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1. 发明授权

US11584956B2 Selectively controllable cleavable linkers 有权
公开(公告)号：US11584956B2
公开(公告)日：2023-02-21
申请号：US16230787
申请日：2018-12-21
申请人： Microsoft Technology Licensing, LLC
发明人： Karin Strauss , Bichlien Hoang Nguyen
IPC分类号： C12Q1/6834 , C07H21/04 , C07K1/04 , C07K1/10 , C07K14/00 , C07H99/00
摘要： Selectively controllable cleavable linkers include electrochemically-cleavable linkers, photolabile linkers, thermolabile linkers, chemically-labile linkers, and enzymatically-cleavable linkers. Selective cleavage of individual linkers may be controlled by changing local conditions. Local conditions may be changed by activating electrodes in proximity to the linkers, exposing the linkers to light, heating the linkers, or applying chemicals. Selective cleaving of enzymatically-cleavable linkers may be controlled by designing the sequences of different sets of the individual linkers to respond to different enzymes. Cleavable linkers may be used to attach polymers to a solid substrate. Selective cleavage of the linkers enables release of specific polymers from the solid substrate. Cleavable linkers may also be used to attach protecting groups to the ends of growing polymers. The protecting groups may be selectively removed by cleavage of the linkers to enable growth of specific polymers.

2. 发明申请

US20220179891A1 SYSTEMS AND METHODS FOR PROVIDING SIMILARITY-BASED RETRIEVAL OF INFORMATION STORED IN DNA 有权
公开(公告)号：US20220179891A1
公开(公告)日：2022-06-09
申请号：US17602075
申请日：2020-04-09
申请人： University of Washington , Microsoft Technology Licensing, LLC
发明人： Luis Ceze , Karin Strauss , Georg Seelig , Callie Bee , Yuan-Jyue Chen
IPC分类号： G06F16/33 , G16B30/10 , G16B40/20
摘要： In some embodiments, techniques are provided for conducting similarity-based searches using DNA. In some embodiments, sets of features that represent stored data sets are encoded in DNA sequences such that a hybridization yield between a molecule having a given stored DNA sequence and a molecule having a reverse complement of a DNA sequence that encodes a set of features that represent a query data set reflects an amount of similarity between the set of features that represent the query data set and the set of features encoded in the given stored DNA sequence. In some embodiments, machine learning techniques are used to determine the DNA sequence encoding. In some embodiments, machine learning techniques are used to predict hybridization yields between DNA molecules.

3. 发明申请

US20210238577A1 ELECTROCHEMICALLY-CLEAVABLE LINKERS 有权
公开(公告)号：US20210238577A1
公开(公告)日：2021-08-05
申请号：US16781987
申请日：2020-02-04
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC
发明人： Bichlien NGUYEN , Jake Smith , Karin Strauss
IPC分类号： C12N9/96 , C12N9/12 , C25B3/00 , C12P19/34
摘要： This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

4. 发明授权

US10774379B2 Random access of data encoded by polynucleotides 有权
公开(公告)号：US10774379B2
公开(公告)日：2020-09-15
申请号：US15459268
申请日：2017-03-15
申请人： Microsoft Technology Licensing, LLC , University of Washington
发明人： Yuan-Jyue Chen , Karin Strauss , Luis H. Ceze , Lee Organick
IPC分类号： C12Q1/6869 , C07H21/02 , C12P19/34 , G06F16/16 , G16B99/00 , G16B50/00 , C07H21/00 , C12Q1/00 , G16B50/40
摘要： This disclosure describes frameworks and techniques related to the random access of digital data encoded by polynucleotides. Digital data of a data file can be encoded as a series of nucleotides and one or more polynucleotide sequences can be generated that encode the digital data for the data file. The bits of the digital data can be segmented to produce multiple polynucleotide sequences that encode the bits of the digital data with each polynucleotide sequence encoding an individual segment of the digital data. The individual segments can be grouped together and associated with a group identifier. Each data file can be associated with a number of group identifiers and the number of segments in each group can be within a specified range. Primers corresponding to the group identifiers can be used to selectively access the polynucleotides that encode the digital data of a data file.

