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1. 发明授权

US08912145B2 Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease 有权
标题翻译：用于预防和/或治疗阿尔茨海默病的疫苗组合物
公开(公告)号：US08912145B2
公开(公告)日：2014-12-16
申请号：US13290960
申请日：2011-11-07
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
IPC分类号： C12N15/62 , C12N15/82 , A61P25/28 , A61K38/00 , A61K38/08 , A61K36/48 , C07K7/06 , C12N15/12 , C12N15/29 , A61K39/00 , C07K14/415 , C07K14/47
CPC分类号： A61K39/0007 , A61K2039/55516 , A61K2039/6031 , C07K14/415 , C07K14/4711 , C12N15/62 , C12N15/8257 , C12N15/8258
摘要： A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.
摘要翻译：一种用于预防和/或治疗阿尔茨海默氏病的疫苗组合物，其包含通过插入单个或串联重复的多个淀粉样蛋白复合物制备的融合蛋白; 具有衍生自淀粉样蛋白N末端的5至15个连续氨基酸残基的抗原肽; 肽成野生型种子储存蛋白。

2. 发明申请

US20120052086A1 VACCINE COMPOSITION FOR PROPHYLAXIS AND/OR THERAPY OF ALZHEIMER'S DISEASE 有权
标题翻译：用于阿尔茨海默病的预防和/或治疗的疫苗组合物
公开(公告)号：US20120052086A1
公开(公告)日：2012-03-01
申请号：US13290960
申请日：2011-11-07
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
IPC分类号： A61K39/00 , A61P37/02 , A61P25/28 , C07K14/415
CPC分类号： A61K39/0007 , A61K2039/55516 , A61K2039/6031 , C07K14/415 , C07K14/4711 , C12N15/62 , C12N15/8257 , C12N15/8258
摘要： A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.
摘要翻译：一种用于预防和/或治疗阿尔茨海默氏病的疫苗组合物，其包含通过插入单个或串联重复的多个淀粉样蛋白复合物制备的融合蛋白; 具有衍生自淀粉样蛋白N末端的5至15个连续氨基酸残基的抗原肽; 肽成野生型种子储存蛋白。

3. 发明申请

US20110243975A1 TRANSFORMED SOYBEAN PLANT WHICH ACCUMULATES VACCINE, AND USE THEREOF 有权
标题翻译：变质大豆植物，其蓄积疫苗及其用途
公开(公告)号：US20110243975A1
公开(公告)日：2011-10-06
申请号：US13130465
申请日：2009-11-26
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Masao Ishimoto , Shigeru Utsumi , Yasuko Utsumi , Mikio Shoji , Takeshi Kawarabayashi
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Masao Ishimoto , Shigeru Utsumi , Yasuko Utsumi , Mikio Shoji , Takeshi Kawarabayashi
IPC分类号： A61K39/00 , A01H5/00 , A01H5/10 , C12N15/82 , A61P25/28 , A61P37/04
CPC分类号： C12N15/8258 , A61K39/0005 , A61K2039/517 , C07K16/18 , C07K2317/13 , C07K2317/34
摘要： A transformed soybean plant having a gene encoding a modified seed storage protein introduced therein, obtained by inserting a gene encoding an Alzheimer's disease vaccine to a variable region(s) of a gene encoding a wild-type seed storage protein, is produced, and said vaccine is produced and accumulated in the seeds thereof.
摘要翻译：制备具有编码经改良的种子贮藏蛋白质的基因的转化大豆植物，其通过将编码阿尔茨海默病疫苗的基因插入编码野生型种子保存蛋白质的基因的可变区而获得，并且所述在其种子中产生并积累疫苗。

