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1. 发明授权

US08871829B2 Radio-opaque marker for medical implants 有权
标题翻译：用于医疗植入物的无线电不透明标记
公开(公告)号：US08871829B2
公开(公告)日：2014-10-28
申请号：US10596797
申请日：2004-09-07
申请人： Bodo Gerold , Claus Harder , Heinz Müller , Eva Heublein , Nora Heublein , Christoph Heublein
发明人： Bodo Gerold , Claus Harder , Bernd Heublein , Heinz Müller
IPC分类号： A61F2/02 , A61F2/82 , A61L31/14 , A61L27/04 , A61L31/18 , A61L27/58
CPC分类号： A61L31/18 , A61F2/82 , A61F2250/0098 , A61L27/047 , A61L27/58 , A61L31/148
摘要： A radio-opaque marker for medical implants comprising between 10 and 90 weight percent of a biodegradable base component, between 10 and 90 weight percent of one or more radio-opaque elements selected from the consisting of I, Au, Ta, Y, Nb, Mo, Ru, Rh, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Re, Os, Ir and Bi as a marker component and 10 weight percent of residual components, the aforementioned components amounting to 100 weight percent.
摘要翻译：用于医用植入物的不透射线的标记物，其包含10-90重量％的可生物降解的基础成分，10-90重量％的一种或多种不透明元素，其选自I，Au，Ta，Y，Nb， Mo，Ru，Rh，Ba，La，Ce，Pr，Nd，Sm，Eu，Gd，Tb，Dy，Ho，Er，Tm，Yb，Lu，Hf，Ta，W，Re，Os，Ir和Bi 标记组分和10重量％的残余组分，前述组分总计为100重量％。

2. 发明授权

US08623097B2 Implant system having a functional implant composed of degradable metal material 有权
标题翻译：植入系统具有由可降解金属材料构成的功能植入物
公开(公告)号：US08623097B2
公开(公告)日：2014-01-07
申请号：US12499137
申请日：2009-07-08
申请人： Bodo Gerold , Bjoern Klocke , Matthias Fringes
发明人： Bodo Gerold , Bjoern Klocke , Matthias Fringes
IPC分类号： A61F2/48 , A61B17/68
CPC分类号： A61B17/72 , A61B5/0031 , A61B5/4839 , A61B5/6846 , A61B17/80 , A61B2017/00004 , A61B2017/00212 , A61B2017/00221 , A61B2017/00734 , A61F2/82 , A61F2002/30062 , A61F2002/30107 , A61F2002/30668 , A61F2210/0004 , A61F2210/0009 , A61F2250/0001 , A61F2250/0043 , A61F2250/0067 , A61F2250/0068
摘要： An implant system comprising a functional implant (5, 6) that fulfills a medical function, particularly a bone implant, which is formed at least in part of a metal material that can be degraded by the body (2) of the implant wearer, as well as a control device (7) for controlling the degradation behavior of the functional implant (5, 6). The control device (7) has a counter-electrode (10) to the functional implant (5, 6), and a voltage source (8) for making available a polarization voltage (ΔU) between functional implant (5, 6, 15) and counter-electrode (10), to control the degradation behavior of the functional implant (5, 6).
摘要翻译：一种植入物系统，其包括实现医疗功能的功能性植入物（5,6），特别是骨植入体，其至少部分地由能够被植入物穿戴者的身体（2）降解的金属材料形成，如以及用于控制功能性植入物（5,6）的降解行为的控制装置（7）。控制装置（7）具有到功能植入物（5,6）的对电极（10）和用于在功能植入物（5,6,13）之间提供极化电压（DeltaU）的电压源（8）和对电极（10），以控制功能性植入物（5,6）的降解行为。

