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1. 发明申请

US20080003229A1 Method for obtaining vaccines for preventing the pathogenic effects related to a retroviral infection 有权
标题翻译：用于获得用于预防与逆转录病毒感染相关的致病作用的疫苗的方法
公开(公告)号：US20080003229A1
公开(公告)日：2008-01-03
申请号：US11826471
申请日：2007-07-16
申请人： Pierre-Francois Serres
发明人： Pierre-Francois Serres
IPC分类号： A61K39/42 , A61K39/21 , A61P31/14 , A61P31/18 , C07H21/00 , C07K16/08 , C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/1063 , C07K16/246 , C07K2317/34 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： A method for obtaining a vaccine against the infection of an animal host by a retrovirus capable of penetrating into a host's target cell, where the target cell possesses a membrane receptor for a protein of the host, by preparing candidate vaccine agents based on a modified polypeptide having at least part of an envelope protein of the retrovirus, where the polypeptide has at least one fragment of an immunodominant region of the envelope protein, the fragment containing at least one conserved amino acid of the immunodominant region present in the pathogenic strain, wherein the polypeptide induces an immune response directed both against the immunodominant region and against the protein of the host; and selecting as a vaccine such a modified polypeptide chosen from those which induce an immune response directed against said immunodominant region of the envelope protein and not against the protein of the host.
摘要翻译：一种用于通过能够穿透宿主的靶细胞的逆转录病毒感染动物宿主的疫苗的方法，其中靶细胞具有宿主的蛋白质的膜受体，通过基于修饰的多肽制备候选疫苗剂具有逆转录病毒的包膜蛋白的至少一部分，其中多肽具有包膜蛋白的免疫显性区的至少一个片段，所述片段含有存在于病原菌株中的免疫显性区的至少一个保守氨基酸，其中，多肽诱导针对免疫显性区域和针对宿主蛋白质的免疫应答; 以及选择这样一种修饰的多肽，其选自诱导针对所述包膜蛋白的所述免疫显性区域的免疫应答的修饰多肽，而不是针对所述宿主的蛋白质。

2. 发明授权

US07829683B2 Polynucleotides encoding modified HIV-1 gp41 membrane polypeptides 有权
标题翻译：编码修饰的HIV-1 gp41膜多肽的多核苷酸
公开(公告)号：US07829683B2
公开(公告)日：2010-11-09
申请号：US11826471
申请日：2007-07-16
申请人： Pierre-Francois Serres
发明人： Pierre-Francois Serres
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/1063 , C07K16/246 , C07K2317/34 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： A method for obtaining a vaccine against the infection of an animal host by a retrovirus capable of penetrating into a host's target cell, where the target cell possesses a membrane receptor for a protein of the host, by preparing candidate vaccine agents based on a modified polypeptide having at least part of an envelope protein of the retrovirus, where the polypeptide has at least one fragment of an immunodominant region of the envelope protein, the fragment containing at least one conserved amino acid of the immunodominant region present in the pathogenic strain, wherein the polypeptide induces an immune response directed both against the immunodominant region and against the protein of the host; and selecting as a vaccine such a modified polypeptide chosen from those which induce an immune response directed against said immunodominant region of the envelope protein and not against the protein of the host.
摘要翻译：一种用于通过能够穿透宿主的靶细胞的逆转录病毒感染动物宿主的疫苗的方法，其中靶细胞具有宿主的蛋白质的膜受体，通过基于修饰的多肽制备候选疫苗剂具有逆转录病毒的包膜蛋白的至少一部分，其中多肽具有包膜蛋白的免疫显性区域的至少一个片段，所述片段含有存在于病原菌株中的免疫显性区域的至少一个保守氨基酸，其中，多肽诱导针对免疫显性区域和针对宿主蛋白质的免疫应答; 以及选择这样一种修饰的多肽，其选自诱导针对所述包膜蛋白的所述免疫显性区域的免疫应答的修饰多肽，而不是针对所述宿主的蛋白质。

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