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    • 4. 发明申请
    • FUSED HETEROCYCLES
    • 熔融杂环
    • US20100029741A1
    • 2010-02-04
    • US12537896
    • 2009-08-07
    • James M. DorseyMichele L. R. HeffernanQun Kevin FangRobert J. FoglesongSeth C. HopkinsCyprian O. OgbuMustapha SoukriKerry L. Spear
    • James M. DorseyMichele L. R. HeffernanQun Kevin FangRobert J. FoglesongSeth C. HopkinsCyprian O. OgbuMustapha SoukriKerry L. Spear
    • A61K31/407A61P25/00
    • A61K31/407C07D491/04C07D495/04
    • This invention provides methods of improving cognitive function by administering to a subject a therapeutically effective amount of a fused heterocycle having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3 is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
    • 本发明提供了通过向受试者施用治疗有效量的具有下式的稠合杂环来提高认知功能的方法:其中R1是选自H,取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R2是选自H取代或未取代的烯基,取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R3是选自H,C1-C6取代或未取代的烷基,取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R4是选自OH和O-X +的成员,其中X +是选自有机正离子和无机阳离子的正离子。 取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式:其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。 索引n是从1到4的整数。