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1. 发明授权

US11318202B2 Antigen binding proteins that bind WISP1 有权
公开(公告)号：US11318202B2
公开(公告)日：2022-05-03
申请号：US16374731
申请日：2019-04-03
申请人： Sorrento Therapeutics, Inc.
发明人： Heyue Zhou , Gunnar F. Kaufmann
IPC分类号： A61K39/395 , C07K16/22 , C07K16/30
摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.

2. 发明申请

US20210130484A1 Variant Antibody That Binds Cd38 有权
公开(公告)号：US20210130484A1
公开(公告)日：2021-05-06
申请号：US17127766
申请日：2020-12-18
申请人： Sorrento Therapeutics, Inc.
发明人： Barbara A. Swanson , Heyue Zhou , Jian Cao
IPC分类号： C07K16/28
摘要： The present disclosure provides anti-CD38 IgG class antibody having improved ability to be manufactured at higher yields compared to the parent antibody having the original wild type sequence. The present disclosure provides a mutated antibody light chain that reduces cleavage heterogeneity for improved production of a homogeneous population of antibody light chains.

3. 发明授权

US10584168B2 Antigen binding proteins that bind PD-1 有权
公开(公告)号：US10584168B2
公开(公告)日：2020-03-10
申请号：US15589051
申请日：2017-05-08
申请人： Sorrento Therapeutics, Inc.
发明人： Heyue Zhou , Barbara A. Swanson , John Dixon Gray , Gunnar F. Kaufmann , Edwige Gros
IPC分类号： C07K16/28 , A61K39/395
摘要： There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-1, PD-1-binding fragments and derivatives of such antibodies, and PD-1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-1 related disorders or conditions, including various inflammatory disorders and various cancers.

4. 发明授权

US10272154B2 Antigen binding proteins that bind WISP1 有权
公开(公告)号：US10272154B2
公开(公告)日：2019-04-30
申请号：US15330956
申请日：2015-04-14
申请人： Sorrento Therapeutics, Inc.
发明人： Heyue Zhou , Gunnar F. Kaufmann
IPC分类号： A61K39/395 , C07K16/30 , C07K16/22
摘要： There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies. More specifically, there is disclosed fully human antibodies that bind WISP1, WISP1-binding fragments and derivatives of such antibodies, and WISP1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having WISP1 related disorders or conditions. There is also disclosed a method for treating or preventing various cancers or inflammatory diseases and various diseases of the heart, bone/joints or lung.

5. 发明授权

US10100126B2 Antibody therapeutics that bind PSMA 有权
公开(公告)号：US10100126B2
公开(公告)日：2018-10-16
申请号：US15066806
申请日：2016-03-10
申请人： Sorrento Therapeutics, Inc.
发明人： Edwige Gros , Silpa Yalamanchili , Heyue Zhou
IPC分类号： C07K16/40 , C07K16/30 , A61K47/68 , A61K39/395 , A61K39/00
摘要： There is disclosed compositions and methods relating to or derived from anti-PSMA antibodies. More specifically, there is disclosed fully human antibodies that bind PSMA, PSMA-antibody binding fragments and derivatives of such antibodies, and PSMA-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease. There is further disclosed targeted therapies for treatment of prostate cancer having the disclosed anti-PSMA antibodies and fragments thereof targeting the therapeutic agent or cell.

6. 发明授权

US09951144B2 Antibody therapeutics that bind CD38 有权
公开(公告)号：US09951144B2
公开(公告)日：2018-04-24
申请号：US15093773
申请日：2016-04-08
申请人： Sorrento Therapeutics, Inc.
发明人： John Dixon Gray , Heyue Zhou
IPC分类号： C07K16/18 , C07K16/30 , C07K16/40 , A61K39/00
CPC分类号： C07K16/2896 , A61K39/00 , A61K39/395 , A61K39/39558 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies. More specifically, there is disclosed fully human antibodies that bind CD38, CD38-antibody binding fragments and derivatives of such antibodies, and CD38-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

