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1. 发明授权

US07684871B2 System, method and apparatus for evaluating tissue temperature 失效
标题翻译：用于评估组织温度的系统，方法和装置
公开(公告)号：US07684871B2
公开(公告)日：2010-03-23
申请号：US11241059
申请日：2005-09-30
申请人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
发明人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
IPC分类号： A61F2/00
CPC分类号： G01K7/38 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61F2/82 , A61F7/12 , A61F2250/0001
摘要： Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.
摘要翻译：用于监测目标组织温度的方法，系统和装置，其中温度传感器被配置为无源谐振电路，每个无源谐振电路在监测温度延伸到选定温度设定点以下时具有独特的谐振特征。谐振电路由具有对应于期望温度设定点的居里温度特性的铁氧体磁芯绕组构成的电感器部件构成。通过选择电感绕组匝数和电容值，可以检测到独特的谐振中心频率。温度监测可以用较低阈值和上限温度响应的植入物进行。此外，较低阈值传感器可与在较高温度极限下具有居里转变的自动调节加热器植入物组合。

2. 发明授权

US07729778B2 System, method and apparatus for evaluating tissue temperature 失效
公开(公告)号：US07729778B2
公开(公告)日：2010-06-01
申请号：US11241226
申请日：2005-09-30
申请人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
发明人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
IPC分类号： A61F2/00
CPC分类号： A61B18/04 , A61B18/18 , A61B2017/00084 , A61F2/82 , A61F7/12 , A61F2250/0001
摘要： Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.

3. 发明授权

US07695505B2 System, method and apparatus for evaluating tissue temperature 失效
公开(公告)号：US07695505B2
公开(公告)日：2010-04-13
申请号：US11241081
申请日：2005-09-30
申请人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
发明人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
IPC分类号： A61F2/00
CPC分类号： G01K7/38 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61F2/82 , A61F7/12 , A61F2250/0001
摘要： Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.

4. 发明授权

US07048756B2 System, method and apparatus for evaluating tissue temperature 失效
标题翻译：用于评估组织温度的系统，方法和装置
公开(公告)号：US07048756B2
公开(公告)日：2006-05-23
申请号：US10733970
申请日：2003-12-11
申请人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
发明人： Philip E. Eggers , John L. Ridihalgh , Mark Mayerchak , Gary Altman
IPC分类号： A61F2/00
CPC分类号： G01K7/38 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61F2/82 , A61F7/12 , A61F2250/0001
摘要： Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each, with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.
摘要翻译：用于监测目标组织温度的方法，系统和装置，其中温度传感器被配置为每个无源谐振电路，在监测温度延伸到选定温度设定点以下时具有独特的谐振特征。谐振电路由具有对应于期望温度设定点的居里温度特性的铁氧体磁芯绕组构成的电感器部件构成。通过选择电感绕组匝数和电容值，可以检测到独特的谐振中心频率。温度监测可以用较低阈值和上限温度响应的植入物进行。此外，较低阈值传感器可与在较高温度极限下具有居里转变的自动调节加热器植入物组合。

5. 发明授权

US07447550B2 System method and apparatus for localized heating of tissue 失效
标题翻译：用于局部加热组织的系统方法和装置
公开(公告)号：US07447550B2
公开(公告)日：2008-11-04
申请号：US11088334
申请日：2005-03-24
申请人： Philip E. Eggers , John L. Ridihalgh
发明人： Philip E. Eggers , John L. Ridihalgh
IPC分类号： A61F2/00
CPC分类号： A61F7/12 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61B2017/22002 , A61N7/02 , G01K7/38
摘要： System method and apparatus for accurately carrying out the in situ heating of a targeted tissue. Small implants are employed with the targeted tissue which exhibit an abrupt change of magnetic permeability at an elected Curie temperature. The permeability state of the implant is monitored utilizing a magnetometer. The implants may be formed as a setpoint temperature determining component combined with a non-magnetic heater component to enhance the tissue heating control of the system. With the system, a very accurate quantum of heat energy can be supplied to a neoplastic lesion or tissue carrying infectious disease so as to maximize the induction of heat shock proteins. The system also may be utilized in conjunction with non-magnetic arterially implanted stents for the hyperthermia therapy treatment of restenosis and in conjunction with the mending of boney tissue.
摘要翻译：准确地进行目标组织的原位加热的系统方法和装置。小植入物与目标组织一起使用，其在所选居里温度下表现出磁导率的突然变化。使用磁力计监测植入物的渗透性状态。植入物可以形成为与非磁性加热器组件组合的设定点温度确定部件，以增强系统的组织加热控制。利用该系统，可以向携带传染病的肿瘤病变或组织提供非常精确的热能量，以便最大限度地诱导热休克蛋白。该系统还可以与非磁性动脉植入支架结合使用，用于热疗治疗再狭窄并结合骨髓组织的修补。

