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1. 发明授权

US10098765B2 Implant and method for producing the same 有权
公开(公告)号：US10098765B2
公开(公告)日：2018-10-16
申请号：US13306412
申请日：2011-11-29
申请人： Bjoern Klocke , Alexander Borck
发明人： Bjoern Klocke , Alexander Borck
IPC分类号： A61F2/82 , A61F2/91
摘要： The present invention relates to an implant (10), and particularly to an intraluminal endoprosthesis, comprising a body and at least one abluminal layer (3) disposed on the body, the abluminal layer preferably containing at least one pharmaceutically active substance. In order to protect the abluminal layer (3) from delamination or shearing, the abluminal layer (3) is additionally fastened to the implant body at least in a transition region (7) by way of at least one anchoring layer (5) disposed on the abluminal layer (3). In addition, methods for producing such an implant are described.

2. 发明授权

US08337548B2 Implant and system of an implant and an excitation device 有权
标题翻译：植入物和植入物和激发装置的系统
公开(公告)号：US08337548B2
公开(公告)日：2012-12-25
申请号：US12171566
申请日：2008-07-11
申请人： Bjoern Klocke , Matthias Fringes , Eugen Hofmann
发明人： Bjoern Klocke , Matthias Fringes , Eugen Hofmann
IPC分类号： A61F2/06 , A61F2/48 , A61K9/22
CPC分类号： A61M31/002 , A61F2/82 , A61F2/91 , A61F2210/0071 , A61F2250/0001 , A61F2250/0068
摘要： An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).
摘要翻译：包括主体（1），至少一种活性药物物质（4）和相对于身体可偏转的元件（5,15,35,45,55）的植入体，其用于释放所述至少一种活性药物物质（ 4）在外部激发偏转期间或之后。还公开了这种植入物和激励装置（30,70）的系统。

3. 发明授权

US08262722B2 Endoprosthesis 有权
标题翻译：内假体
公开(公告)号：US08262722B2
公开(公告)日：2012-09-11
申请号：US12613480
申请日：2009-11-05
申请人： Bjoern Klocke , Johannes Riedmueller
发明人： Bjoern Klocke , Johannes Riedmueller
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2220/005 , A61F2250/0098 , A61L31/10 , A61L31/18
摘要： An endoprosthesis, in particular an intraluminal endoprosthesis, for example a stent, having a base body composed at least partially of a metallic material, and having a functional element which is attached to the base body or imbedded therein and which contains material that is radiopaque and/or X-ray opaque and has a different material composition, at least in a portion of its volume, compared to the material of the base body. To avoid contact corrosion and undesired corrosion, the functional element is provided with a barrier layer which electrically insulates the radiopaque and/or X-ray opaque material from the base body.
摘要翻译：内置假体，特别是管腔内假体，例如支架，其具有至少部分由金属材料构成的基体，并且具有连接到基体或嵌入其中并且包含不透射线的材料的功能元件， /或X射线不透明，并且与基体的材料相比，至少在其体积的一部分中具有不同的材料组成。为了避免接触腐蚀和不期望的腐蚀，功能元件设置有将不透射线和/或X射线不透明材料与基体电绝缘的阻挡层。

4. 发明申请

US20120150281A1 IMPLANT MADE OF BIOCORRODIBLE MATERIAL AND WITH A COATING CONTAINING A TISSUE ADHESIVE 审中-公开
标题翻译：生物可降解材料的植入物和包含组织粘合剂的涂层
公开(公告)号：US20120150281A1
公开(公告)日：2012-06-14
申请号：US13312017
申请日：2011-12-06
申请人： Bjoern Klocke , Matthias Gratz
发明人： Bjoern Klocke , Matthias Gratz
IPC分类号： A61F2/82
CPC分类号： A61L31/148 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： The invention relates to an implant having a base body made of a biocorrodible material. A surface of the implant has a coating at least in some regions, wherein the coating comprises a tissue adhesive.
摘要翻译：本发明涉及具有由生物可腐蚀材料制成的基体的植入物。植入物的表面至少在一些区域具有涂层，其中涂层包括组织粘合剂。

