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1. 发明授权

US11678805B2 Active remote sensing system using time-of-flight sensor combined with cameras and wearable devices 有权
公开(公告)号：US11678805B2
公开(公告)日：2023-06-20
申请号：US17832340
申请日：2022-06-03
申请人： Omni Medsci, Inc.
发明人： Mohammed N. Islam
IPC分类号： A61B5/00 , G01J3/10 , G01J3/28 , G01J3/14 , G01J3/453 , G01J3/42 , G01J3/02 , G01N21/35 , G16H40/67 , G01N21/359 , A61B5/145 , G01N33/15 , G01N33/49 , G01N21/3563 , G01N21/39 , G01N33/02 , G01N33/44 , G01N21/88 , A61B5/1455 , G16Z99/00 , A61C19/04 , G01N21/3504 , H01S3/30 , G01J3/18 , G01J3/12 , G01N21/85 , G01N21/95 , H01S3/067 , H01S3/00 , G01M3/38 , A61C1/00
CPC分类号： A61B5/0088 , A61B5/0013 , A61B5/0022 , A61B5/0075 , A61B5/0086 , A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/4547 , A61B5/6801 , A61B5/7203 , A61B5/7257 , A61B5/742 , A61B5/7405 , A61C19/04 , G01J3/02 , G01J3/0218 , G01J3/108 , G01J3/14 , G01J3/28 , G01J3/2823 , G01J3/42 , G01J3/453 , G01N21/35 , G01N21/3504 , G01N21/359 , G01N21/3563 , G01N21/39 , G01N21/88 , G01N33/02 , G01N33/025 , G01N33/15 , G01N33/442 , G01N33/49 , G16H40/67 , G16Z99/00 , A61B5/0024 , A61B2562/0233 , A61B2562/0238 , A61B2562/146 , A61B2576/02 , A61C1/0046 , G01J3/1838 , G01J2003/104 , G01J2003/1208 , G01J2003/2826 , G01M3/38 , G01N21/85 , G01N21/9508 , G01N2021/3513 , G01N2021/3595 , G01N2021/399 , G01N2201/061 , G01N2201/062 , G01N2201/06113 , G01N2201/08 , G01N2201/12 , G01N2201/129 , H01S3/0092 , H01S3/06758 , H01S3/302 , Y02A90/10
摘要： An active remote sensing system is provided with an array of laser diodes that generate light directed to an object having one or more optical wavelengths that include at least one near-infrared wavelength between 700 nanometers and 2500 nanometers. One of the laser diodes pulses with pulse duration of approximately 0.5 to 2 nanoseconds at repetition rate between one kilohertz and about 100 megahertz. A beam splitter receives the laser light, separates the light into a plurality of spatially separated lights and directs the lights to the object. A detection system includes a photodiode array synchronized to the array of laser diodes and performs a time-of-flight measurement by measuring a temporal distribution of photons received from the object. The time-of-flight measurement is combined with images from a camera system, and the remote sensing system is configured to be coupled to a wearable device, a smart phone or a tablet.

2. 发明授权

US10466102B2 Spectroscopy system with laser and pulsed output beam 有权
公开(公告)号：US10466102B2
公开(公告)日：2019-11-05
申请号：US16028473
申请日：2018-07-06
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： G01J3/10 , G02F1/365 , H01S5/00 , H01S3/067 , H01S3/30 , G01B9/02 , G01J3/02 , H01S5/10 , H01S5/14 , G01J3/42 , G02B6/293 , H01S3/094 , H01S5/40 , G02F1/35 , H01S3/102
摘要： A spectroscopy system includes a light source having an input light source, including semiconductor diodes generating an input beam with a wavelength shorter than 2.5 microns. Cladding-pumped fiber amplifiers receive the input beam and form an amplified optical beam having a spectral width. A nonlinear element broadens the spectral width of the amplified optical beam to 100 nm or more through a nonlinear effect forming an output beam that is pulsed. A filter is coupled to at least one of a lens and a mirror that receives the output beam and delivers the filtered output beam to a sample. A detection system includes detectors configured to receive the output beam reflected or transmitted from the sample. The detection system is configured to use a lock-in technique with the pulsed output beam and the spectroscopy system is adapted to detect chemicals in the sample.