6. 发明授权

US06850804B2 System method and apparatus for localized heating of tissue 失效
标题翻译：用于局部加热组织的系统方法和装置
公开(公告)号：US06850804B2
公开(公告)日：2005-02-01
申请号：US10310475
申请日：2002-12-05
申请人： Philip E. Eggers , John L. Ridihalgh
发明人： Philip E. Eggers , John L. Ridihalgh
IPC分类号： A61B17/00 , A61B17/22 , A61B18/04 , A61B18/18 , A61F7/12 , A61N7/02 , G01K7/38 , A61F2/00
CPC分类号： G01K7/38 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61B2017/22002 , A61F2/82 , A61F7/12 , A61N7/02
摘要： System method and apparatus for accurately carrying out the in situ heating of a targeted tissue. Small implants are employed with the targeted tissue which exhibit an abrupt change of magnetic permeability at an elected Curie temperature. The permeability state of the implant is monitored utilizing a magnetometer. The implants may be formed as a setpoint temperature determining component combined with a non-magnetic heater component to enhance the tissue heating control of the system. With the system, a very accurate quantum of heat energy can be supplied to a neoplastic lesion or tissue carrying infectious disease so as to maximize the induction of heat shock proteins. The system also may be utilized in conjunction with non-magnetic arterially implanted stents for the hyperthermia therapy treatment of restenosis and in conjunction with the mending of boney tissue.
摘要翻译：准确地进行目标组织的原位加热的系统方法和装置。小植入物与目标组织一起使用，其在所选居里温度下表现出磁导率的突然变化。使用磁力计监测植入物的渗透性状态。植入物可以形成为与非磁性加热器组件组合的设定点温度确定部件，以增强系统的组织加热控制。利用该系统，可以向携带传染病的肿瘤病变或组织提供非常精确的热能量，以便最大限度地诱导热休克蛋白。该系统还可以与非磁性动脉植入支架结合使用，用于热疗治疗再狭窄并结合骨髓组织的修补。

7. 发明授权

US07567843B2 System method and apparatus for localized heating of tissue 失效
标题翻译：用于局部加热组织的系统方法和装置
公开(公告)号：US07567843B2
公开(公告)日：2009-07-28
申请号：US11036276
申请日：2005-01-14
申请人： Philip E. Eggers , John L. Ridihalgh
发明人： Philip E. Eggers , John L. Ridihalgh
IPC分类号： A61F7/00 , A61F2/00
CPC分类号： G01K7/38 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61B2017/22002 , A61F2/82 , A61F7/12 , A61N7/02
摘要： System method and apparatus for accurately carrying out the in situ heating of a targeted tissue. Small implants are employed with the targeted tissue which exhibit an abrupt change of magnetic permeability at an elected Curie temperature. The permeability state of the implant is monitored utilizing a magnetometer. The implants may be formed as a setpoint temperature determining component combined with a non-magnetic heater component to enhance the tissue heating control of the system. With the system, a very accurate quantum of heat energy can be supplied to a neoplastic lesion or tissue carrying infectious disease so as to maximize the induction of heat shock proteins. The system also may be utilized in conjunction with non-magnetic arterially implanted stents for the hyperthermia therapy treatment of restenosis and in conjunction with the mending of boney tissue.
摘要翻译：准确地进行目标组织的原位加热的系统方法和装置。小植入物与目标组织一起使用，其在所选居里温度下表现出磁导率的突然变化。使用磁力计监测植入物的渗透性状态。植入物可以形成为与非磁性加热器组件组合的设定点温度确定部件，以增强系统的组织加热控制。利用该系统，可以向携带传染病的肿瘤病变或组织提供非常精确的热能量，以便最大限度地诱导热休克蛋白。该系统还可以与非磁性动脉植入支架结合使用，用于热疗治疗再狭窄并结合骨髓组织的修补。

8. 发明授权

US06993394B2 System method and apparatus for localized heating of tissue 失效
公开(公告)号：US06993394B2
公开(公告)日：2006-01-31
申请号：US10246347
申请日：2002-09-18
申请人： Philip E. Eggers , John L. Ridihalgh
发明人： Philip E. Eggers , John L. Ridihalgh
IPC分类号： A61F2/00
CPC分类号： A61F7/12 , A61B18/04 , A61B18/18 , A61B2017/00084 , A61B2017/22002 , A61N7/02 , G01K7/38
摘要： System method and apparatus for accurately carrying out the in situ heating of a targeted tissue. Small implants are employed with the targeted tissue which exhibit an abrupt change of magnetic permeability at an elected Curie temperature. The permeability state of the implant is monitored utilizing a magnetometer. The implants may be formed as a setpoint temperature determining component combined with a non-magnetic heater component to enhance the tissue heating control of the system. With the system, a very accurate quantum of heat energy can be supplied to a neoplastic lesion or tissue carrying infectious disease so as to maximize the induction of heat shock proteins. The system also may be utilized in conjunction with non-magnetic arterially implanted stents for the hyperthermia therapy treatment of restenosis and in conjunction with the mending of boney tissue.

