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1. 发明申请

US20090325822A1 Apparatus For Increasing The Reaction Efficiency, Especially The Binding Efficiency, Between Molecules And Molecular Moieties 审中-公开
标题翻译：用于增加反应效率的装置，特别是分子和分子之间的结合效率
公开(公告)号：US20090325822A1
公开(公告)日：2009-12-31
申请号：US12296524
申请日：2007-04-11
申请人： Rudolf Heer , Christa Noehammer , Joerg Schotter , Moritz Eggeling , Rudolf Pichler , Markus Mansfeld
发明人： Rudolf Heer , Christa Noehammer , Joerg Schotter , Moritz Eggeling , Rudolf Pichler , Markus Mansfeld
IPC分类号： C40B60/00
CPC分类号： B01F13/0809 , B01F13/0059 , B01L3/5027
摘要： An apparatus for enhancing the contact frequency between two reactants capable of binding to one another, preferably between an analyzer molecule and an analyte molecule, especially for enhancing the binding effectiveness in bioanalysis arrays with the aid of micro- or nanomagnetic particles (75) set in motion in a controlled manner in the fluid reaction medium by means of magnetic fields generated by variably feedable electromagnets (3, 2, 20) arranged on both sides of the reaction fluid film. On one side of a reaction fluid film, especially of a microscope slide (4) comprising the reactants (63), the reaction liquid (70) comprising the reactants (73) and preferably a glass plate (5) covering the microbioanalysis array (6), is arranged close to a two-dimensional matrix (20) having a multitude of miniature or millimagnetic coils (2) feedable individually with magnetization current of variable strength and/or voltage as a function of time—corresponding to a time-dependent variable magnetization pattern desired in each case—and, on the other side of the reaction vessel, especially the microscope slide (4) with the (micro)bioanalysis array (6), in whose vicinity is positioned only one magnetic coil (3) likewise feedable with variable magnetization current and whose magnetic field permeates the entire reaction vessel, especially the microbioanalysis array (6).
摘要翻译：一种用于增强能够彼此结合的两种反应物之间的接触频率的装置，优选在分析器分子和分析物分子之间，特别是借助于设置在微生物或纳米磁性颗粒中的增强生物分析阵列的结合效果通过设置在反应流体膜两侧的可变输入电磁体（3,2,20）产生的磁场，在流体反应介质中以受控的方式运动。在反应流体膜的一侧，特别是包含反应物（63）的显微镜载片（4）的一侧，包含反应物（73）的反应液（70）和优选覆盖微生物分析阵列（6）的玻璃板（5））布置成靠近二维矩阵（20），该二维矩阵（20）具有多个微型或微电磁线圈（2），该二维矩阵能够单独地馈送作为时间的函数的可变强度和/或电压的磁化电流 - 对应于时间因变量在每种情况下都需要磁化图案，并且在反应容器的另一侧，特别是具有（微）生物分析阵列（6）的显微镜载玻片（4），其附近仅定位一个电磁线圈（3），同样可进给具有可变的磁化电流并且其磁场渗透整个反应容器，特别是微量分析阵列（6）。

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