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1. 发明申请

US20220244251A1 Targets and Methods of Diagnosing and Monitoring Lyme Disease 有权
公开(公告)号：US20220244251A1
公开(公告)日：2022-08-04
申请号：US17614168
申请日：2020-05-27
申请人： Board of regents of the Nevada System of Higher Education on Behalf of the University of Nevada Reno
发明人： David AUCOIN , Kathryn J. PFLUGHOEFT
IPC分类号： G01N33/564
摘要： Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a veterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. burgdorferi-associated condition, such as Lyme disease. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. burgdorferi-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. burgdorferi, such as Lyme disease.

2. 发明授权

US10927604B2 Systems and methods for enhancing energy extraction from geothermal wells 有权
公开(公告)号：US10927604B2
公开(公告)日：2021-02-23
申请号：US16090097
申请日：2017-03-31
申请人： Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
发明人： George L. Danko
IPC分类号： E21B43/26 , E21B7/04 , F24T10/20 , E21B33/12 , E21B33/138 , E21B47/022 , E21B47/06 , E21B47/10 , E21B49/00
摘要： Disclosed herein are embodiments of engineered geothermal systems (EGS). Also disclosed are methods and devices for the construction and use of planar artificial fractures in EGS wells, including wells that contain both an injection and extraction points.

3. 发明授权

US10028992B2 Methods of treating muscular dystrophy 有权
公开(公告)号：US10028992B2
公开(公告)日：2018-07-24
申请号：US14426928
申请日：2013-09-10
申请人： Dean Burkin , Ryan Wuebbles
发明人： Dean Burkin , Ryan Wuebbles
IPC分类号： A61K31/415 , A61K31/405 , A61K38/05 , A61K31/16 , A61K31/343 , A61K31/4418 , A61K31/444 , A61K31/4709 , A61K31/53 , A61K31/5375 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K31/57 , A61K31/661 , A61K45/06 , A61K31/20 , A61K31/4178 , A61K31/5365 , A61K31/575 , A61K38/39 , A61K31/19 , A61K31/277 , A61K31/341 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/4035 , A61K31/41 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/4365 , A61K31/4402 , A61K31/47 , A61K31/473 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/541 , A61K31/4164 , A61K31/404
摘要： Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.

4. 发明授权

US09561493B2 Synthesis of pyrochlore nanostructures and uses thereof 有权
标题翻译：烧绿石纳米结构的合成及其用途
公开(公告)号：US09561493B2
公开(公告)日：2017-02-07
申请号：US14552230
申请日：2014-11-24
申请人： Vaidyanathan Subramanian , Sankaran Murugesan
发明人： Vaidyanathan Subramanian , Sankaran Murugesan
IPC分类号： B01J23/18 , B82Y30/00 , B82Y40/00 , C01G29/00
CPC分类号： B01J23/18 , B82Y30/00 , B82Y40/00 , C01G29/00 , C01P2002/36 , C01P2002/72 , C01P2002/84 , C01P2004/03 , C01P2004/04 , C01P2004/16 , Y10T428/2913 , Y10T428/298 , Y10T428/2982
摘要： A template-free reverse micelle (RM) based method is used to synthesize pyrochlore nanostructures having photocatalytic activity. In one embodiment, the method includes separately mixing together a first acid stabilized aqueous solution including pyrochlore precursor A and a second acid stabilized aqueous solution including pyrochlore precursor B with an organic solution including a surfactant to form an oil-in-water emulsion. Next, equimolar solutions of the first and second acid stabilized oil-in-water emulsions are mixed together. Then, the mixture of the first and second acid stabilized oil-in-water emulsion is treated with a base to produce a precipitate including pyrochlore precursors A and B. After which, the precipitate is dried to remove volatiles. The precipitate is then calcined in the presence of oxygen to form a pyrochlore nanostructure, such as a bismuth titanate (Bi2Ti2O7) pyrochlore nanorod. The method of synthesizing the pyrochlore nanorod is template-free.
摘要翻译：使用无模板的基于反胶束（RM）的方法合成具有光催化活性的烧绿石纳米结构。在一个实施方案中，该方法包括将包含烧绿石前体A的第一酸稳定水溶液和包含烧绿石前体B的第二酸稳定水溶液与包含表面活性剂的有机溶液分开混合在一起以形成水包油乳液。接下来，将第一和第二酸稳定的水包油乳液的等摩尔溶液混合在一起。然后，将第一和第二酸稳定的水包油乳液的混合物用碱处理以产生包含烧绿石前体A和B的沉淀物。之后，将沉淀物干燥以除去挥发物。然后将沉淀物在氧的存在下煅烧以形成烧绿石纳米结构，例如钛酸铋（Bi 2 Ti 2 O 7）烧绿石纳米棒。合成烧绿石纳米棒的方法是无模板的。

