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1. 发明申请

US20120208218A1 METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权
标题翻译：使用差异蛋白质糖蛋白检测预先糖尿病和糖尿病的方法
公开(公告)号：US20120208218A1
公开(公告)日：2012-08-16
申请号：US13457243
申请日：2012-04-26
申请人： Srinivasa R. Nagalla , Charles T. Roberts
发明人： Srinivasa R. Nagalla , Charles T. Roberts
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译：本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。还提供了用于鉴定糖尿病受试者的方法。还公开了用于鉴定患有糖尿病并发症的个体的方法。所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。

2. 发明申请

US20130274123A1 MATERNAL BIOMARKERS FOR GESTATIONAL DIABETES 有权
公开(公告)号：US20130274123A1
公开(公告)日：2013-10-17
申请号：US13792844
申请日：2013-03-11
申请人： DIABETOMICS, LLC
发明人： Srinivasa R. Nagalla
IPC分类号： G01N33/68 , G01N33/76
CPC分类号： G01N33/689 , G01N33/74 , G01N33/76 , G01N2333/471 , G01N2333/78 , G01N2800/042 , G01N2800/368 , G01N2800/60
摘要： Embodiments herein relate to the field of screening tools for fetal/maternal wellness, and, more specifically, to biomarkers for gestational diabetes. In various embodiments, the methods may provide non-invasive and minimally-invasive screening tools for gestational diabetes that involve detection of changes in a proteomic profile of a test sample relative to a reference sample. In particular embodiments, the method may include determining whether a proteomic profile of a test sample from the subject includes at least one expression signature characteristic of gestational diabetes, wherein the proteomic profile comprises information on the expression of glycosylated fibronectin and glycosylated PSG, for example information on levels of fibronectin-SNA or a fibronectin-antibody complex, and PSG-AAL or a PSG-antibody complex. In some embodiments, the proteomic profile may also include information on the expression of adiponectin, sex hormone binding globulin (SHBG), C-reactive protein (CRP), a ratio of human chorionic gonadotropin (hCG) to placental lactogen, or a combination thereof.

3. 发明授权

US08168396B2 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权
标题翻译：使用差异蛋白糖基化检测糖尿病前期和糖尿病的方法
公开(公告)号：US08168396B2
公开(公告)日：2012-05-01
申请号：US12777955
申请日：2010-05-11
申请人： Srinivasa R. Nagalla , Charles T. Roberts
发明人： Srinivasa R. Nagalla , Charles T. Roberts
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译：本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。还提供了用于鉴定糖尿病受试者的方法。还公开了用于鉴定患有糖尿病并发症的个体的方法。所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。

4. 发明授权

US10996228B2 Biomarkers for assessment of preeclampsia 有权
公开(公告)号：US10996228B2
公开(公告)日：2021-05-04
申请号：US15833656
申请日：2017-12-06
申请人： DiabetOmics, LLC
发明人： Srinivasa R. Nagalla , Eric S. Bean
IPC分类号： G01N33/68
摘要： Disclosed herein are screening tools for fetal/maternal wellness, such as biomarkers for assessing preeclampsia. More specifically, methods are disclosed for assessing the risk of preeclampsia in a subject, the methods including obtaining a first serum sample from the subject, determining a level of glycosylated fibronectin (GlyFn) in the first serum sample, and comparing the determined level of GlyFn with a control value, wherein an elevation in the determined level of GlyFn in the first serum sample relative to the control value indicates that the subject is at increased risk of preeclampsia. Also disclosed are methods of determining the risk of preeclampsia in a subject during a first, second, or third trimester, methods of assessing severity and progression of preeclampsia and complications of a risk of low birth weight or HELLP syndrome.

5. 发明授权

US08497077B2 Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权
公开(公告)号：US08497077B2
公开(公告)日：2013-07-30
申请号：US13457243
申请日：2012-04-26
申请人： Srinivasa R. Nagalla , Charles T. Roberts
发明人： Srinivasa R. Nagalla , Charles T. Roberts
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.

6. 发明申请

US20120214179A1 METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权
公开(公告)号：US20120214179A1
公开(公告)日：2012-08-23
申请号：US13457225
申请日：2012-04-26
申请人： Srinivasa R. Nagalla , Charles T. Roberts
发明人： Srinivasa R. Nagalla , Charles T. Roberts
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.

7. 发明申请

US20110124022A1 METHODS FOR DETECTING PRE-DIABETES AND DIABETES 有权
标题翻译：检测预先糖尿病和糖尿病的方法
公开(公告)号：US20110124022A1
公开(公告)日：2011-05-26
申请号：US13055605
申请日：2009-07-23
申请人： Srinivasa R. Nagalla , Charles T. Roberts , Vishnupriya Rao Paturi
发明人： Srinivasa R. Nagalla , Charles T. Roberts , Vishnupriya Rao Paturi
IPC分类号： C12Q1/48
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Non-invasive methods are provided herein for the diagnosis of pre-diabetes and diabetes using biomarkers identified in a biological fluid, such as saliva. These biomarkers can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
摘要翻译：本文提供了非侵入性方法，用于使用生物流体（例如唾液）中鉴定的生物标志物来诊断糖尿病前和糖尿病。可以使用蛋白质组学方法鉴定这些生物标志物，包括但不限于基于抗体的方法，例如酶联免疫吸附测定（ELISA），放射免疫测定（RIA）或侧流免疫测定。