9. 发明授权

US5705162A FeLV therapeutic agent, method of its preparation, and method of treating FeLV infection therewith 失效
标题翻译： FeLV治疗剂，其制备方法及其治疗FeLV感染的方法
公开(公告)号：US5705162A
公开(公告)日：1998-01-06
申请号：US543820
申请日：1995-10-16
申请人： Richard G. Olsen , John L. Ridihalgh
发明人： Richard G. Olsen , John L. Ridihalgh
IPC分类号： A61K35/12 , A61K35/26 , A61K39/00 , C12N5/078 , A61K39/21
CPC分类号： A61K35/26 , C12N5/0651 , A61K2035/124 , A61K2039/5158 , C12N2501/23 , Y10S424/819
摘要： The present invention broadly relates to a therapeutic agent effective in mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV. A feline is an animal of the family Felidae. The novel therapeutic agent is composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier. Mitogenic stimulation conditions include culturing the excised lymph nodes in the presence of Interleukin-2. Optionally, culture conditions can include the presence of allogeneic or autologous FeLV tumor. The inventive therapeutic agent is prepared by excising lymph nodes from a feline infected the FeLV, mitogenically stimulating said excised lymph nodes for their expansion, and administering to the infected feline the expanded lymph nodes. Multidose regimens can be used as is necessary or desirable in convenient fashion. The method for mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV is composed of administering to the diseased feline the therapeutic agent composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier.
摘要翻译：本发明广泛地涉及有效减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的治疗剂。猫是猫科动物。该新型治疗剂由已经进行有丝分裂刺激扩散分散在药学上可接受的载体中的猫切除的淋巴结组成。有丝分裂刺激条件包括在白细胞介素-2存在下培养切除的淋巴结。任选地，培养条件可以包括同种异体或自体FeLV肿瘤的存在。本发明的治疗剂通过从感染了FeLV的猫科的淋巴结中切除，有丝分裂刺激所述切除的淋巴结进行扩增，以及向感染的猫科管理扩大的淋巴结来制备。可以以方便的方式使用多药方案作为必要或需要的。用于减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的方法包括向患病猫施用由已经进行有丝分裂刺激扩散分散在药物中的猫切除的淋巴结组成的治疗剂可接受的载体。

10. 发明授权

US4666659A Shipping and storage container for spent nuclear fuel 失效
标题翻译：废核燃料的运输和储存容器
公开(公告)号：US4666659A
公开(公告)日：1987-05-19
申请号：US545228
申请日：1983-10-25
申请人： Elmer C. Lusk , John L. Ridihalgh
发明人： Elmer C. Lusk , John L. Ridihalgh
IPC分类号： G21F5/008 , G21F5/10 , G21F5/00
CPC分类号： G21F5/008 , G21F5/10 , Y10T29/531
摘要： A shipping and transport cask for spent nuclear fuel elements. The cask includes a cylindrical cask body having an outer shell and a concentric inner tube. Four quadrant baskets are mounted within the inner tube. Each quadrant basket includes radial and peripheral walls of high thermal conductivity material. A plurality of fuel element-receiving modules and an inner quadrant heat conducting member are mounted within the quadrant baskets. The peripheral walls of the quadrant baskets are held firmly against the inner wall of the body by shims inserted between the radial walls of adjacent quadrant baskets. During assembly, the quadrant baskets are initially forced outwardly against the inner wall by means of expandable spreaders. The cask also includes removable trunnions and primary and secondary external fluid chambers filled with a neutron-attenuating fluid. A siphon tube interconnects the chambers so that the primary chamber which surrounds the major portion of the cask remains filled despite changes in temperature of the fluid.
摘要翻译：用于乏核燃料元件的运输和运输桶。该桶包括具有外壳和同心内管的圆柱形桶体。四个象限篮子安装在内管内。每个象限篮包括高导热材料的径向和周边壁。多个燃料元件接收模块和内部象限导热构件安装在象限篮内。象限篮子的周围墙壁通过插入相邻的象限篮子的径向壁之间的垫片牢固地靠在身体的内壁上。在装配过程中，象限篮最初通过可扩张的吊具向内抵靠内壁。该桶还包括可移除的耳轴以及填充有中子衰减流体的初级和次级外部流体室。虹吸管将腔室相互连接，使得围绕着桶的主要部分的主室仍保持填充，尽管流体的温度发生变化。

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