5. 发明申请

US20170141793A1 ERROR CORRECTION FOR NUCLEOTIDE DATA STORES 审中-公开
公开(公告)号：US20170141793A1
公开(公告)日：2017-05-18
申请号：US15004827
申请日：2016-01-22
申请人： Microsoft Technology Licensing, LLC , University of Washington
发明人： Karin Strauss , Siena Dumas Ang , Luis H. Ceze , James Bornholt
IPC分类号： H03M13/05 , G06F19/28 , H03M13/00 , G06F19/16
CPC分类号： H03M13/05 , G16B15/00 , G16B50/00 , H03M13/09 , H03M13/098 , H03M13/373 , H03M13/611
摘要： This disclosure provides techniques for adding error correction to information in a data store that encodes information as a sequence of bases in polynucleotides. Errors may be introduced through creation of the database (e.g., oligonucleotide synthesis) and/or reading information from the database (e.g., polynucleotide sequencing). Additional polynucleotides added to the database can provide error correction through redundancy. The sequence of polynucleotides that provide error correction may be designed by performing an invertible summary operation on information to be stored in the database. One example of an invertible summary operation is the exclusive or operation (XOR). This disclosure also provides techniques for storing metadata related to organization of a database and structure of information on polynucleotides within the database. Metadata may be encoded in polynucleotides and added to the data store. The polynucleotides holding metadata may be designed with unique primer sites so that the metadata can be selectively amplified and sequenced.

6. 发明授权

US09367519B2 Sparse matrix data structure 有权
标题翻译：稀疏矩阵数据结构
公开(公告)号：US09367519B2
公开(公告)日：2016-06-14
申请号：US14015894
申请日：2013-08-30
申请人： Microsoft Technology Licensing, LLC
发明人： Karin Strauss , Jeremy Fowers , Kalin Ovtcharov
IPC分类号： G06F7/00 , G06F17/16
CPC分类号： G06F17/16
摘要： Various embodiments relating to encoding a sparse matrix into a data structure format that may be efficiently processed via parallel processing of a computing system are provided. In one embodiment, a sparse matrix may be received. A set of designated rows of the sparse matrix may be traversed until all non-zero elements in the sparse matrix have been placed in a first array. Each time a row in the set is traversed, a next non-zero element in that row may be placed in the first array. If all non-zero elements for a given row of the set of designated rows have been placed in the first array, the given row may be replaced in the set of designated rows with a next unprocessed row of the sparse matrix. The data structure in which the sparse matrix is encoded may be outputted. The data structure may include the first array.
摘要翻译：提供了关于将稀疏矩阵编码成可以通过计算系统的并行处理而被有效地处理的数据结构格式的各种实施例。在一个实施例中，可接收稀疏矩阵。可以遍历稀疏矩阵的一组指定行，直到稀疏矩阵中的所有非零元素已经被放置在第一阵列中。每次遍历集合中的一行时，该行中的下一个非零元素可以放置在第一个数组中。如果指定行集合中给定行的所有非零元素都已放置在第一个数组中，则可以在指定行集合中替换给定行，并使用稀疏矩阵的下一个未处理行。可以输出其中编码稀疏矩阵的数据结构。数据结构可以包括第一阵列。

7. 发明申请

US20220380403A1 PHOTON GENERATING SUBSTRATES FOR OLIGONUCLEOTIDE SYNTHESIS 有权
公开(公告)号：US20220380403A1
公开(公告)日：2022-12-01
申请号：US17331321
申请日：2021-05-26
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC
发明人： Bichlien Hoang Nguyen , Karin Strauss , Jake Allen Smith , Richard Prescott Rouse , Douglas Mitchell Carmean , Matthew David Turner , Gagan Gupta
IPC分类号： C07H21/04 , B01J19/12 , B01J19/00
摘要： Photon generating substrates for light-directed oligonucleotide synthesis are disclosed. Light is generated within a solid-state stack that supports growing oligonucleotides. The light may be generated by microLEDs, a pass-through liquid crystal panel, or an LCoS system. Light passes through a transmissive layer on which growing oligonucleotides are attached. Patterning of the light is controlled by selective activation of the microLEDs or by selective control of the transparency of a liquid crystal layer. Photolabile blocking groups are selectively removed by exposure to patterned light emitted from the photon generating substrate.

