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1. 发明授权

US11911757B2 Pipetting device for pulsed pipetting with a pipetting piston movement controlled on the basis of a detection of the piston position 有权
公开(公告)号：US11911757B2
公开(公告)日：2024-02-27
申请号：US17258488
申请日：2019-07-09
申请人： Hamilton Bonaduz AG
发明人： Hanspeter Romer , Reto Ettinger , Fridolin Gysel , Jürg Rast , Jonas Hilti
IPC分类号： B01L3/02
CPC分类号： B01L3/0227 , B01L3/0237 , B01L3/0268 , B01L2200/14 , B01L2300/0663 , B01L2400/043 , B01L2400/0478
摘要： A pipetting device includes a pipetting channel at least partially filled with working gas, a pipetting tip accessible through a pipetting opening such that the volume of dosing liquid drawn into the receiving chamber can be varied by changing the pressure of the working gas in the receiving chamber, a pipetting piston for changing the pressure of the working gas and accommodated in the pipetting channel to be movable along the pipetting channel, a drive driving the pipetting piston to perform a movement along the pipetting channel, a control device controlling the drive, and a pressure sensor sensing the pressure of the working gas. The control device controls the drive to generate a pressure pulse in the pipetting channel based on the pressure signal output by the pressure sensor whereby the pressure of the working gas during the pulse follows a predefined working gas target pressure pulse curve.

2. 发明申请

US20220023852A1 LIQUID-METERING DEVICE FOR BALLISTICALLY DISCHARGING METERED AMOUNTS IN THE NANOLITER RANGE, LIQUID-METERING METHOD AND PIPETTING TIP THEREFOR 有权
公开(公告)号：US20220023852A1
公开(公告)日：2022-01-27
申请号：US17299900
申请日：2019-12-02
申请人： HAMILTON BONADUZ AG , BIOFLUIDIX GMBH
发明人： Jörg Pochert , Andreas Ernst , Nils Lass
IPC分类号： B01L3/02
摘要： A liquid-metering device for discharging metered liquid in the nanometer range, includes a pipetting-tip receiving device defining, at least in a metering-ready operating position of the liquid-metering device, a receiving space that runs along a virtual receiving axis and is designed to receive a portion of a pipetting-tip. The liquid-metering device also includes a triggering plunger moveable relative to the pipetting-tip receiving device, between a standby position and a triggering position. The liquid-metering device also includes movement drive, which is coupled to the triggering plunger so as to transmit motion, and a control device for controlling operation of the movement drive. A first and second deformation formation define therebetween an axial longitudinal region of the receiving space as a deformation region, in which region the first and second formations can be brought closer or farther away to/from one another. The triggering plunger is located in the deformation region.

3. 发明申请

US20210322969A1 DEVICE AND METHOD FOR DETERMINING THE QUALITY OF PULSED DISPENSING OF LIQUID ACCORDING TO THE AIR DISPLACEMENT PRINCIPLE 有权
公开(公告)号：US20210322969A1
公开(公告)日：2021-10-21
申请号：US17283296
申请日：2019-10-08
申请人： HAMILTON BONADUZ AG
发明人： Jonas Hilti
IPC分类号： B01L3/02
摘要： A pipette device comprises a pipette channel filled with compressible working gas, a pipette piston movable along the pipette path, a piston drive, which drives the pipette piston, a control device, a data memory connected to the control device for signal transmission, a pressure sensor which detects the pressure of the working gas and which is connected to the control device, a position sensor which detects a position of the pipette piston and which is connected to the control device. The control device is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid remaining in the pipette channel, of a working gas pressure and of an end position of the pipette piston, in each case after the end of the dispensing sequence, and to output the determined quality.

