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1. 发明申请

US20110081423A1 Tissue Stabilization for Heart Failure 有权
标题翻译：组织稳定心力衰竭
公开(公告)号：US20110081423A1
公开(公告)日：2011-04-07
申请号：US12845414
申请日：2010-07-28
申请人： Norman R. Weldon , Matthew F. Ogle
发明人： Norman R. Weldon , Matthew F. Ogle
IPC分类号： A61K31/353 , A61K31/7034 , A61K36/63 , A61K36/00 , A61K36/82 , A61K36/484 , A61K36/886 , A61K35/56 , A61K31/11 , A61K31/13 , A61K31/336 , A61K31/655 , A61P9/04 , A61P9/00 , A61M25/00 , B82Y5/00
CPC分类号： A61M25/00 , A61L27/227 , A61L27/24 , A61L27/54 , A61L2300/252 , A61L2430/20
摘要： Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir. Controlled placement and release of the therapeutic composition can be achieved using a delivery vehicle to formulate the composition.
摘要翻译：讨论了使用治疗组合物稳定心脏组织以治疗充血性心力衰竭的方法和装置。治疗组合物可以包括弹性蛋白稳定剂，胶原稳定剂或其组合，并且使用具有连接的储存器的导管型装置将其施加到心包的外表面或其组合。治疗组合物的控制放置和释放可以使用递送载体来制备组合物来实现。

2. 发明授权

US08496911B2 Tissue stabilization for heart failure 有权
标题翻译：心力衰竭组织稳定
公开(公告)号：US08496911B2
公开(公告)日：2013-07-30
申请号：US12845414
申请日：2010-07-28
申请人： Norman R. Weldon , Matthew F. Ogle
发明人： Norman R. Weldon , Matthew F. Ogle
IPC分类号： A61K49/00
CPC分类号： A61M25/00 , A61L27/227 , A61L27/24 , A61L27/54 , A61L2300/252 , A61L2430/20
摘要： Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir. Controlled placement and release of the therapeutic composition can be achieved using a delivery vehicle to formulate the composition.
摘要翻译：讨论了使用治疗组合物稳定心脏组织以治疗充血性心力衰竭的方法和装置。治疗组合物可以包括弹性蛋白稳定剂，胶原稳定剂或其组合，并且使用具有连接的储存器的导管型装置将其施加到心包的外表面或其组合。治疗组合物的控制放置和释放可以使用递送载体来制备组合物来实现。

3. 发明授权

US08444624B2 Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections 有权
标题翻译：具有密封元件的血管医疗器械和用于治疗隔离血管切片的程序
公开(公告)号：US08444624B2
公开(公告)日：2013-05-21
申请号：US12581311
申请日：2009-10-19
申请人： Matthew F. Ogle , Jason C. Isenburg
发明人： Matthew F. Ogle , Jason C. Isenburg
IPC分类号： A61M31/00 , A61M29/00
CPC分类号： A61M25/1002 , A61B17/12045 , A61B17/12109 , A61B17/12113 , A61B17/12136 , A61K31/05 , A61M25/0032 , A61M25/10 , A61M2025/0681 , A61M2025/1015 , A61M2025/1052
摘要： Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device comprises an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration means to improve the effectiveness of the treatment.
摘要翻译：描述用于隔离容器的选定部分的装置。在一些实施例中，该装置包括可相对于彼此移动的引导器护套和密封导管，以产生具有可调大小和位置的隔离体积。描述了使用该装置治疗血管动脉瘤的方法。通过将有效量的稳定剂递送到包含动脉瘤的分离体积来实现治疗。该装置可选地具有提高治疗效果的抽吸装置。

