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1. 发明授权

US09425032B2 Optimizing drag field voltages in a collision cell for multiple reaction monitoring (MRM) tandem mass spectrometry 有权
标题翻译：优化用于多反应监测（MRM）串联质谱的碰撞池中的阻力场电压
公开(公告)号：US09425032B2
公开(公告)日：2016-08-23
申请号：US14742115
申请日：2015-06-17
申请人： Thermo Finnigan LLC
发明人： Oleg Silivra , Harald Oser , Joshua T. Maze , Terry Olney , Alan E. Schoen
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/005 , H01J49/4215 , H01J49/4225 , H01J49/429
摘要： A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition. The method further includes varying a drag field by adjusting the voltages applied to drag vane terminals in opposite directions to identify a drag field value with a cross talk below a cross talk threshold, varying the vane offset voltage by adjusting the voltages applied to the drag vane terminals to maximize the intensity of the transition while preserving the drag field, and operating the collision cell at the vane offset voltage and drag field to monitor the transition.
摘要翻译：碰撞单元具有围绕轴向中心线相对排列的多个杆电极以及布置在杆电极之间的间隙空间中的多个牵引叶片。操作碰撞单元包括：向杆电极施加杆偏移电压，以及改变施加到牵引叶片的偏移电压，以识别具有用于转变的最大强度的叶片偏移电压。该方法还包括通过调整施加到相反方向上的牵引叶片端子的电压来改变阻力场，以通过串扰低于串扰阈值来识别阻力场值，通过调节施加到牵引叶片的电压来改变叶片偏移电压终端，以最大化过渡的强度，同时保持拖曳场，并且在叶片偏移电压和阻力场处操作碰撞单元以监视转换。

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