4. 发明申请

US20200278371A9 PIPETTING DEVICE HAVING A DISPLACEABLE PIPETTING CHANNEL HAVING ENLARGED SUPPORTING LOCATION SPACING 审中-公开
公开(公告)号：US20200278371A9
公开(公告)日：2020-09-03
申请号：US16315923
申请日：2017-07-03
申请人： Hamilton Bonaduz AG
发明人： Hanspeter Romer , Silvio Walpen
IPC分类号： G01N35/10
摘要： A pipetting apparatus (10) having a guidance frame (12) having a first linear guidance rail (52) and having a second linear guidance rail (56), the first and the second linear guidance rail (52, 56) proceeding parallel to one another along a displacement axis (VL) and being provided at a distance from one another orthogonally to the displacement axis (VL), and having a pipetting channel (14) which extends along a channel axis (K14) that is nonparallel, preferably orthogonal, to the displacement axis (VL) and which is guided displaceably along the displacement axis (VL) with a first bearing component (54) on the first linear guidance rail (52) and with a second bearing component (58) on the second linear guidance rail (56), is characterized in that the first and the second bearing component (54, 58) are arranged with a spacing (A) from one another along the displacement axis (VL).

5. 发明申请

US20190226010A1 SAMPLE HANDLING SYSTEM WITH DOSING DEVICE AND THERMAL CYCLER 审中-公开
公开(公告)号：US20190226010A1
公开(公告)日：2019-07-25
申请号：US16373148
申请日：2019-04-02
申请人： HAMILTON Bonaduz AG
发明人： Martin GAJEWSKI , Mario ARANGIO
IPC分类号： C12Q1/686 , G01N35/10 , G01N35/02 , G01N35/00
摘要： A sample handling system and a process for the handling of chemical or biological samples is provided. The system includes a dosing device with a receiving plate configured in an essentially horizontal position in a plane defined by a first and a second axis. The dosing device has at least one working arm that is movable. The pipetting mechanism includes at least one pipetting channel that is movable and has a pipette tip mounted or mountable thereon. The system further includes at least one thermal cycler provided in the area of the receiving plate. The thermal cycler is configured on the receiving plate in such a way that the pipetting mechanism is movable in a position above the sample vessels in the thermal cycler, in a setting that allows a pipetting step to be carried out into the sample vessels in the thermal cycler by the pipetting mechanism in the position above the sample vessels in the thermal cycler.

6. 发明申请

US20190032002A1 CELL SEPARATION DEVICE AND USE OF A FLOW FORMATION FOR THE CELL SEPARATION DEVICE 审中-公开
公开(公告)号：US20190032002A1
公开(公告)日：2019-01-31
申请号：US16077588
申请日：2017-02-09
申请人： Hamilton Bonaduz AG , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： Tom Kissling , Jens Grosch , Thomas Zumstein , Andrea Traube , Carsten Etzold , Tobias Seiler
IPC分类号： C12M1/00
摘要： A cell separation apparatus a container for reception of a cell suspension and a conduit connected to the container for the conveyance of cell suspension out of the container. The conduit extends along a notional conduit path passing centrally through the conduit, the conduit path defining in the conduit an axial direction proceeding along the conduit path, a radial direction orthogonal to the conduit path, and a circumferential direction proceeding around the conduit path. A segment of the conduit constitutes a turbulent flow segment including a flow configuration. The flow configuration includes at least two axial configuration segments located axially behind one another to accelerate a cell suspension.

7. 发明授权

US09689884B2 Pipetting machine having a disposal container 有权
公开(公告)号：US09689884B2
公开(公告)日：2017-06-27
申请号：US14387896
申请日：2013-04-14
申请人： HAMILTON BONADUZ AG
发明人： Torsten Peetz , Andreas Städler
IPC分类号： G01N35/10 , B01L9/00
CPC分类号： G01N35/1074 , B01L9/543 , G01N2035/103
摘要： A metering apparatus includes a base and a vertical support coupled to the base and extending upwardly from the base. The metering apparatus also includes a transverse support coupled to the vertical support, vertically spaced from the base. The metering apparatus also includes a pipetting device coupled to the transverse support, the pipetting device including at least one pipetting channel configured to attach to a pipetting tip. The metering apparatus also includes a disposal container configured to receive used pipetting tips from the pipetting channel, detachably coupled to the vertical support. The pipetting device is movable in first, second, and third directions substantially orthogonal to each other. The disposal container is moveable in one of the first, second, and third directions.

