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1. 发明授权

US5411494A Sponge bath machine and method for using 失效
标题翻译：海绵浴机及使用方法
公开(公告)号：US5411494A
公开(公告)日：1995-05-02
申请号：US126929
申请日：1993-09-27
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61F7/00 , A61F7/02 , A61M35/00
CPC分类号： A61F7/00 , A61F2007/0059 , A61F2007/0086 , A61F2007/026 , A61F7/0085 , A61F7/0097
摘要： A therapeutic method for treating hypothermia and hyperthermia conditions in human patients by applying a continuous flow of temperature-controlled warmed water over a substantial area of the body of the patient to effect sensible heat transfer between the body and the water. Apparatus is provided for warming, delivering, and distributing the water flow over at least fifty percent of the patient's body and for collecting spent water into a receptacle. A network of water-permeable tubes delivers a flow of warmed water to an absorbent web draped over the body of the patient, thereby to distribute the water flow over a large area and in close proximity to and wetting the surface of the patient's body, thereby to effect sensible heat transfer over a large area. Evaporative heat loss may be minimized by reducing air convection adjacent the water flow.
摘要翻译：一种通过在患者身体的大部分区域上施加连续流动的温度控制的温水以在身体和水之间实现明显的热传递来治疗人类患者体温低温和高热症状的治疗方法。提供了用于在至少百分之五十的患者身体上升温，输送和分配水流并将废水收集到容器中的装置。透水管网络将一束暖水提供给覆盖在患者身体上的吸收性纤维网，从而将水流分布在大面积上，并且紧邻并润湿患者身体的表面，由此在大面积上实现明显的热传递。通过减少邻近水流的空气对流可以减少蒸发热损失。

2. 发明授权

US07858602B2 Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growth factors of stem cells 有权
标题翻译：细胞特异性碳酸酐酶在治疗由于氧化应激引起的老化障碍和作为干细胞生长因子的治疗和预防用途
公开(公告)号：US07858602B2
公开(公告)日：2010-12-28
申请号：US11801870
申请日：2007-05-12
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61K31/593 , A61K33/30 , A61K31/315 , A61K31/405 , A61K31/23 , A61K31/145 , A61P25/28
CPC分类号： A61K38/27 , A61K31/00 , A61K33/30 , A61K38/51 , Y10S514/879
摘要： A method for the treatment and prophylaxis of conditions of aging due oxidative stress and as growth factors of stem cells. Such conditions due to oxidative stress are associated with a decreased presence of one or more cell-specific carbonic anhydrase enzymes in the tissue of a subject. Such conditions include but are not limited to alzheimer's disease, parkinson's disease, multiple sclerosis, autism, lou gehrig's disease, huntington's disease, diabetes mellitus, amyloid diseases, atherosclerosis, arthritis, osteoporosis, cystic fibrosis. The method comprises administering to the patient a pharmaceutically effective, non-toxic amount of one or more compounds that increases the presence of one or more Carbonic Anhydrase Isozymes whose levels have been reduced in the subject. Such compound maybe the Cell Specific Carbonic Anhydrase Enzymes, a compound that when absorbed reacts or dissociates to form cell specific carbonic enzymes or a compound that when administered promotes the natural generation of the cell specific carbonic anhydrase enzymes within the subject.This method also uses one or more cells specific carbonic anhydrase as growth factors of stem cells for replacing tissues due to injuries or diseases in humans.These methods includes the administering of these compounds over an extended period of time ranging from 6 months until the subject dies.
摘要翻译：一种治疗和预防老化因氧化应激状况和干细胞生长因子的方法。由于氧化应激引起的这种病症与受试者组织中一种或多种细胞特异性碳酸酐酶的存在减少有关。这些病症包括但不限于阿尔茨海默病，帕金森病，多发性硬化症，自闭症，洛氏病，亨廷顿病，糖尿病，淀粉样蛋白病，动脉粥样硬化，关节炎，骨质疏松症，囊性纤维化。该方法包括向患者施用药物有效的无毒量的一种或多种化合物，其增加其水平已经在受试者中降低的一种或多种碳酸酐酶同功酶的存在。这种化合物可以是细胞特异性碳酸酐酶，当被吸收时被吸收反应或解离以形成细胞特异性碳酸酶或当被施用时化合物促进受试者内的细胞特异性碳酸酐酶的天然产生。该方法还使用一种或多种细胞特异性碳酸酐酶作为干细胞的生长因子，用于由于人类的损伤或疾病而替代组织。这些方法包括在6个月至受试者死亡的延长时间段内施用这些化合物。

