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1. 发明授权

US07662802B2 Halide-free glucosamine-acidic drug complexes 失效
标题翻译：不含卤化物的氨基葡萄糖酸性药物复合物
公开(公告)号：US07662802B2
公开(公告)日：2010-02-16
申请号：US11731294
申请日：2007-03-31
申请人： Vilas M. Chopdekar , Michael J. Torntore
发明人： Vilas M. Chopdekar , Michael J. Torntore
IPC分类号： A01N43/04 , A01N43/08 , C07H5/04 , C07H5/06 , C07H17/04
CPC分类号： A61K31/7008 , A61K9/50
摘要： A complex of glucosamine having a purity of at least about 99 wt. % and a maximum halide content of about 0.01 wt. %, and a therapeutic drug having a pKa of less than 7. Preferably, the complex is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers, povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated complex will be stable upon exposure to ambient temperature and/or the atmosphere. Suitable therapeutic drugs fall into the following classes: α- and β-Adrenergic Agonists; Narcotic and Non-Narcotic Analgesics; Anorexics; Antiallergics; Antianginals; Antiarrhythmics; Antiasthmatics; Antibiotics; Anticoagulants; Anticonvulsants; Antidepressants; Antidiabetics; Antihistaminics; Antihypertensives; Nonsteroidal Anti-Inflammatories; Antimigraines; Antineoplastics; Antiparkinsonians; Antipsychotics; Antipyretics; Antispasmodics; Antithrombotics; Antiulceratives; Anxiolytics; Decongestants; Diuretics; Hepatoprotectants; Sedatives; and Vasodilators.
摘要翻译：具有至少约99重量％的纯度的葡糖胺的复合物％和最大卤化物含量为约0.01wt。％，以及pKa小于7的治疗药物。优选地，通过用包含水溶性，水不混溶和/或水可溶胀的均聚物和/或共聚物的至少一种药学上可接受的聚合物包衣来稳定复合物。合适的聚合物包括羧基聚亚甲基均聚物和共聚物; 聚乙二醇均聚物和共聚物，聚维酮均聚物和共聚物; 聚丙烯酸均聚物和共聚物; 聚丙烯酰胺均聚物和共聚物; 多糖; 以及两种或更多种上述聚合物的混合物。所得涂覆的复合物在暴露于环境温度和/或气氛下将是稳定的。合适的治疗药物分为以下几类：α-和β-肾上腺素能激动剂; 麻醉和非麻醉止痛药; 厌食症抗过敏药; Antianginals; 抗心律失常药抗哮喘药抗生素; 抗凝剂抗惊厥药; 抗抑郁药抗糖尿病患者抗组胺药抗高血压药非甾体抗炎药; 反义词抗肿瘤药物抗帕金森病抗精神病药解热药解痉药抗血栓药抗溃疡药抗焦虑药减充血剂利尿剂肝保护剂; 镇静剂和血管扩张剂。

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