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1. 发明授权

US08202690B2 Cancer marker and therapeutic agent for cancer 有权
标题翻译：癌症标志物和癌症治疗剂
公开(公告)号：US08202690B2
公开(公告)日：2012-06-19
申请号：US12626346
申请日：2009-11-25
申请人： Yasutoshi Tatsumi , Akira Nakagawara
发明人： Yasutoshi Tatsumi , Akira Nakagawara
IPC分类号： C12Q1/68
CPC分类号： G01N33/57434 , A61K31/7105 , A61K31/713 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57407 , G01N33/57423 , G01N33/57442 , G01N33/57446 , G01N2333/4707
摘要： A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of prostate cancer, lung cancer, gastric cancer, bladder cancer, and uterine cancer.
摘要翻译：提供了一种新的癌症标志物。提供了使用BMCC1基因表达水平作为指标检测癌症的方法，其中癌症选自前列腺癌，肺癌，胃癌，膀胱癌和子宫癌。

2. 发明授权

US07335755B2 Nucleic acids isolated in neuroblastoma 有权
标题翻译：神经母细胞瘤中分离的核酸
公开(公告)号：US07335755B2
公开(公告)日：2008-02-26
申请号：US10478914
申请日：2002-05-30
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C07H21/02
CPC分类号： C07K14/47
摘要： There are disclosed a nucleic acid whose expression is enhanced in human neuroblastoma with unfavorable prognosis based on comparison between human neuroblastoma with favorable prognosis and human neuroblastoma with unfavorable prognosis, the nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:69 in the Sequence Listing, a nucleic acid comprising a portion of any of those base sequences, and an isolated nucleic acid capable of hybridizing to a complementary base sequence of the foregoing under stringent conditions. It discloses gene sequences relating to favorable or unfavorable prognosis of neuroblastoma and will enable the provision of their genetic information and the diagnosis of favorable or unfavorable prognosis.
摘要翻译：已经公开了基于具有良好预后的人神经母细胞瘤和具有不利预后的人神经母细胞瘤之间的比较，在具有不利预后的人神经母细胞瘤中其表达增强的核酸，所述核酸包含SEQ ID NO：1至SEQ ID NO：序列表中的NO：69，包含这些碱基序列中任一种的一部分的核酸，以及在严格条件下能够与上述互补碱基序列杂交的分离的核酸。它公开了与神经母细胞瘤有利或不利预后相关的基因序列，并且能够提供其遗传信息和诊断有利或不利的预后。

3. 发明授权

US4992374A Mutant vaccinia virus and process for production thereof 失效
标题翻译：突变痘苗病毒及其生产方法
公开(公告)号：US4992374A
公开(公告)日：1991-02-12
申请号：US79680
申请日：1987-07-30
申请人： Masanobu Sugimoto , Fukumi Nishimaki , Tadashi Maruyama , Keizaburo Miki , Michio Morita , Kazuyoshi Suzuki
发明人： Masanobu Sugimoto , Fukumi Nishimaki , Tadashi Maruyama , Keizaburo Miki , Michio Morita , Kazuyoshi Suzuki
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C12N7/00 , C12N7/06 , C12N15/00 , C12N15/863
CPC分类号： C12N15/86 , C12N15/00 , C12N7/00 , C12N2710/24121 , C12N2710/24143 , C12N2710/24162
摘要： An improved mutant vaccinia virus providing a pock and plaque size on RK13 cells that is approximately the same as those of the Lister original, having a proliferation potency on YTV cells that is approximately the same as that of the Lister original, and having a neurovirulence, assessed by a recovery of an intrabrain virus, that is lower than that of the Lister original; and a process for the production thereof.

4. 发明申请

US20220193241A1 AGENT TARGETING DOUBLE-MEMBRANE ORGANELLE DNA 有权
公开(公告)号：US20220193241A1
公开(公告)日：2022-06-23
申请号：US17603145
申请日：2020-03-19
申请人： CHIBA-PREFECTURE
发明人： Hiroki NAGASE , Takayoshi WATANABE , Nobuko KOSHIKAWA , Nanami YASUI
IPC分类号： A61K47/54 , A61K31/4178 , A61P35/00 , A61K45/06
摘要： The present invention provides a drug for a pathological condition including mitochondria-related disease by a conjugate of a double-membrane organelle DNA sequence recognizing compound and a double-membrane organelle localizable compound. The present invention provides a conjugate in which a double-membrane organelle localizable lipophilic cation is attached to linear PI polyamide that specifically binds to a double-membrane organelle DNA sequence, a linear PI polyamide-TPP conjugate targeting the mitochondrial DNA mutation or polymorphism, comprising the conjugate, and a pharmaceutical composition comprising the conjugate.

5. 发明授权

US11193172B2 Method for predicting prognosis of patient with cancer or inflammatory disease 有权
公开(公告)号：US11193172B2
公开(公告)日：2021-12-07
申请号：US15542267
申请日：2016-01-08
申请人： The University of Tokyo , CHIBA PREFECTURE
发明人： Yuya Terashima , Kouji Matsushima , Etsuko Toda , Mikiya Otsuji , Meiji Itakura
IPC分类号： C12Q1/6886 , C12Q1/04 , G01N33/53 , C12Q1/6883 , G01N33/68 , G01N33/574 , C12Q1/02
摘要： Novel means that enables prediction of prognosis of a patient with cancer or inflammatory disease is disclosed. In the method for prediction of prognosis of a patient with cancer or inflammatory disease according to the present invention, the expression level of the FROUNT gene in a sample collected from the patient is measured. Since FROUNT is a poor prognostic factor, the lower the expression level of the FROUNT gene is, the better the prognosis in the patient is predicted to be. Or, the expression level of the CC chemokine receptor/ligand gene in a sample collected from the patient is measured. Since the CC chemokine receptor/ligand gene such as CCR2 or CCR5 is a good prognostic factor, the higher the expression level of the CC chemokine receptor/ligand gene is, the better the prognosis in the patient is predicted to be.