3. 发明授权

US08603569B2 Implant and method for producing a degradation-inhibiting layer on the surface of an implant body 有权
标题翻译：用于在植入物本体的表面上产生降解抑制层的植入物和方法
公开(公告)号：US08603569B2
公开(公告)日：2013-12-10
申请号：US12566571
申请日：2009-09-24
申请人： Ullrich Bayer , Baerbel Becher , Bernd Block
发明人： Ullrich Bayer , Baerbel Becher , Bernd Block
IPC分类号： A61L33/00 , B05D3/00 , B05D1/18
CPC分类号： A61L31/148 , A61L31/022 , A61L31/08
摘要： A method for manufacturing a degradation-inhibiting first layer on the surface of an implant body, in particular an intraluminal endoprosthesis, whereby the body has at least one metallic material, which is at least largely biodegradable, comprising the following steps: preparing the body of the implant, and applying the first layer to at least a portion of the body surface, whereby the first layer contains magnesium stearate. An implant obtainable by such a method.
摘要翻译：一种用于在植入物主体的表面上制造降解抑制的第一层的方法，特别是管腔内假体，其中主体具有至少一种至少大部分可生物降解的金属材料，其包括以下步骤：所述植入物，以及将所述第一层施加到所述身体表面的至少一部分，由此所述第一层含有硬脂酸镁。可通过这种方法获得的植入物。

4. 发明授权

US08603155B2 Stent having improved stent design 有权
标题翻译：支架改良支架设计
公开(公告)号：US08603155B2
公开(公告)日：2013-12-10
申请号：US13344142
申请日：2012-01-05
申请人： Steffen Mews , Frank Bakczewitz
发明人： Steffen Mews , Frank Bakczewitz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583
摘要： A stent is provided having a base body circumscribing a cylindrical shape and radially expandable from a contracted starting position into a dilated support position, including a plurality of meander-shaped struts disposed in the circumferential direction and arrayed on one another in the axial direction, each strut being meander-shaped in its coarse structure and made of a flexible material, and at least one axial connector in the axial direction, connecting the meander-shaped struts of two axially adjacent meandering curves, wherein the at least one axial connector connects the inside radius of a zenith point of a first meandering curve with a second meandering curve, characterized in that the at least one axial connector at the inside radius of the zenith point of the first meandering curve has an at least double-arm structure.
摘要翻译：提供一种支架，其具有包围圆筒形状的基体，并且从收缩起始位置径向扩张到扩张支撑位置，包括沿圆周方向设置并沿轴向彼此排列的多个曲折形支柱，每个支撑位置支柱在其粗糙结构中形成为曲折形状并由柔性材料制成，并且在轴向方向上具有至少一个轴向连接器，连接两个轴向相邻曲折曲线的曲折形支柱，其中至少一个轴向连接器连接内部具有第二曲折曲线的第一曲折曲线的天顶点的半径，其特征在于，所述第一曲折曲线的天顶点的内半径处的所述至少一个轴向连接器具有至少双臂结构。

5. 发明授权

US08507101B2 Biocorrodible implant having a corrosion-inhibiting coating 有权
标题翻译：具有腐蚀抑制性涂层的生物腐蚀性植入物
公开(公告)号：US08507101B2
公开(公告)日：2013-08-13
申请号：US12915331
申请日：2010-10-29
申请人： Alexander Rzany , Heinz Mueller
发明人： Alexander Rzany , Heinz Mueller
IPC分类号： A61F2/28 , B05D3/02
CPC分类号： A61L27/047 , A61L27/306 , A61L27/50 , A61L27/58 , A61L31/022 , A61L31/088 , A61L31/14 , A61L31/148 , A61L2400/18
摘要： A biocorrodible implant includes a base formed from magnesium or a biocorrodible magnesium alloy, whose surface has a corrosion-inhibiting coating. A diffusion layer, which covers the base, differs in composition from the implant material. The diffusion layer contains at least one metallic element of the implant material and at least one corrosion-inhibiting element selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE, where RE stands for rare earth metals. The implant optionally includes a metal layer of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer, and a passivating layer of metal oxides, metal nitrides or metal fluorides of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer or the metal layer.
摘要翻译：生物腐蚀性植入物包括由镁或生物可腐蚀的镁合金形成的基底，其表面具有腐蚀抑制性涂层。覆盖基底的扩散层在组成上与植入材料不同。扩散层含有至少一种植入材料的金属元素和至少一种选自Al，Zn，Ca，Si，In，Mn，Sc和RE的腐蚀抑制元素，其中RE表示稀土金属。所述植入物任选地包括选自从覆盖扩散层的Al，Zn，Ca，Si，In，Mn，Sc和RE中的至少一种腐蚀抑制元素的金属层和金属氧化物的钝化层，选自由覆盖扩散层或金属层的Al，Zn，Ca，Si，In，Mn，Sc和RE中的至少一种腐蚀抑制元素的金属氮化物或金属氟化物。