3. 发明授权

US10271904B2 Laser-based method and system for selectively processing target tissue material in a patient and optical catheter assembly for use therein 有权
公开(公告)号：US10271904B2
公开(公告)日：2019-04-30
申请号：US14719262
申请日：2015-05-21
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： A61B18/20 , A61F9/008 , A61B18/22 , H01S3/00 , H01S3/067 , H01S3/094 , H01S3/16 , H01S3/30 , A61B18/00
摘要： A system and method for selectively processing target tissue material in a patient include a laser subsystem for generating an output laser beam and a catheter assembly including an optical fiber for guiding the output laser beam. The beam has a predetermined selected wavelength between 900 nm and 2600 nm. The catheter assembly is sized to extend through an opening in a first part of the patient to a tissue material processing site within the patient. A beam delivery and focusing subsystem includes a focal distance, which may be adjustable, that positions the beam into at least one focused spot on the target tissue material disposed within a second part of the patient for a duration sufficient to allow laser energy to be absorbed by the target tissue material and converted to heat to produce a desired physical change in the target tissue material without causing undesirable changes to adjacent non-target material.

4. 发明授权

US10098546B2 Wearable devices using near-infrared light sources 有权
公开(公告)号：US10098546B2
公开(公告)日：2018-10-16
申请号：US15860065
申请日：2018-01-02
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： G01J3/00 , A61B5/00 , G01N33/49 , G01N33/44 , G01N33/15 , G01N33/02 , G01N21/88 , G01N21/3563 , G01N21/359 , G01J3/453 , A61B5/145 , A61B5/1455 , G01N21/39 , G01M3/38 , G01J3/28 , G01J3/10 , G01J3/18 , G01J3/14 , H01S3/30
摘要： A wearable device includes a measurement device having light emitting diodes (LEDs) measuring a physiological parameter. The measurement device modulates the LEDs to generate an optical beam having a near-infrared wavelength between 700-2500 nanometers. Lenses receive and deliver the optical beam to tissue, which reflects the optical beam to a receiver having spatially separated detectors coupled to analog-to-digital converters configured to generate receiver outputs. The receiver captures light while the LEDs are off, and reflected light from the tissue while the LEDs are on, to generate first and second signals, respectively. Signal-to-noise ratio is improved by differencing the first and second signals and by differencing the receiver outputs. The measurement device further improves signal-to-noise ratio of the reflected optical beam by increasing light intensity of the LEDs relative to an initial light intensity. The measurement device generates an output signal representing a non-invasive measurement on blood contained within the tissue.

5. 发明授权

US09500635B2 Short-wave infrared super-continuum lasers for early detection of dental caries 有权
标题翻译：用于早期检测龋齿的短波红外超连续激光器
公开(公告)号：US09500635B2
公开(公告)日：2016-11-22
申请号：US14651367
申请日：2013-12-17
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： G01J3/00 , G01N33/15 , A61B5/1455 , A61B5/00 , G01J3/10 , G01J3/28 , G01J3/453 , G01N21/359 , A61B5/145 , G01N33/49 , H01S3/30 , G01J3/14 , G01J3/18
CPC分类号： A61B5/0088 , A61B5/0013 , A61B5/0022 , A61B5/0075 , A61B5/0086 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/4547 , A61B5/6801 , A61B5/7257 , A61B5/7405 , A61B5/742 , A61B2562/0233 , A61B2562/0238 , A61B2562/146 , A61B2576/02 , G01J3/0218 , G01J3/108 , G01J3/14 , G01J3/1838 , G01J3/28 , G01J3/2823 , G01J3/42 , G01J3/453 , G01J2003/104 , G01J2003/1208 , G01J2003/2826 , G01M3/38 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/39 , G01N21/85 , G01N21/88 , G01N21/9508 , G01N33/02 , G01N33/025 , G01N33/15 , G01N33/442 , G01N33/49 , G01N2021/3595 , G01N2021/399 , G01N2201/061 , G01N2201/06113 , G01N2201/062 , G01N2201/08 , G01N2201/12 , G01N2201/129 , G06F19/00 , G16H40/67 , H01S3/0092 , H01S3/06758 , H01S3/302
摘要： A system and method for using near-infrared or short-wave infrared (SWIR) sources such as lamps, thermal sources, LED's, laser diodes, super-luminescent laser diodes, and super-continuum light sources for early detection of dental caries measure transmission and/or reflectance. In the SWIR wavelength range, solid, intact teeth may have a low reflectance or high transmission with very few spectral features while a carious region exhibits more scattering, so the reflectance increases in amplitude. The spectral dependence of the transmitted or reflected light from the tooth may be used to detect and quantify the degree of caries. Instruments for applying SWIR light to one or more teeth may include a C-clamp design, a mouth guard design, or hand-held devices that may augment other dental tools. The measurement device may communicate with a smart phone or tablet, which may transmit a related signal to the cloud, where additional value-added services are performed.
摘要翻译：使用近红外或短波红外（SWIR）源的系统和方法，例如灯，热源，LED，激光二极管，超发光激光二极管和超连续光源，用于早期检测龋齿测量传输和/或反射率。在SWIR波长范围内，固体，完整的牙齿可能具有低反射率或高透射率，光谱特征非常少，而龋齿区域表现出更多的散射，因此反射率增加。来自牙齿的透射光或反射光的光谱依赖性可用于检测和量化龋齿的程度。将SWIR光应用于一个或多个牙齿的仪器可以包括可以增加其它牙科工具的C形夹设计，口罩设计或手持式装置。测量设备可以与智能电话或平板电脑进行通信，智能电话或平板电脑可以向云进行相关信号的传输，其中执行附加的增值业务。