8. 发明授权

US11059016B2 Silica encapsulated DNA on magnetic nanoparticles 有权
公开(公告)号：US11059016B2
公开(公告)日：2021-07-13
申请号：US16017682
申请日：2018-06-25
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC
发明人： Karin Strauss , Weida Chen , Robert Grass , Alexander Xavier Christof Kohll , Bichlien Hoang Nguyen
IPC分类号： B01J13/22 , C07H21/04 , G16B30/00 , B82Y10/00
摘要： A data storage medium is disclosed comprising a substrate covered with alternating layers of a polycationic molecule and artificially synthesized DNA molecules encoding digital information. The magnetic substrate may be a metallic nanoparticle formed from a metal such as iron or cobalt. The polycationic molecule may be polyethyleneimine (PEI). The DNA is protected from degradation by encapsulation in silica. A process for stably storing DNA is also disclosed. Stored DNA may be freed from the silica for sequencing or other analysis by washing the silica-coated DNA with a buffered hydrogen fluoride solution. Storage densities of more than 7% DNA by weight are achieved on nanoparticles.

9. 发明申请

US20180265921A1 RANDOM ACCESS OF DATA ENCODED BY POLYNUCLEOTIDES 审中-公开
公开(公告)号：US20180265921A1
公开(公告)日：2018-09-20
申请号：US15459268
申请日：2017-03-15
申请人： Microsoft Technology Licensing, LLC , University of Washington
发明人： Yuan-Jyue Chen , Karin Strauss , Luis H. Ceze , Lee Organick
IPC分类号： C12Q1/68 , C07H21/02 , G06F17/30 , G06F19/10 , C12P19/34
摘要： This disclosure describes frameworks and techniques related to the random access of digital data encoded by polynucleotides. Digital data of a data file can be encoded as a series of nucleotides and one or more polynucleotide sequences can be generated that encode the digital data for the data file. The bits of the digital data can be segmented to produce multiple polynucleotide sequences that encode the bits of the digital data with each polynucleotide sequence encoding an individual segment of the digital data. The individual segments can be grouped together and associated with a group identifier. Each data file can be associated with a number of group identifiers and the number of segments in each group can be within a specified range. Primers corresponding to the group identifiers can be used to selectively access the polynucleotides that encode the digital data of a data file.

10. 发明申请

US20180223341A1 Primer Design for Retrieval of Stored Nucleotides 审中-公开
公开(公告)号：US20180223341A1
公开(公告)日：2018-08-09
申请号：US15427808
申请日：2017-02-08
申请人： Microsoft Technology Licensing, LLC
发明人： Yuan-Jyue Chen , Karin Strauss , Luis H. Ceze , Siena Dumas Ang , Sergey Yekhanin
IPC分类号： C12Q1/68
摘要： This disclosure describes techniques to improve the accuracy of random access of data stored in polynucleotide sequence data storage systems. Primers used in polynucleotide sequence replication and amplification can be scored against a number of criteria that indicate the fitness of sequences of nucleotides to function as primers. Primers having scores that indicate a particular fitness to function as primers can be added to a specific group of primers. The primers from the group of primers can be used in amplification and replication of polynucleotide sequences that encode digital data. Additionally, an amount of overlap between primer targets and payloads encoding digital data can be determined. Minimizing the amount of overlap between primer targets and payloads can improve the efficiency of polynucleotide replication and amplification. The bits of the digital data can be randomized to minimize the amount of overlap between payloads encoding the digital data and primer targets.

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