8. 发明申请

US20100285498A1 METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权
标题翻译：使用差异蛋白质糖蛋白检测预先糖尿病和糖尿病的方法
公开(公告)号：US20100285498A1
公开(公告)日：2010-11-11
申请号：US12777955
申请日：2010-05-11
申请人： Srinivasa R. Nagalla , Charles T. Roberts
发明人： Srinivasa R. Nagalla , Charles T. Roberts
IPC分类号： G01N33/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译：本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。还提供了用于鉴定糖尿病受试者的方法。还公开了用于鉴定患有糖尿病并发症的个体的方法。所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。

9. 发明申请

US20150276723A1 SALIVARY PROTEIN GLYCOSYLATION TEST FOR DIAGNOSIS AND MONITORING OF DIABETES 有权
标题翻译：糖尿病诊断和监测的唾液蛋白糖蛋白测试
公开(公告)号：US20150276723A1
公开(公告)日：2015-10-01
申请号：US14226131
申请日：2014-03-26
申请人： DiabetOmics, LLC
发明人： Srinivasa R. Nagalla , Eric S. Bean
IPC分类号： G01N33/52 , G01N33/68
CPC分类号： G01N33/525 , G01N21/78 , G01N33/66 , G01N33/6872 , G01N2800/042 , G01N2800/56 , Y10T436/143333 , Y10T436/144444 , Y10T436/200833
摘要： Disclosed herein are methods and tests for diagnosing and/or monitoring a metabolic condition such as diabetes in a subject, wherein the methods and tests measure salivary glycoproteins. Some of the methods are based on the oxidation of glycoproteins in a sample from the subject, such as saliva or urine, for example using sodium metaperiodate, and then detecting the aldehydes generated during oxidation using a chemical detection method. Also disclosed are kits and lateral flow devices for detecting glycoproteins in a saliva sample.
摘要翻译：本文公开了用于诊断和/或监测受试者中的代谢病症如糖尿病的方法和测试，其中所述方法和测试测量唾液糖蛋白。一些方法基于来自受试者的样品（例如唾液或尿液）中糖蛋白的氧化，例如使用偏高碘酸钠，然后使用化学检测方法检测在氧化期间产生的醛。还公开了用于检测唾液样品中的糖蛋白的试剂盒和侧流装置。

10. 发明授权

US08975034B2 Maternal biomarkers for gestational diabetes 有权
标题翻译：产妇妊娠糖尿病生物标志物
公开(公告)号：US08975034B2
公开(公告)日：2015-03-10
申请号：US14085974
申请日：2013-11-21
申请人： DiabetOmics, LLC
发明人： Srinivasa R. Nagalla
IPC分类号： G01N33/53 , G01N33/68 , G01N33/76 , G01N33/74
CPC分类号： G01N33/689 , G01N33/74 , G01N33/76 , G01N2333/471 , G01N2333/78 , G01N2800/042 , G01N2800/368 , G01N2800/60
摘要： Embodiments herein relate to the field of screening tools for fetal/maternal wellness, and, more specifically, to biomarkers for gestational diabetes. In various embodiments, the methods may provide non-invasive and minimally-invasive screening tools for gestational diabetes that involve detection of changes in a proteomic profile of a test sample relative to a reference sample. In particular embodiments, the method may include determining whether a proteomic profile of a test sample from the subject includes at least one expression signature characteristic of gestational diabetes, wherein the proteomic profile comprises information on the expression of glycosylated fibronectin and glycosylated PSG, for example information on levels of fibronectin-SNA or a fibronectin-antibody complex, and PSG-AAL or a PSG-antibody complex. In some embodiments, the proteomic profile may also include information on the expression of adiponectin, sex hormone binding globulin (SHBG), C-reactive protein (CRP), a ratio of human chorionic gonadotropin (hCG) to placental lactogen, or a combination thereof.
摘要翻译：本文的实施方案涉及用于胎儿/母亲健康的筛选工具领域，更具体地，涉及用于妊娠糖尿病的生物标志物的领域。在各种实施方案中，所述方法可以提供用于妊娠糖尿病的非侵入性和最小侵入性筛选工具，其涉及检测测试样品相对于参考样品的蛋白质组图谱的变化。在具体实施方案中，该方法可以包括确定来自受试者的测试样品的蛋白质组图谱是否包括妊娠糖尿病特征的至少一个表达特征，其中蛋白质组学特征包括关于糖基化纤连蛋白和糖基化PSG的表达的信息，例如信息纤连蛋白-SNA或纤连蛋白 - 抗体复合物水平，PSG-AAL或PSG-抗体复合物。在一些实施方案中，蛋白质组学特征还可以包括关于脂联素，性激素结合球蛋白（SHBG），C-反应蛋白（CRP），人绒毛膜促性腺激素（hCG）与胎盘乳糖的比例或其组合的表达的信息。

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