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1. 发明授权

US07949411B1 Epicardial lead 有权
标题翻译：心外膜导联
公开(公告)号：US07949411B1
公开(公告)日：2011-05-24
申请号：US11626132
申请日：2007-01-23
申请人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
发明人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/057
摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.
摘要翻译：实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

2. 发明授权

US07899555B2 Intrapericardial lead 有权
标题翻译：心包积液
公开(公告)号：US07899555B2
公开(公告)日：2011-03-01
申请号：US11691335
申请日：2007-03-26
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到大面积空间之后，再膨胀至其正常状态，以相对于心包组织锚固引线主体的远端部分。

3. 发明申请

US20070239244A1 INTRAPERICARDIAL LEAD 有权
标题翻译：国内领先
公开(公告)号：US20070239244A1
公开(公告)日：2007-10-11
申请号：US11691335
申请日：2007-03-26
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到大面积空间之后，再膨胀至其正常状态，以相对于心包组织锚固引线主体的远端部分。

4. 发明授权

US08406902B2 Intrapericardial lead with precurved distal end portion 有权
标题翻译：具有前端远端部分的心包内引线
公开(公告)号：US08406902B2
公开(公告)日：2013-03-26
申请号：US13005448
申请日：2011-01-12
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲的远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。

5. 发明申请

US20110106233A1 INTRAPERICARDIAL LEAD 有权
标题翻译：国内领先
公开(公告)号：US20110106233A1
公开(公告)日：2011-05-05
申请号：US13005448
申请日：2011-01-12
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。

6. 发明授权

US08012143B1 Intrapericardial delivery tools and methods 有权
标题翻译：心包内递送工具和方法
公开(公告)号：US08012143B1
公开(公告)日：2011-09-06
申请号：US11609751
申请日：2006-12-12
申请人： Greg Kampa , Anna Barlow , Kevin L. Morgan , Michael Yang , Steven R. Conger , Stuart Rosenberg , Wenbo Hou
发明人： Greg Kampa , Anna Barlow , Kevin L. Morgan , Michael Yang , Steven R. Conger , Stuart Rosenberg , Wenbo Hou
IPC分类号： A61M25/00
CPC分类号： A61M25/0041 , A61M25/0054 , A61M25/0147 , A61M25/0662 , A61M25/1002
摘要： An introducer sheath is disclosed herein. The sheath includes a tubular body. The tubular body has a proximal zone, an intermediate zone and a distal zone. The proximal zone is generally straight. The intermediate zone extends from a distal end of the proximal zone and curves in a first direction. The distal zone extends from a distal end of the intermediate zone and curves in a second direction different from the first direction.
摘要翻译：本文公开了导引鞘。鞘包括管状体。管状体具有近端区，中间区和远端区。近端区域通常是直的。中间区域从近端区域的远端延伸并沿第一方向弯曲。远端区域从中间区域的远端延伸并且沿与第一方向不同的第二方向弯曲。

7. 发明授权

US09002478B1 Passive fixation for epicardial lead 有权
标题翻译：被动固定为心外膜导联
公开(公告)号：US09002478B1
公开(公告)日：2015-04-07
申请号：US13036821
申请日：2011-02-28
申请人： Michael Yang , Wenbo Hou , Sheldon Williams
发明人： Michael Yang , Wenbo Hou , Sheldon Williams
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0587
摘要： An epicardial lead is passively fixed in a pericardial space by a passive fixation member. The passive fixation member extends from a distal portion of an epicardial lead and acts against a pericardial layer and an epicardial layer to hold the lead in place. The epicardial lead may include an electrode that is connected to a conductor that extends from a distal portion of the lead. In some embodiments the epicardial lead includes a material that promotes fibrosis to fix the lead to heart tissue. The passive fixation member may include a shocking coil.
摘要翻译：心外膜由被动固定构件被动地固定在心包空间中。被动固定构件从心外膜引导件的远端部分延伸并作用于心包层和心外膜层以将引线保持在适当位置。心外膜引线可以包括连接到从引线的远端部分延伸的导体的电极。在一些实施方案中，心外膜引线包括促进纤维化以将引线固定到心脏组织的材料。被动固定构件可包括震动线圈。