5. 发明申请

US20120016466A1 ABLUMINALLY COATED DRUG-ELUTING STENTS HAVING A FORM-FITTING PROTECTIVE LAYER 有权
标题翻译：带有形成保护层的ABLUMINALLY涂层药水枪
公开(公告)号：US20120016466A1
公开(公告)日：2012-01-19
申请号：US13177865
申请日：2011-07-07
申请人： Bjoern Klocke , Claus Harder , Alexander Borck
发明人： Bjoern Klocke , Claus Harder , Alexander Borck
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L31/022 , A61L31/045 , A61L31/10 , A61L31/148 , A61L2420/08
摘要： A drug-eluting stent, comprising a base body that is made of an implant material, the base body being partially or entirely covered on the abluminal side with an active ingredient-releasing coating that comprises or is made of a polymer and an active ingredient having an antiproliferative effect, characterized in that the stent's luminal surface and the abluminal surface carrying the active ingredient-releasing coating are covered by a biocorrodible protective layer in a form-fitting manner.
摘要翻译：一种药物洗脱支架，其包括由植入物材料制成的基体，所述基体部分地或完全地覆盖在所述外侧面上，所述活性成分释放涂层包含聚合物或由聚合物制成的活性成分和活性成分，所述活性成分具有抗增殖作用，其特征在于支架的腔表面和携带有效成分释放的涂层的囊膜表面以形状配合的方式被生物防腐保护层覆盖。

6. 发明申请

US20100324666A1 IMPLANT AND METHOD FOR PRODUCTION OF THE SAME 有权
标题翻译：植物及其生产方法
公开(公告)号：US20100324666A1
公开(公告)日：2010-12-23
申请号：US12820639
申请日：2010-06-22
申请人： Bjoern Klocke , Ullrich Bayer
发明人： Bjoern Klocke , Ullrich Bayer
IPC分类号： A61F2/82 , B05D7/00
CPC分类号： A61L31/022 , A61L31/082 , A61L31/148
摘要： One example embodiment of the present invention relates to an implant, particularly an intraluminal endoprosthesis, having a body that contains metallic material, preferably iron. The implant body has a first layer with at least one ionic compound that contains ions of at least one halogen, particularly chloride ions and/or bromide ions, on at least part of its surface. Furthermore, a method for the production of such an implant is described.
摘要翻译：本发明的一个示例性实施例涉及具有包含金属材料，优选铁的主体的植入物，特别是管腔内假体。植入体具有至少一种离子化合物的第一层，该离子化合物在其表面的至少一部分上含有至少一种卤素，特别是氯离子和/或溴离子的离子。此外，描述了用于生产这种植入物的方法。

7. 发明申请

US20100191324A1 ENDOPROSTHESIS AND METHOD FOR MANUFACTURING SAME 有权
标题翻译：内部生物学及其制造方法
公开(公告)号：US20100191324A1
公开(公告)日：2010-07-29
申请号：US12507367
申请日：2009-07-22
申请人： Bjoern Klocke
发明人： Bjoern Klocke
IPC分类号： A61B17/82 , B05D3/10
CPC分类号： A61L31/022 , A61F2250/0036 , A61L31/10 , A61L31/148 , A61L31/16 , C08L65/04
摘要： An endoprosthesis, in particular an intraluminal endoprosthesis, for example a stent, having a basic mesh composed of an at least predominantly biodegradable material, and a coating provided on the biodegradable material is proposed. For better control of the degradation the basic mesh is essentially completely covered by a coating which contains parylene, preferably at least predominantly parylene, particularly preferably parylene C or parylene N, and the basic mesh is essentially completely covered by the coating, whereby the thickness of the coating is between approximately 0.1 μm and approximately 10 μm, preferably between approximately 0.4 μm and approximately 7 μm, particularly preferably between approximately 1 μm and approximately 5 μm. Also proposed is a method for manufacturing such an endoprosthesis.
摘要翻译：提出内置假体，特别是管腔内假体，例如支架，具有由至少主要是可生物降解的材料构成的基本网眼，以及在可生物降解的材料上提供的涂层。为了更好地控制降解，碱性网基本上完全被包含聚对二甲苯（优选至少主要是聚对二甲苯），特别优选对二甲苯C或聚对二甲苯N的涂层所覆盖，碱性网基本上被涂层完全覆盖，涂层在约0.1μm至约10μm之间，优选在约0.4μm至约7μm之间，特别优选在约1μm至约5μm之间。还提出了一种用于制造这种假体的方法。

