专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11000630B2 Hydrogel precursors having nanoparticles 有权
公开(公告)号：US11000630B2
公开(公告)日：2021-05-11
申请号：US16428534
申请日：2019-05-31
申请人： THE UNIVERSITY OF KANSAS
发明人： Michael Detamore , Emily Beck , Stevin Gehrke , Cory Berkland
IPC分类号： A61L27/48 , A61L27/20 , A61L27/38 , A61L27/54 , A61L27/52 , A61L27/50
摘要： An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.

2. 发明授权

US10881718B2 Bifunctional conjugate compositions and associated methods 有权
公开(公告)号：US10881718B2
公开(公告)日：2021-01-05
申请号：US15072559
申请日：2016-03-17
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Joshua Sestak , Teruna J. Siahaan
IPC分类号： A61K39/395 , A61K39/00 , A61K39/385 , A61K47/54 , A61K47/61 , A61K47/59 , A61K47/69 , C07B43/00 , A61K31/436
摘要： Bifunctional conjugate compositions are provided comprising a Signal-1 moiety bound to a first polymer carrier, wherein the combined size of the Signal-1 moiety and the first polymer carrier is about 1 nanometer to about 500 nanometers; and a Signal-2 moiety bound to a second polymer carrier, wherein the combined size of the Signal-2 moiety and the second polymer carrier is about 1 nanometer to about 500 nanometers. In some embodiments, the Signal-1 moiety and the Signal-2 moiety are bound to the same polymer carrier. Associated methods are also provided.

3. 发明申请

US20130319410A1 INHALATION DEVICE, SYSTEMS, AND METHODS FOR ADMINISTERING POWDERED MEDICAMENTS TO MECHANICALLY VENTILATED SUBJECTS 审中-公开
标题翻译：吸入装置，系统和方法将粉末药物施用于机械通风的物品
公开(公告)号：US20130319410A1
公开(公告)日：2013-12-05
申请号：US13906215
申请日：2013-05-30
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Warangkana Pornputtapitak , Parthiban Selvam , Nashwa El-Gendy
IPC分类号： A61M16/10 , A61M16/04 , A61M16/20 , A61M15/00 , A61M16/00
CPC分类号： A61M16/10 , A61M11/003 , A61M15/0028 , A61M15/0035 , A61M16/0057 , A61M16/0434 , A61M16/0463 , A61M16/0816 , A61M16/0833 , A61M16/14 , A61M16/20 , A61M2202/064
摘要： Inhalation devices, systems, and methods for the administration of powdered medicaments to mechanically ventilated subjects are provided. In one embodiment, an inhalation device adaptively connected at one end to an air source and at the other end is operatively disposed to a ventilator circuit is provided. The inhalation devices are capable of causing a powdered medicament within a container held by the device to be dispensed from the container into the lungs of a mechanically ventilated subject.
摘要翻译：提供了用于向机械通气的受试者施用粉末药物的吸入装置，系统和方法。在一个实施例中，设置在一端自适应地连接到空气源并且在另一端处的吸入装置可操作地设置在通气机回路上。吸入装置能够使由装置保持的容器内的粉末药物从容器分配到机械通气的受试者的肺中。

4. 发明授权

US11460356B2 Functional soft materials and methods of making and using thereof 有权
公开(公告)号：US11460356B2
公开(公告)日：2022-10-04
申请号：US16895965
申请日：2020-06-08
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Jonathan Whitlow , Jean Salash
IPC分类号： G01L1/12 , C09D11/037 , C09D11/102 , H01F7/20 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29K509/08 , H01F1/032 , B29C64/118 , B29K83/00 , B29K105/16
摘要： Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include and elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these materials.

5. 发明授权

US10335515B2 Hydrogel precursors having nanoparticles 有权
公开(公告)号：US10335515B2
公开(公告)日：2019-07-02
申请号：US14918229
申请日：2015-10-20
申请人： The University of Kansas
发明人： Michael Detamore , Emily Beck , Stevin Gehrke , Cory Berkland
IPC分类号： A61L27/48 , A61L27/52 , A61L27/54 , A61L27/20 , A61L27/38 , A61L27/50
摘要： An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.

