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    • 2. 发明授权
    • Cephem compound having pyridinium group
    • 具有吡啶鎓基的头孢烯化合物
    • US09242999B2
    • 2016-01-26
    • US14129631
    • 2012-06-26
    • Yasuhiro NishitaniToshiaki Aoki
    • Yasuhiro NishitaniToshiaki Aoki
    • C07D501/36C07D501/60C07D505/00
    • C07D501/60C07D501/36C07D505/00
    • The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
    • 本发明提供了具有广谱抗菌谱的新型化合物,特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。 具体提供的是:式(I)表示的化合物,其中每个符号的含义如说明书中所定义,具有位置上具有环上的氨基的化合物的类型的氨基保护形式, 7侧链,或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物,氨基保护形式或药学上可接受的盐的药物组合物。
    • 4. 发明申请
    • CEPHEM COMPOUND HAVING PYRIDINIUM GROUP
    • 具有吡咯烷基的化合物
    • US20140114060A1
    • 2014-04-24
    • US14129631
    • 2012-06-26
    • Yasuhiro NishitaniToshiaki Aoki
    • Yasuhiro NishitaniToshiaki Aoki
    • C07D501/60
    • C07D501/60C07D501/36C07D505/00
    • The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
    • 本发明提供了具有广谱抗菌谱的新型化合物,特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。 具体提供的是:式(I)表示的化合物,其中每个符号的含义如说明书中所定义,具有位置上具有环上的氨基的化合物的类型的氨基保护形式, 7侧链,或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物,氨基保护形式或药学上可接受的盐的药物组合物。
    • 5. 发明申请
    • NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN
    • 用于治疗疼痛的新型药物组合物
    • US20110152268A1
    • 2011-06-23
    • US13061219
    • 2009-09-10
    • Nobuaki TakeshitaFusako NishigakiToshiaki AokiSeiji TamuraKazumi KikuchiAkio Kuroda
    • Nobuaki TakeshitaFusako NishigakiToshiaki AokiSeiji TamuraKazumi KikuchiAkio Kuroda
    • A61K31/5375C07D265/30A61P29/00
    • C07D265/30A61K31/5375
    • The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
    • 本发明涉及用于治疗伤害性疼痛的药物组合物,其含有吗啉衍生物或其药学上可接受的盐作为活性成分。 本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。 此外,本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物:选自类风湿性关节炎,类风湿性脊椎炎,骨关节炎,变形性椎关节强硬症,痛风性关节炎,幼年型关节炎,肩周炎性关节炎和子宫颈综合征, 腰痛,腰痛伴椎关节僵硬,麻痹症,炎症,手术或损伤后疼痛,咽后切除术后的疼痛,以及癌症疼痛。 此外,本发明特别可用于缓解软骨损伤区域的疼痛,特别适用于NSAIDs无效的骨关节炎。
    • 7. 发明申请
    • NOVEL PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY
    • 新型预防和/或治疗糖尿病神经病变药物
    • US20100113451A1
    • 2010-05-06
    • US12530745
    • 2008-03-14
    • Toshiaki AokiNobuhito MuraiSeiji TamuraHiroko YamamotoNozomu Hamakawa
    • Toshiaki AokiNobuhito MuraiSeiji TamuraHiroko YamamotoNozomu Hamakawa
    • A61K31/5375A61P25/00
    • C07D265/30A61K31/5375
    • The present invention relates to an agent for preventing and/or treating diabetic neuropathy comprising a 2-[(substituted-inden-7-yloxy)methyl]morpholine of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The invention is useful for providing an excellent agent for preventing and/or treating diabetic neuropathy, and particularly useful for providing an agent for preventing and/or treating diabetic motor neuropathy (such as muscle weakness disorder (such as muscle weakness disorder with inability to walk independently)), diabetic sensory neuropathy (such as paresthesia (such as vibration perception abnormality), allodynia, hypoesthesia (such as numbness of extremities or cold sensation), or pain), or diabetic autonomic neuropathy (such as stool abnormality (such as constipation or diarrhea), urination disorder, impotence, orthostatic hypotension, sudomotor dysfunction, abnormal heart rate variability, or delayed gastric emptying). Further, the invention is particularly useful for providing an agent for improving pathophysiology of diabetic neuropathy.
    • 本发明涉及用于预防和/或治疗糖尿病性神经病变的药剂,其包含式(I)的2 - [(取代 - 茚-7-基氧基)甲基]吗啉或其药学上可接受的盐作为活性成分。 本发明可用于提供用于预防和/或治疗糖尿病性神经病变的优异剂,特别可用于提供用于预防和/或治疗糖尿病运动神经病变(如肌肉无力障碍(例如无力行走的肌肉无力障碍) 独立)),糖尿病感觉神经病变(如感觉异常(如振动感知异常),异常性疼痛,麻醉(如四肢麻木或感冒)或疼痛)或糖尿病性自主神经病变(如便秘便秘) 或腹泻),排尿障碍,阳ence,直立性低血压,苏体功能障碍,异常心率变异性或延迟胃排空)。 此外,本发明特别可用于提供改善糖尿病性神经病变病理生理学的药剂。