6. 发明授权

US08257729B2 Implants with membrane diffusion-controlled release of active ingredient 有权
标题翻译：具有膜扩散控制释放活性成分的植入物
公开(公告)号：US08257729B2
公开(公告)日：2012-09-04
申请号：US12331567
申请日：2008-12-10
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , Claus Harder , Bjoern Klocke , Heyo K. Kroemer , Werner Weitschies
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , Claus Harder , Bjoern Klocke , Heyo K. Kroemer , Werner Weitschies
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/43
摘要： An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.
摘要翻译：一种用于植入人或动物体内的植入物，其具有如下结构：a）植入物基体; b）部分或完全施加到植入物表面的底漆层; c）由完全或部分施加到底漆层的表面上的一种，两种，三种或更多种活性成分组成的活性成分层; 和d）扩散控制层，其部分或全部施用于活性成分层，并且任选地施加到底漆层，其中控制活性成分层的活性成分的扩散。还公开了一种植入物的制造方法。

7. 发明申请

US20110311456A1 MARKER ALLOY 有权
标题翻译：标记合金
公开(公告)号：US20110311456A1
公开(公告)日：2011-12-22
申请号：US13164666
申请日：2011-06-20
申请人： Bruno Zberg , Bodo Gerold , Joerg Loeffler
发明人： Bruno Zberg , Bodo Gerold , Joerg Loeffler
IPC分类号： A61K49/04 , C22C23/06 , C22C28/00
CPC分类号： A61L31/18 , A61L31/022 , A61L31/088 , A61L31/148
摘要： A marker alloy foreign implant made of a biodegradable metallic material and having the composition MgxYbyMz wherein x is equal to 10-60 atomic percent; y is equal to 40-90 atomic percent; z is equal to 0-10 atomic percent; M is one or more element selected from the group consisting of Ag, Zn, Au, Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, and Ge; and wherein x, y, and z, together, and including contaminants caused by production, result in 100 atomic percent.
摘要翻译：由可生物降解的金属材料制成并具有Mg x Y y M zz的组成的标记合金外来植入物，其中x等于10-60原子％; y等于40-90原子％; z等于0-10原子％; M是选自Ag，Zn，Au，Ga，Pd，Pt，Al，Sn，Ca，Nd，Ba，Si和Ge中的一种或多种元素; 并且其中x，y和z一起并包括由生产引起的污染物，导致100原子百分比。

