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1. 发明申请

US20080026485A1 Antibody profiling for determination of patient responsiveness 审中-公开
标题翻译：用于确定患者反应性的抗体谱
公开(公告)号：US20080026485A1
公开(公告)日：2008-01-31
申请号：US11788232
申请日：2007-04-18
申请人： Wolfgang Hueber , William Robinson , Lawrence Steinman , Paul Utz , Mark Genovese
发明人： Wolfgang Hueber , William Robinson , Lawrence Steinman , Paul Utz , Mark Genovese
IPC分类号： G01N33/564
CPC分类号： G01N33/6869 , G01N33/564 , G01N33/6854 , G01N33/6863 , G01N2333/522 , G01N2333/523 , G01N2333/525 , G01N2333/5412 , G01N2333/5421 , G01N2333/545 , G01N2800/102 , G01N2800/52
摘要： Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and/or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and/or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and/or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.
摘要翻译：提供组合物和方法用于将自身免疫性疾病患者预后分类为亚型，其中亚型对患者对治疗的需要和对感兴趣的治疗的反应性提供信息。血清自身抗体和/或细胞因子的循环血液水平的模式提供了可以识别可能受益于治疗性干预的患者的签名模式，以及将具有低概率的那些对治疗具有高反应性概率的患者区分开来的反应。另外，可以利用血清自身抗体和/或细胞因子特征图来监测对治疗的反应。因此，患者自身抗体和/或细胞因子的这种特征图案的评估因此允许改进的护理方法。在本发明的一个实施方案中，自身免疫性疾病是类风湿性关节炎。

2. 发明授权

US07592819B2 Microprocessor-based capacitance measurement 有权
标题翻译：基于微处理器的电容测量
公开(公告)号：US07592819B2
公开(公告)日：2009-09-22
申请号：US11678158
申请日：2007-02-23
申请人： Keith W. Kawate , John A. Powning , Mark Genovese , Eric M. Visser
发明人： Keith W. Kawate , John A. Powning , Mark Genovese , Eric M. Visser
IPC分类号： G01R27/26
CPC分类号： G01R27/2605 , G01D5/24
摘要： An improved system and method of performing capacitance measurements that provides a fast digital response and a reduced output error. The capacitance measurement system includes a circuit configuration that has a variable capacitor and at least one reference capacitor connected to one another at a common node, which in turn is connected to the input of an analog-to-digital converter. The circuit configuration further includes an array of switches coupled between the variable and reference capacitors and the supply voltage, a reference voltage, and ground, respectively. The switched variable and reference capacitors are employed in conjunction with the A-to-D converter to perform, at the common node, a plurality of direct voltage measurements for use in generating an expression defining the capacitance of the variable capacitor.
摘要翻译：改进的提供快速数字响应和减少的输出误差的电容测量的系统和方法。电容测量系统包括具有可变电容器和在公共节点处彼此连接的至少一个参考电容器的电路配置，该公共节点又连接到模数转换器的输入。电路配置还包括分别耦合在可变参考电容器和参考电容器之间的开关阵列和电源电压，参考电压和接地。开关可变和参考电容器与A-D转换器一起使用，以在公共节点处执行多个直接电压测量，以用于产生定义可变电容器的电容的表达式。

3. 发明申请

US20080204049A1 Microprocessor-Based Capacitance Measurement 有权
标题翻译：基于微处理器的电容测量
公开(公告)号：US20080204049A1
公开(公告)日：2008-08-28
申请号：US11678158
申请日：2007-02-23
申请人： Kawate W. Kawate , John A. Powning , Mark Genovese , Eric M. Visser
发明人： Kawate W. Kawate , John A. Powning , Mark Genovese , Eric M. Visser
IPC分类号： G01R27/26
CPC分类号： G01R27/2605 , G01D5/24
摘要： An improved system and method of performing capacitance measurements that provides a fast digital response and a reduced output error. The capacitance measurement system includes a circuit configuration that has a variable capacitor and at least one reference capacitor connected to one another at a common node, which in turn is connected to the input of an analog-to-digital converter. The circuit configuration further includes an array of switches coupled between the variable and reference capacitors and the supply voltage, a reference voltage, and ground, respectively, The switched variable and reference capacitors are employed in conjunction with the A-to-D converter to perform, at the common node, a plurality of voltage measurements for use in generating an expression defining the capacitance of the variable capacitor, The generated expression of variable capacitance is independent of a number of specified output error sources including but not limited to a sample-and-hold capacitance, the parasitic capacitance at the input of the A-to-D converter, a sample-and-hold offset voltage, and the leakage current at the input of the A-to-D converter.
摘要翻译：改进的提供快速数字响应和减少的输出误差的电容测量的系统和方法。电容测量系统包括具有可变电容器和在公共节点处彼此连接的至少一个参考电容器的电路配置，该公共节点又连接到模数转换器的输入。电路配置还包括耦合在可变参考电容器和电源电压，参考电压和接地之间的开关阵列。开关可变和参考电容器与A-D转换器结合使用以执行在公共节点处，用于产生限定可变电容器的电容的表达式的多个电压测量值。所产生的可变电容的表达式与指定的输出误差源的数量无关，包括但不限于样本和 A-D转换器输入端的寄生电容，采样保持偏移电压以及A-D转换器输入端的漏电流。

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