3. 发明授权

US06821997B1 Therapeutic and prophylactic treatment of aging and disorders of aging in humans 失效
标题翻译：治疗和预防性治疗老化和人类衰老的障碍
公开(公告)号：US06821997B1
公开(公告)日：2004-11-23
申请号：US10077719
申请日：2002-02-15
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61K31417
CPC分类号： A61K38/51 , A61K31/00 , A61K33/30 , Y10S514/878 , Y10S514/879
摘要： A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain, such as conditions associated with chronic neurodegenerative conditions including dementia such as Alzheimer's disease, which method includes the administering over an extended period of time, ranging from 6 months to 5 years, of a pharmaceutically effective, non-toxic amount of a compound that increases the presence of cell-specific carbonic anhydrase enzymes in the brain. That compound may be the cell-specific carbonic anhydrase enzyme, a compound that when absorbed by the body reacts or dissociates to form the cell-specific carbonic anhydrase enzyme, or a compound that promotes the natural generation of the cell-specific carbonic anhydrase enzyme within the body.
摘要翻译：用于治疗和预防人类老化状况的方法，与脑中细胞特异性碳酸酐酶的存在减少相关的老化状况，例如与慢性神经变性病症（包括痴呆症如阿尔茨海默氏病）相关的病症，其中，方法包括在6个月至5年的较长时期内施用药物有效的无毒量的增加脑中细胞特异性碳酸酐酶存在的化合物。该化合物可以是细胞特异性碳酸酐酶，当被身体吸收时，化合物反应或解离以形成细胞特异性碳酸酐酶，或者促进天然产生细胞特异性碳酸酐酶的化合物身体。

4. 发明授权

US5570477A Portable toilet bowl ventilator 失效
标题翻译：便携式马桶通风机
公开(公告)号：US5570477A
公开(公告)日：1996-11-05
申请号：US490956
申请日：1995-06-15
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： E03D9/05 , E03D9/052
CPC分类号： E03D9/052
摘要： A portable fan apparatus is provided for ventilating toilet bowls by forced ventilation wherein air from the toilet bowl is exhausted by the fan via a tube that extends through the water trap formed by water in the trap formed partly by the bottom of the toilet bowl and partly by the drain portion of the toilet, thereby exhausting the foul air into the drain line of the building's plumbing system. The apparatus can be carried by a traveler from toilet to toilet, thereby to provide the desired ventilation for any toilet facility the traveler may visit.
摘要翻译：提供一种便携式风扇装置，用于通过强制通风来通风马桶碗，其中来自马桶的空气由风扇排出，所述管通过管延伸通过由位于马桶的底部部分形成的捕集器中的水形成的捕集阱，通过马桶的排水部分，从而将污浊空气排出到建筑物的管道系统的排水管线中。该装置可以由旅行者从厕所运送到马桶，从而为旅行者可以访问的任何厕所设施提供期望的通风。

