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1. 发明申请

US20080206791A1 METHOD FOR DETECTING AN UNKNOWN CONTAMINANT CONCENTRATION IN A SUBSTANCE 失效
标题翻译：检测物质中未知的污染物浓度的方法
公开(公告)号：US20080206791A1
公开(公告)日：2008-08-28
申请号：US11860180
申请日：2007-09-24
申请人： Yanbin Li , Xiao-Li Su
发明人： Yanbin Li , Xiao-Li Su
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/54373
摘要： A method for determining a concentration of a contaminant in a first sample, the method including producing the first sample, including adding a plurality of immuno-beads to a test substance; exposing a crystal microbalance immunosensor to the first sample; determining a change in a first motional resistance of the crystal microbalance immunosensor following exposure to the first sample (ΔR1); and determining the concentration of the contaminant in the first sample according to ΔR1.
摘要翻译：一种确定第一样品中污染物浓度的方法，所述方法包括生产第一样品，包括向测试物质中加入多个免疫珠粒; 将晶体微量天平免疫传感器暴露于第一个样品; 确定在暴露于第一样品之后晶体微量天平免疫传感器的第一运动电阻的变化（ΔR1> 1）; 以及根据ΔR1 1确定第一样品中污染物的浓度。

2. 发明授权

US07939343B2 Method for detecting an unknown contaminant concentration in a substance 失效
标题翻译：检测物质中未知污染物浓度的方法
公开(公告)号：US07939343B2
公开(公告)日：2011-05-10
申请号：US11860180
申请日：2007-09-24
申请人： Yanbin Li , Xiao-Li Su
发明人： Yanbin Li , Xiao-Li Su
IPC分类号： G01N33/543 , G01N13/00
CPC分类号： G01N33/56911 , G01N33/54373
摘要： A method for determining a concentration of a contaminant in a first sample, the method including producing the first sample, including adding a plurality of immuno-beads to a test substance; exposing a crystal microbalance immunosensor to the first sample; determining a change in a first motional resistance of the crystal microbalance immunosensor following exposure to the first sample (ΔR1); and determining the concentration of the contaminant in the first sample according to ΔR1.
摘要翻译：一种确定第一样品中污染物浓度的方法，所述方法包括生产第一样品，包括向测试物质中加入多个免疫珠粒; 将晶体微量天平免疫传感器暴露于第一个样品; 确定在暴露于第一样品（＆Dgr; R1）之后晶体微量天平免疫传感器的第一运动电阻的变化; 并根据＆Dgr; R1确定第一样品中污染物的浓度。

3. 发明授权

US08545773B2 Versatile multichannel capillary biosensor system 失效
标题翻译：多功能多通道毛细管生物传感器系统
公开(公告)号：US08545773B2
公开(公告)日：2013-10-01
申请号：US12670467
申请日：2008-07-24
申请人： Xiao-Li Su , Zungzhong Ye , Qian Sun , Yanbin Li
发明人： Xiao-Li Su , Zungzhong Ye , Qian Sun , Yanbin Li
IPC分类号： B01L99/00
CPC分类号： G01N35/1097 , B01L3/5027 , G01N33/04
摘要： The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules.
摘要翻译：多通道毛细管生物传感器系统包括用于选择样品或试剂的选择阀系统。选择阀系统连接到容纳感测通道和第一旁路通道的第二阀系统。第二阀系统连接到具有至少两个位置的定向阀系统，其中第一位置连接到第二旁路通道，第二位置连接到用于检测分析物的检测器。该装置具有在一端连接到第二旁路通道和检测器并且在第二端连接到废物容器的泵。该装置还具有用于控制装置的控制系统。分析物可以选自微生物，大分子和小分子。

