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    • 5. 发明授权
    • Method of administration of chemotherapy to tumors
    • 肿瘤化疗方法
    • US4558690A
    • 1985-12-17
    • US343011
    • 1982-01-26
    • Patrick J. Joyce
    • Patrick J. Joyce
    • A61F7/00A61K9/00A61K9/16A61B19/00A61M5/00
    • A61K9/0009A61F7/00A61K9/1635A61F2007/0089
    • An improved method of administration of microspheres of cytotoxic chemicals to tumor sites without effect on non tumor tissue is disclosed. The method comprises injection of chemotherapeutic agents coated with a thermoplastic polymer having a melting point above normal body temperature (in a melting point range of about 40.degree.-46.degree. C.) accompanied by dielectric radio-frequency localized heating of the tumor to elevate its interior temperature above the melting point of the encapsulating thermoplastic polymer. The tumor is partially necrosed and sensitized by the R.F. nonionizing radiation bombardment and the entry of the chemotherapy agent triggered by the removal of the protective coat of thermoplastic polymer.A preferred embodiment of the invention is a dose of 30 mg of methotrexate (A-methopterin) in the form of spherical microscapsules having an average of 200-800 microns diameter and a polymer of polystearyl acrylate encapsulating coating of an average thickness of 1-50 microns. This dose is injected into the tumor and released by a 30-60 minute irradiation of the tumor by 175-200 watts of R.F. non-ionizing radiation at a frequency of 13.56 megahertz from a set of capacitive plates positioned on opposite sides of the impregnated tumors. The tumor temperature is elevated to a threshold temperature of 43.degree. C. which is the melting point and release point of the encapsulated acrylic resin. The temperature of the rest of the organism outside the tumor remains at 39.degree.-40.degree. C. which is below the release temperature of the resin.
    • 公开了一种将肿瘤细胞毒性微球施用于非肿瘤组织的改进方法。 该方法包括注射涂覆有熔点高于正常体温(约40-46℃的熔点)的热塑性聚合物的化学治疗剂,伴随着肿瘤的介电射频局部加热以升高其 内部温度高于包封热塑性聚合物的熔点。 肿瘤被R.F.部分坏死并致敏。 通过除去热塑性聚合物的保护层引起的非电离辐射轰击和化学药剂的进入。 本发明的一个优选实施方案是30mg具有平均直径为200-800微米的球形微球形式的甲氨蝶呤(A-甲蝶呤)剂量,丙烯酸聚硬脂酸酯包封涂层的聚合物的平均厚度为1-50 微米。 将该剂量注射到肿瘤中,并通过肿瘤的30-60分钟照射175-200瓦的R.F. 来自位于浸渍的肿瘤的相对侧上的一组电容板,频率为13.56MHz的非电离辐射。 将肿瘤温度升高到43℃的阈值温度,其为包封的丙烯酸树脂的熔点和释放点。 肿瘤外部生物体的其余部分的温度保持在39℃-40℃,低于树脂的释放温度。