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1. 发明申请

US20080207592A1 Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof 审中-公开
标题翻译：具有改进性能的新型1,4-苯并硫氮杂-1,1-二氧化物衍生物，其制备方法，含有该化合物的药物及其用途
公开(公告)号：US20080207592A1
公开(公告)日：2008-08-28
申请号：US11970293
申请日：2008-01-07
申请人： Wendelin FRICK , Heiner GLOMBIK , Hubert HEUER , Hans-Ludwig SCHAEFER , Stefan THEIS
发明人： Wendelin FRICK , Heiner GLOMBIK , Hubert HEUER , Hans-Ludwig SCHAEFER , Stefan THEIS
IPC分类号： A61K31/554 , C07D281/10 , A61P3/00
CPC分类号： C07D281/10
摘要： The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.
摘要翻译：本发明涉及式（A）的化合物以及其生理上可接受的盐。该化合物适合作为例如降血脂药。

2. 发明申请

US20080207534A1 1,4-BENZOTHIAZEPINE 1,1-DIOXIDE DERIVATIVE, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND USE THEREOF AS A HYPOLIPIDAEMIC 失效
标题翻译： 1,4-BENZOTHIAZEPINE 1,1-二氧化物衍生物，其制备方法，包含该化合物的药物及其作为高血压药物的用途
公开(公告)号：US20080207534A1
公开(公告)日：2008-08-28
申请号：US11970281
申请日：2008-01-07
申请人： Wendelin FRICK , Heiner GLOMBIK , Hubert HEUER , Hans-Ludwig SCHAEFER , Stefan THEIS
发明人： Wendelin FRICK , Heiner GLOMBIK , Hubert HEUER , Hans-Ludwig SCHAEFER , Stefan THEIS
IPC分类号： A61K31/7052 , C07H17/00 , A61P3/00
CPC分类号： C07H13/12
摘要： The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.
摘要翻译：本发明涉及式（A）的化合物以及其生理上可接受的盐。该化合物适合作为例如降血脂药。

3. 发明申请

US20100261664A1 Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof 审中-公开
标题翻译：新型杂环核苷酸衍生物，含有这些化合物的药物及其用途
公开(公告)号：US20100261664A1
公开(公告)日：2010-10-14
申请号：US12786943
申请日：2010-05-25
申请人： Wendelin FRICK , Heiner GLOMBIK , Werner KRAMER , Hubert HEUER , Harm BRUMMERHOP , Oliver PLETTENBURG
发明人： Wendelin FRICK , Heiner GLOMBIK , Werner KRAMER , Hubert HEUER , Harm BRUMMERHOP , Oliver PLETTENBURG
IPC分类号： A61K31/7042 , C07H15/18 , A61K31/7032 , C07H17/00 , C07H17/02 , A61P3/10
CPC分类号： C07H17/02 , C07H17/00
摘要： Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereofThe invention relates to substituted heterocyclic fluoroglycoside derivatives of the formula I in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译：新型杂环氟代果糖苷衍生物，含有这些化合物的药物及其用途本发明涉及式Ⅰ的取代杂环氟代果糖衍生物及其生理学上可耐受的盐及其制备方法。该化合物适合于例如抗糖尿病药。

4. 发明申请

US20080274947A1 Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia 审中-公开
标题翻译：羟基取代的二苯基氮杂环丁酮用于治疗高脂血症
公开(公告)号：US20080274947A1
公开(公告)日：2008-11-06
申请号：US12122991
申请日：2008-05-19
申请人： Gerhard JAEHNE , Wendelin FRICK , Andreas LINDENSCHMIDT , Hubert HEUER , Hans-Ludwig SCHAEFER , Werner KRAMER , Wolfgang SCHMIDER
发明人： Gerhard JAEHNE , Wendelin FRICK , Andreas LINDENSCHMIDT , Hubert HEUER , Hans-Ludwig SCHAEFER , Werner KRAMER , Wolfgang SCHMIDER
IPC分类号： A61K38/28 , C07D403/12 , A61P3/10 , A61P9/10 , A61K31/496
CPC分类号： C07D205/08 , C07D401/12 , C07D403/12 , C07D487/08
摘要： The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising diphenylazetidinones compounds which have an additional hydroxy function in the 2″ position and their salts. The invention therefore relates to compounds of formula I: in which the meanings R1, R2, R3, R4, R5, R6 are defined herein.
摘要翻译：本发明包括用于治疗代谢性疾病的化合物和组合物，更具体地，涉及血液中的这些胰岛素相关代谢紊乱，例如高脂血症，糖尿病，胰岛素抵抗等，其包含在2位中具有额外羟基功能的二苯基氮杂环丁酮化合物的位置和盐。因此，本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6的定义在本文中。