4. 发明申请

US20080135490A1 Quantum dot biolabeling and immunomagnetic separation for detection of contaminants 审中-公开
标题翻译：用于检测污染物的量子点生物标记和免疫磁性分离
公开(公告)号：US20080135490A1
公开(公告)日：2008-06-12
申请号：US11328020
申请日：2006-01-09
申请人： Yanbin Li , Xiao-Li Su , Liju Yang
发明人： Yanbin Li , Xiao-Li Su , Liju Yang
IPC分类号： C02F1/48 , B03C1/30
CPC分类号： G01N33/54326 , B82Y15/00 , G01N33/588 , G01N35/0098
摘要： Methods are provided for detecting, separating, isolating and quantifying contaminants in starting materials by separating the contaminant from the starting material using a bead coupled to an affinity moiety and quantum dot-labeling the contaminant. The contaminant is detected by the characteristic emission spectrum of the quantum dot. Also, competitive binding methods are provided wherein the starting material and a control material are contacted with a quantum dot coupled to an affinity moiety capable of binding the contaminant and a competitor complex. A decrease in the intensity of the characteristic emission spectrum of the quantum dot associated with the competitor complex from the starting material as compared to that of the control material is indicative of the presence of the contaminant in the starting material.
摘要翻译：提供了用于通过使用耦合到亲和部分的珠粒和污染物的量子点标记来分离原料中的污染物以从起始物质中分离，分离和分配污染物的方法。污染物由量子点的特征发射光谱检测。此外，提供竞争性结合方法，其中起始材料和对照材料与偶联到能够结合污染物的亲和部分和竞争剂复合物的量子点接触。与起始材料相比，与对照材料相比较的与竞争剂复合物相关的量子点的特征发射光谱的强度的降低表明原料中存在污染物。

5. 发明申请

US20100285522A1 Versatile Multichannel Capillary Biosensor System 失效
标题翻译：多功能多通道毛细管生物传感器系统
公开(公告)号：US20100285522A1
公开(公告)日：2010-11-11
申请号：US12670467
申请日：2008-07-24
申请人： Xiao-Li Su , Zunzhong Ye , Qian Sun , Yanbin Li
发明人： Xiao-Li Su , Zunzhong Ye , Qian Sun , Yanbin Li
IPC分类号： C12Q1/04 , C12M1/36 , C12Q1/00 , G01N33/487
CPC分类号： G01N35/1097 , B01L3/5027 , G01N33/04
摘要： The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having at least two positions, with a first position being connected to a second bypass channel and a second position being connected to a detector for detecting the analyte. The device has a pump connected at one end to the second bypass channel and the detector and at a second end to a waste vessel. The device also has a control system for controlling the device. The analyte can be selected from the group of microorganisms, macromolecules, and small molecules.
摘要翻译：多通道毛细管生物传感器系统包括用于选择样品或试剂的选择阀系统。选择阀系统连接到容纳感测通道和第一旁路通道的第二阀系统。第二阀系统连接到具有至少两个位置的定向阀系统，其中第一位置连接到第二旁路通道，第二位置连接到用于检测分析物的检测器。该装置具有在一端连接到第二旁路通道和检测器并且在第二端连接到废物容器的泵。该装置还具有用于控制装置的控制系统。分析物可以选自微生物，大分子和小分子。

6. 发明申请

US20060217893A1 Method for detecting an unknown contaminant concentration in a substance 审中-公开
标题翻译：检测物质中未知污染物浓度的方法
公开(公告)号：US20060217893A1
公开(公告)日：2006-09-28
申请号：US11329009
申请日：2006-01-09
申请人： Yanbin Li , Xiao-Li Su
发明人： Yanbin Li , Xiao-Li Su
IPC分类号： G06F19/00
CPC分类号： G01N33/56911 , G01N33/54373
摘要： A method for detecting contaminants in a solution by determining a change in resonant frequency (ΔF) and motional resistance (ΔR) of a crystal microbalance (CM) immunosensor is presented. The method includes measuring ΔF and determining ΔR of a CM immunosenor exposed to various samples including known concentrations and a sample including an unknown concentration of the contaminant. The unknown contaminant concentration may be determined according to ΔR of the samples with the known and unknown contaminant concentrations, or ΔF of the same. If ΔR of the CM immunosensor exposed to the samples with the known contaminant concentrations more accurately reflects the known contaminant concentrations than ΔF does, the unknown contaminant concentration may be determined according to ΔR of the samples with the known contaminant concentrations and the unknown contaminant concentration. Otherwise, the unknown contaminant concentration may be determined according to ΔF of the same.
摘要翻译：提出了通过确定晶体微量天平（CM）免疫传感器的谐振频率（DeltaF）和运动电阻（DeltaR）的变化来检测溶液中的污染物的方法。该方法包括测量ΔF并确定暴露于包括已知浓度的各种样品的CM免疫荧光素的DeltaR和包含未知浓度的污染物的样品。未知的污染物浓度可以根据具有已知和未知污染物浓度的样品的DeltaR或其DeltaF值来确定。如果暴露于具有已知污染物浓度的样品的CM免疫传感器的DeltaR更准确地反映已知的污染物浓度，则ΔD可以根据具有已知污染物浓度和未知污染物浓度的样品的ΔR来确定未知污染物浓度。否则，未知的污染物浓度可以根据其的DeltaF来确定。

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