4. 发明授权

US07879062B2 Fiber based embolism protection device 有权
标题翻译：纤维基栓塞保护装置
公开(公告)号：US07879062B2
公开(公告)日：2011-02-01
申请号：US10795131
申请日：2004-03-06
申请人： Jason A. Galdonik , Matthew F. Ogle , Jim Pokorney , Thomas F. Hinnenkamp
发明人： Jason A. Galdonik , Matthew F. Ogle , Jim Pokorney , Thomas F. Hinnenkamp
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/09 , A61M2025/09175 , B33Y80/00
摘要： Improved embolism protection devices comprises fibers that can have one configuration for delivery of the device and a second configuration in which the device is deployed for filtering of flow within a vessel. In some embodiments, the fibers can be connected to a fiber support, which is connected to an actuating element. The actuating element controls the transition from the delivery configuration to the deployed configuration. The embolism protection device can comprise a guidewire. The fibers can be attached at one end to a fiber support structure and at another end to the guidewire. A hypotube can be attached to the proximal end of the fibers while the guidewire is attached at the distal end of the fibers with the guidewire extending within a central channel of the hypotube. The hypotube can be used to guide the delivery of treatment structures, such as a balloon and/or a stent.
摘要翻译：改进的栓塞保护装置包括可以具有用于装置的输送的一种配置的纤维和其中部署用于过滤容器内的流动的装置的第二配置。在一些实施例中，纤维可以连接到连接到致动元件的纤维支撑件。致动元件控制从传送配置到部署配置的过渡。栓塞保护装置可以包括导丝。纤维的一端可以连接到纤维支撑结构，另一端可以连接到导丝。海波管可以附着在纤维的近端，而导丝被连接在纤维的远端，导丝延伸在海波管的中心通道内。海波管可用于引导治疗结构的传送，例如气囊和/或支架。

5. 发明授权

US06491617B1 Medical devices that resist restenosis 失效
标题翻译：抗再狭窄的医疗器械
公开(公告)号：US06491617B1
公开(公告)日：2002-12-10
申请号：US09476745
申请日：1999-12-30
申请人： Matthew F. Ogle , Peter S. Dardi
发明人： Matthew F. Ogle , Peter S. Dardi
IPC分类号： A61N500
CPC分类号： A61F2/82 , A61F2250/0067 , A61K51/1282 , A61L15/44 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/102 , A61L2300/114 , A61L2300/416 , A61L2300/44 , A61M2025/105 , A61N5/1002
摘要： Medical devices include biocomatible materials and a plurality of exogenous storage structures. The exogenous storage structures store a therapeutic agent which acts to inhibit restenosis. In some embodiments, the therapeutic agents are radioactive metal ions. In other embodiments, the medical device has an expandable structure with particles of therapeutic agent on its surface. The particles of therapeutic agent are delivered into a region susceptible to restenosis by direct application of the medical device against the adjacent wall.
摘要翻译：医疗装置包括生物相容性材料和多种外源储存结构。外源储存结构储存用于抑制再狭窄的治疗剂。在一些实施方案中，治疗剂是放射性金属离子。在其它实施例中，医疗装置具有在其表面上具有治疗剂颗粒的可扩张结构。通过将医疗装置直接施加到相邻的壁上，治疗剂的颗粒被递送到易于再狭窄的区域中。

6. 发明授权

US06468660B2 Biocompatible adhesives 有权
标题翻译：生物相容性粘合剂
公开(公告)号：US06468660B2
公开(公告)日：2002-10-22
申请号：US09751963
申请日：2000-12-29
申请人： Matthew F. Ogle , Andrea L. McConico
发明人： Matthew F. Ogle , Andrea L. McConico
IPC分类号： B32B2736
CPC分类号： C09J163/00 , A61L24/046 , Y10T428/31511 , Y10T428/31515 , C08L63/00
摘要： Novel adhesive compositions are described that include an epoxyamine and, preferably, a curing agent. The adhesive composition can be used in surgical settings such as implanting bioprostheses and/or in manufacturing of bioprostheses. Biocompatible substrates can be adhered together by an adhesive bond formed by curing of the epoxyamine adhesive composition.
摘要翻译：描述了包括环氧胺和优选固化剂的新型粘合剂组合物。粘合剂组合物可用于手术设置，例如植入生物预处理和/或生产生物假体的制造。可通过由环氧胺粘合剂组合物的固化形成的粘合剂粘结生物相容的基材。

