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1. 发明申请

US20060074451A1 Method and system for the prediction of cardiac arrhythmias, myocardial ischemia, and other diseased condition of the heart associated with elevated sympathetic neural discharges 有权
标题翻译：用于预测心律失常，心肌缺血和其他与交感神经放电升高相关的心脏疾病状况的方法和系统
公开(公告)号：US20060074451A1
公开(公告)日：2006-04-06
申请号：US11205923
申请日：2005-08-16
申请人： Peng-Sheng Chen , Shengmei Zhou
发明人： Peng-Sheng Chen , Shengmei Zhou
IPC分类号： A61N1/36
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/4035 , A61N1/0551 , A61N1/36114 , A61N1/362 , A61N1/3702 , A61N1/37258 , A61N1/37282
摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.
摘要翻译：提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性增加与患者交感神经放电升高相关。方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。可用于与递送有关的药理学试剂包括已知能发挥抗心律不齐作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

2. 发明授权

US08744571B2 Method and system for the prediction of cardiac arrhythmias, myocardial ischemia, and other diseased condition of the heart associated with elevated sympathetic neural discharges 失效
标题翻译：用于预测心律失常，心肌缺血和其他与交感神经放电升高相关的心脏疾病状况的方法和系统
公开(公告)号：US08744571B2
公开(公告)日：2014-06-03
申请号：US12755139
申请日：2010-04-06
申请人： Peng-Sheng Chen , Shengmei Zhou
发明人： Peng-Sheng Chen , Shengmei Zhou
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/4035 , A61N1/0551 , A61N1/36114 , A61N1/362 , A61N1/3702 , A61N1/37258 , A61N1/37282
摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.
摘要翻译：提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性增加与患者交感神经放电升高相关。方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。可用于与递送有关的药理学试剂包括已知能发挥抗心律不齐作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

3. 发明申请

US20100268289A1 METHOD AND SYSTEM FOR THE PREDICTION OF CARDIAC ARRHYTHMIAS, MYOCARDIAL ISCHEMIA, AND OTHER DISEASED CONDITION OF THE HEART ASSOCIATED WITH ELEVATED SYMPATHETIC NEURAL DISCHARGES 失效
标题翻译：心脑血管病，心肌梗死及其他与高血压症状神经放电相关的心脏疾病的预测方法与系统
公开(公告)号：US20100268289A1
公开(公告)日：2010-10-21
申请号：US12755139
申请日：2010-04-06
申请人： Peng-Sheng Chen , Shengmei Zhou
发明人： Peng-Sheng Chen , Shengmei Zhou
IPC分类号： A61N1/00 , A61M37/00
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/4035 , A61N1/0551 , A61N1/36114 , A61N1/362 , A61N1/3702 , A61N1/37258 , A61N1/37282
摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.
摘要翻译：提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性与增加的交感神经放电相关的增加的可能性。方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。可用于与递送有关的药理学试剂包括已知能发挥抗心律失常作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

4. 发明授权

US07725178B2 Method and system for the prediction of cardiac arrhythmias, myocardial ischemia, and other diseased condition of the heart associated with elevated sympathetic neural discharges 有权
标题翻译：用于预测心律失常，心肌缺血和其他与交感神经放电升高相关的心脏疾病状况的方法和系统
公开(公告)号：US07725178B2
公开(公告)日：2010-05-25
申请号：US11205923
申请日：2005-08-16
申请人： Peng-Sheng Chen , Shengmei Zhou
发明人： Peng-Sheng Chen , Shengmei Zhou
IPC分类号： A61N1/08
CPC分类号： A61B5/4094 , A61B5/04001 , A61B5/4035 , A61N1/0551 , A61N1/36114 , A61N1/362 , A61N1/3702 , A61N1/37258 , A61N1/37282
摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.
摘要翻译：提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性与增加的交感神经放电相关的增加的可能性。方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。可用于与递送有关的药理学试剂包括已知能发挥抗心律失常作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

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