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1. 发明授权

US08864840B2 Intragastric implants with collapsible frames 有权
标题翻译：具有可折叠框架的内部植入物
公开(公告)号：US08864840B2
公开(公告)日：2014-10-21
申请号：US13272131
申请日：2011-10-12
申请人： Zachary Dominguez , Mitchell H. Babkes , Justin Schwab , Christopher S. Mudd , Jason Hoover
发明人： Zachary Dominguez , Mitchell H. Babkes , Justin Schwab , Christopher S. Mudd , Jason Hoover
IPC分类号： A61F2/04
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了跨腹部肥胖症治疗装置及其相关操作方法，其占据胃内的空间和/或刺激胃壁。经腹肥胖治疗装置和相关方法旨在帮助患者保持健康的体重。器件的特征包括经皮插入和无侵入性手术，无相关患者的侵入性手术风险，无明显的患者不适。这些装置的使用寿命可能依赖于酸性胃内的长期生存能力，但意图持续一年或更长时间。这些装置具有在尺寸上变化的能力，并且希望是自动致动，因为它们使用内部电动机或致动器改变形状和/或体积。设备的变化特征有助于防止人的胃部补偿植入物，例如有时会发生静态胃内装置。

2. 发明申请

US20120095494A1 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 有权
标题翻译：具有可拉框的INTRAGASTRIC植入物
公开(公告)号：US20120095494A1
公开(公告)日：2012-04-19
申请号：US13272131
申请日：2011-10-12
申请人： Zachary Dominguez , Mitchell H. Babkes , Justin Schwab , Christopher S. Mudd , Jason Hoover
发明人： Zachary Dominguez , Mitchell H. Babkes , Justin Schwab , Christopher S. Mudd , Jason Hoover
IPC分类号： A61M29/00 , A61M29/02
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了跨腹部肥胖症治疗装置及其相关操作方法，其占据胃内的空间和/或刺激胃壁。经腹肥胖治疗装置和相关方法旨在帮助患者保持健康的体重。器件的特征包括经皮插入和无侵入性手术，无相关患者的侵入性手术风险，无明显的患者不适。这些装置的使用寿命可能依赖于酸性胃内的长期生存能力，但意图持续一年或更长时间。这些装置具有在尺寸上变化的能力，并且希望是自动致动，因为它们使用内部电动机或致动器改变形状和/或体积。设备的变化特征有助于防止人的胃部补偿植入物，例如有时会发生静态胃内装置。

3. 发明授权

US08956380B2 Reactive intragastric implant devices 有权
标题翻译：反应性胃内植入装置
公开(公告)号：US08956380B2
公开(公告)日：2015-02-17
申请号：US13276182
申请日：2011-10-18
申请人： Zachary Dominguez , Justin Schwab , Mitchell H. Babkes
发明人： Zachary Dominguez , Justin Schwab , Mitchell H. Babkes
IPC分类号： A61M29/00 , A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three-dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
摘要翻译：提供经口三维正交的胃内弹簧系统，装置，操作和制造方法。经口三维正交的胃内弹簧系统和/或装置（以及相关的制造和手术方法）可以通过刺激患者的胃壁来减轻肥胖或体重。三维正交的胃内弹簧装置可以是纯粹的机械装置，其包括柔性体，该弹性体响应于一个方向上的输入力而变形并引起在正交方向上的合成位移，从而对内壁壁施加压力的病人。或者，三维正交的胃内弹簧装置可以包括构造成占据患者胃中的体积的可变大小的气囊，从而减少患者胃中的空间量。

4. 发明申请

US20120095496A1 REACTIVE INTRAGASTRIC IMPLANT DEVICES 有权
标题翻译：反应性入口植入装置
公开(公告)号：US20120095496A1
公开(公告)日：2012-04-19
申请号：US13276182
申请日：2011-10-18
申请人： Zachary Dominguez , Justin Schwab , Mitchell H. Babkes
发明人： Zachary Dominguez , Justin Schwab , Mitchell H. Babkes
IPC分类号： A61M29/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three-dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
摘要翻译：提供经口三维正交的胃内弹簧系统，装置，操作和制造方法。经口三维正交的胃内弹簧系统和/或装置（以及相关的制造和手术方法）可以通过刺激患者的胃壁来减轻肥胖或体重。三维正交的胃内弹簧装置可以是纯粹的机械装置，其包括柔性体，该弹性体响应于一个方向上的输入力而变形并引起在正交方向上的合成位移，从而对内壁壁施加压力的病人。或者，三维正交的胃内弹簧装置可以包括构造成占据患者胃中的体积的可变大小的气囊，从而减少患者胃中的空间量。

5. 发明申请

US20120095495A1 SPACE-FILLING INTRAGASTRIC IMPLANTS WITH FLUID FLOW 有权
标题翻译：带流体的空间填充入口植入物
公开(公告)号：US20120095495A1
公开(公告)日：2012-04-19
申请号：US13275211
申请日：2011-10-17
申请人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab
发明人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab
IPC分类号： A61M29/00
CPC分类号： A61F5/0033 , A61F5/0003 , A61F5/0013 , A61F5/003 , A61F5/0036 , A61F5/0079 , A61F5/0086
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可能占据胃内的体积，从而降低进气能力。此外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，以刺激饱腹引起的神经。此外，某些装置通过阻塞或阻碍通过幽门括约肌的流动来缓慢胃排空。许多装置组合了这些饱腹感特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。