6. 发明申请

US20190290773A1 NOVEL ALKYLATING AGENT FOR ALKYLATING TARGET WITH DRIVER ONCOGENE MUTATION 审中-公开
公开(公告)号：US20190290773A1
公开(公告)日：2019-09-26
申请号：US16377867
申请日：2019-04-08
申请人： Chiba Prefecture
发明人： Hiroki Nagase , Hiroshi Sugiyama , Toshikazu Bando
IPC分类号： A61K47/64 , C08G73/06 , C07D403/14
摘要： The present invention provides a novel alkylating agent specifically binding to the genetic mutation site of a driver oncogene. There are provided are a complex formed by binding an alkylating agent to a pyrrole imidazole polyamide specifically binding to the genetic mutation site of a driver oncogene, a driver oncogene mutation-specific alkylating agent comprising the aforementioned complex, and a pharmaceutical composition comprising the aforementioned complex.

7. 发明申请

US20190262457A1 NOVEL ALKYLATING AGENT 审中-公开
公开(公告)号：US20190262457A1
公开(公告)日：2019-08-29
申请号：US16334967
申请日：2017-09-21
申请人： CHIBA-PREFECTURE
发明人： Hiroki NAGASE , Asuka HATTORI , Takayoshi WATANABE , Atsushi TAKATORI
IPC分类号： A61K47/54 , A61P35/00 , A61K31/787
摘要： An object of the present invention is to provide a novel alkylating agent that specifically binds to an immune checkpoint gene to induce cell death, and has tumor-specific accumulating properties. The present invention provides a conjugate comprising an alkylating agent bonded to a polyamide that specifically binds to a gene encoding an immune checkpoint molecule, an alkylating agent specific for a gene encoding an immune checkpoint molecule, comprising the conjugate, and a pharmaceutical composition comprising the conjugate.

8. 发明申请

US20100279312A1 METHOD OF SCREENING APOPTOSIS ACCELERATING COMPOUND OR ANTI-APOPTOTIC COMPOUND AND METHOD OF DETERMINING MALIGNANCY OF NEURODEGENERATIVE DISEASE 有权
标题翻译：筛选加速化合物或抗微生物化合物的方法和确定神经营养因子疾病恶性的方法
公开(公告)号：US20100279312A1
公开(公告)日：2010-11-04
申请号：US12063381
申请日：2006-08-09
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/68
CPC分类号： G01N33/574 , G01N33/5011 , G01N33/6896 , G01N2333/4748 , G01N2500/02 , G01N2510/00
摘要： Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.
摘要翻译：用于测定促凋亡化合物或抗凋亡化合物的筛选方法包括在存在和不存在测试化合物的情况下测量p53和NEDL1之间的相互作用，并且比较p53和NEDL1在存在和不存在下的相互作用强度的试验化合物。

9. 发明授权

US07618787B2 Method of screening compound capable of accelerating or inhibiting apoptosis, apoptosis accelarator and apoptosis inhibitor 失效
标题翻译：筛选加速抑制细胞凋亡的化合物，凋亡加速剂和凋亡抑制剂的方法
公开(公告)号：US07618787B2
公开(公告)日：2009-11-17
申请号：US10594448
申请日：2005-03-23
申请人： Akira Nakagawara , Toshinori Ozaki
发明人： Akira Nakagawara , Toshinori Ozaki
IPC分类号： G01N33/53
CPC分类号： G01N33/502 , A61K38/00 , C07K14/4747 , G01N33/5008 , G01N2510/00
摘要： A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.
摘要翻译：一种用于筛选促凋亡化合物的方法，包括测定步骤，其确定增强p73和IKK-α之间相互作用的化合物作为促凋亡化合物。

10. 发明授权

US07358349B2 Nucleic acids having expression differentials between hepatoblastoma and normal liver 失效
标题翻译：在肝母细胞瘤和正常肝脏之间具有表达差异的核酸
公开(公告)号：US07358349B2
公开(公告)日：2008-04-15
申请号：US10487422
申请日：2002-08-26
申请人： Akira Nakagawara
发明人： Akira Nakagawara
IPC分类号： C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： G01N33/57496 , C07K14/4748 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： A nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:104 in the Sequence Listing and a protein encoded by the nucleic acid, particularly a nucleic acid displaying differential expression levels in hepatoblastoma and normal liver based on comparison therebetween and a protein encoded by the nucleic acid as well as tumor detection utilizing the foregoing.
摘要翻译：包含序列表中SEQ ID NO：1至NO：104所示的碱基序列中的任一种的核酸和由核酸编码的蛋白质，特别是基于比较显示肝母细胞瘤和正常肝脏中差异表达水平的核酸和由核酸编码的蛋白质以及利用前述物质的肿瘤检测。

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