5. 发明授权

US09403935B2 Two dimensional polymers and methods of making same 有权
标题翻译：二维聚合物及其制备方法
公开(公告)号：US09403935B2
公开(公告)日：2016-08-02
申请号：US13950995
申请日：2013-07-25
申请人： Benjamin T. King
发明人： Benjamin T. King
IPC分类号： C08F32/00 , C08G61/02 , C08G61/10
CPC分类号： C08G61/02 , C08F32/00
摘要： The present invention relates to two dimensional polymers and methods of making the same. Irradiation of polycyclic, three bladed monomers, such as polyaromatic, three bladed monomers or an antrip monomer, derivatives or analogs thereof, with ultraviolet radiation provides the two dimensional polymers, which may be used in membrane applications.
摘要翻译：本发明涉及二维聚合物及其制备方法。用紫外线辐照的多环三叶片单体如多芳族，三叶片单体或其反射单体，其衍生物或类似物，可以提供可用于膜应用的二维聚合物。

6. 发明授权

US09310365B2 Method of diagnosing and treating melioidosis 有权
标题翻译：诊断和治疗恶病质的方法
公开(公告)号：US09310365B2
公开(公告)日：2016-04-12
申请号：US13639450
申请日：2011-04-12
申请人： Thomas Kozel , David Aucoin
发明人： Thomas Kozel , David Aucoin
IPC分类号： G01N33/569 , C07K16/12
CPC分类号： G01N33/56911 , C07K16/1214 , G01N2333/21 , G01N2800/52
摘要： Non-invasive methods are provided herein for the diagnosis of melioidosis with specific antibodies capable of detecting molecules associated with melioidosis in a biological fluid, such as urine or serum. These molecules can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay. Methods of inducing an immune response to melioidosis are also disclosed. The methods include the use of the immunogenic melioidosis polypeptides, nucleic acids encoding these polypeptides, and/or viral vectors encoding an immunogenic melioidosis polypeptide, alone or in conjunction with other agents, such as traditional melioidosis therapies. Also disclosed are methods for treating a subject having melioidosis. These methods include inducing an immune response to melioidosis and/or using an inhibitory nucleic acid, such as a siRNA or antisense molecule, to decrease a melioidosis associated molecule expression in order to treat melioidosis.
摘要翻译：本文提供了非侵入性方法，用于诊断具有能够检测与生物流体例如尿液或血清中的黑素综合征有关的分子的特异性抗体的嗜酸性粒细胞减少症。可以使用蛋白质组学方法鉴定这些分子，包括但不限于基于抗体的方法，例如酶联免疫吸附测定（ELISA），放射免疫测定（RIA）或侧流免疫测定。还公开了诱导对嗜酸性粒细胞减少症的免疫应答的方法。所述方法包括单独使用免疫原性黑麦病多糖，编码这些多肽的核酸和/或编码免疫原性黑麦病多肽的病毒载体，或与其它试剂例如传统的黑素综合征疗法联合使用。还公开了用于治疗患有黑痴病的受试者的方法。这些方法包括诱导针对嗜酸性粒细胞减少症的免疫应答和/或使用抑制性核酸如siRNA或反义分子来降低与相似的分子表达的melioidosis相关的分子表达以治疗黑麦病。

7. 发明授权

US09279808B2 Method of detecting and identifying circulating antigens in human biological samples 有权
标题翻译：检测和鉴定人类生物样品中循环抗原的方法
公开(公告)号：US09279808B2
公开(公告)日：2016-03-08
申请号：US14573933
申请日：2014-12-17
申请人： David P. AuCoin , Thomas R. Kozel , Claire Smalley
发明人： David P. AuCoin , Thomas R. Kozel , Claire Smalley
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/554 , G01N33/569 , C12Q1/04 , G01N33/536
CPC分类号： G01N33/56911 , C12Q1/04 , G01N33/536 , G01N33/569 , G01N2469/10 , G01N2570/00 , G01N2800/26 , G01N2800/52
摘要： Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of identifying diagnostic indicators/targets for a given condition or disease are disclosed which include immunizing a verterinary subject with biological fluids obtained from a human infected with particular antigens to identify diagnostic targets for immunoassay. Also disclosed are methods of diagnosing and monitoring a B. pseudomallei-associated condition, such as melioidosis. Point-of-care immunoassays are also provided that can be used to diagnose or monitor the efficacy of a B. pseudomallei-associated condition treatment. These immunoassays can also be used for rapid diagnosis of infection produced by B. pseudomallei, such as meliodosis.
摘要翻译：本文公开了一种检测和鉴定在感染期间流入人体液中的抗原的方法。所公开的方法允许与特定感染相关的循环抗原在与测试相关的几天或几个小时内进行检测，与当前方法所需的天数相比。公开了用于鉴定给定病症或疾病的诊断指标/靶标的方法，其包括用从特定抗原感染的人获得的生物液体免疫一个先验受试者以鉴定免疫测定的诊断靶标。还公开了诊断和监测假单胞菌相关病症如蜜id病的方法。还提供了可用于诊断或监测假单胞菌相关病症治疗的功效的点护理免疫测定。这些免疫测定也可用于快速诊断由假单胞菌产生的感染，如蜜iod病。