5. 发明申请

US20100135980A1 Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging, disorders of aging, cancer, as growth factors, and as an alternative to stem cell therapy 审中-公开
标题翻译：细胞特异性碳酸酐酶在治疗老化，衰老障碍，癌症，作为生长因子的治疗和预防用途以及作为干细胞治疗的替代方法
公开(公告)号：US20100135980A1
公开(公告)日：2010-06-03
申请号：US12655783
申请日：2010-01-07
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61K38/51 , A61P35/00 , A61P19/08 , A61P19/02 , A61P37/00 , A61P25/00 , A61P17/00
CPC分类号： A61K38/51
摘要： A method for the treatment and prophylaxis of diseases or conditions associated with aging which includes oxidative stress and cancer. Such diseases or conditions are associated with a decrease or increase presence of one or a combination of one or more Carbonic Anhydrase isozymes I TO VII in the tissue of a subject. These diseases include but are not limited to chronic neurodegenerative diseases such as Alzheimer's disease, parkinson's disease, multiple sclerosis, autism, lou gehrig's disease, huntington's disease, immune disorders which includes systemic lupus erythematosus, diabetes mellitus; musculo-skeletal disorders which includes osteoporosis,arthritis, osteomalacia. Cancer which includes the breast, lung, colon, prostate gland, ovary, esophagus, liver, rectum. The method comprises administering to the patient a pharmaceutically effective non toxic amount of one or a combination of one or more compounds that increases or decreases the level of one or more Cell Specific Carbonic Anhydrase Enzymes whose levels have been increased or decreased in the tissue of the subject. Such compound maybe the Cell Specific Carbonic Anhydrase Enzymes I to VII. A compound that when absorbed reacts or dissociates to form cell specific carbonic enzymes or one or more compounds that when administered promotes the increase or decrease level of one or more cell specific Carbonic anhydrase I,II,III,IV,V,VI,VII. As growth factors of stem cells as an alternative to stem cell therapy. These methods includes the administering of one or a combination of one or more of these compounds over an extended period of time ranging from 6 months until the patient dies.
摘要翻译：一种治疗和预防与老化有关的疾病或病症的方法，包括氧化应激和癌症。这样的疾病或病症与受试者组织中一种或多种碳酸酐酶同功酶I至VII的一种或组合的存在减少或增加相关。这些疾病包括但不限于慢性神经变性疾病如阿尔茨海默氏病，帕金森病，多发性硬化症，孤独症，洛氏病，亨廷顿舞蹈病，包括系统性红斑狼疮的免疫疾病，糖尿病; 肌肉骨骼疾病，包括骨质疏松症，关节炎，骨软化症。包括乳腺癌，肺癌，结肠癌，前列腺癌，卵巢癌，食管癌，肝癌，直肠癌的癌症。该方法包括向患者施用药学有效的无毒量的一种或多种化合物的组合，其增加或降低一种或多种细胞特异性碳酸酐酶的水平，其水平已经增加或降低学科。这种化合物可能是细胞特异性碳酸酐酶Ⅰ至VII。当被吸收反应或解离以形成细胞特异性碳酸酶或一种或多种化合物时，当被吸收时促进一种或多种细胞特异性碳酸酐酶I，II，III，IV，V，VI，VII的增加或减少的化合物。作为干细胞替代治疗干细胞的生长因子。这些方法包括在6个月至患者死亡的延长时间段内施用这些化合物中的一种或多种的一种或多种的组合。

6. 发明授权

US07256184B2 Treatment of aging disorders in humans 失效
标题翻译：治疗人类老龄化障碍
公开(公告)号：US07256184B2
公开(公告)日：2007-08-14
申请号：US10858091
申请日：2004-06-01
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61K31/593 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： A61K33/30 , A61K31/00 , A61K38/51 , Y10S514/878 , Y10S514/879 , Y10S514/903
摘要： A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of one or more cell-specific carbonic anhydrase enzymes. Such conditions include chronic neurodegenerative conditions including dementia such as Alzheimer's disease. The method comprises administering to the patient a pharmaceutically effective, non-toxic amount of a compound that increases the presence of one or more cell-specific carbonic anhydrase enzymes whose levels are reduced in the patient. Such compound may be the cell-specific carbonic anhydrase enzyme, a compound that when absorbed by the body reacts or dissociates to form the cell-specific carbonic anhydrase enzyme, or a compound that promotes the natural generation of the cell-specific carbonic anhydrase enzyme within the body.
摘要翻译：用于治疗和预防人类衰老状况的方法，与一种或多种细胞特异性碳酸酐酶的存在减少相关的老化状况。这些病症包括慢性神经退行性疾病，包括痴呆症如阿尔茨海默病。该方法包括向患者施用药物有效的无毒量的化合物，其增加患者体内水平降低的一种或多种细胞特异性碳酸酐酶的存在。这种化合物可以是细胞特异性碳酸酐酶，当被身体吸收时反应或解离形成细胞特异性碳酸酐酶的化合物或促进天然产生细胞特异性碳酸酐酶的化合物身体。

