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1. 发明授权

US11289179B1 Automated medication compliance assurance system 有权
公开(公告)号：US11289179B1
公开(公告)日：2022-03-29
申请号：US15428999
申请日：2017-02-09
申请人： Steven Brown , Steven Dickerson
发明人： Steven Brown , Steven Dickerson
IPC分类号： G16H20/10
摘要： Provided is a system providing a solution for improving prescription drug compliance monitoring and compliance. Prescription drug compliance monitoring may be achieved by using patient's electronic device to initiate secure digital imaging. Medications may be dispensed in containers with pre-printed encoded unique identifiers and markings. The patient may use the digital camera in their smart phone to take a picture of the dispensed blister pack which may be processed and analyzed. Analysis may include assessment of the number of pills taken from and remaining in the uniquely identified blister pack. Package identification and consumption information may then be linked with other prescription information to determine if the observed rate of use is compliant with the legal prescription and to document that the imaged medication package is the same as the dispensed medication package. Data may also be linked with pharmacologic and clinical data to categorize risk and urgency of misuse.

2. 发明授权

US11454196B1 Fuel bowl 有权
公开(公告)号：US11454196B1
公开(公告)日：2022-09-27
申请号：US12150765
申请日：2008-04-30
申请人： Steven Brown
发明人： Steven Brown
IPC分类号： F02M21/04 , F02M21/02
摘要： A fuel bowl is disclosed. The fuel bowl comprises a body having an interior opposite an exterior, four sides, and a bottom opposite an opening. The opening is configured to be in fluid communication with a carburetor or an adaptor. The fuel bowl also comprises a fuel inlet port disposed in at least one of the four sides and configured to receive a gaseous fuel from a fuel regulator. The gaseous fuel expands and contracts within the body. A carburetor system is also disclosed. The carburetor system comprises a gaseous fuel, a fuel regulator configured to receive and deliver the gaseous fuel, a fuel bowl in fluid communication with the fuel regulator and a carburetor, a final fuel metering restriction disposed in an inlet supply port of a cylinder of the carburetor, and a venturi disposed in the carburetor.

3. 发明授权

US08858600B2 Dynamic spinal stabilization device 有权
标题翻译：动态脊柱稳定装置
公开(公告)号：US08858600B2
公开(公告)日：2014-10-14
申请号：US12103576
申请日：2008-04-15
申请人： Steven Brown , Manoj Krishna , Tai Friesem , Jose Fernandez
发明人： Steven Brown , Manoj Krishna , Tai Friesem , Jose Fernandez
IPC分类号： A61B17/70 , A61F2/44
CPC分类号： A61B17/7023 , A61B17/7001 , A61B17/7004 , A61B17/7014 , A61B17/7025 , A61B17/7032 , A61B17/7041 , A61B17/7049 , A61B17/7064 , A61F2/442
摘要： The present invention provides a dynamic stabilization device positionable about a portion of a spinal column. The stabilization device may generally include a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion. The stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement. In addition, one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another. The stabilization device may further define a joint having three degrees of freedom to adapt to movement of a spinal column.
摘要翻译：本发明提供了可围绕脊柱的一部分定位的动态稳定装置。稳定装置通常可以包括第一部件和第二部件，其中第一和第二部件彼此可移动地联接以限定弓形运动路径。稳定装置还可以包括可定位在第一和第二调节开口内的一个或多个调节元件，以影响第一和第二部件之间的运动路径和/或运动的行为和特征。此外，一个或多个电阻元件可以可调节地定位在第一和第二调节开口内和/或两者中，以提供当第一和第二部件相对于彼此移动时所经受的力的电阻和/或阻尼。稳定装置还可以限定具有三个自由度以适应脊柱的运动的关节。

4. 发明授权

US08796318B2 Modulators of sphingosine phosphate receptors 有权
标题翻译：新型磷酸腺苷受体调节剂
公开(公告)号：US08796318B2
公开(公告)日：2014-08-05
申请号：US12465767
申请日：2009-05-14
申请人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
发明人： Edward Roberts , Hugh Rosen , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06 , A61K31/4245 , C07D263/32 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
摘要翻译：提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。某些化合物选择性地激活了关于鞘氨醇 - 1-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗病症，其中在医学上指示S1P1的活化，激动，抑制或拮抗作用。

5. 发明授权

US08629255B2 Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol 有权
标题翻译：赋予提高乙醇耐受性的核酸分子和对乙醇具有增强耐受性的微生物
公开(公告)号：US08629255B2
公开(公告)日：2014-01-14
申请号：US13112641
申请日：2011-05-20
申请人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
发明人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
IPC分类号： C07H21/00 , C12P7/02 , C12N1/00 , C12N15/75 , C12N1/15
CPC分类号： C12N9/0006 , C12P7/10 , Y02E50/16
摘要： The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
摘要翻译：本发明提供了分离的核酸分子，其编码突变乙醛-CoA /醇脱氢酶或突变型醇脱氢酶并赋予对乙醇增强的耐受性。本发明还提供相关表达载体，具有增强的对乙醇的耐受性的遗传工程微生物，以及基于生物质材料的发酵制备和使用这些基因修饰的微生物生产生物燃料的方法。

