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1. 发明授权

US11278734B2 Systems and methods for nail treatment 有权
公开(公告)号：US11278734B2
公开(公告)日：2022-03-22
申请号：US16838172
申请日：2020-04-02
申请人： BLOSSOM INNOVATIONS, LLC
发明人： Vincent Zuo
IPC分类号： A61N5/06 , A61N5/067
摘要： Exemplary system and method are provided for affecting nail growth rate, which can use a light dosage and a wavelength of light to affect a growth rate of a nail of a subject. For example, it is possible to detect a presence of a nail using, e.g., a presence detector. The nail can be irradiated over a treatment time with a light having a wavelength and a power, e.g., using a narrowband light source. Further, using a controller, it is possible to control one or more of the power and the treatment time to irradiate the nail with a light dosage that is within a biphasic light dosage range bounded by a lesser light dosage and a greater light dosage. The wavelength of the light and the light dosage can be configured to affect a growth rate of the nail.

2. 发明授权

US11191446B2 Devices, systems and methods for tissue analysis, locaton determination and tissue ablation 有权
公开(公告)号：US11191446B2
公开(公告)日：2021-12-07
申请号：US17105420
申请日：2020-11-25
申请人： BLOSSOM INNOVATIONS, LLC
发明人： Joe Ting , Tania To , Vincent Zuo , James Wright , Ben Apollonio , Charles Holland Dresser
IPC分类号： A61B5/06 , A61B5/00 , A61B5/0538 , A61B5/05 , A61B18/08 , A61B18/14 , A61B10/02 , A61B18/00
摘要： An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Based on such determination, it is possible to effectuate ablation or heating of tissue by applying RF energy across the electrically conductive layers.

3. 发明授权

US10973578B2 Method and apparatus for selective treatment of biological tissue 有权
公开(公告)号：US10973578B2
公开(公告)日：2021-04-13
申请号：US15853318
申请日：2017-12-22
申请人： The General Hospital Corporation , Blossom Innovations, LLC
发明人： Richard Rox Anderson , Dieter Manstein , Henry Hin Lee Chan , Vincent Zuo
IPC分类号： A61B18/20 , A61B18/00
摘要： An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

4. 发明申请

US20220395189A1 DEVICES, SYSTEMS AND METHODS FOR TISSUE DETECTION, POSITION DETERMINATION AND TISSUE ABLATION 有权
公开(公告)号：US20220395189A1
公开(公告)日：2022-12-15
申请号：US17283406
申请日：2020-11-25
申请人： BLOSSOM INNOVATIONS, LLC
发明人： TANIA TO , JOE TING , VINCENT ZUO , BEN APOLLONIO , CHARLES HOLLAND DRESSER , JAMES WRIGHT
IPC分类号： A61B5/0538 , A61B10/02 , A61B18/08 , A61B5/00 , A61B18/14 , A61B5/06
摘要： An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Based on such determination, it is possible to effectuate ablation or heating of tissue by applying RF energy across the electrically conductive layers.

5. 发明授权

US11172987B2 Method and apparatus for selective treatment of biological tissue 有权
公开(公告)号：US11172987B2
公开(公告)日：2021-11-16
申请号：US17227918
申请日：2021-04-12
申请人： The General Hospital Corporation , Blossom Innovations, LLC
发明人： Richard Rox Anderson , Dieter Manstein , Henry Hin Lee Chan , Vincent Zuo
IPC分类号： A61B18/20 , A61B18/00
摘要： An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

6. 发明申请

US20210298828A1 METHOD AND APPARATUS FOR SELECTIVE TREATMENT OF BIOLOGICAL TISSUE 有权
公开(公告)号：US20210298828A1
公开(公告)日：2021-09-30
申请号：US17227918
申请日：2021-04-12
申请人： The General Hospital Corporation , Blossom Innovations, LLC
发明人： RICHARD ROX ANDERSON , DIETER MANSTEIN , HENRY HIN LEE CHAN , VINCENT ZUO
IPC分类号： A61B18/20
摘要： An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

7. 发明申请

US20220133152A1 METHOD FOR RELEASING A SUBSTANCE INTO A SUBJECT USING AN INSERTION ARRANGEMENT (as amended) 有权
公开(公告)号：US20220133152A1
公开(公告)日：2022-05-05
申请号：US17577929
申请日：2022-01-18
申请人： BLOSSOM INNOVATIONS, LLC
发明人： JOE TING , TANIA TO , VINCENT ZUO , Ben APOLLONIO , Charles Holland DRESSER , James WRIGHT
IPC分类号： A61B5/00 , A61B10/04
摘要： An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the First electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion or the insertion device/apparatus. Another exemplary apparatus can include, for example, a base structure comprising a lumen extending along a length thereof, and at least one optically-transmissive layer circumferentially surrounding the base structure and provided at least at a distal end of the base structure. For example, in operation, the optically-transmissive layer can be configured to transmit a particular optical radiation at the distal end thereof toward a target tissue.

8. 发明申请

US20220095925A1 DEVICES, SYSTEMS AND METHODS FOR TISSUE ANALYSIS, LOCATION DETERMINATION AND THERAPY THEREOF USING OPTICAL RADIATION 有权
公开(公告)号：US20220095925A1
公开(公告)日：2022-03-31
申请号：US17438816
申请日：2020-03-13
申请人： BLOSSOM INNOVATIONS, LLC
发明人： JOE TING , TANIA TO , VINCENT ZUO , Ben APOLLONIO , Charles Holland DRESSER , James WRIGHT
IPC分类号： A61B5/00 , A61B10/04
摘要： An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type rising impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Another exemplary apparatus can include, for example, a base structure comprising a lumen extending along a length thereof, and at least one optically-transmissive layer circumferentially surrounding the base structure and provided at least at a distal end of the base structure. For example, in operation, the optically-transmissive layer can be configured to transmit a particular optical radiation at the distal end thereof toward a target tissue.

9. 发明申请

US20220160252A1 DEVICES, SYSTEMS AND METHODS FOR TISSUE ANALYSIS, LOCATON DETERMINATION AND TISSUE ABLATION 有权
公开(公告)号：US20220160252A1
公开(公告)日：2022-05-26
申请号：US17543196
申请日：2021-12-06
申请人： BLOSSOM INNOVATIONS, LLC
发明人： JOE TING , TANIA TO , VINCENT ZUO , JAMES WRIGHT , BEN APOLLONIO , CHARLES HOLLAND DRESSER
IPC分类号： A61B5/06 , A61B5/00 , A61B5/0538 , A61B5/05 , A61B18/08 , A61B18/14 , A61B10/02
摘要： An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Based on such determination, it is possible to effectuate ablation or heating of tissue by applying RF energy across the electrically conductive layers.

10. 发明申请

US20220133407A1 METHOD AND APPARATUS FOR SELECTIVE TREATMENT OF BIOLOGICAL TISSUE 有权
公开(公告)号：US20220133407A1
公开(公告)日：2022-05-05
申请号：US17499467
申请日：2021-10-12
申请人： The General Hospital Corporation , Blossom Innovations, LLC
发明人： RICHARD ROX ANDERSON , DIETER MANSTEIN , HENRY HIN LEE CHAN , VINCENT ZUO
IPC分类号： A61B18/20
摘要： An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

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