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1. 发明授权

US10174300B2 Polypeptide 有权
公开(公告)号：US10174300B2
公开(公告)日：2019-01-08
申请号：US15171448
申请日：2016-06-02
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： C07K14/31 , C07K16/40 , C12N9/36 , G01N33/569 , A61K38/00
摘要： The invention relates to a polypeptide, a corresponding nucleic acid molecule, a construct and/or vector and/or cell comprising such nucleic acid molecule and/or a composition comprising said polypeptide, nucleic acid molecule, construct, vector and/or cell. The invention further relates to such composition for medical use, preferably for use in treating an infectious disease. Furthermore, the invention relates to the use of said polypeptide, nucleic acid molecule, construct, vector, cell and/or composition as an antimicrobial, preferably as a food additive or disinfectant, or for detecting bacteria, preferably in a diagnostic application.

2. 发明申请

US20180237760A1 A novel endolysin polypeptide 审中-公开
公开(公告)号：US20180237760A1
公开(公告)日：2018-08-23
申请号：US15759883
申请日：2016-09-12
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： C12N9/36 , A61K38/47 , A01N43/50
摘要： The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention relates to a novel endolysin polypeptide specifically targeting a bacterial Staphylococcus cell. The invention further relates to said endolysin polypeptide for medical use, preferably for treating an individual suffering from a condition associated with Staphylococcus infection.

3. 发明授权

US09789167B2 Polypeptide mixes with antibacterial activity 有权
公开(公告)号：US09789167B2
公开(公告)日：2017-10-17
申请号：US14399643
申请日：2013-05-07
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： A61K38/46 , A23L3/3463 , C12N9/50 , C12N9/80 , C12N9/00 , A23B4/22 , A61K38/16 , A61K38/54 , A61K38/48 , A61K38/50 , A61K45/06 , A61K38/43
CPC分类号： A61K38/46 , A23B4/22 , A23L3/3463 , A23L3/34635 , A23V2002/00 , A61K38/162 , A61K38/43 , A61K38/48 , A61K38/50 , A61K38/54 , A61K45/06 , C12N9/00 , C12N9/503 , C12N9/80
摘要： The invention relates to the field of microbiology, specifically to a combination of a source of a first enzymatic active domain and a source of a second enzymatic active domain and to a composition comprising said combination. The invention further relates to a composition comprising said combination for use as a medicament, to the use of said composition as an antimicrobial agent and to a method for controlling microbial contamination in a food- or feed product, on and/or in food- or feed processing equipment, on and/or in food- or feed containers.

4. 发明申请

US20230140823A1 A stabilized protein of interest. 有权
公开(公告)号：US20230140823A1
公开(公告)日：2023-05-04
申请号：US17912050
申请日：2021-03-18
申请人： Micreos Human Health B.V.
发明人： Fritz Eichenseher
IPC分类号： C12N9/96 , A61K38/46 , A61K47/46 , A61K9/00 , A61K9/06 , A61K9/14 , A61K9/19 , A61P17/00 , C12N9/36
摘要： The present invention relates to the field of medicine, specifically to the field of treatment of a malignant condition associated with infection with a bacterium that aggravates and/or induces proliferation of the malignant conditions.

5. 发明申请

US20210130802A1 Novel endolysin polypeptide 有权
公开(公告)号：US20210130802A1
公开(公告)日：2021-05-06
申请号：US17092382
申请日：2020-11-09
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： C12N9/36 , C07K14/31 , A01N43/50 , A61K38/47
摘要： The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention relates to a novel endolysin polypeptide specifically targeting a bacterial Staphylococcus cell. The invention further relates to said endolysin polypeptide for medical use, preferably for treating an individual suffering from a condition associated with Staphylococcus infection.