7. 发明授权

US5755237A Therapeutic use of acetazolamide for the treatment of brain edema 失效
标题翻译：治疗用途乙酰唑胺治疗脑水肿
公开(公告)号：US5755237A
公开(公告)日：1998-05-26
申请号：US490110
申请日：1995-06-07
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： C07D285/135 , A61K31/00 , A61K31/41 , A61K31/433 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00 , A61B19/00
CPC分类号： A61K31/00 , A61K31/433
摘要： A method for treating victims of cerebral edema is presented that includes the intravenous injection of acetazolamide (A.K.A., DIAMOX.RTM.), which is a readily-available and often-prescribed diuretic. Such edema, or brain swelling may be caused as a result of ischemic strokes especially, but also swelling due to tumors, surgeries, or cerebral trauma. It is preferred to combine the acetazolamide therapy with hyperventilation of the lungs, even including the use of supplemental oxygen, thereby to reduce the concentration of carbon dioxide in the blood and hence in the brain.
摘要翻译：提出了一种治疗脑水肿受害者的方法，包括静脉注射乙酰唑胺（A.K.A.，DIAMOX TM），它是一种易于使用且常用的利尿剂。这种水肿或脑肿胀可能是由于缺血性中风的结果而引起的，特别是由于肿瘤，手术或脑损伤引起的肿胀。优选将乙酰唑胺治疗与肺过度换气相结合，甚至包括使用补充氧，从而降低血液中，因此降低脑中二氧化碳的浓度。

8. 发明申请

US20110091576A1 Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growrh factors of stem cells 审中-公开
标题翻译：细胞特异性碳酸酐酶在治疗由于氧化应激引起的老化障碍和干细胞生长因子的治疗和预防用途
公开(公告)号：US20110091576A1
公开(公告)日：2011-04-21
申请号：US12928145
申请日：2010-12-04
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61K33/32 , A61K31/22 , A61K31/4164 , A61K31/4035 , A61K31/59 , A61K31/56 , A61K31/135 , A61K31/34 , A61P9/10 , A61P11/00 , A61P19/10 , A61P25/28 , A61P37/00 , A61P17/00
CPC分类号： A61K38/27 , A61K31/00 , A61K33/30 , A61K38/51 , Y10S514/879
摘要： A method for the treatment and prophylaxis of conditions of aging due oxidative stress and as growth factors of stem cells. Such conditions due to oxidative stress are associated with a decreased presence of one or more cell-specific carbonic anhydrase enzymes in the tissue of a subject. Such conditions include but are not limited to alzheimer's disease, parkinson's disease, multiple sclerosis, autism, lou gehrig's disease, huntington's disease, diabetes mellitus, amyloid diseases, atherosclerosis, arthritis, osteoporosis, cystic fibrosis. The method comprises administering to the patient a pharmaceutically effective, non-toxic amount of one or more compounds that increases the presence of one or more Carbonic Anhydrase Isozymes whose levels have been reduced in the subject. Such compound maybe the Cell Specific Carbonic Anhydrase Enzymes, a compound that when absorbed reacts or dissociates to form cell specific carbonic enzymes or a compound that when administered promotes the natural generation of the cell specific carbonic anhydrase enzymes within the subject.This method also uses one or more cells specific carbonic anhydrase as growth factors of stem cells for replacing tissues due to injuries or diseases in humans.These methods includes the administering of these compounds over an extended period of time ranging from 6 months until the subject dies.
摘要翻译：一种治疗和预防老化因氧化应激状况和干细胞生长因子的方法。由于氧化应激引起的这种病症与受试者组织中一种或多种细胞特异性碳酸酐酶的存在减少有关。这些病症包括但不限于阿尔茨海默病，帕金森病，多发性硬化症，自闭症，洛氏病，亨廷顿病，糖尿病，淀粉样蛋白病，动脉粥样硬化，关节炎，骨质疏松症，囊性纤维化。该方法包括向患者施用药物有效的无毒量的一种或多种化合物，其增加其水平已经在受试者中降低的一种或多种碳酸酐酶同功酶的存在。这种化合物可以是细胞特异性碳酸酐酶，当被吸收时被吸收反应或解离以形成细胞特异性碳酸酶或当被施用时化合物促进受试者内的细胞特异性碳酸酐酶的天然产生。该方法还使用一种或多种细胞特异性碳酸酐酶作为干细胞的生长因子，用于由于人类的损伤或疾病而替代组织。这些方法包括在6个月至受试者死亡的延长时间段内施用这些化合物。