8. 发明授权

US07920928B1 Passive fixation for epicardial lead 有权
标题翻译：被动固定为心外膜导联
公开(公告)号：US07920928B1
公开(公告)日：2011-04-05
申请号：US11669797
申请日：2007-01-31
申请人： Michael Yang , Wenbo Hou , Sheldon Williams
发明人： Michael Yang , Wenbo Hou , Sheldon Williams
IPC分类号： A61N1/00
CPC分类号： A61N1/0587
摘要： An epicardial lead is passively fixed in a pericardial space by a passive fixation member. The passive fixation member extends from a distal portion of an epicardial lead and acts against a pericardial layer and an epicardial layer to hold the lead in place. The epicardial lead may include an electrode that is connected to a conductor that extends from a distal portion of the lead. In some embodiments the epicardial lead includes a material that promotes fibrosis to fix the lead to heart tissue. The passive fixation member may include a shocking coil.
摘要翻译：心外膜由被动固定构件被动地固定在心包空间中。被动固定构件从心外膜引导件的远端部分延伸并作用于心包层和心外膜层以将引线保持在适当位置。心外膜引线可以包括连接到从引线的远端部分延伸的导体的电极。在一些实施方案中，心外膜引线包括促进纤维化以将引线固定到心脏组织的材料。被动固定构件可包括震动线圈。

9. 发明授权

US07922648B1 Myocardial infarction patch for minimally invasive implant 有权
标题翻译：用于微创植入物的心肌梗死贴片
公开(公告)号：US07922648B1
公开(公告)日：2011-04-12
申请号：US11354698
申请日：2006-02-14
申请人： Wenbo Hou , Sheldon Williams
发明人： Wenbo Hou , Sheldon Williams
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61F2/2481
摘要： A fixation section and a rim form a myocardial patch for implant in the pericardial space. The fixation section is adapted to promote fibrosis to secure the patch in place. The rim is secured to and surrounds at least a portion of the fixation section and has a lumen. The patch is adapted to transition between a collapsed state and an expanded state. A stylet is passed through the lumen to force the patch into a collapsed state and is removed when the patch is positioned to allow the patch to expand and engage the epicardial surface.
摘要翻译：固定部分和边缘形成用于在心包空间中植入的心肌贴片。固定部分适于促进纤维化以将贴片固定到位。轮缘被固定到并围绕固定部分的至少一部分并且具有内腔。贴片适于在折叠状态和展开状态之间转换。探针通过管腔以迫使贴片处于折叠状态，并且当贴片被定位以允许贴片膨胀并接合心外膜表面时被移除。

10. 发明授权

US08447389B2 Methods and systems to monitor and identify transient ischemia 有权
标题翻译：监测和鉴别短暂性脑缺血的方法和系统
公开(公告)号：US08447389B2
公开(公告)日：2013-05-21
申请号：US12861573
申请日：2010-08-23
申请人： Steve Koh , Michael Yang , Ryan Rooke , Stuart Rosenberg , Wenbo Hou
发明人： Steve Koh , Michael Yang , Ryan Rooke , Stuart Rosenberg , Wenbo Hou
IPC分类号： A61B5/0452
CPC分类号： A61B5/0422 , A61B5/686 , A61B5/7282 , A61B2576/023 , A61N1/365 , A61N1/3702
摘要： A system and method are provided for monitoring ischemic development. The system and method identify a non-physiologic event and obtain cardiac signals along multiple sensing vectors, wherein at least a portion of the sensing vectors extend to or from electrodes located proximate to the left ventricle. The system and method monitor a segment of interest in the cardiac signals obtained along the multiple sensing vectors to identify deviations in the segment of interest from a baseline. The system and method record at least one of timing or segment shift information associated with the deviations in the segments of interest; and identify at least one of size, direction of development or rate of progression of an ischemia region based on the at least one of timing or segment shift information.
摘要翻译：提供了一种用于监测缺血发育的系统和方法。系统和方法识别非生理事件并且沿着多个感测向量获得心脏信号，其中至少一部分感测向量延伸到位于靠近左心室的电极。系统和方法监测沿着多个感测向量获得的心脏信号中的感兴趣区段，以识别感兴趣区段中的偏离基线。系统和方法记录与感兴趣的部分中的偏差相关联的定时或分段移位信息中的至少一个; 并且基于定时或段位移信息中的至少一个来识别缺血区域的大小，发育方向或进展速度中的至少一个。

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