8. 发明申请

US20100171492A1 DEGRADATION AND INTEGRITY MEASURING DEVICE FOR ABSORBABLE METAL IMPLANTS 有权
标题翻译：用于可吸收金属植入物的降解和完整性测量装置
公开(公告)号：US20100171492A1
公开(公告)日：2010-07-08
申请号：US12691329
申请日：2010-01-21
申请人： Bjoern Klocke , Olaf Skerl
发明人： Bjoern Klocke , Olaf Skerl
IPC分类号： G01R33/12
CPC分类号： A61B5/062 , A61B5/6852 , A61B34/20 , A61B2034/2051
摘要： The present invention relates to a measuring device including a sensor catheter, an evaluation unit, and means for receiving a magnetic field and converting the magnetic field to an electrical measurement signal which are situated in the sensor catheter and connected to the evaluation unit. The evaluation unit is designed to evaluate the electrical measurement signal.
摘要翻译：本发明涉及包括传感器导管，评估单元和用于接收磁场并将磁场转换成位于传感器导管中并连接到评估单元的电测量信号的装置的测量装置。评估单元用于评估电气测量信号。

9. 发明授权

US08623097B2 Implant system having a functional implant composed of degradable metal material 有权
标题翻译：植入系统具有由可降解金属材料构成的功能植入物
公开(公告)号：US08623097B2
公开(公告)日：2014-01-07
申请号：US12499137
申请日：2009-07-08
申请人： Bodo Gerold , Bjoern Klocke , Matthias Fringes
发明人： Bodo Gerold , Bjoern Klocke , Matthias Fringes
IPC分类号： A61F2/48 , A61B17/68
CPC分类号： A61B17/72 , A61B5/0031 , A61B5/4839 , A61B5/6846 , A61B17/80 , A61B2017/00004 , A61B2017/00212 , A61B2017/00221 , A61B2017/00734 , A61F2/82 , A61F2002/30062 , A61F2002/30107 , A61F2002/30668 , A61F2210/0004 , A61F2210/0009 , A61F2250/0001 , A61F2250/0043 , A61F2250/0067 , A61F2250/0068
摘要： An implant system comprising a functional implant (5, 6) that fulfills a medical function, particularly a bone implant, which is formed at least in part of a metal material that can be degraded by the body (2) of the implant wearer, as well as a control device (7) for controlling the degradation behavior of the functional implant (5, 6). The control device (7) has a counter-electrode (10) to the functional implant (5, 6), and a voltage source (8) for making available a polarization voltage (ΔU) between functional implant (5, 6, 15) and counter-electrode (10), to control the degradation behavior of the functional implant (5, 6).
摘要翻译：一种植入物系统，其包括实现医疗功能的功能性植入物（5,6），特别是骨植入体，其至少部分地由能够被植入物穿戴者的身体（2）降解的金属材料形成，如以及用于控制功能性植入物（5,6）的降解行为的控制装置（7）。控制装置（7）具有到功能植入物（5,6）的对电极（10）和用于在功能植入物（5,6,13）之间提供极化电压（DeltaU）的电压源（8）和对电极（10），以控制功能性植入物（5,6）的降解行为。

10. 发明授权

US08257729B2 Implants with membrane diffusion-controlled release of active ingredient 有权
标题翻译：具有膜扩散控制释放活性成分的植入物
公开(公告)号：US08257729B2
公开(公告)日：2012-09-04
申请号：US12331567
申请日：2008-12-10
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , Claus Harder , Bjoern Klocke , Heyo K. Kroemer , Werner Weitschies
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , Claus Harder , Bjoern Klocke , Heyo K. Kroemer , Werner Weitschies
IPC分类号： A61F13/00 , A61F2/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/43
摘要： An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.
摘要翻译：一种用于植入人或动物体内的植入物，其具有如下结构：a）植入物基体; b）部分或完全施加到植入物表面的底漆层; c）由完全或部分施加到底漆层的表面上的一种，两种，三种或更多种活性成分组成的活性成分层; 和d）扩散控制层，其部分或全部施用于活性成分层，并且任选地施加到底漆层，其中控制活性成分层的活性成分的扩散。还公开了一种植入物的制造方法。

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