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1. 发明申请

US20140288076A1 HETEROARYL COMPOUNDS AND THEIR USES 审中-公开
标题翻译： HETEROARYL化合物及其用途
公开(公告)号：US20140288076A1
公开(公告)日：2014-09-25
申请号：US14295398
申请日：2014-06-04
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D401/04
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

2. 发明申请

US20110028492A1 Heteroaryl Compounds and Their Uses 失效
标题翻译：杂芳基化合物及其用途
公开(公告)号：US20110028492A1
公开(公告)日：2011-02-03
申请号：US12843494
申请日：2010-07-26
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： A61K31/497 , C07D213/02 , C07D401/04 , A61K31/444 , A61K31/506 , A61P31/18 , A61P35/00
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

3. 发明授权

US08415381B2 Heteroaryl compounds and their uses 失效
标题翻译：杂芳基化合物及其用途
公开(公告)号：US08415381B2
公开(公告)日：2013-04-09
申请号：US12843494
申请日：2010-07-26
申请人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
发明人： Paul A. Barsanti , Cheng Hu , Jeff Jin , Robert Keyes , Robert Kucejko , Xiaodong Lin , Yue Pan , Keith B. Pfister , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： A61K31/497 , C07D213/74 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，对映体，立体异构体，旋转异构体，互变异构体，非对映体或其外消旋物。还提供了治疗由CDK9介导的疾病或病症的方法。

4. 发明申请

US20130303507A1 SUBSTITUTED HETERO-BIARYL COMPOUNDS AND THEIR USES 审中-公开
标题翻译：取代的杂环化合物及其用途
公开(公告)号：US20130303507A1
公开(公告)日：2013-11-14
申请号：US13981283
申请日：2012-01-20
申请人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric Martin , Yue Pan , Xiaodong Lin , Keith B. Pfister , Paul A. Renhowe , Martin Sendzik , James Sutton , Lifeng Wan
发明人： William R. Antonios-McCrea , Paul A. Barsanti , Cheng Hu , Xianming Jin , Eric Martin , Yue Pan , Xiaodong Lin , Keith B. Pfister , Paul A. Renhowe , Martin Sendzik , James Sutton , Lifeng Wan
IPC分类号： C07D401/14 , C07D401/04 , C07D491/107 , C07D409/14 , C07D413/14 , C07D487/04 , C07D213/74 , C07D405/14
CPC分类号： C07D401/14 , C07D213/74 , C07D401/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D487/04 , C07D491/107
摘要： The present invention provides a compound of formula (II): where R1 is a substituted alkyl, heterocyclic, or cycloalkyl, group, and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof, and pharmaceutical compositions comprising these compounds. Also provided are methods of using these compounds to treat a disease or condition mediated by CDK9, such as cancers and other conditions described herein.
摘要翻译：本发明提供式（II）化合物：其中R 1是取代的烷基，杂环或环烷基，基团及其药学上可接受的盐，对映异构体，立体异构体，旋转异构体，互变异构体，非对映异构体或外消旋物，以及包含它们的药物组合物化合物。还提供了使用这些化合物治疗由CDK9介导的疾病或病症的方法，例如本文所述的癌症和其它病症。

5. 发明授权

US07932262B2 Quinazolines for PDK1 inhibition 失效
标题翻译：喹唑啉用于PDK1抑制
公开(公告)号：US07932262B2
公开(公告)日：2011-04-26
申请号：US12295967
申请日：2007-04-05
申请人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号： A61K31/517
CPC分类号： C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要： The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译：本发明提供作为PDK1抑制剂的喹唑啉化合物。还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。

6. 发明申请

US20100048561A1 QUINAZOLINES FOR PDK1 INHIBITION 失效
标题翻译：用于PDK1抑制剂的喹唑啉
公开(公告)号：US20100048561A1
公开(公告)日：2010-02-25
申请号：US12295967
申请日：2007-04-05
申请人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号： A61K31/517 , C07D401/12 , C07D401/14 , C07D239/84 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要： The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译：本发明提供作为PDK1抑制剂的喹唑啉化合物。还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。

