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1. 发明授权

US11499647B2 Remotely actuated valve for a biological liquid treatment system 有权
公开(公告)号：US11499647B2
公开(公告)日：2022-11-15
申请号：US16708030
申请日：2019-12-09
申请人： GE Healthcare Bio-Sciences AB
发明人： Klaus Heinrich Gebauer , Stefan Sjolander
IPC分类号： F16K31/12 , F16K7/12 , B01D15/10 , B01D29/90 , C12M1/00 , C12M1/34
摘要： The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.

2. 发明申请

US20210123010A1 DETECTION OF FOAM LEVELS 有权
公开(公告)号：US20210123010A1
公开(公告)日：2021-04-29
申请号：US16328431
申请日：2017-08-28
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： KLAUS GEBAUER , PIERRE LE GREVES , ANDREW DAVID PRIS , JOZSEF VASI , SAM PETROCELLI , HANNO EHRING , ESMAEIL HEIDARI , ALI CAN
IPC分类号： C12M1/21 , C12M1/00 , C12M1/36
摘要： A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.

3. 发明授权

US10746708B2 Rotary valve and a chromatography system 有权
公开(公告)号：US10746708B2
公开(公告)日：2020-08-18
申请号：US15562632
申请日：2016-03-23
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Bjorn Markus Olovsson
IPC分类号： F16K11/074 , G01N30/20
摘要： The present invention relates to a rotary valve and to a chromatography system comprising such a rotary valve. The rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor (1) is rotatably movable to a plurality of rotor positions about a rotational axis (RA) relative to the inner stator face (202), wherein the stator comprises ports and orifices and the rotor comprises two or more rotor interconnection paths for selective fluidic interconnection of said orifices with respect to the rotor position and wherein the rotor interconnection paths are arranged to in a rotary position connect the first orifice (S) to the fourth orifice (LF), the second orifice (W) to the third orifice (LE). And in a rotary position connect the eight orifice (SP) to the seventh orifice (PCFP). And in a rotary position connect the eight orifice (SP) to the fifth orifice (TC), the sixth orifice (FC) to the seventh orifice (PCFP). And in a rotary position connect the eight orifice (SP) to the third orifice (LE), the fourth orifice (LF) to the fifth orifice (TC), the sixth orifice (FC) to the seventh orifice (PCFP).

4. 发明授权

US10732176B2 Method for specific identification of target biomolecules 有权
公开(公告)号：US10732176B2
公开(公告)日：2020-08-04
申请号：US14128379
申请日：2012-06-27
申请人： Lennart Bjorkesten , Sofia Edlund , Asa Hagner-McWhirter
发明人： Lennart Bjorkesten , Sofia Edlund , Asa Hagner-McWhirter
IPC分类号： G01N33/543 , G01N33/561 , G01N27/447
摘要： The present invention relates to a method for identification of specific target proteins in a protein sample following a detection procedure, such as a Western blotting procedure, wherein the membrane is probed with at least two primary antibodies directed against the same and/or different epitopes of the same target protein, and wherein specific binding to the target protein in a sample is differentiated from unspecific binding to the target protein by comparing the resulting sample patterns, such as bands or spot patterns, with each other.In a further step signals from the true target proteins are enhanced while signals resulting from unspecific binding are diminished.

5. 发明授权

US10663461B2 Screening method 有权
公开(公告)号：US10663461B2
公开(公告)日：2020-05-26
申请号：US13990759
申请日：2011-11-29
申请人： Markku Hamalainen , Hakan Roos
发明人： Markku Hamalainen , Hakan Roos
IPC分类号： G01N33/48 , G01N33/543 , C40B30/04 , G06G7/58 , G16C20/20 , G16B35/00 , G16C20/60
摘要： A method of screening a plurality of fluid samples for the presence of species capable of specifically binding to a binding partner immobilized on a sensing surface of a sensor is disclosed. The method comprises contacting each sample with the sensing surface and a reference surface, and subjecting the sensing surface responses obtained for all samples to a computational process which comprises fitting al responses to a model equation for the relationship between a response at the sensing surface and the corresponding response at the reference surface. In an iterative process residuals above a pre-determined threshold value are removed, the model equation is adjusted, and all remaining samples are refitted to the adjusted model equation until the model equation at least substantially converges. Residuals above the predetermined threshold value are considered as species specifically binding to the binding partner. The method may be computer-implemented, and a computer program product therefore comprises instructions for causing a computer to perform the computational process.