4. 发明授权

US08937218B2 Transformed soybean plant which accumulates vaccine, and use thereof 有权
标题翻译：积累疫苗的转化大豆植物及其用途
公开(公告)号：US08937218B2
公开(公告)日：2015-01-20
申请号：US13130465
申请日：2009-11-26
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Masao Ishimoto , Mikio Shoji , Takeshi Kawarabayashi , Yasuko Utsumi
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Masao Ishimoto , Shigeru Utsumi , Mikio Shoji , Takeshi Kawarabayashi
IPC分类号： C12N15/62 , A01H5/00 , A01H5/10 , A61K38/00 , A61K38/08 , A61P25/28 , C12N15/82 , C12N5/04 , C07K7/06 , A61K36/48 , C07K16/18 , A61K39/00
CPC分类号： C12N15/8258 , A61K39/0005 , A61K2039/517 , C07K16/18 , C07K2317/13 , C07K2317/34
摘要： A transformed soybean plant having a gene encoding a modified seed storage protein introduced therein, obtained by inserting a gene encoding an Alzheimer's disease vaccine to a variable region(s) of a gene encoding a wild-type seed storage protein, is produced, and said vaccine is produced and accumulated in the seeds thereof.
摘要翻译：制备具有编码经改良的种子贮藏蛋白质的基因的转化大豆植物，其通过将编码阿尔茨海默病疫苗的基因插入编码野生型种子保存蛋白质的基因的可变区而获得，并且所述在其种子中产生并积累疫苗。

5. 发明授权

US06388174B1 Gene encoding &agr;-subunit of rice anthranilate synthase and DNA relating thereto 失效
标题翻译：基因编码水稻邻氨基苯甲酸合酶的α-亚基和与之有关的DNA
公开(公告)号：US06388174B1
公开(公告)日：2002-05-14
申请号：US09486382
申请日：2000-04-25
申请人： Kyo Wakasa , Yuzuru Tozawa , Teruhiko Terakawa , Hisakazu Hasegawa
发明人： Kyo Wakasa , Yuzuru Tozawa , Teruhiko Terakawa , Hisakazu Hasegawa
IPC分类号： C12N1579
CPC分类号： C12N15/8254 , C12N9/88 , C12N15/8207 , C12N15/8209 , C12N15/8216 , C12N15/8251 , C12Y401/03027
摘要： A DNA sequence is provided, which encodes an enzyme that is the &agr;-subunit of the first isozyme of rice anthranilate synthase (ASA). Transformed plants having a high tryptophan content can be regenerated by culturing the plant cells having introduced therein such a recombinant vector which contains, at a position downstream of a promoter, an inserted DNA fragment carrying the above DNA sequence. In addition, methods of selecting transformed plant cells are disclosed, wherein plant cells transformed with the discloses DNA are resistant to inhibitory concentrations of tryptophan or tryptophan analogues.
摘要翻译：提供了一种DNA序列，其编码作为水稻邻氨基苯甲酸合酶（ASA）的第一同工酶的α-亚基的酶。具有高色氨酸含量的转化植物可以通过培养其中引入其中的植物细胞来再生，所述重组载体在启动子下游的位置包含携带上述DNA序列的插入DNA片段。此外，公开了选择转化的植物细胞的方法，其中用公开的DNA转化的植物细胞对色氨酸或色氨酸类似物的抑制浓度具有抗性。

6. 发明申请

US20090158469A1 HERBICIDE-RESISTANCE GENE AND UTILIZATION THEREOF 有权
标题翻译：抗药性基因及其利用
公开(公告)号：US20090158469A1
公开(公告)日：2009-06-18
申请号：US11719509
申请日：2005-11-08
申请人： Hisakazu Hasegawa , Teruhiko Terakawa , Kiyoshi Hirazawa
发明人： Hisakazu Hasegawa , Teruhiko Terakawa , Kiyoshi Hirazawa
IPC分类号： A01H5/00 , C07K14/00 , C12N15/11 , C12N15/00
CPC分类号： C12N15/8277 , C12N9/1029 , C12N15/8274
摘要： To provide a novel herbicide-resistance gene and a plant imparted a resistance to herbicides by using this gene, a plant having a resistance to herbicides is constructed by transforming a plant cell by a DNA encoding the following protein (A) or (B) and then regenerating the thus transformed plant cell in a plant. (A) A protein having the amino acid sequence represented by SEQ ID NO:2. (B) A protein having an amino acid sequence of SEQ ID NO:2 including substitution, deletion, insertion or addition of one or plural amino acids and having a herbicide-resistant activity.
摘要翻译：为了提供新型除草剂抗性基因和通过使用该基因赋予除草剂抗性的植物，通过用编码以下蛋白质（A）或（B）的DNA转化植物细胞和（B）和然后在植物中再生这样转化的植物细胞。（A）具有SEQ ID NO：2所示的氨基酸序列的蛋白质。（B）具有SEQ ID NO：2的氨基酸序列的蛋白质，包括取代，缺失，插入或添加一个或多个氨基酸并具有除草剂抗性活性。

