日：2005-04-27
申请人： Michael F. Hess , Eduardo N. Warman
发明人： Michael F. Hess , Eduardo N. Warman
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A device for delivering pacing therapy includes an atrial and ventricular leads, sensing circuitry connected to the leads for detecting depolarizations, and pulse generation circuitry for delivering ventricular pacing pulses based on sensed atrial depolarizations. The device includes control circuitry for controlling the pulse generation circuitry in a first mode in which the pulse generation circuitry delivers atrial synchronized pulses to both the right and left ventricular leads in response to each atrial depolarization sensed. In response to a detected atrial arrhythmia, the control circuitry causes the pulse generation circuitry to deliver atrial synchronized ventricular pacing pulses in response only to selected atrial depolarizations.
摘要翻译：用于输送起搏治疗的装置包括心房和心室引线，连接到用于检测去极化的引线的感测电路以及用于基于感测的心房去极化来输送心室起搏脉冲的脉冲产生电路。该装置包括用于在第一模式中控制脉冲发生电路的控制电路，其中脉冲发生电路响应于感测到的每个心房去极化而将心房同步脉冲输送到右心室和左心室引线。响应于检测到的心房心律失常，控制电路使得脉冲发生电路仅响应于所选择的心房去极化来递送心房同步心室起搏脉冲。

3. 发明授权

US06876880B2 Automated reapplication of atrial pacing therapies 有权
标题翻译：心房起搏治疗的自动再次应用
公开(公告)号：US06876880B2
公开(公告)日：2005-04-05
申请号：US10034060
申请日：2001-12-20
申请人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
发明人： Michael F. Hess , Rahul Mehra , Eduardo N. Warman , Nirav V. Sheth , Mark L. Brown , David Ritscher
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624
摘要： The invention relates to the use of atrial pacing therapies to treat atrial tachycardia (AT). When an AT episode is detected, an implantable medical device applies an ATP therapy. If the AT episode persists, the ATP therapy may be automatically reapplied at a later time during the course of the same AT episode. In particular, previously used ATP therapies are reapplied when episodic conditions, such as cycle length or cycle regularity, change. Although a particular ATP therapy initially may be unsuccessful in terminating the AT, it may prove successful when the cycle length or regularity of the atrial rhythm changes. As the rhythm slows down, the AT may be more responsive to ATP therapies that were previously unsuccessful. As a result, potentially efficacious ATP therapies can be reapplied to terminate AT episodes, and reduce the number of episodes that require more aggressive termination by painful, atrial shocks.
摘要翻译：本发明涉及心房起搏疗法用于治疗房性心动过速（AT）的用途。当检测到AT发作时，可植入医疗装置应用ATP疗法。如果AT发作持续存在，ATP疗法可能会在相同的AT发作过程中的较晚时间自动重新应用。特别是，当诸如循环长度或循环规律性等情况时，先前使用的ATP疗法将被重新应用。尽管特定的ATP疗法最初可能不能终止AT，但是当心房节律的周期长度或规律性发生变化时，可能会成功。随着节奏减慢，AT可能对以前不成功的ATP疗法更有反应。因此，可以重新应用潜在有效的ATP疗法来终止AT发作，并通过痛苦的心房休克减少需要更积极终止的发作次数。

4. 发明授权

US09179860B2 Determining a location of a member 有权
标题翻译：确定会员的位置
公开(公告)号：US09179860B2
公开(公告)日：2015-11-10
申请号：US12423466
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05 , A61B5/06 , A61B5/0432 , A61B5/044 , A61B5/042 , A61B5/053 , A61B19/00 , A61B5/0428 , A61B8/06 , A61B8/00 , A61B17/00 , A61B17/22
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者的体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

5. 发明授权

US08831701B2 Uni-polar and bi-polar switchable tracking system between 有权
标题翻译：单极和双极可切换跟踪系统之间
公开(公告)号：US08831701B2
公开(公告)日：2014-09-09
申请号：US12423521
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04 , A61B5/06 , A61B5/0428
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

6. 发明授权

US08777874B2 Acoustic based cough detection 有权
标题翻译：声学咳嗽检测
公开(公告)号：US08777874B2
公开(公告)日：2014-07-15
申请号：US13114838
申请日：2011-05-24
申请人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
发明人： Xusheng Zhang , Vinod Sharma , Eduardo N. Warman
IPC分类号： A61B7/00
CPC分类号： A61B5/0823 , A61B5/0205 , A61B5/11 , A61B5/686 , A61B2562/0204 , A61B2562/0219 , A61N1/3621 , A61N1/3627
摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.
摘要翻译：本公开涉及使用声信号检测咳嗽和咳嗽发作。在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。在一些示例中，可植入医疗装置还执行咳嗽严重度评估。在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

7. 发明授权

US08660640B2 Determining a size of a representation of a tracked member 失效
标题翻译：确定被跟踪成员的表示的大小
公开(公告)号：US08660640B2
公开(公告)日：2014-02-25
申请号：US12423454
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/04
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

8. 发明授权

US08532734B2 Method and apparatus for mapping a structure 有权
标题翻译：用于映射结构的方法和装置
公开(公告)号：US08532734B2
公开(公告)日：2013-09-10
申请号：US12421332
申请日：2009-04-09
申请人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
发明人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
IPC分类号： A61B5/04
CPC分类号： G06T19/003 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B5/066 , A61B5/068 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/102 , A61B2034/105 , A61B2034/2051 , A61B2034/2068 , A61B2034/2072 , A61B2090/061 , A61B2090/063 , A61B2090/371 , A61B2090/376 , A61B2090/378
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

9. 发明申请

US20120232606A1 USING FOCAL MYOCARDIAL STIMULATION TO DISTINGUISH SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 审中-公开
公开(公告)号：US20120232606A1
公开(公告)日：2012-09-13
申请号：US13357659
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

10. 发明授权

US08214018B2 Determining a flow characteristic of a material in a structure 失效
标题翻译：确定结构中材料的流动特性
公开(公告)号：US08214018B2
公开(公告)日：2012-07-03
申请号：US12422681
申请日：2009-04-13
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

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