5. 发明申请

US20080167339A1 AZOLOPYRIDIN-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS 有权
标题翻译：作为脂质体和磷脂酰抑制剂的AZOLOPYRIDIN-2-ONE衍生物
公开(公告)号：US20080167339A1
公开(公告)日：2008-07-10
申请号：US11950932
申请日：2007-12-05
申请人： Gerhard ZOLLER , Stefan PETRY , Gunter MULLER , Hubert HEUER , Norbert TENNAGELS
发明人： Gerhard ZOLLER , Stefan PETRY , Gunter MULLER , Hubert HEUER , Norbert TENNAGELS
IPC分类号： A61K31/4355 , C07D498/04 , A61P3/00 , A61P9/00
CPC分类号： C07D498/04
摘要： The present invention provides compounds which have an inhibitory effect on hormone-sensitive lipase or endothelial lipase. The compounds of the invention are azolopyridin-2-one derivatives of the general formula I wherein the substituents are as defined herein. The compounds of formula I wherein R2 is hydrogen are distinguished by favorable effects on disorders of lipid metabolism. They beneficially influence the HDL to LDL ratio and increase in particular the HDL level and are suitable for the prevention and treatment of dyslipidemias and metabolic syndrome and their diverse sequelae such as atherosclerosis, coronary heart disease, heart failure, obesity and diabetes. The compounds of formula I wherein R1 and R2 together form a ring system are distinguished by favorable effects on metabolic disorders. They beneficially influence lipid and sugar metabolism; in particular they lower the triglyceride level and are suitable for the prevention and treatment of type II diabetes and arteriosclerosis and the diverse sequelae thereof.
摘要翻译：本发明提供对激素敏感性脂肪酶或内皮脂肪酶具有抑制作用的化合物。本发明的化合物是通式I的偶氮吡啶-2-酮衍生物，其中取代基如本文所定义。其中R2是氢的式I化合物的特征在于对脂质代谢紊乱的有利影响。它们有利地影响HDL与LDL的比例，特别是HDL水平的升高，适用于预防和治疗血脂异常和代谢综合征及其各种后遗症如动脉粥样硬化，冠心病，心力衰竭，肥胖和糖尿病。其中R1和R2一起形成环系的式I化合物的特征在于对代谢紊乱的有利影响。它们有利地影响脂质和糖代谢; 特别是它们降低甘油三酯水平，并且适合于预防和治疗II型糖尿病和动脉硬化及其各种后遗症。

6. 发明申请

US20100152246A1 5-Oxoisoxazoles as inhibitors of lipases and phospholipases 有权
标题翻译： 5-氧杂异恶唑作为脂肪酶和磷脂酶的抑制剂
公开(公告)号：US20100152246A1
公开(公告)日：2010-06-17
申请号：US12573335
申请日：2009-10-05
申请人： Stefan PETRY , Manfred SEIDEL , Gerhard ZOLLER , Gunter MÜLLER , Karl-Heinz BARINGHAUS , Hubert HEUER
发明人： Stefan PETRY , Manfred SEIDEL , Gerhard ZOLLER , Gunter MÜLLER , Karl-Heinz BARINGHAUS , Hubert HEUER
IPC分类号： A61K31/4439 , C07D261/04 , A61K31/42 , C07D413/12 , C07D261/20 , A61K31/423 , A61P3/10 , A61P3/00 , A61P9/10
CPC分类号： C07D261/12 , C07D261/20 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present invention relates to 5-oxoisoxazole derivatives of the formula I, the pharmaceutically usable salts thereof and the use thereof as medicinal substances.
摘要翻译：本发明涉及式I的5-氧代异恶唑衍生物，其可药用盐及其作为药用物质的用途。