8. 发明申请

US20110190869A1 ENDOPROSTHESIS 有权
公开(公告)号：US20110190869A1
公开(公告)日：2011-08-04
申请号：US12955829
申请日：2010-11-29
申请人： Robert Schmiedl
发明人： Robert Schmiedl
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/90 , A61F2/91 , A61F2220/0016 , A61F2220/0075 , A61F2250/0012 , A61F2250/0018
摘要： An endoprosthesis, particularly an intraluminal endoprosthesis, having a basic structure that is preferably configured in the shape of a hollow cylinder, preferably configured as a basic lattice. In the expanded state, an inner volume enclosed by the basic structure can be changed by means of the elasticity of the basic structure, where the basic structure can assume a normal state and a state of significant compression, with regard to its compression behavior, for further improvement of the healing progression when using an endoprosthesis according to the invention, where in the state of significant compression, the elasticity of the basic structure is significantly reduced as compared with the elasticity in the normal state. The state of significant compression is characterized by the fact that an inside diameter threshold value of the basic structure is not reached, or that a compression pressure threshold value is exceeded. In this connection, the inside diameter threshold value preferably amounts to about 75% of a nominal inside diameter, or the compression pressure threshold value preferably amounts to about 0.2 bar.
摘要翻译：具有基本结构的内置假体，特别是管腔内假体，其优选地构造为中空圆柱体的形状，优选地构造为基本格子。在膨胀状态下，可以通过基本结构的弹性来改变由基本结构包围的内部容积，其中基本结构可以承受正常状态和显着压缩的状态，关于其压缩行为，用于当使用根据本发明的内置假体时，进一步改善愈合进展，其中在显着压缩的状态下，与正常状态的弹性相比，基本结构的弹性显着降低。显着压缩的状态的特征在于，没有达到基本结构的内径阈值或超过压缩压力阈值的事实。在这方面，内径阈值优选地约为标称内径的约75％，或者压缩压力阈值优选地为约0.2巴。

9. 发明申请

US20110137395A1 CATHETER SYSTEM 审中-公开
标题翻译：导管系统
公开(公告)号：US20110137395A1
公开(公告)日：2011-06-09
申请号：US12952054
申请日：2010-11-22
申请人： Amir Fargahi
发明人： Amir Fargahi
IPC分类号： A61F2/84 , A61M25/10
CPC分类号： A61F2/95 , A61F2/97 , A61M25/09 , A61M2025/0183 , A61M2025/0675
摘要： A catheter system, comprising a catheter having a distal end and a proximal end; a functional section situated close to the distal end of the catheter; an inner shaft having a guidewire lumen; an outer tubing, such that the outer tubing completely or partially surrounds the functional section; a guidewire outlet having a distal portion and a proximal portion, such that the guidewire outlet passes through the inner shaft and the outer tubing; a guidewire, such that the guidewire is situated on the distal end of the catheter inside the guidewire lumen and is guided out of the catheter through the guidewire outlet, such that the guidewire outlet is attached close to the distal end of the catheter and proximally of the functional section; a cutting device for severing the outer tubing in retraction of same is attached to the distal portion of the guidewire outlet.
摘要翻译：一种导管系统，包括具有远端和近端的导管; 位于靠近导管远端的功能部分; 具有导丝管腔的内轴; 外管，使得外管完全或部分地围绕功能部分; 导丝出口，其具有远侧部分和近端部分，使得导丝出口穿过内轴和外管; 导丝，使得导丝位于导丝管内部的导管的远端上，并且通过导丝出口被引导出导管，使得导丝出口附接到导管远端附近功能部分; 用于在其缩回时切断外管的切割装置附接到导丝出口的远端部分。

10. 发明申请

US20110130823A1 STENT HAVING FUNCTION ELEMENTS 审中-公开
标题翻译：具有功能元素
公开(公告)号：US20110130823A1
公开(公告)日：2011-06-02
申请号：US12945049
申请日：2010-11-12
申请人： Bodo Gerold , Dietmar Esperschidt
发明人： Bodo Gerold , Dietmar Esperschidt
IPC分类号： A61F2/82
CPC分类号： A61F2/95 , A61F2/91 , A61F2/915 , A61F2230/0013 , A61F2250/003 , A61F2250/006 , A61F2250/0068 , Y10T29/49927
摘要： An endoprosthesis, in particular an intraluminal endoprosthesis, including a tubular base body and at least one function element, the at least one function element also being tubular and being arranged on the base body in such a way that the at least one function element surrounds the base body at least partially and in at least partial areas, so that it is aligned concentrically with the base body.
摘要翻译：内假体，特别是管腔内假体，包括管状基体和至少一个功能元件，所述至少一个功能元件也是管状的，并且被布置在基体上，使得至少一个功能元件围绕基体至少部分地并且在至少部分区域中，使得其与基体同心对准。

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