6. 发明申请

US20140188094A1 FOCUSED NEAR-INFRARED LASERS FOR NON-INVASIVE VARICOSE VEINS AND OTHER THERMAL COAGULATION OR OCCLUSION PROCEDURES 审中-公开
标题翻译：聚焦的近红外激光器用于非入侵的VARICOSE VEINS和其他热凝聚或消融程序
公开(公告)号：US20140188094A1
公开(公告)日：2014-07-03
申请号：US14108974
申请日：2013-12-17
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00404 , A61B2018/00589 , A61B2018/20351 , A61B2018/20355 , A61B2018/207 , A61B2018/2211
摘要： Focused infrared light may be used in a non-invasive varicose vein treatment procedure with infrared light from a plurality of laser diodes that are combined in a multiplexer and coupled to a multi-mode fiber coupled to another fiber or fiber bundle that delivers the light to a lens/mirror assembly for application in the non-invasive procedures. The wavelength of light may be selected near 980 nm, 1210 nm, or 1720 nm to achieve a desired penetration depth and/or for absorption in a particular tissue type or water. Wavelengths near approximately 1100 nm, 1310 nm or 1650 nm may be advantageous for non-invasive procedures through the skin. The light may be focused with lower intensity on the skin or outer tissue to reduce collateral damage and higher intensity at a desired depth to induce thermal coagulation or occlusion at depths of about 1-2 mm or more. Surface cooling techniques, such as cryogenic sprays or contact cooling may be provided.
摘要翻译：聚焦的红外光可以用于非侵入性静脉曲张静脉治疗程序，其中红外光来自多个激光二极管，其组合在多路复用器中并且耦合到耦合到另一光纤或光纤束的多模光纤，所述另一光纤或光纤束将光传送到用于非侵入性手术的镜片/镜组件。光的波长可以选择在980nm，1210nm或1720nm附近，以获得期望的穿透深度和/或在特定组织类型或水中吸收。约1100nm，1310nm或1650nm附近的波长对通过皮肤的非侵入性程序可能是有利的。光可以以较低的强度聚焦在皮肤或外部组织上，以减少所需深度的附带损伤和较高强度，以在约1-2mm或更大的深度引起热凝结或闭塞。可以提供表面冷却技术，例如低温喷雾或接触冷却。

7. 发明授权

US11596311B2 Remote sensing and measurement system using time-of-flight detectors 有权
公开(公告)号：US11596311B2
公开(公告)日：2023-03-07
申请号：US17666518
申请日：2022-02-07
申请人： Omni Medsci, Inc.
发明人： Mohammed N. Islam
IPC分类号： A61B5/00 , G01J3/10 , G01J3/28 , G01J3/14 , G01J3/453 , G01J3/42 , G01J3/02 , G01N21/35 , G16H40/67 , G01N21/359 , A61B5/145 , G01N33/15 , G01N33/49 , G01N21/3563 , G01N21/39 , G01N33/02 , G01N33/44 , G01N21/88 , A61B5/1455 , G16Z99/00 , A61C19/04 , G01N21/3504 , H01S3/30 , G01J3/18 , G01J3/12 , G01N21/85 , G01N21/95 , H01S3/067 , H01S3/00 , G01M3/38 , A61C1/00
摘要： A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.