6. 发明授权

US09095405B2 Space-filling intragastric implants with fluid flow 有权
标题翻译：填充胃内植入物与流体流动
公开(公告)号：US09095405B2
公开(公告)日：2015-08-04
申请号：US13275211
申请日：2011-10-17
申请人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab
发明人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0003 , A61F5/0013 , A61F5/003 , A61F5/0036 , A61F5/0079 , A61F5/0086
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可能占据胃内的体积，从而降低进气能力。此外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，以刺激饱腹引起的神经。此外，某些装置通过阻塞或阻碍通过幽门括约肌的流动来缓慢胃排空。许多装置组合了这些饱腹感特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。

7. 发明申请

US20120095497A1 NON-INFLATABLE GASTRIC IMPLANTS AND SYSTEMS 审中-公开
标题翻译：不可燃气体植入物和系统
公开(公告)号：US20120095497A1
公开(公告)日：2012-04-19
申请号：US13276904
申请日：2011-10-19
申请人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab , Jason Hoover
发明人： Mitchell H. Babkes , Zachary Dominguez , Justin Schwab , Jason Hoover
IPC分类号： A61M29/00
CPC分类号： A61F5/0036 , A61F5/0089
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, or the greater and lesser curvatures in the middle of the stomach, to stimulate satiety-inducing nerves. Some devices may combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可能占据胃内的体积，从而降低进气能力。另外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，或胃中部的较大和较小的曲率，以刺激饱腹引起的神经。一些装置可以组合这些饱腹感诱发特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。

8. 发明申请

US20120095385A1 INTRAGASTRIC IMPLANTS WITH DUODENAL ANCHORS 审中-公开
标题翻译：带有DUODENAL锚杆的INTRAGASTRIC植入物
公开(公告)号：US20120095385A1
公开(公告)日：2012-04-19
申请号：US13276174
申请日：2011-10-18
申请人： Zachary Dominguez , Joseph S. Raven , Mitchell H. Babkes
发明人： Zachary Dominguez , Joseph S. Raven , Mitchell H. Babkes
IPC分类号： A61F2/04 , A61M29/02
CPC分类号： A61F5/0033 , A61F5/0036 , A61F5/0079
摘要： Intragastric fluid transfer devices and related methods for operation thereof are disclosed. The intragastric fluid transfer devices and related methods are intended to assist a patient in maintaining a healthy body weight by stimulating the inner stomach walls and/or the inner duodenum walls. Features of the intragastric fluid transfer device include insertion of the devices transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these intragastric fluid transfer devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer.
摘要翻译：公开了胃内液体输送装置及其操作方法。胃内液体输送装置和相关方法旨在通过刺激内部胃壁和/或十二指肠内壁来帮助患者维持健康体重。胃内液体输送装置的特征包括经皮和无侵入性手术的装置插入，无相关患者的侵入性手术风险，并且没有实质的患者不适。这些胃内液体输送装置的使用寿命可以依赖于酸性胃内的长期存活性，但是其持续一年或更长时间。

9. 发明申请

US20120095499A1 UPPER STOMACH GASTRIC IMPLANTS 有权
标题翻译：上面的花岗岩植物
公开(公告)号：US20120095499A1
公开(公告)日：2012-04-19
申请号：US13275166
申请日：2011-10-17
申请人： Mitchell H. Babkes , Zachary Dominguez
发明人： Mitchell H. Babkes , Zachary Dominguez
IPC分类号： A61M29/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may provide slowed entry into the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Some devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse. The implants are formed of materials that permit the implant to be compressed into a substantially linear transoral delivery configuration and that will resist degradation over a period of at least six months within the stomach
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可以提供进入胃的缓慢进入，从而降低吸入能力。此外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，以刺激饱腹引起的神经。一些装置结合了这些饱腹感诱发特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。植入物由允许植入物压缩成基本上线性的经口输送构型的材料形成，并且将在胃内至少6个月的时间内抵抗降解

10. 发明授权

US09498365B2 Intragastric implants with multiple fluid chambers 有权
标题翻译：具有多个流体腔的内部植入物
公开(公告)号：US09498365B2
公开(公告)日：2016-11-22
申请号：US13275224
申请日：2011-10-17
申请人： Mitchell H. Babkes , Zachary Dominguez , Christopher S. Mudd , Craig Olroyd , Jonathan Daugusta
发明人： Mitchell H. Babkes , Zachary Dominguez , Christopher S. Mudd , Craig Olroyd , Jonathan Daugusta
IPC分类号： A61M29/00 , A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： An intragastric obesity treatment implant promotes a feeling of satiety in the patient by contacting the insides of the stomach wall, reducing the space in the stomach, or otherwise reducing the amount of food consumed. One intragastric obesity treatment implant two inflatable balloons coupled via a flow restrictor through which fluid may flow in response to peristaltic motions of a patient's stomach. Additionally, one implant comprises a pumping chamber coupled to a reservoir, where the pumping chamber moves stomach fluids into the reservoir in response to peristaltic motions of the patient's stomach.
摘要翻译：胃内肥胖治疗植入物通过接触胃壁的内部，减少胃中的空间或以其他方式减少消耗的食物量来促进患者的饱腹感。一个胃内肥胖症治疗植入两个通过限流器联接的可充气气囊，流体可以响应于患者胃的蠕动运动而流动。此外，一个植入物包括联接到储存器的泵送室，其中泵送室响应于患者胃的蠕动运动而将胃液移动到储存器中。

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