6. 发明申请

US20160369255A1 Polypeptide 审中-公开
标题翻译：多肽
公开(公告)号：US20160369255A1
公开(公告)日：2016-12-22
申请号：US15171448
申请日：2016-06-02
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： C12N9/36
CPC分类号： C12N9/2462 , A61K38/00 , C07K14/31 , G01N33/56938
摘要： The invention relates to a polypeptide, a corresponding nucleic acid molecule, a construct and/or vector and/or cell comprising such nucleic acid molecule and/or a composition comprising said polypeptide, nucleic acid molecule, construct, vector and/or cell. The invention further relates to such composition for medical use, preferably for use in treating an infectious disease. Furthermore, the invention relates to the use of said polypeptide, nucleic acid molecule, construct, vector, cell and/or composition as an antimicrobial, preferably as a food additive or disinfectant, or for detecting bacteria, preferably in a diagnostic application.
摘要翻译：本发明涉及多肽，相应的核酸分子，包含此类核酸分子的构建体和/或载体和/或细胞和/或包含所述多肽，核酸分子，构建体，载体和/或细胞的组合物。本发明还涉及这种用于医疗用途的组合物，优选用于治疗感染性疾病。此外，本发明涉及所述多肽，核酸分子，构建体，载体，细胞和/或组合物作为抗微生物剂，优选作为食品添加剂或消毒剂或用于检测细菌，优选在诊断应用中的用途。

7. 发明申请

US20150118189A1 POLYPEPTIDE MIXES WITH ANTIBACTERIAL ACTIVITY 有权
标题翻译：具有抗菌活性的多肽混合物
公开(公告)号：US20150118189A1
公开(公告)日：2015-04-30
申请号：US14399643
申请日：2013-05-07
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： A61K38/46 , A23L3/3463 , A61K38/48 , A61K45/06 , A61K38/50
CPC分类号： A61K38/46 , A23B4/22 , A23L3/3463 , A23L3/34635 , A23V2002/00 , A61K38/162 , A61K38/43 , A61K38/48 , A61K38/50 , A61K38/54 , A61K45/06 , C12N9/00 , C12N9/503 , C12N9/80
摘要： The invention relates to the field of microbiology, specifically to a combination of a source of a first enzymatic active domain and a source of a second enzymatic active domain and to a composition comprising said combination. The invention further relates to a composition comprising said combination for use as a medicament, to the use of said composition as an antimicrobial agent and to a method for controlling microbial contamination in a food- or feed product, on and/or in food- or feed processing equipment, on and/or in food- or feed containers.
摘要翻译：本发明涉及微生物学领域，具体涉及第一酶活性结构域的来源和第二酶活性结构域的来源以及包含所述组合的组合物的组合。本发明还涉及一种组合物，其包含用作药物的所述组合，所述组合物作为抗微生物剂的用途以及用于控制食品或饲料产品中的微生物污染的方法和/或食品或饲料饲料加工设备，在和/或食品或饲料容器中。

8. 发明申请

US20220184187A1 Combination treatment for atopic dermatitis 有权
公开(公告)号：US20220184187A1
公开(公告)日：2022-06-16
申请号：US17687789
申请日：2022-03-07
申请人： Micreos Human Health B.V.
发明人： Mark Leonard Offerhaus , Fritz Eichenseher , Martin Johannes Loessner
IPC分类号： A61K38/47 , A61K38/16 , A61K38/21 , A61K31/573 , A61K31/56 , A61K45/06
摘要： The invention relates to the field of medicine, specifically to the field of treatment of dermatitis or eczema, even more specifically to the field of treatment of atopic dermatitis. The invention relates to a novel composition and a novel kit of parts, both comprising an anti-inflammatory compound and a compound specifically targeting a bacterial cell, preferably a gram positive bacterial cell. The invention further relates to said composition and/or kit of parts for medical use, preferably for treating an individual suffering from eczema.

9. 发明授权

US11339386B2 Endolysin polypeptide 有权
公开(公告)号：US11339386B2
公开(公告)日：2022-05-24
申请号：US17092382
申请日：2020-11-09
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： A61K39/00 , C12N9/36 , C07K14/31 , A01N43/50 , A61K38/47 , A61K38/00
摘要： The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention relates to a novel endolysin polypeptide specifically targeting a bacterial Staphylococcus cell. The invention further relates to said endolysin polypeptide for medical use, preferably for treating an individual suffering from a condition associated with Staphylococcus infection.

10. 发明授权

US10829749B2 Endolysin polypeptide 有权
公开(公告)号：US10829749B2
公开(公告)日：2020-11-10
申请号：US15759883
申请日：2016-09-12
申请人： Micreos Human Health B.V.
发明人： Martin Johannes Loessner , Fritz Eichenseher
IPC分类号： A61K39/00 , C12N9/36 , C07K14/31 , A01N43/50 , A61K38/47 , A61K38/00
摘要： The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention relates to a novel endolysin polypeptide specifically targeting a bacterial Staphylococcus cell. The invention further relates to said endolysin polypeptide for medical use, preferably for treating an individual suffering from a condition associated with Staphylococcus infection.

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