专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07485730B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US07485730B2
公开(公告)日：2009-02-03
申请号：US11134502
申请日：2005-05-23
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
IPC分类号： A61K31/4162 , C07D495/14
CPC分类号： C07D495/04
摘要： Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: A represents a group selected from one of the following: (CH2)t—, —(CH2)—S(O)z—, or —S(O)z—(CH2)—, B is a heteroaryl, optionally substituted; R is a group selected from the following: alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; R′ is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″, a ketonic group of formula —C(O)-Z′, a substituent having an hydroxyl function of formula —CH(OH)-Z′; and an amide substituent of formula —C(O)—NH-T′.
摘要翻译：具有对大麻素能CB1和/或CB2受体具有亲和力的下式（I）的三环吡唑衍生物：其中：A表示选自以下之一的基团：（CH 2）t - ， - （CH 2）-S（O） Z - 或-S（O）z - （CH 2） - ，B是任选取代的杂芳基; R是选自以下的基团：未被取代或具有1-4个取代基的烷基，芳基，芳基烷基或芳基烯基，彼此相等或不同; R'是选自以下的基团：式 - （CH 2）-O-（CH 2）v -R''的醚基团，式-C（O）-Z'的酮基，具有羟基的取代基式-CH（OH）-Z'的功能; 和式-C（O）-NH-T'的酰胺取代基。

2. 发明授权

US08609659B2 Substituted 3,8-diazabicyclo[3.2.1]octane compounds 失效
标题翻译：取代的3,8-二氮杂双环[3.2.1]辛烷化合物
公开(公告)号：US08609659B2
公开(公告)日：2013-12-17
申请号：US12966371
申请日：2010-12-13
申请人： Paolo Lazzari , Giovanni Loriga , Stefania Ruiu , Gabriele Murineddu , Luca Pani , Gerard Aime Pinna
发明人： Paolo Lazzari , Giovanni Loriga , Stefania Ruiu , Gabriele Murineddu , Luca Pani , Gerard Aime Pinna
IPC分类号： A61K31/495
CPC分类号： C07D471/08 , C07D487/08
摘要： Diazapolycyclic compounds having affinity for the opioidergic receptors, preferably for the delta opioidergic receptors, with central and/or peripheral activity, having formula: A1-D1-T1 (I) wherein: A1 is a group of formula (II): wherein: R1 is phenyl wherein one of the ring hydrogen atoms is substituted with a group selected from C(O)R′, C(O)OR′, C(O)NHR′ or C(O)NR3R4, R′, R3 and R4, being as defined in the application; R2 is phenyl, optionally substituted D1 is a diazapolycyclic group T1 is a group selected from H, alkyl, alkenyl, alkynyl and from the following optionally substituted groups: cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl or heteroarylalkyl, and their hydrates and solvates and pharmaceutically acceptable salts.
摘要翻译： A1-D1-T1（Ⅰ）其中：A1是式（Ⅱ）的基团：其中：R1（ⅰ），其中R1为具有中性和/或外周活性的阿片样物质受体的阿片样物质受体，是其中一个环状氢原子被选自C（O）R'，C（O）OR'，C（O）NHR'或C（O）NR 3 R 4，R'，R 3和R 4的基团取代的苯基，正如申请中所定义的; R2是苯基，任意取代的D1是一个二氮杂多环基团，T1是选自H，烷基，烯基，炔基和下列任选取代的基团：环烷基，杂环烷基，芳基，杂芳基，环烷基烷基，杂环烷基烷基，芳基烷基或杂芳基烷基，水合物和溶剂化物和药学上可接受的盐。

3. 发明授权

US08106218B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US08106218B2
公开(公告)日：2012-01-31
申请号：US12330434
申请日：2008-12-08
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
IPC分类号： A61K31/4162 , C07D495/04
CPC分类号： C07D495/04
摘要： Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: A represents a group selected from one of the following: (CH2)t—, —(CH2)—S(O)z—, or —S(O)z—(CH2)—, B is a heteroaryl, optionally substituted; R is a group selected from the following: alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; R′ is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″, a ketonic group of formula —C(O)—Z′, wherein Z′ is as defined below; a substituent having an hydroxyl function of formula —CH(OH)—Z′; an amide substituent of formula —C(O)—NH-T′.
摘要翻译：具有对大麻素能CB1和/或CB2受体具有亲和力的下式（I）的三环吡唑衍生物：其中：A表示选自以下之一的基团：（CH 2）t - ， - （CH 2）-S（O） Z - 或-S（O）z - （CH 2） - ，B是任选取代的杂芳基; R是选自以下的基团：未被取代或具有1-4个取代基的烷基，芳基，芳基烷基或芳基烯基，彼此相等或不同; R'是选自以下的基团：式 - （CH 2）-O-（CH 2）v -R“的醚基团，式-C（O）-Z'的酮基，其中Z'如所定义下面; 具有式-CH（OH）-Z'的羟基官能团的取代基; 式-C（O）-NH-T'的酰胺取代基。