8. 发明授权

US09599596B2 Optical sensor element 有权
公开(公告)号：US09599596B2
公开(公告)日：2017-03-21
申请号：US14403881
申请日：2013-05-29
申请人： HAMILTON Bonaduz AG
发明人： Dirk Schoenfuss , Claudius-Michael Ortega Schulte
IPC分类号： G01N31/22 , G01N21/64 , G01N21/77
CPC分类号： G01N31/225 , G01N21/6408 , G01N21/6428 , G01N21/643 , G01N21/77 , G01N2021/6432 , G01N2021/6439 , G01N2021/773 , G01N2021/7786 , G01N2021/7796 , G01N2201/062
摘要： The invention relates to an optical sensor element, comprising indicators (2), selected from luminescence-active means that are of the same type or different, and indicator protectors (1), and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.

9. 发明授权

US09567561B2 Single-use biomass sensing device, method for producing this device and single-use bioreactor incorporating this sensor 有权
标题翻译：一次性生物质传感装置，用于生产该装置的方法和结合该传感器的一次性生物反应器
公开(公告)号：US09567561B2
公开(公告)日：2017-02-14
申请号：US13055836
申请日：2009-07-24
申请人： Frederic Ossart
发明人： Frederic Ossart
IPC分类号： C12M1/34 , G01N27/22 , G01N33/487 , C12M1/00
CPC分类号： C12M41/46 , C12M23/28 , C12M41/36 , G01N27/221 , G01N33/48735 , Y10T29/49002
摘要： A single-use bioreactor or container including an enclosure provided for containing a biological medium, and at least one device for making at least one impedance measurement in a physical, physico-chemical and/or biological process in this medium. The sensing device is fixed through a wall of the enclosure in such a way as to be an integral part thereof and includes a detection part in direct contact with an inside of the bioreactor or container and a connection part extending towards an outside of the enclosure.
摘要翻译：一种包括提供用于容纳生物介质的外壳的一次性生物反应器或容器，以及用于在该介质中在物理，物理化学和/或生物过程中进行至少一个阻抗测量的至少一个装置。感测装置通过外壳的壁固定成为其整体部分，并且包括与生物反应器或容器的内部直接接触的检测部分和朝向外壳的外部延伸的连接部分。

10. 发明授权

US09415388B2 Pipette tip, pipette device, and combination of pipette tip and pipette device 有权
标题翻译：移液器吸头，移液器装置以及移液器吸头和移液器装置的组合
公开(公告)号：US09415388B2
公开(公告)日：2016-08-16
申请号：US11247073
申请日：2005-10-11
申请人： Armin Panzer , Johann L. Camenisch
发明人： Armin Panzer , Johann L. Camenisch
IPC分类号： B01L3/02
CPC分类号： B01L3/0279
摘要： A pipette device has a coupling stud on which a pipette tip can be stuck in a slipping-on direction for coupling. The coupling stud has an adjustable prestress member that can be adjusted into a prestress state and a release state via an actuation device which is provided in the coupling stud. The pipette tip has an axial stop which interacts with a counter-stop of the coupling stud in an axial coupling position of the pipette tip. The prestress member in its prestress state acts upon a working surface of the stuck-on pipette tip having a surface component of the pipette tip, which extends radially inward, turned away from the stuck on direction, in such a way that it abuts sealingly on the working surface, and prestresses the pipette tip on the pipette unit into the axial coupling position. The prestress member, in its releasing state, substantially releases the working surface of the pipette tip (101).
摘要翻译：移液管装置具有联接螺柱，移液管末端可以以滑动方向粘合在其上用于联接。联接螺柱具有可调节的预应力构件，其可以经由设置在联接柱中的致动装置调节到预应力状态和释放状态。移液管末端具有轴向止动件，其与吸头尖端的轴向联接位置与联接柱的反向止动相互作用。在其预应力状态下的预应力构件作用在粘性移液管尖端的工作表面上，该工作表面具有移液管尖端的表面部分，其径向向内延伸，远离卡住的方向转动，使得其紧密地邻接工作表面，并将移液管单元上的移液器末端预应力到轴向联接位置。处于其释放状态的预应力构件基本上释放移液管尖端（101）的工作表面。

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