8. 发明授权

US09068397B2 Drilling apparatus and method 有权
标题翻译：钻孔设备及方法
公开(公告)号：US09068397B2
公开(公告)日：2015-06-30
申请号：US13553668
申请日：2012-07-19
申请人： George L. Danko
发明人： George L. Danko
IPC分类号： E21B10/36 , E21B4/06 , E21B10/62 , E21B7/06 , E21B21/08
CPC分类号： E21B4/06 , E21B1/00 , E21B7/06 , E21B10/36 , E21B10/62 , E21B21/08
摘要： The present disclosure provides a drilling method and drill. According to a disclosed method, multiple reciprocating rock-breaking elements, including a hammer drill bit, are used. The elements are moved in alternation to each other such that the net volume displacement by the moving parts is reduced for reducing compression work and thus for losing useful energy from the available amount from the drill bit engine for rock breaking. If desired, a small component of the net volume displacement is kept for enhancing PVW for enhancing rock chipping by tensile strength. The method also includes synchronizing the peak of the pressure depression wave with that of the impact moment of the drill bit's reciprocating motion to enhance, rather than hamper, rock breaking by the creation of PVW.
摘要翻译：本公开提供了一种钻孔方法和钻孔。根据所公开的方法，使用包括锤钻的多个往复式破碎元件。这些元件彼此交替移动，使得减少运动部件的净体积位移以减少压缩工作，从而从用于岩石破碎的钻头发动机的可用量中减少有用能量。如果需要，保持净体积位移的一小部分以增强PVW以通过拉伸强度增强岩石碎裂。该方法还包括使压力下降波峰与钻头的往复运动的冲击力的峰值同步，从而通过创建PVW来增强而不是阻碍岩石破碎。

9. 发明授权

US08999718B2 Vapochromic materials and methods of making and using same 有权
标题翻译：成色材料及其使用方法
公开(公告)号：US08999718B2
公开(公告)日：2015-04-07
申请号：US13537396
申请日：2012-06-29
申请人： Vincent J. Catalano , Christoph E. Strasser
发明人： Vincent J. Catalano , Christoph E. Strasser
IPC分类号： G01N33/00 , C07F1/08 , C07F1/12 , G01N21/77
CPC分类号： C07F1/08 , C07F1/12 , G01N2021/7786 , Y10T436/14 , Y10T436/16 , Y10T436/17 , Y10T436/173845 , Y10T436/182 , Y10T436/200833 , Y10T436/203332 , Y10T436/204165
摘要： A vapochromic gold-copper complex [AuL2(Cu(Y)n)2](X)3 exhibiting luminescence is provided, where L is an N-heterocyclic carbene; Y is a heteroatom-containing ligand; X is an anion, and n is an integer having a value of 1 or 2, and solvates thereof. A reaction of [AuL2(Cu(Y)n)2](X)3 with water vapor or an organic compound vapor, for example, affords a modified complex that yields a change in luminescence color under UV excitation. These tricationic vapochromic materials exhibit large changes in the emission through ligand substitution reactions between the solid complex and vapors, which permit use in luminescent vapochromic sensors.
摘要翻译：提供表现出发光性的荧光金 - 铜络合物[AuL2（Cu（Y）n）2]（X）3，其中L是N-杂环卡宾; Y是含杂原子的配体; X是阴离子，n是1或2的整数，并且其溶剂化。例如，[AuL 2（Cu（Y）n）2]（X）3与水蒸汽或有机化合物蒸气的反应提供了在UV激发下产生发光颜色变化的改性络合物。这些化学成分的色散材料通过固体复合物和蒸气之间的配体取代反应发射出很大的变化，这些反应允许在发光色差传感器中使用。

10. 发明授权

US08853450B2 Nitrile hydration catalyzed by recyclable ruthenium complexes 有权
标题翻译：由可回收钌络合物催化的腈水合
公开(公告)号：US08853450B2
公开(公告)日：2014-10-07
申请号：US13654895
申请日：2012-10-18
申请人： Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
发明人： Brian J. Frost , Wei-Chih Lee
IPC分类号： C07C231/06 , C07D213/81
CPC分类号： C07C231/065 , C07D213/81 , Y02P20/582 , C07C233/65 , C07C235/46 , C07C233/09 , C07C233/05 , C07C233/11 , C07C235/84
摘要： A method for hydrating a nitrile derivative to generate an amide derivative is provided. The method includes mixing the nitrile derivative with a ruthenium catalyst complex in an aqueous solution to form a mixture, and reacting the nitrile derivative with water in the aqueous solution and in the presence of the ruthenium catalyst complex to form a reacted mixture comprising the amide derivative. The ruthenium catalyst complex is represented by the following structural formula: RuX2(L)n, wherein X is an anionic ligand, L is a bifunctional phosphine ligand, and n is 3 or 4.
摘要翻译：提供了使腈衍生物水合以产生酰胺衍生物的方法。该方法包括将腈衍生物与钌催化剂配合物在水溶液中混合以形成混合物，并使腈衍生物与水在水溶液中反应，并在钌催化剂配合物存在下反应，形成含有酰胺衍生物。钌催化剂络合物由以下结构式表示：RuX 2（L）n，其中X为阴离子配体，L为双功能膦配体，n为3或4。

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