4. 发明授权

US08227620B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US08227620B2
公开(公告)日：2012-07-24
申请号：US12645415
申请日：2009-12-22
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
IPC分类号： A61K31/4155 , A61K31/454
CPC分类号： C07D409/04
摘要： Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″ wherein v is equal to 1 or 2; R″ is as defined in the present application; a ketone group of formula —C(O)—Z′, wherein Z′ is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)—Z′, being as defined in the present application; an amide substituent of formula —C(O)—NH-T′, T′ being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.
摘要翻译：具有对大麻素能CB1和/或CB2受体的亲和力的下式（I）的吡唑衍生物：其中：R是选自C1-C10烷基的基团; 未被取代或具有1-4个取代基的芳基，芳基烷基或芳基烯基，彼此相等或不同; A是选自以下的基团：式 - （CH 2）-O-（CH 2）v -R“的醚基，其中v等于1或2; R“如本申请中所定义; 式-C（O）-Z'的酮基，其中Z'如本申请中所定义; 具有式-CH（OH）-Z'羟基官能团的取代基，如本申请中所定义; 式-C（O）-NH-T'，T'的酰胺取代基如本申请中所定义; B是本申请中定义的组; D是任选取代的杂芳基。

5. 发明授权

US07659407B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US07659407B2
公开(公告)日：2010-02-09
申请号：US11134627
申请日：2005-05-23
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Aime Pinna , Gabriele Murineddu
IPC分类号： A61K31/4155 , A61K31/454 , C07D409/04 , C07D409/14
CPC分类号： C07D409/04
摘要： Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from: C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″ wherein v is equal to 1 or 2; R″ is as defined in the present application; a ketone group of formula —C(O)—Z′, wherein Z′ is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)—Z′, Z′ being as defined in the present application; an amide substituent of formula —C(O)—NH—T′, T′ being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.
摘要翻译：具有对大麻素能CB1和/或CB2受体的亲和力的下式（I）的吡唑衍生物：其中：R是选自：C 1 -C 10烷基; 未被取代或具有1-4个取代基的芳基，芳基烷基或芳基烯基，彼此相等或不同; A是选自以下的基团：式 - （CH 2）-O-（CH 2）v -R'的醚基，其中v等于1或2; R“如本申请中所定义; 式-C（O）-Z'的酮基，其中Z'如本申请中所定义; 具有式-CH（OH）-Z'，Z'的羟基官能团的取代基如本申请中所定义; 式-C（O）-NH-T'，T'的酰胺取代基如本申请中所定义; B是本申请中定义的组; D是任选取代的杂芳基。

6. 发明申请

US20100105896A1 PHARMACEUTICAL COMPOUNDS 失效
标题翻译：药物化合物
公开(公告)号：US20100105896A1
公开(公告)日：2010-04-29
申请号：US12645415
申请日：2009-12-22
申请人： Paolo Lazzari , Stefania Rulu , Gerard Aime Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Rulu , Gerard Aime Pinna , Gabriele Murineddu
IPC分类号： C07D403/14 , C07D231/10 , C07D401/14
CPC分类号： C07D409/04
摘要： Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″ wherein v is equal to 1 or 2; R″ is as defined in the present application; a ketone group of formula —C(O)—Z′, wherein Z′ is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)—Z′, being as defined in the present application; an amide substituent of formula —C(O)—NH-T′, T′ being as defined in the present application; B is a group as defined in the present application; D is an heteroaryl optionally substituted.
摘要翻译：具有对大麻素能CB1和/或CB2受体的亲和力的下式（I）的吡唑衍生物：其中：R是选自C1-C10烷基的基团; 未被取代或具有1-4个取代基的芳基，芳基烷基或芳基烯基，彼此相等或不同; A是选自以下的基团：式 - （CH 2）-O-（CH 2）v -R“的醚基，其中v等于1或2; R“如本申请中所定义; 式-C（O）-Z'的酮基，其中Z'如本申请中所定义; 具有式-CH（OH）-Z'羟基官能团的取代基，如本申请中所定义; 式-C（O）-NH-T'，T'的酰胺取代基如本申请中所定义; B是本申请中定义的组; D是任选取代的杂芳基。