7. 发明申请

US20100121052A1 Novel compounds for treating proliferative diseases 审中-公开
标题翻译：用于治疗增殖性疾病的新型化合物
公开(公告)号：US20100121052A1
公开(公告)日：2010-05-13
申请号：US12456032
申请日：2009-06-09
申请人： Rama Jain , Xiaodong Lin , Simon C. Ng , Keith B. Pfister , Savithri Ramurthy , Alice Rico , Sharadha Subramanian , Xiaojing Michael Wang
发明人： Rama Jain , Xiaodong Lin , Simon C. Ng , Keith B. Pfister , Savithri Ramurthy , Alice Rico , Sharadha Subramanian , Xiaojing Michael Wang
IPC分类号： C07D239/84 , C07D417/10 , C07D401/12 , C07D413/12 , C07D401/14 , C07D413/14
CPC分类号： C07D417/04 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译：本发明提供了作为PDK1抑制剂的新型化合物。还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。

8. 外观设计

USD917772S1 Desk lamp 有权
公开(公告)号：USD917772S1
公开(公告)日：2021-04-27
申请号：US29766658
申请日：2021-01-18
申请人： Xiaodong Lin
设计人： Xiaodong Lin

9. 发明授权

US09513977B2 ISA bridging with callback 有权
标题翻译： ISA与回调桥接
公开(公告)号：US09513977B2
公开(公告)日：2016-12-06
申请号：US13995935
申请日：2012-01-10
申请人： Jianhui Li , Ling Lin , Yong Wu , Xiaodong Lin , Wen Tan , Honesty Cheng Young , Yihua Jin
发明人： Jianhui Li , Ling Lin , Yong Wu , Xiaodong Lin , Wen Tan , Honesty Cheng Young , Yihua Jin
IPC分类号： G06F3/00 , G06F9/54 , G06F9/455
CPC分类号： G06F9/54 , G06F9/45504 , G06F9/541
摘要： Methods, apparatuses and storage medium associated with ISA bridging with callback, are disclosed. In various embodiments, at least one computer-readable storage medium may include instructions configured to enable a target device with a target ISA, in response to execution of the instructions, to provide an ISA bridging layer to the target device to facilitate a library service to callback a callback function of an application. The library service may be implemented for the target ISA, and the application may be implemented at least partially for a source ISA that may be different from the target ISA. The ISA bridging layer may include a source ISA emulator and a library emulator configured to cooperate to enable the application to call the library service, and the library service to callback the callback function, across the two instruction set architectures. Other embodiments may be disclosed or claimed.
摘要翻译：公开了与与回调桥接的ISA相关联的方法，装置和存储介质。在各种实施例中，至少一个计算机可读存储介质可以包括被配置为使得具有目标ISA的目标设备响应于指令的执行而向目标设备提供ISA桥接层以促进图书馆服务回调一个应用程序的回调函数。可以为目标ISA实现库服务，并且应用可以至少部分地针对可能与目标ISA不同的源ISA来实现。 ISA桥接层可以包括源ISA仿真器和库仿真器，其被配置为协作以使应用能够调用库服务，并且库服务在两个指令集体系结构之间回调回调函数。可以公开或要求保护其他实施例。

10. 发明授权

US09174978B2 Monobactam organic compounds for the treatment of bacterial infections 有权
标题翻译：单链有机化合物用于治疗细菌感染
公开(公告)号：US09174978B2
公开(公告)日：2015-11-03
申请号：US14665245
申请日：2015-03-23
申请人： Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
发明人： Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
IPC分类号： A61K31/40 , C07D417/14 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K45/06
CPC分类号： A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481
摘要： This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
摘要翻译：本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。在某些方面，本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。

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