7. 发明授权

US06451537B1 Gene of rice dihydrodipicolinate synthase and DNA relating to the same 失效
标题翻译：基因水稻二氢吡啶二羧酸合酶和DNA相关
公开(公告)号：US06451537B1
公开(公告)日：2002-09-17
申请号：US09673397
申请日：2000-11-30
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Masanori Yamaguchi
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Masanori Yamaguchi
IPC分类号： C12Q168
CPC分类号： C12N9/88 , C12N15/8207 , C12N15/8209 , C12N15/8254
摘要： In accordance with this invention, there is provided a DNA sequence which can encode an enzyme protein functioning as the rice dihydrodipicolinate synthase (DHDPS). One example of the DNA sequence according to this invention is the DNA having the nucleotide sequence shown in SEQ ID No. 1 of Sequence Listing. Additionally, this invention provides the DNA having the nucleotide sequence of SEQ ID No. 5, as well as the DNA having the nucleotide sequence of SEQ ID No. 7 of Sequence Listing, as the DNA which is capable of encoding the protein having the DHDPS activity. When cultivation is made of the plant cells in which there has been introduced a recombinant vector having carried therein a DNA fragment containing the DNA of this invention as inserted at downstream of the promoter of said recombinant vector, it is feasible to regenerate from said plant cells a transgenic plant having a high lysine content.
摘要翻译：根据本发明，提供了可以编码作为水稻二氢吡啶二羧酸合酶（DHDPS）起作用的酶蛋白质的DNA序列。根据本发明的DNA序列的一个实例是具有序列表的SEQ ID No.1所示的核苷酸序列的DNA。此外，本发明提供具有SEQ ID No.5的核苷酸序列的DNA以及具有序列表的SEQ ID No.7的核苷酸序列的DNA作为能够编码具有DHDPS的蛋白质的DNA 活动。当在其中已经引入了植物细胞的培养物中携带其中含有插入在所述重组载体的启动子下游的本发明的DNA的DNA片段的重组载体时，可以从所述植物细胞再生具有高赖氨酸含量的转基因植物。

8. 发明授权

US07795505B2 Herbicide-resistance gene and utilization thereof 有权
标题翻译：除草剂抗性基因及其利用
公开(公告)号：US07795505B2
公开(公告)日：2010-09-14
申请号：US11719509
申请日：2005-11-08
申请人： Hisakazu Hasegawa , Teruhiko Terakawa , Kiyoshi Hirazawa
发明人： Hisakazu Hasegawa , Teruhiko Terakawa , Kiyoshi Hirazawa
IPC分类号： A01H5/10 , C12N15/52 , C12N15/82 , C12N9/10
CPC分类号： C12N15/8277 , C12N9/1029 , C12N15/8274
摘要： A DNA encoding a phosphinothricin acetyltransferase protein obtained from Streptomyces sp. AB3534 strain is described which imparts a resistance to herbicides, particularly the herbicide phosphinothricin (PPT). Plants having a herbicide resistance are constructed by transforming a plant cell with DNA encoding the phosphinothricin acetyltransferase protein and then regenerating the transformed plant cell into a plant. A recombinant protein having the herbicide-resistant activity is also described.
摘要翻译：编码从链霉菌属（Streptomyces sp。）获得的膦丝菌素乙酰转移酶蛋白质的DNA 描述了对除草剂，特别是除草剂膦丝菌素（PPT）具有抗性的AB3534菌株。通过用编码膦丝菌素乙酰转移酶蛋白的DNA转化植物细胞，然后将转化的植物细胞再生成植物来构建具有除草剂抗性的植物。还描述了具有除草剂抗性活性的重组蛋白。

