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1. 发明申请

US20210132023A1 METHODS OF IDENTIFYING POTENTIAL COMPONENTS FOR TARGETED DRUG DELIVERY COMPOSITIONS 有权
公开(公告)号：US20210132023A1
公开(公告)日：2021-05-06
申请号：US17140752
申请日：2021-01-04
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Victor Kelley , Roger E. Harrington
IPC分类号： G01N33/15 , A61K47/60 , A61K33/06
摘要： Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.

2. 发明授权

US10098970B2 Compostions and methods for diagnosis of axial pain with or without radiculopathy 有权
公开(公告)号：US10098970B2
公开(公告)日：2018-10-16
申请号：US15484877
申请日：2017-04-11
申请人： WARSAW ORTHOPEDIC, INC. , MEDTRONIC, INC.
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.

3. 发明申请

US20150150903A1 COMPOSITIONS COMPRISING BIOMEMBRANE SEALING AGENT FOR TREATMENT OF NEURONAL INJURY, AND METHODS OF USE 审中-公开
标题翻译：包含用于治疗神经损伤的生物膜密封剂的组合物及其使用方法
公开(公告)号：US20150150903A1
公开(公告)日：2015-06-04
申请号：US14610479
申请日：2015-01-30
申请人： WARSAW ORTHOPEDIC, INC.
发明人： Josee Roy , William F. McKay , Jeffrey C. Marx
IPC分类号： A61K33/06 , A61K31/765
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/56 , A61K31/65 , A61K31/765 , A61K47/10
摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何其组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

4. 发明申请

US20150140543A1 COMPOSITIONS AND METHODS FOR ENHANCING THE VIABILITY OF ANIMAL CELLS, TISSUES, AND ORGAN EXPLANTS 审中-公开
公开(公告)号：US20150140543A1
公开(公告)日：2015-05-21
申请号：US14582837
申请日：2014-12-24
申请人： Warsaw Orthopedic, Inc.
发明人： Daniel Andrew Shimko , Scott P. Noel , Susan J. Drapeau , Josee Roy
IPC分类号： A01N1/02 , C12N5/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/021 , C12N5/0018 , C12N2500/30 , C12N2500/46 , C12N2500/60
摘要： Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site of recipient implantation, all without significant loss of cell viability, biological activity, and/or tissue integrity.

5. 发明申请

US20150010650A1 COMPOSITIONS COMPRISING BIOMEMBRANE SEALING AGENT FOR TREATMENT OF PAIN OR INFLAMMATION, AND METHODS OF USE 审中-公开
标题翻译：包含用于治疗疼痛或炎症的生物膜密封剂的组合物及其使用方法
公开(公告)号：US20150010650A1
公开(公告)日：2015-01-08
申请号：US14493002
申请日：2014-09-22
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , William f. McKay , Jeffrey C. Marx
IPC分类号： A61K33/14 , A61K31/765 , A61K9/00 , A61K33/06
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0085 , A61K31/717 , A61K31/765 , A61K31/787 , A61K33/06 , A61K2300/00
摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供了治疗疼痛或炎症的方法和试剂盒。在一个实施方案中，试剂盒包括生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近病理状况及其任何组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

6. 发明申请

US20130345314A1 Compositions and methods for treating a damaged cardiovascular element 有权
公开(公告)号：US20130345314A1
公开(公告)日：2013-12-26
申请号：US13974903
申请日：2013-08-23
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Hezi-Yamit Ayala , Carol Sullivan , Mingfei Chen
IPC分类号： A61K31/765 , A61K45/06
CPC分类号： A61K31/765 , A61K9/0014 , A61K9/0019 , A61K31/00 , A61K45/06 , A61K47/10 , A61L31/06 , A61L31/16 , A61L2300/402 , A61L2400/06 , C08L71/02
摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.

7. 发明申请

US20170216459A1 COMPOSTIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
公开(公告)号：US20170216459A1
公开(公告)日：2017-08-03
申请号：US15484877
申请日：2017-04-11
申请人： WARSAW ORTHOPEDIC, INC. , MEDTRONIC, INC.
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.