6. 发明授权

US10620172B2 Method and apparatus for performing liquid chromatography purification 有权
公开(公告)号：US10620172B2
公开(公告)日：2020-04-14
申请号：US15526506
申请日：2015-11-16
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Lena Nyholm , Lotta Hedkvist , Johan Arthursson , Eva Cecilia Olsson , Henrik Larsson
IPC分类号： G01N30/86 , B01D15/24 , G01N30/82 , B01D15/10
CPC分类号： G01N30/8631 , B01D15/247 , G01N30/82 , G01N30/8644 , B01D15/10 , B01D15/24
摘要： The present invention relates to a method for performing liquid chromatography purification of one or more target molecules from a sample comprising: providing an eluent flow having one or more target molecules, measuring an output parameter indicative of the content of the one or more target molecules in the eluent flow, storing output parameter data, and dividing the eluent flow into consecutive eluent fractions, dividing the output parameter data into corresponding data fractions, in each data fraction obtaining a value indicative of characteristic behavior of the measured output parameter, identifying trends in the measured output parameter based upon the obtained value in consecutive data fractions, and identifying peak(s) in the measured output parameter correlated to eluent fractions based upon the identified trends, whereby information of identified peak(s) and correlated eluent fraction(s) can be presented and purified sample(s) from the eluent may be collected.

7. 发明授权

US10598640B2 Method for baseline correction in a chromatogram 有权
公开(公告)号：US10598640B2
公开(公告)日：2020-03-24
申请号：US15066429
申请日：2016-03-10
申请人： GE Healthcare Bio-Sciences AB
发明人： Gunnar Malmquist , Martin Hall , Nils Stafstrom
IPC分类号： G01N30/86 , G01N30/74 , G01N30/34
摘要： The invention discloses a method for correcting a baseline in a chromatogram obtained using a buffer with at least one UV-absorbing component which is a weak acid or a weak base. The method comprises the steps of:a) providing a chromatography system with a chromatography column and a UV detector downstream of the chromatography column;b) providing UV extinction coefficients at a wavelength λ for the acid form and the base form of the UV-absorbing component(s) and a dissociation constant for the component(s),c) obtaining a chromatogram with the UV detector at wavelength λ using the buffer under a set of conditions where pH and/or conductivity is varied between these conditions,d) for a plurality of said conditions calculating the concentrations of the acid and base forms using the dissociation constant(s) and values for pH and conductivity values, ande) calculating UV absorption values of the acid and base forms from the concentrations and UV extinction coefficients under the conditions in question and subtracting the UV absorption values from the chromatogram.

8. 发明授权

US10589239B2 Fluid mixing in a disposable fluid processing system 有权
公开(公告)号：US10589239B2
公开(公告)日：2020-03-17
申请号：US13808606
申请日：2011-06-27
申请人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
发明人： Klaus Gebauer , Patric Fricking , Bjorn Jaderlund
IPC分类号： B01F15/02 , G05D11/13 , G01N30/34 , B01D15/16 , B01D15/12 , G01N30/86
摘要： High accuracy mixing of fluids in a disposable fluid processing system with at least two pumps is provided by a method where a calibration fluid volume is pumped through each pump via a flow meter at at least one calibration pump speed while registering the flow rate using data output from the flow meter, a pump calibration function is calculated from the calibration pump speed and flow rate data and two or more operation fluids are mixed to a predetermined mixture ratio and predetermined flow rate by controlling the pump speed of the respective pumps in accordance with the pump calibration functions.

9. 发明授权

US10551303B2 Flow cell optical detection system 有权
公开(公告)号：US10551303B2
公开(公告)日：2020-02-04
申请号：US15633678
申请日：2017-06-26
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Hakan Frojdh , Mikael Hornqvist , Stig Tormod , Patrik Akerstrom
IPC分类号： G01N21/33 , G01J3/02 , G01N21/05 , G01J3/42 , G01N21/51 , G01J3/433 , G01N21/03
摘要： The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

10. 发明授权

US10545090B2 Method and system for more reliable determination of interaction parameters for low affinity analytes 有权
公开(公告)号：US10545090B2
公开(公告)日：2020-01-28
申请号：US13512362
申请日：2010-11-29
申请人： Olof Karlsson
发明人： Olof Karlsson
IPC分类号： G01N33/557 , G01N21/552
摘要： A method of determining one or more interaction parameters for the interaction between an analyte and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with a control analyte, C: registering the sensor response from binding of the control analyte to binding sites of the ligand, D: determining the control saturation response (RmaxC) for the interaction between the control analyte and the ligand, E: transforming the control saturation response (RmaxC) to an analyte saturation response (RmaxA) using the relative molar response contribution of the analyte and the control analyte. F: contacting the sensor surface with one or more samples containing different concentrations of the analyte, G: registering the sensor response from binding of the analyte to the binding sites, and H: fitting the registered sensor response to a predetermined interaction model using the analyte saturation response (RmaxA) to determine the interaction parameters.

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