7. 发明授权

US09873741B2 Antibody therapeutics that bind TIM3 有权
公开(公告)号：US09873741B2
公开(公告)日：2018-01-23
申请号：US15061832
申请日：2016-03-04
申请人： Sorrento Therapeutics, Inc.
发明人： John Dixon Gray , Heyue Zhou , Irina Krapf
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K2317/21 , C07K2317/73 , C07K2317/75 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-TIM3 antibodies. More specifically, there is disclosed fully human antibodies that bind TIM3, TIM3-antibody binding fragments and derivatives of such antibodies, and TIM3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

8. 发明申请

US20170342156A1 FULLY HUMAN ANTI-CXC CHEMOKINE RECEPTOR 5 (CXCR5) ANTIBODIES 审中-公开
公开(公告)号：US20170342156A1
公开(公告)日：2017-11-30
申请号：US15674401
申请日：2017-08-10
申请人： Sorrento Therapeutics, Inc.
发明人： Dingqiu Huang , Barbara A. Swanson , Heyue Zhou
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CXCR5 antibodies. More specifically, there is disclosed fully human antibodies that bind CXCR5, CXCR5-binding fragments and derivatives of such antibodies, and CXCR5-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CXCR5 related disorders or conditions, including various inflammatory disorders and various cancers.

9. 发明授权

US09631009B2 Anti-infective binding proteins that bind AIP2 有权
公开(公告)号：US09631009B2
公开(公告)日：2017-04-25
申请号：US14473916
申请日：2014-08-29
申请人： Sorrento Therapeutics, Inc.
发明人： Gunnar F. Kaufmann , Heyue Zhou , Guodi Lu
IPC分类号： A61K38/00 , C07K16/12
CPC分类号： C07K16/1271 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-AIP2 antibodies. More specifically, there is disclosed fully human antibodies that bind AIP2, AIP2-binding fragments and derivatives of such antibodies, and AIP2-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having AIP2 related disorders or conditions. There is also disclosed a method to treat S. aureus infections by administering an anti-AIP2 antibody described herein.

10. 发明申请

US20170037129A1 ANTIBODY THERAPEUTICS THAT BIND CD147 审中-公开
标题翻译：抗体治疗方法CD147
公开(公告)号：US20170037129A1
公开(公告)日：2017-02-09
申请号：US15304358
申请日：2015-04-14
申请人： SORRENTO THERAPEUTICS, INC.
发明人： Edwige Gros , Heyue Zhou
IPC分类号： C07K16/28 , C07K16/30
CPC分类号： C07K16/2803 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/92
摘要： There is disclosed compositions and methods relating to or derived from anti-CD147 antibodies. More specifically, there is disclosed fully human antibodies that bind CD147, CD147-binding fragments and derivatives of such antibodies, and CD147-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having CD147 related disorders or conditions. There is also disclosed a method for treating CD147-expressing tumors, including hepatocellular carcinomas and squamous carcinomas, and non-oncology diseases selected from the group consisting of rheumatoid arthritis, experimental lung injury, atherosclerosis, chronic liver disease induced by hepatitis C vims, ischemic myocardial injury and heart failure.
摘要翻译：公开了与抗CD147抗体有关或衍生自抗CD147抗体的组合物和方法。更具体地，公开了结合CD147，CD147-结合片段和此类抗体的衍生物的完全人抗体，以及包含此类片段的CD147结合多肽。此外，还公开了编码这种抗体的核酸，抗体片段和衍生物和多肽，包含这种多核苷酸的细胞，制备这种抗体的方法，抗体片段和衍生物和多肽，以及使用这些抗体，抗体片段和衍生物和多肽的方法包括治疗或诊断具有CD147相关疾病或病症的受试者的方法。还公开了一种治疗CD147表达肿瘤的方法，包括肝细胞癌和鳞状细胞癌，以及选自类风湿关节炎，实验性肺损伤，动脉粥样硬化，丙型肝炎病毒诱导的慢性肝病，缺血性疾病的非肿瘤学疾病心肌损伤和心力衰竭。

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