7. 发明申请

US20050261281A1 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US20050261281A1
公开(公告)日：2005-11-24
申请号：US11134627
申请日：2005-05-23
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Pinna , Gabriele Murineddu
IPC分类号： A61K31/4155 , A61K31/4453 , A61K31/55 , A61K47/20 , A61P1/08 , A61P1/16 , A61P3/00 , A61P7/06 , A61P9/00 , A61P11/00 , A61P13/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D409/04 , A61K31/53 , A61K31/416 , A61K31/454 , C07D49/02
CPC分类号： C07D409/04
摘要： Pyrazole derivatives of the following formula (I), having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: R is a group selected from: C1-C10 alkyl; aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; A is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″ wherein v is equal to 1 or 2; R″ is as defined in the present application; a ketone group of formula —C(O)-Z′, wherein Z′ is as defined in the present application; a substituent having an hydroxyl function of formula —CH(OH)-Z′, Z′ being as defined in the present application; Description of the industrial invention in the name of: NEUROSCIENZE S.c. a r.l., of Italian nationality, with head office in Cagliari, via Palabanda 9.
摘要翻译：具有对大麻素能CB1和/或CB2受体的亲和力的下式（I）的吡唑衍生物：其中：R是选自以下的基团：C 1 -C 10 - 烷基; 未被取代或具有1-4个取代基的芳基，芳基烷基或芳基烯基，彼此相等或不同; A是选自以下的基团：式 - （CH 2）2 - 的醚基团 - （CH 2 CH 2）v -R “其中v等于1或2; R“如本申请中所定义; 式-C（O）-Z'的酮基，其中Z'如本申请中所定义; 具有式-CH（OH）-Z'，Z'的羟基官能团的取代基如本申请中所定义; 工业发明的描述，名称为：NEUROSCIENZE S. 一个意大利国籍的r.l.，总部设在卡利亚里，通过Palabanda 9。

8. 发明申请

US20050282798A1 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US20050282798A1
公开(公告)日：2005-12-22
申请号：US11134502
申请日：2005-05-23
申请人： Paolo Lazzari , Stefania Ruiu , Gerard Pinna , Gabriele Murineddu
发明人： Paolo Lazzari , Stefania Ruiu , Gerard Pinna , Gabriele Murineddu
IPC分类号： A61K31/4162 , A61K31/454 , A61K51/00 , A61P1/08 , A61P3/04 , A61P7/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/00 , A61P13/12 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/36 , A61P27/02 , A61P29/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D231/54 , C07D495/04 , A61K31/55 , C07D498/02
CPC分类号： C07D495/04
摘要： Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: A represents a group selected from one of the following: (CH2)t—, —(CH2)—S(O)z—, or —S(O)z—(CH2)—, B is a heteroaryl, optionally substituted; R is a group selected from the following: alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; R′ is a group selected from the following: an ether group of formula —(CH2)—O—(CH2)v—R″, a ketonic group of formula —C(O)-Z′, wherein Z′ is as defined below; a substituent having an hydroxyl function of formula —CH(OH)-Z′; an amide substituent of formula —C(O)—NH-T′.
摘要翻译：具有对大麻素能CB1和/或CB2受体具有亲和性的下式（I）的三环吡唑衍生物：其中：A表示选自以下之一的基团：（CH 2）2 - （CH 2 - ） - S（O）z - ，或-S（O）z - （CH B是任选取代的杂芳基; R是选自以下的基团：未被取代或具有1-4个取代基的烷基，芳基，芳基烷基或芳基烯基，彼此相等或不同; R'是选自以下的基团：式 - （CH 2 CH 2）-O-（CH 2）2 - 的醚基 - R“，式-C（O）-Z'的酮基，其中Z'如下所定义; 具有式-CH（OH）-Z'的羟基官能团的取代基; 式-C（O）-NH-T'的酰胺取代基。

9. 发明申请

US20070173535A1 Oxadiazoles having antiproliferative activity 审中-公开
标题翻译：恶二唑具有抗增殖活性
公开(公告)号：US20070173535A1
公开(公告)日：2007-07-26
申请号：US11596392
申请日：2003-01-31
申请人： Giorgio Cignarella , Gerardo Pinna , Gabriele Murineddu
发明人： Giorgio Cignarella , Gerardo Pinna , Gabriele Murineddu
IPC分类号： A61K31/4245 , C07D209/56
CPC分类号： C07D413/04 , C07D209/60 , C07D209/70
摘要： Oxadiazole derivatives of general formula (1) in which X, Y, R and R2 have the meanings defined in the disclosure. The compounds have antiproliferative activity against a number of human tumors cell lines and can therefore be used for the preparation of antitumor medicaments.
摘要翻译：通式（1）的恶二唑衍生物，其中X，Y，R和R 2具有本发明中定义的含义。这些化合物对许多人类肿瘤细胞系具有抗增殖活性，因此可用于制备抗肿瘤药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式