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1. 发明授权

US07723304B2 Systems for delivery and release of angiotensin-(1-7) 有权
标题翻译：血管紧张素（1-7）的输送和释放系统
公开(公告)号：US07723304B2
公开(公告)日：2010-05-25
申请号：US10494758
申请日：2002-11-05
申请人： Rubén D. S. Millan , Robson A. S. Dos Santos , Fréderic J. G. Frezad , Ana P. Nadu
发明人： Rubén D. S. Millan , Robson A. S. Dos Santos , Fréderic J. G. Frezad , Ana P. Nadu
IPC分类号： A61K38/08
CPC分类号： B82Y5/00 , A61K9/1271 , A61K9/1647 , A61K38/085 , A61K47/6951
摘要： The prior art lacks a formulation, application or product of D-Ala7-Angiotensin-(1-7) (A-779) and analogues and derivatives, D-Pro7-Angiotensin-(1-7) and analogues or derivatives or of Ang-(1-7) analogues or derivatives using cyclodextrins, liposomes, biodegradable polymers and its derivatives for the study or treatment of arterial hypertension and other cardiovascular diseases, wounds, burns, arrhythmia, tumors, diabetes mellitus, sperm mobility, nephropathy, gastrointestinal and gynaecologicalgynecological disorders, angiogenesis, angioplatsy, alopecia and blood diseases in warm blooded animals, or as ligands for de G-protein-coupled receptor MAS. This characterizes the present invention as a more effective option for the study and treatment of pathologies associated or not to this receptor. A combination of two different technologies are provided: the molecular encapsulation of the peptide angiotensin-(1-7) and its analogues and derivates in cyclodextrin and the microencapsulation in biodegradable polymers and liposomes. It is also characterized by the increase of this peptides and its analogues and derivatives using the formulation.
摘要翻译：现有技术缺乏D-Ala7-血管紧张素（1-7）（A-779）及其类似物和衍生物D-Pro7-血管紧张素 - （1-7）及类似物或衍生物或Ang - （1-7）类似物或衍生物，用于研究或治疗动脉高血压和其他心血管疾病，伤口，烧伤，心律失常，肿瘤，糖尿病，精子移动，肾病，胃肠道和妇科妇科疾病，血管发生，血管平滑，脱发和血液病，或作为G蛋白偶联受体MAS的配体。这表明本发明是研究和治疗与该受体相关或不相关的病理学的更有效的选择。提供了两种不同技术的组合：肽血管紧张素（1-7）及其类似物和衍生物在环糊精中的分子封装和可生物降解的聚合物和脂质体中的微胶囊化。其特征还在于使用该制剂增加了该肽及其类似物和衍生物。

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