7. 发明授权

US06302909B1 Calcification-resistant biomaterials 失效
标题翻译：耐钙生物材料
公开(公告)号：US06302909B1
公开(公告)日：2001-10-16
申请号：US08690661
申请日：1996-07-31
申请人： Matthew F. Ogle , Richard F. Schroeder
发明人： Matthew F. Ogle , Richard F. Schroeder
IPC分类号： A61F202
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/50 , A61L2400/02 , Y10S623/901 , Y10S623/925
摘要： The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than about 0.5 mg metal cations per gram of biocompatible material. The calcification inhibitors preferably decrease calcium deposition by greater than 95% relative to untreated tissue. The calcification inhibitors are bonded to the bioprosthetic material preferably at a pH between about 6.0 and 8.5.
摘要翻译：本发明涉及一种生物假体制品，其包括具有至少一种结合的外源储存结构的生物相容性材料，所述储存结构具有大于约0.5mg金属阳离子/克生物相容性材料。钙化抑制剂相对于未处理的组织优选减少钙沉积大于95％。钙化抑制剂优选在约6.0-8.5之间的pH下结合到生物假体材料上。

8. 发明授权

US06206917B1 Differential treatment of prosthetic devices 失效
公开(公告)号：US06206917B1
公开(公告)日：2001-03-27
申请号：US08850812
申请日：1997-05-02
申请人： R. Brian Williams , Richard F. Schroeder , Matthew F. Ogle
发明人： R. Brian Williams , Richard F. Schroeder , Matthew F. Ogle
IPC分类号： A61F210
CPC分类号： A61F2/2415 , A61F2/062
摘要： An apparatus is disclosed for differentially treating a medical device. One portion of the device is treated with a first fluid and a separate portion is treated with a second fluid. The second fluid generally is substantially different from the first fluid. The first fluid can be contacted with an flow region of the medical device. The apparatus can include a conduit system, where fluid flowing through the conduit system flows through the flow region. Sheet material can be treated differentially on the opposite surfaces of the sheet. The medical device can include vascular tissue.

9. 发明授权

US06190407B1 Medical article with adhered antimicrobial metal 失效
标题翻译：带有抗菌金属的医疗用品
公开(公告)号：US06190407B1
公开(公告)日：2001-02-20
申请号：US09224178
申请日：1998-12-31
申请人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
发明人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
IPC分类号： A61F206
CPC分类号： A61L31/16 , A01N59/16 , A61F2/2412 , A61L15/18 , A61L15/44 , A61L15/46 , A61L27/30 , A61L27/306 , A61L27/54 , A61L29/10 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/45 , Y10S623/901 , Y10T428/31692 , Y10T428/31707 , A01N2300/00
摘要： A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.
摘要翻译：可以使用各种新的方法将抗微生物元素金属与医疗制品相关联。相关的抗微生物金属降低与医疗用品的医疗用途相关的感染的风险。新的医疗用品是通过其中一些新方法生产的。一些方法涉及调节相关元素金属的解离速率的方法，使得可以在选定的时间段内实现所需程度的抗微生物活性。

10. 发明授权

US6132473A Differential treatment of prosthetic devices 失效
公开(公告)号：US6132473A
公开(公告)日：2000-10-17
申请号：US86193
申请日：1998-05-28
申请人： R. Brian Williams , Richard F. Schroeder , Matthew F. Ogle
发明人： R. Brian Williams , Richard F. Schroeder , Matthew F. Ogle
IPC分类号： A61F2/06 , A61F2/24 , A61P43/00 , A61F2/02
CPC分类号： A61F2/2415 , A61F2/062
摘要： An apparatus is disclosed for differentially treating a medical device. One portion of the device is treated with a first fluid and a separate portion is treated with a second fluid. The second fluid generally is substantially different from the first fluid. The first fluid can be contacted with an flow region of the medical device. The apparatus can include a conduit system, where fluid flowing through the conduit system flows through the flow region. Sheet material can be treated differentially on the opposite surfaces of the sheet. The medical device can include vascular tissue.

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