8. 发明授权

US11241156B2 Time-of-flight imaging and physiological measurements 有权
公开(公告)号：US11241156B2
公开(公告)日：2022-02-08
申请号：US17135233
申请日：2020-12-28
申请人： Omni Medsci, Inc.
发明人： Mohammed N. Islam
IPC分类号： G01J3/00 , A61B5/00 , A61C19/04 , G16Z99/00 , G16H40/67 , A61B5/145 , A61B5/1455 , G01J3/02 , G01J3/10 , G01J3/14 , G01J3/28 , G01J3/42 , G01J3/453 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/39 , G01N21/88 , G01N33/02 , G01N33/15 , G01N33/44 , G01N33/49 , H01S3/067 , H01S3/00 , A61C1/00 , G01J3/18 , G01J3/12 , G01M3/38 , G01N21/85 , G01N21/95 , H01S3/30
摘要： A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.

9. 发明授权

US11160455B2 Multi-wavelength wearable device for non-invasive blood measurements in tissue 有权
公开(公告)号：US11160455B2
公开(公告)日：2021-11-02
申请号：US17078771
申请日：2020-10-23
申请人： OMNI MEDSCI, INC.
发明人： Mohammed N. Islam
IPC分类号： G01J3/00 , A61B5/00 , A61B5/145 , A61B5/1455 , G16H40/67 , G06F19/00 , G01J3/02 , G01J3/10 , G01J3/14 , G01J3/28 , G01J3/42 , G01J3/453 , G01N21/35 , G01N21/3563 , G01N21/359 , G01N21/39 , G01N21/88 , G01N33/02 , G01N33/15 , G01N33/44 , G01N33/49 , G01J3/18 , G01J3/12 , G01M3/38 , G01N21/85 , G01N21/95 , H01S3/00 , H01S3/067 , H01S3/30
摘要： A system for measuring one or more physiological parameters is provided with a wearable device that includes a light source comprising a driver and a plurality of semiconductor sources that generate an output optical light. The wearable device comprises: one or more lenses to receive at least a portion of the output optical light and to deliver a lens output light to tissue, and a detection system to receive at least a portion of the lens output light reflected from the tissue and to generate an output signal having a signal-to-noise ratio, and to be synchronized to the light source. The detection system comprises at least one analog to digital converter coupled to at least one spatially separated detector. The plurality of semiconductor sources comprises six light emitting diodes, and wherein the plurality of semiconductor sources and the plurality of spatially separated detectors are located on one or more arcs.

10. 发明授权

US10918287B2 System for non-invasive measurement using cameras and time of flight detection 有权
公开(公告)号：US10918287B2
公开(公告)日：2021-02-16
申请号：US16880095
申请日：2020-05-21
申请人： Omni Medsci, Inc.
发明人： Mohammed N. Islam
IPC分类号： G01J3/00 , A61B5/00 , G01J3/10 , G01J3/28 , G01J3/14 , G01J3/453 , G01J3/42 , G01J3/02 , G01N21/35 , G16H40/67 , G01N21/359 , A61B5/145 , G01N33/15 , G01N33/49 , G01N21/3563 , G01N21/39 , G01N33/02 , G01N33/44 , G01N21/88 , A61B5/1455 , H01S3/30 , G01J3/18 , G01J3/12 , G01N21/85 , G01N21/95 , H01S3/067 , H01S3/00 , G01M3/38
摘要： A measurement system comprises a pulsed laser diode array that includes one or more Bragg reflectors, and wherein the light generated by the array penetrates tissue comprising skin. At least some of the wavelengths of light are in the near infrared. The detection system is synchronized to the laser diode array and comprises an infrared camera and a first receiver comprising a plurality of detectors. The first receiver comprises one or more detector arrays and performs a time-of-flight measurement. The measurement system generates an image, the detection system non-invasively measures blood in blood vessels within or below a dermis layer within the skin based at least in part on near-infrared diffuse reflection from the skin, and the detection system measures absorption of hemoglobin between 700 and 1300 nanometers wavelength range. A processor compares the absorption of hemoglobin between different tissue spatial locations, and the measurement system processes the time-of-flight measurement.

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