6. 发明申请

US20180289819A1 POLYAMINE-DIHYDROXYBENZOIC ACID CONJUGATE HYDROGELS AS IRON CHELATORS 审中-公开
公开(公告)号：US20180289819A1
公开(公告)日：2018-10-11
申请号：US15984675
申请日：2018-05-21
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Zahra Mohammadi
IPC分类号： A61K47/54 , A61K31/785 , C08F8/00 , C08F28/02 , A61K47/59 , A61K47/58 , C08F18/22 , C08G69/48 , A61K9/00 , C08F126/02 , C08G69/10 , C08F26/02
摘要： Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.

7. 发明申请

US20160038643A1 HYDROGEL PRECURSORS HAVING NANOPARTICLES 审中-公开
标题翻译：具有纳米颗粒的HYDROGEL PRECURSORS
公开(公告)号：US20160038643A1
公开(公告)日：2016-02-11
申请号：US14918229
申请日：2015-10-20
申请人： The University of Kansas
发明人： Michael Detamore , Emily Beck , Stevin Gehrke , Cory Berkland
IPC分类号： A61L27/48 , A61L27/52 , A61L27/54 , A61L27/20 , A61L27/38
CPC分类号： A61L27/48 , A61L27/20 , A61L27/3817 , A61L27/383 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2430/06 , A61L2430/32 , C08L5/08
摘要： An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.
摘要翻译：可植入水凝胶前体组合物可以包括：可生物相容的可交联聚合物基质; 和可交联聚合物基质中的多个聚合物颗粒。可交联聚合物基质可以包括具有可交联官能团的可交联的透明质酸聚合物。透明质酸聚合物可以是甲基丙烯酸酯化的透明质酸聚合物。甲基丙烯酸酯化的透明质酸聚合物可以具有约500kDa至约1.8MDa的分子量。聚合物颗粒可以包括交联的透明质酸。具有聚合物颗粒的可交联聚合物基质具有屈服应力。具有聚合物颗粒的可交联聚合物基质在生理温度下具有形状保持性。组合物可以包括可交联聚合物基质中的活细胞。组合物可以在可交联的聚合物基质中包括生物活性剂。

8. 发明申请

US20220204911A1 FERROMAGNETIC MATERIAL WITH REMOTE RESPONSIVE CONTROL FOR DYNAMIC CELL CULTURE 有权
公开(公告)号：US20220204911A1
公开(公告)日：2022-06-30
申请号：US17560870
申请日：2021-12-23
申请人： The University of Kansas
发明人： Bryce Stottlemire , Mei He , Cory Berkland
IPC分类号： C12M1/42 , C12N5/0775 , C12M1/12 , C12M1/32
摘要： Described herein is a system to remote-control magnetic actuation of dynamic cell culture. The systems described herein can include a porous, magnetic, elastomeric construct. The porous, magnetic, elastomeric construct can be formed from a composite including a biocompatible elastomer and a population of magnetic particles dispersed within the biocompatible elastomer.

9. 发明授权

US10039836B2 Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators 有权
公开(公告)号：US10039836B2
公开(公告)日：2018-08-07
申请号：US15225524
申请日：2016-08-01
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Zahra Mohammadi
IPC分类号： C08F8/00 , A61K47/48 , C08F26/02 , A61K31/785 , A61K9/00 , C08F126/02 , C08G69/10 , C08G69/48 , C08F18/22 , A61K47/54 , A61K47/58 , A61K47/59
摘要： Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.

10. 发明授权

US09974863B2 Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators 有权
公开(公告)号：US09974863B2
公开(公告)日：2018-05-22
申请号：US15225307
申请日：2016-08-01
申请人： THE UNIVERSITY OF KANSAS
发明人： Cory Berkland , Zahra Mohammadi
IPC分类号： C08F8/00 , A61K47/48 , C08F28/02 , A61K31/785 , A61K9/00 , C08F126/02 , C08G69/10 , C08G69/48 , C08F18/22 , A61K47/54 , A61K47/58 , A61K47/59
CPC分类号： A61K47/547 , A61K9/0019 , A61K9/0056 , A61K31/785 , A61K47/58 , A61K47/595 , C08F8/00 , C08F18/22 , C08F26/02 , C08F28/02 , C08F126/02 , C08F2810/20 , C08G69/10 , C08G69/48 , C08G2210/00
摘要： Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式