8. 发明授权

US09717756B2 Method of treating traumatic brain or spinal cord injury with biomembrane sealing agent and magnesium compounds 有权
公开(公告)号：US09717756B2
公开(公告)日：2017-08-01
申请号：US14493002
申请日：2014-09-22
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , William F. McKay , Jeffrey C. Marx
IPC分类号： A61K9/08 , A61K33/06 , A61K33/14 , A61K31/765 , A61K9/00 , A61K31/717 , A61K31/787
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0085 , A61K31/717 , A61K31/765 , A61K31/787 , A61K33/06 , A61K2300/00
摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

9. 发明授权

US09023023B2 Nerve and soft tissue ablation device 有权
标题翻译：神经和软组织消融装置
公开(公告)号：US09023023B2
公开(公告)日：2015-05-05
申请号：US13835155
申请日：2013-03-15
申请人： Warsaw Orthopedic, Inc.
发明人： William F. McKay , Josee Roy
IPC分类号： A61B18/18 , A61B18/02 , A61B18/00
CPC分类号： A61B18/0218 , A61B18/02 , A61B2018/00434 , A61B2018/0044 , A61B2018/0262 , A61B2018/0293 , A61B2218/002
摘要： Ablation devices useful for removing nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a plurality of probes each comprising an interior surface defining an internal passage and an exterior surface comprising a tip. The internal passage has a filament comprising an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the probe to a selected temperature. A plurality of introducers are provided each comprising an interior surface configured for engagement with the probe where at least one air gap is produced by the introducer and probe engagement and an exterior surface comprising a heat conductive tip where the probe tip is snap fixed with the introducer tip in a configuration for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.
摘要翻译：提供了用于通过微创程序去除神经和软组织以减轻疼痛的消融装置。该装置包括多个探针，每个探针包括限定内部通道的内表面和包括尖端的外表面。内部通道具有灯丝，其包括构造成将加压材料释放到探针的内表面中的开口，以便将探针的外表面冷却到所选择的温度。提供了多个引导器，每个引导器包括构造成与探针接合的内表面，其中通过引导器和探针接合产生至少一个气隙，并且外表面包括导热末端，其中探针末端与导引器尖端处于消融神经和/或软组织的构型中。还提供了利用消融装置消融神经和/或软组织的方法。

10. 发明申请

US20150104439A1 PHARMACEUTICAL REMOVAL OF NEURONAL EXTENSIONS FROM A DEGENERATING DISC 审中-公开
标题翻译：从退化椎间盘中去除神经延伸的药物
公开(公告)号：US20150104439A1
公开(公告)日：2015-04-16
申请号：US14577307
申请日：2014-12-19
申请人： Warsaw Orthopedic, Inc.
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx
IPC分类号： A61K38/48 , A61K31/5415 , A61K31/496 , A61K31/65 , A61K36/31 , A61K33/02 , A61K31/55
CPC分类号： A61K38/4893 , A61K31/11 , A61K31/125 , A61K31/225 , A61K31/4709 , A61K31/485 , A61K31/496 , A61K31/5415 , A61K31/55 , A61K31/56 , A61K31/65 , A61K31/655 , A61K31/737 , A61K33/02 , A61K36/31 , A61K36/9066 , A61K38/168 , A61K38/4886 , C12Y304/24069
摘要： The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
摘要翻译：本发明提供了一种通过施用破坏椎间盘中的神经元和/或血管元件（通常是退化的椎间盘）的治疗剂来减轻椎间盘突出症的方法。磁盘中的神经元元件的破坏包括破坏神经末梢，而不会显着影响神经的中枢体，抑制神经末梢的激活，并抑制神经末梢进入椎间盘的生长。血管元件的破坏包括使血管延伸部从圆盘缩回，或抑制这种延伸部的形成。治疗剂可以通过体内泵，推注或贮库局部给药，或者可以全身给药。

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