9. 发明授权

US5944021A Therapeutic use of a carbonic anhydrase enzyme inhibitor for the treatment of brain edema 失效
标题翻译：治疗性使用碳酸酐酶抑制剂治疗脑水肿
公开(公告)号：US5944021A
公开(公告)日：1999-08-31
申请号：US23062
申请日：1998-02-13
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： C07D285/135 , A61B19/00 , A61K31/00 , A61K31/41 , A61K31/433 , A61K45/00 , A61P7/10 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00
CPC分类号： A61K31/433 , A61K31/00
摘要： A method for treating victims of cerebral edema is presented that includes the intravenous injection of a carbonic anhydrase enzyme inhibitor that passes through the blood-brain barrier, such as acetazolamide (A.K.A., DIAMOX.RTM.), which is a readily-available and often-prescribed diuretic. Such edema, or brain swelling may be caused as a result of ischemic strokes especially, but also swelling due to tumors, surgeries, or cerebral trauma. It is preferred to combine the a carbonic anhydrase enzyme inhibitor therapy with hyperventilation of the lungs, even including the use of supplemental oxygen, thereby to reduce the concentration of carbon dioxide in the blood and hence in the brain.
摘要翻译：提出了一种治疗脑水肿受害者的方法，其中包括静脉注射通过血脑屏障的碳酸酐酶抑制剂，如乙酰唑胺（AKA，DIAMOX TM），它是一种易于获得且经常处方的利尿这种水肿或脑肿胀可能是由于缺血性中风的结果而引起的，特别是由于肿瘤，手术或脑损伤引起的肿胀。优选将碳酸酐酶抑制剂治疗与肺的过度换气相结合，甚至包括使用补充氧，从而降低血液中和因此在脑中二氧化碳的浓度。

10. 发明授权

US5411493A Sponge bath garment and method for using 失效
标题翻译：海绵浴服和使用方法
公开(公告)号：US5411493A
公开(公告)日：1995-05-02
申请号：US126928
申请日：1993-09-27
申请人： Victorio C. Rodriguez
发明人： Victorio C. Rodriguez
IPC分类号： A61F7/00 , A61F7/02 , A61M35/00
CPC分类号： A61F7/02 , A61F2007/0018 , A61F2007/026
摘要： A method for treating hypothermia or hyperthermia patients is presented wherein the upper torso of the patient is maintained in close contact with a wet absorbent material in a vestlike garment that carries a water supply to maintain the absorbent material wet to effect sensible heat transfer between the patient and the water. In one embodiment, evaporative cooling is moderated by an overgarment of a waterproof material.
摘要翻译：提出了一种治疗体温过低或高热症患者的方法，其中患者的上身保持与背心衣服中的湿吸收材料紧密接触，该湿吸收材料承载供水以保持吸收材料的湿润，以在患者之间进行明显的热传递和水。在一个实施方案中，通过防水材料的外衣调节蒸发冷却。

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