6. 发明申请

US20120329840A1 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS 有权
公开(公告)号：US20120329840A1
公开(公告)日：2012-12-27
申请号：US13605561
申请日：2012-09-06
申请人： Edward Roberts , Hugh Rose , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
发明人： Edward Roberts , Hugh Rose , Steven Brown , Miguel A. Guerrero , Xuemei Peng , Ramulu Poddutoori
IPC分类号： A61K31/4245 , A61P11/00 , A61P37/06 , C07D271/06 , A61P25/00
CPC分类号： C07D271/06 , A61K31/4245 , C07D263/32 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

7. 发明授权

US08147518B2 Dynamic connector for spinal device 失效
标题翻译：脊柱装置的动态连接器
公开(公告)号：US08147518B2
公开(公告)日：2012-04-03
申请号：US12124374
申请日：2008-05-21
申请人： Steven Brown , Manoj Krishna , Tai Friesem
发明人： Steven Brown , Manoj Krishna , Tai Friesem
IPC分类号： A61B17/70
CPC分类号： A61B17/7023 , A61B17/7001 , A61B17/7004 , A61B17/7014 , A61B17/7025 , A61B17/7032 , A61B17/7041 , A61B17/7049 , A61F2/442
摘要： The present invention provides a dynamic stabilization device positionable about a portion of a spinal column. The stabilization device may generally include a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion. The stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement. In addition, one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another. The stabilization device may further define a joint having three degrees of freedom to adapt to movement of a spinal column.
摘要翻译：本发明提供了可围绕脊柱的一部分定位的动态稳定装置。稳定装置通常可以包括第一部件和第二部件，其中第一和第二部件彼此可移动地联接以限定弓形运动路径。稳定装置还可以包括可定位在第一和第二调节开口内的一个或多个调节元件，以影响第一和第二部件之间的运动路径和/或运动的行为和特征。此外，一个或多个电阻元件可以可调节地定位在第一和第二调节开口内和/或两者中，以提供当第一和第二部件相对于彼此移动时所经受的力的电阻和/或阻尼。稳定装置还可以限定具有三个自由度以适应脊柱的运动的关节。

8. 发明申请

US20110287499A1 Nucleic Acid Molecules Conferring Enhanced Ethanol Tolerance And Microorganisms Having Enhanced Tolerance To Ethanol 有权
标题翻译：赋予增强乙醇耐受性和增强乙醇耐受性的微生物的核酸分子
公开(公告)号：US20110287499A1
公开(公告)日：2011-11-24
申请号：US13112641
申请日：2011-05-20
申请人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
发明人： Steven Brown , Adam Guss , Shihui Yang , Tatiana Karpinets , Lee Lynd , Xiongjun Shao
IPC分类号： C12P7/02 , C12N15/75 , C12N1/00 , C12N1/15 , C12N15/80 , C12N1/21 , C12N15/81 , C07H21/00 , C12N15/74
CPC分类号： C12N9/0006 , C12P7/10 , Y02E50/16
摘要： The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
摘要翻译：本发明提供了分离的核酸分子，其编码突变乙醛-CoA /醇脱氢酶或突变型醇脱氢酶并赋予对乙醇的增强的耐受性。本发明还提供相关表达载体，具有增强的对乙醇的耐受性的遗传工程微生物，以及基于生物质材料的发酵制备和使用这些基因修饰的微生物生产生物燃料的方法。

9. 外观设计

USD618348S1 Spinal stabilization device 有权
标题翻译：脊柱稳定装置
公开(公告)号：USD618348S1
公开(公告)日：2010-06-22
申请号：US29326534
申请日：2008-10-20
申请人： Manoj Krishna , Tai Friesem , Steven Brown
设计人： Manoj Krishna , Tai Friesem , Steven Brown

10. 发明申请

US20100152638A1 Heel Ulcer Prevention and Cushioning Boot 有权
标题翻译：足跟溃疡预防和缓解靴
公开(公告)号：US20100152638A1
公开(公告)日：2010-06-17
申请号：US12709633
申请日：2010-02-22
申请人： Lawrence G. Ponsi , Barbara T. Skiba , Steven Brown
发明人： Lawrence G. Ponsi , Barbara T. Skiba , Steven Brown
IPC分类号： A61F5/00
CPC分类号： A61F5/0111 , A61F5/012
摘要： A cushioning boot for bed-ridden patients. The boot includes a thickly-padded leg engaging portion and foot engaging portion with a front opening for easy insertion of a patient foot and leg. A series of stretchable, adjustable closure panels are removably secured to the boot for positioning and inserted leg in the proper orientation and retaining it in place.
摘要翻译：卧床的患者的缓冲靴。靴子包括厚填充的腿部接合部分和具有前开口的脚部接合部分，用于容易地插入患者脚和腿部。一系列可拉伸，可调节的封闭面板可拆卸地固定在靴子上，用于定位和插入腿部，并将其保持在适当位置。

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