7. 发明申请

US20100286133A1 Diacyl indazole derivatives as lipase and phospholipase inhibitors 有权
标题翻译：二酰基吲唑衍生物作为脂肪酶和磷脂酶抑制剂
公开(公告)号：US20100286133A1
公开(公告)日：2010-11-11
申请号：US12839863
申请日：2010-07-20
申请人： Gerhard ZOLLER , Stefan PETRY , Gunter MÜLLER , Hubert HEUER , Norbert TENNAGELS
发明人： Gerhard ZOLLER , Stefan PETRY , Gunter MÜLLER , Hubert HEUER , Norbert TENNAGELS
IPC分类号： A61K31/416 , C07D403/14 , C07D495/04 , C07D417/14 , C07D401/14 , C07D231/56 , A61K31/497 , A61K31/444 , A61K31/541 , A61K31/4545 , A61P3/00 , A61P3/10 , A61P3/06 , A61P9/10
CPC分类号： C07D231/56 , C07D401/14 , C07D471/04 , C07D495/04
摘要： The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of these compounds as pharmaceutical products.
摘要翻译：本发明涉及通式（I）或（II）的二酰基吲唑衍生物及其药学上可接受的盐：其中X，R 1和R 2如本文所定义。本发明还涉及这些化合物作为药物产品的用途。

8. 发明申请

US20100190801A1 TRIAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES 审中-公开
标题翻译：作为药物和磷脂的抑制剂的三唑吡啶衍生物
公开(公告)号：US20100190801A1
公开(公告)日：2010-07-29
申请号：US12731225
申请日：2010-03-25
申请人： Stefan PETRY , Gerhard ZOLLER , Günter MÜLLER , Karl-Heinz BARINGHAUS , Hubert HEUER
发明人： Stefan PETRY , Gerhard ZOLLER , Günter MÜLLER , Karl-Heinz BARINGHAUS , Hubert HEUER
IPC分类号： A61K31/4995 , A61K31/438 , A61K31/4545 , A61K31/4725 , C07D401/14 , C07D221/20 , C07D471/04 , C07D217/26 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to triazolopyridine derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.
摘要翻译：本发明涉及通式（I）的三唑并吡啶衍生物，其定义如本说明书中引用的其药学上可应用的盐及其作为药物的用途。

9. 发明申请

US20100173961A1 BENZOOXAZOL-2-ONE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS 审中-公开
标题翻译：苯扎昔单抗衍生物作为脂质体和磷脂酶抑制剂
公开(公告)号：US20100173961A1
公开(公告)日：2010-07-08
申请号：US12726633
申请日：2010-03-18
申请人： Gerhard ZOLLER , Stefan PETRY , Gunter MÜLLER , Hubert HEUER , Norbert TENNAGELS
发明人： Gerhard ZOLLER , Stefan PETRY , Gunter MÜLLER , Hubert HEUER , Norbert TENNAGELS
IPC分类号： A61K31/423 , C07D263/58 , A61P9/10 , A61P3/00 , A61P3/10 , A61P3/06
CPC分类号： C07D263/58
摘要： The invention relates to benzooxazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances.
摘要翻译：本发明涉及通式（I）的苯并恶唑-2-酮衍生物，其具有说明书中所述的含义，其药学上可用的盐及其作为药用物质的用途。

10. 发明申请

US20100144862A1 USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME 有权
标题翻译：使用替代吡咯烷酮衍生物治疗代谢综合征
公开(公告)号：US20100144862A1
公开(公告)日：2010-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
发明人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
IPC分类号： A61K31/351 , C07D309/40 , C07D309/38 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P3/06 , A61P1/18 , A61P35/00 , A61P25/28 , A61P25/16 , A61P17/10 , A61P17/00 , A61P11/06
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译：本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。

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