9. 发明申请

US20090100552A1 TRANSGENIC PLANT TRANSFORMED WITH STRESS-RESPONSIVE GENE 审中-公开
标题翻译：具有应激反应基因转化的转基因植物
公开(公告)号：US20090100552A1
公开(公告)日：2009-04-16
申请号：US12162309
申请日：2007-01-16
申请人： Tomokazu Koshiba , Teruhiko Terakawa , Hisakazu Hasegawa , Setsuko Komatsu , Takashi Okamoto , Toshiko Furukawa , Kentaroh Shimaya
发明人： Tomokazu Koshiba , Teruhiko Terakawa , Hisakazu Hasegawa , Setsuko Komatsu , Takashi Okamoto , Toshiko Furukawa , Kentaroh Shimaya
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8273 , Y02A40/146
摘要： A plant having improved heat tolerance and/or increased growth is produced by steps of: introducing DNA into a plant cell to produce a transformed plant cell, wherein the DNA is selected from the group consisting of: (a) DNA coding for a protein consisting of the amino acid sequence represented by SEQ ID NO: 2, (b) DNA including the coding region of the nucleotide sequence represented by SEQ ID NO: 1, (c) DNA coding for a protein having an amino acid sequence represented by SEQ ID NO: 2 in which one or a few amino acids are substituted, deleted, inserted, and/or added, and being involved in growth promoting effect and heat tolerance, (d) DNA hybridizing with DNA consisting of the nucleotide sequence represented by SEQ ID NO: 1 under stringent conditions and coding for a protein which is involved in growth promoting effect and heat tolerance, and (e) DNA coding for a protein having an amino acid sequence having 90% or more identity with the amino acid sequence represented by SEQ ID NO: 2 and being involved in growth promoting effects, heat tolerance, drought tolerance and salt tolerance; and regenerating a transformed plant from the transformed plant cell.
摘要翻译：通过以下步骤产生具有改善的耐热性和/或增加生长的植物：将DNA引入植物细胞以产生转化的植物细胞，其中所述DNA选自：（a）编码蛋白质的DNA SEQ ID NO：2所示的氨基酸序列的DNA，（b）包含由SEQ ID NO：1表示的核苷酸序列的编码区的DNA，（c）编码具有SEQ ID NO：其中一个或几个氨基酸被取代，缺失，插入和/或添加并参与生长促进作用和耐热性的NO：2，（d）与由SEQ ID NO：在编码引起生长促进作用和耐热性的蛋白质的编码下，编码NO：1，和（e）编码与SEQ ID NO：1所示的氨基酸序列具有90％以上同一性的氨基酸序列的蛋白质的DNA 证件号码： 2，参与生长促进作用，耐热性，耐旱性和耐盐性; 并从转化的植物细胞再生转化的植物。

10. 发明申请

US20120331591A1 METHOD OF PRODUCING CYCLAMEN WITH MULTI-PETALED FLOWERS 有权
标题翻译：用多花瓣生产环孢菌素的方法
公开(公告)号：US20120331591A1
公开(公告)日：2012-12-27
申请号：US13516505
申请日：2010-12-16
申请人： Teruhiko Terakawa , Tomomichi Yamamura , Masao Sugiyama , Masaru Takagi , Nobutaka Mitsuda
发明人： Teruhiko Terakawa , Tomomichi Yamamura , Masao Sugiyama , Masaru Takagi , Nobutaka Mitsuda
IPC分类号： A01N43/50 , A01P21/00 , A01H5/00
CPC分类号： C12N15/827 , C12N15/8216
摘要： A method of producing a multi-petaled cyclamen plant having an increased number of petals, including at least inhibiting the function of a transcription factor involved in morphogenesis of a floral organ of cyclamen.
摘要翻译：一种生产花瓣数目增多的多花瓣仙客花植物的方法，包括至少抑制参与仙客来花器官形态发生的转录因子的功能。

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